Homo sapiens (human): 1615
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Entry
1615 CDS
T01001
Symbol
DARS1, DARS, HBSL, aspRS
Name
(RefSeq) aspartyl-tRNA synthetase 1
KO
K22503
aspartyl-tRNA synthetase [EC:
6.1.1.12
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00970
Aminoacyl-tRNA biosynthesis
Disease
H02433
Hypomyelination with brainstem and spinal cord involvement and leg spasticity
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
1615 (DARS1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
1615 (DARS1)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
1615 (DARS1)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.12 aspartate---tRNA ligase
1615 (DARS1)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class II (A)
1615 (DARS1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Multi-aminoacyl-tRNA synthetase complex (MSC)
1615 (DARS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_2
tRNA_anti-codon
tRNA-synt_2d
S-AdoMet_synt_N
Motif
Other DBs
NCBI-GeneID:
1615
NCBI-ProteinID:
NP_001340
OMIM:
603084
HGNC:
2678
Ensembl:
ENSG00000115866
UniProt:
P14868
A0A140VJW5
Structure
PDB
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All DBs
Position
2:complement(135905881..135985684)
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AA seq
501 aa
AA seq
DB search
MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV
WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV
RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL
DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF
KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH
EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV
EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM
RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF
LGLHNVRQTSMFPRDPKRLTP
NT seq
1506 nt
NT seq
+upstream
nt +downstream
nt
atgcccagcgccagcgccagccgcaagagtcaggagaagccgcgggagatcatggacgcg
gcggaagattatgctaaagagagatatggaatatcttcaatgatacaatcacaagaaaaa
ccagatcgagttttggttcgggttagagacttgacaatacaaaaagctgatgaagttgtt
tgggtacgtgcaagagttcatacaagcagagctaaagggaaacagtgcttcttagtccta
cgtcagcagcagtttaatgtccaggctcttgtggcggtgggagaccatgcaagcaagcag
atggttaaatttgctgccaacatcaacaaagagagcattgtggatgtagaaggtgttgtg
agaaaagtgaatcagaaaattggaagctgtacacagcaagacgttgagttacatgttcag
aagatttatgtgatcagtttggctgaaccccgtctgcccctgcagctggatgatgctgtt
cggcctgaggcagaaggagaagaggaaggaagagctactgttaaccaggatacaagatta
gacaacagagtcattgatcttaggacatcaactagtcaggcagtcttccgtctccagtct
ggcatctgccatctcttccgagaaactttaattaacaaaggttttgtggaaatccaaact
cctaaaattatttcagctgccagtgaaggaggagccaatgtttttactgtgtcatatttt
aaaaataatgcatacctggctcagtccccacagctatataagcaaatgtgcatttgtgct
gattttgagaaggttttctctattggaccagtattcagagcggaagactctaatacccat
agacatctaactgagtttgttggtttggacattgaaatggcttttaattaccattaccac
gaagttatggaagaaattgctgacaccatggtacaaatattcaaaggacttcaagaaagg
tttcagactgaaattcaaacagtgaataaacagttcccatgtgagccattcaaatttttg
gagccaactctaagactagaatattgtgaagcattggctatgcttagggaagctggagtc
gaaatgggagatgaagacgatctgagcacaccaaatgaaaagctgttgggtcatttggta
aaggaaaagtatgatacagatttttatattcttgataaatatccattggctgtaagacct
ttctataccatgcctgacccaagaaatcccaaacagtccaactcttacgatatgttcatg
agaggagaagaaatattgtcaggagctcaaagaatacatgatcctcaactgctaacagag
agagctttacatcatggaattgatttggagaaaattaaggcttacattgattccttccgc
tttggagcccctcctcatgctggtggaggcattggattggaacgagttactatgctgttt
ctgggattgcataatgttcgtcagacctccatgttccctcgtgatcccaaacgactcact
ccttaa
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