Homo sapiens (human): 1659
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Entry
1659 CDS
T01001
Symbol
DHX8, DDX8, Dhr2, HRH1, PRP22, PRPF22
Name
(RefSeq) ATP-dependent RNA helicase DHX8 isoform 1
KO
K12818
ATP-dependent RNA helicase DHX8/PRP22 [EC:
5.6.2.6
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03040
Spliceosome
Network
nt06547
Spliceosome
Element
N01993
Spliceosome catalysis (exon ligation)
N01994
Spliceosome disassembly
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09121 Transcription
03040 Spliceosome
1659 (DHX8)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03041 Spliceosome [BR:
hsa03041
]
1659 (DHX8)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.6 RNA 3'-5' helicase
1659 (DHX8)
Spliceosome [BR:
hsa03041
]
Complex C
Other components
Step II factors
1659 (DHX8)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
OB_NTP_bind
HA2_C
S1
Helicase_C
WHD_HA2
DEAD
AAA_22
GIPC1_GH2
AAA_19
nSTAND3
Flavi_DEAD
T2SSE
AAA_16
Sigma54_activ_2
PhoH
TsaE
nSTAND_NTPase5
OB_RRP5_4th
Motif
Other DBs
NCBI-GeneID:
1659
NCBI-ProteinID:
NP_004932
OMIM:
600396
HGNC:
2749
Ensembl:
ENSP00000262415.2
UniProt:
Q14562
Q86YB2
Q05CV4
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:43483975..43544799
Genome browser
AA seq
1220 aa
AA seq
DB search
MAVAVAMAGALIGSEPGPAEELAKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKN
TTFDTFKASLVKNGAEFTDSLISNLLRLIQTMRPPAKPSTSKDPVVKPKTEKEKLKELFP
VLCQPDNPSVRTMLDEDDVKVAVDVLKELEALMPSAAGQEKQRDAEHRDRTKKKKRSRSR
DRNRDRDRDRERNRDRDHKRRHRSRSRSRSRTRERNKVKSRYRSRSRSQSPPKDRKDRDK
YGERNLDRWRDKHVDRPPPEEPTIGDIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISEL
RREGRVANVADVVSKGQRVKVKVLSFTGTKTSLSMKDVDQETGEDLNPNRRRNLVGETNE
ETSMRNPDRPTHLSLVSAPEVEDDSLERKRLTRISDPEKWEIKQMIAANVLSKEEFPDFD
EETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPIKIVKNPDGSLSQAAMMQS
ALAKERRELKQAQREAEMDSIPMGLNKHWVDPLPDAEGRQIAANMRGIGMMPNDIPEWKK
HAFGGNKASYGKKTQMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQ
YLAEAGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKY
MTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTSATL
DAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPETDYLDASLITVMQIHLTEPPGDILVFL
TGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATN
IAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCY
RLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQ
LYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYR
PKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRK
QMLGIMDRHKLDVVSCGKSTVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSA
LFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTKLSKQKKQQRLEP
LYNRYEEPNAWRISRAFRRR
NT seq
3663 nt
NT seq
+upstream
nt +downstream
nt
atggctgtggctgtagccatggcgggagccttaatcgggtcggagccaggccccgcggaa
gaacttgccaaactcgagtacctgtctttggtgtcaaaggtttgcactgagctggacaat
cacttggggatcaacgacaaggaccttgctgaatttgtgatcagtcttgctgagaaaaat
accacctttgatacttttaaggcttctctcgtcaaaaatggtgcagaatttacggattct
cttattagtaacttgctgcgtctcatacaaaccatgcggcctccagcgaagccttccact
agcaaagatccagttgttaaacctaaaacagaaaaagaaaagctgaaggaactcttccca
gtcctttgccaaccggacaacccttctgttcggaccatgttggatgaagatgatgtgaaa
gttgctgtggatgtcctgaaagaactggaagctttaatgcccagcgcagcaggccaggag
aagcaaagagatgctgaacaccgggacaggacaaagaagaagaagcggagtcgaagccga
gatcgaaaccgagatcgagacagagatagggaacgaaaccgagatagagaccacaagcgg
agacaccgatcccgctctcgatcacgttccaggacccgggagaggaataaagtgaagtct
agatatcggtccaggagcaggagtcagagtccccccaaagaccggaaggaccgggacaaa
tatggagagcggaatctggatagatggcgggataagcatgtggaccgccctcctccagaa
gagcccaccattggtgacatttataatggcaaagttaccagcatcatgcagtttggttgc
tttgtgcagctggaaggactaaggaagcggtgggaaggcctggtgcacatctctgagctc
cggcgggagggtcgtgtggccaatgtagctgatgtcgtgagcaaaggccagagggtcaaa
gtcaaagtgctgtccttcactgggaccaagaccagcctgagcatgaaggatgtggatcaa
gagactggagaagatctaaacccaaatagacggcgaaatcttgtcggggagaccaatgag
gagacctcaatgcggaatcctgatagacccactcacttgtcccttgtcagtgctcctgaa
gtagaggacgactcactggaacgcaagcgcctcacccgaatctctgacccagagaagtgg
gagatcaaacagatgattgctgccaatgtcctttccaaagaagaatttccagactttgat
gaagagactggcattctccctaaggtggatgatgaagaagatgaggaccttgagattgaa
ttggttgaggaagagcctccattcctgagagggcacactaagcaaagcatggacatgagc
cccattaaaattgtcaagaacccagacggctccctctcccaagcagcaatgatgcagagt
gccttggccaaagaaaggcgggaactcaaacaggcccagcgggaagctgagatggattct
attcccatgggactcaacaaacactgggttgaccctctgcctgatgcggaaggcagacag
attgctgccaacatgaggggtattgggatgatgcccaatgatattcctgagtggaagaag
catgcctttgggggcaacaaagcctcttacggaaaaaagacccagatgtcaatccttgag
cagagggagagcctgcccatctacaaactgaaggagcaattggtccaggccgtccatgac
aatcagatcctgattgtcattggtgagacaggatctggaaagacaacacagatcacccag
tacctggcggaggcaggctacacttccaggggcaagattgggtgtacccagcccagaaga
gtggcagctatgtcggtggccaaaagagtgtcagaggagtttggttgttgcttaggccaa
gaggtgggctacaccattcgatttgaggactgcactagccctgaaacagtcatcaagtac
atgacagatgggatgttgcttagagagtgcttgattgaccctgacctcactcagtacgcg
atcatcatgttggacgaggcacatgagaggacaattcacactgatgtgctctttggattg
ttgaaaaagacagttcagaaacggcaggacatgaagctgattgtcacctcagccaccttg
gatgcagtgaagttttctcaatacttctatgaagctcccattttcaccatcccaggtcga
acatatccagtggaaatactgtacacaaaggaacctgagacagattatctggatgccagc
ctgattactgttatgcagattcatttaacagaaccaccaggtgatatcctggtcttcctg
actggtcaggaagaaattgatactgcttgtgagatcctgtatgaaagaatgaaatccctg
ggacctgatgttccagagttaattatcctcccagtgtactctgctcttcccagtgagatg
cagacccgaatctttgacccagctccaccaggcagcagaaaggttgtgattgccaccaat
atcgcagagacatcgctgactattgatggtatctactatgtggtggacccaggattcgtg
aaacagaaagtttacaattccaagacagggattgaccagctcgtggtgacgcctatttct
caggctcaggcaaagcaacgagctggcagagctgggagaacaggcccagggaagtgttac
aggttgtacacagaacgtgcctaccgagatgaaatgctgaccaccaacgtgccggaaatc
cagagaaccaacttagcaagcacagtgctgtcactcaaggccatgggtatcaatgatctg
ctgtcctttgatttcatggatgccccacctatggaaactttgatcacagccatggagcag
ctgtacacactgggggccctggatgacgagggcctgctcactcgcttgggccgccggatg
gcagagttccctctggagccaatgctatgcaaaatgctcatcatgtctgtgcatctgggc
tgcagtgaggaaatgctgaccattgtatccatgctgtctgtgcagaacgtcttctatagg
cccaaggataaacaagcccttgcagatcagaagaaggccaaattccaccagactgaaggg
gaccacctcaccctgctagctgtgtacaactcctggaagaacaacaagttctccaaccca
tggtgctatgagaactttatccaggctcgttccctgcgccgggcccaggacattcgcaag
cagatgttaggcataatggacagacacaagctggatgttgtttcctgtggcaagtccaca
gtccgagtgcagaaggccatctgcagtgggttcttccgtaatgctgccaagaaagacccg
caggagggttaccggacactgatcgaccagcaggtggtctatatccatccttccagtgcc
ctcttcaacagacagccagaatgggtggtgtaccatgagctggtgctcaccaccaaggaa
tacatgcgtgaagttaccaccatcgaccctcggtggcttgtggagtttgccccagccttc
ttcaaggtctcagacccaactaagctaagcaaacagaagaagcaacagcgtcttgaaccc
ttgtacaaccgctatgaggaacccaatgcctggagaatatctcgagctttccgacggcgc
tga
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integrated database retrieval system
