Homo sapiens (human): 1735
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Entry
1735 CDS
T01001
Symbol
DIO3, 5DIII, D3, DIOIII, TXDI3
Name
(RefSeq) iodothyronine deiodinase 3
KO
K07754
thyroxine 5-deiodinase [EC:
1.21.99.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04919
Thyroid hormone signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
1735 (DIO3)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.21 Catalysing the reaction X-H + Y-H = X-Y
1.21.99 With unknown physiological acceptors
1.21.99.3 thyroxine 5-deiodinase
1735 (DIO3)
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Gene cluster
GFIT
Motif
Pfam:
T4_deiodinase
AhpC-TSA
Redoxin
Motif
Other DBs
NCBI-GeneID:
1735
NCBI-ProteinID:
NP_001353
OMIM:
601038
HGNC:
2885
Ensembl:
ENSG00000197406
UniProt:
P55073
Q86TU3
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All DBs
Position
14:101561495..101563452
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AA seq
304 aa
AA seq
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MPRQATSRLVVGEGEGSQGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLW
LLDFLCIRKHFLGRRRRGQPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHG
QKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAF
QRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCA
LVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGAR
PRRV
NT seq
915 nt
NT seq
+upstream
nt +downstream
nt
atgcctcgccaggccacgtcgcggttggtggtcggagagggcgaggggtcccagggggct
tcggggcctgcagccaccatgctccgctccctgctgcttcactccttgaggctctgcgcc
cagaccgcctcgtgcctcgtgctcttcccgcgcttcctcggcacggccttcatgctctgg
cttctcgatttcttgtgtatccgcaagcatttcctgggccgccgccgccgggggcagccc
gagcccgaagtggagctcaacagtgaaggcgaggaggtgcctcccgatgacccgcccatc
tgcgtgtccgacgacaaccgcctgtgcaccctggcgtcgctcaaggcggtgtggcatggc
cagaagttggatttcttcaagcaggcgcacgagggcggtccggcgcccaactccgaggtg
gttctgcccgacggcttccagagccagcacatcctcgactacgcgcaagggaaccgcccg
ctggttctcaatttcggcagctgcacctgaccaccgttcatggcgcgcatgagcgccttc
cagcgcctggtcactaagtaccagcgcgacgtcgacttcctcatcatctacatcgaggaa
gcgcacccctccgacggctgggtcaccacggactctccctacatcatcccacagcaccgg
agcctggaggaccgggtcagcgcagcgagggtactgcagcaaggtgcacccggctgcgct
ctggtcctcgacaccatggccaactccagcagctcggcctatggcgcctacttcgagcgt
ctctatgtcatccagagtggcactattatgtaccagggcggccgtggccccgacggctac
caggtctctgagctgcgcacttggttggaacgctatgatgagcaactgcacggcgctcgg
ccccggagggtgtaa
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