KEGG   Homo sapiens (human): 1769
Entry
1769              CDS       T01001                                 
Symbol
DNAH8, ATPase, SPGF46, hdhc9
Name
(RefSeq) dynein axonemal heavy chain 8
  KO
K10408  dynein axonemal heavy chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
Disease
H01282  Spermatogenic failure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    1769 (DNAH8)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    1769 (DNAH8)
   05016 Huntington disease
    1769 (DNAH8)
   05022 Pathways of neurodegeneration - multiple diseases
    1769 (DNAH8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    1769 (DNAH8)
   04812 Cytoskeleton proteins [BR:hsa04812]
    1769 (DNAH8)
Cilium and associated proteins [BR:hsa03037]
 Motile cilia and associated proteins
  Dynein arm
   1769 (DNAH8)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     1769 (DNAH8)
SSDB
Motif
Pfam: DHC_N1 AAA_6 DHC_N2 Dynein_C AAA_8 AAA_9 AAA_7 AAA_lid_11 MT Dynein_heavy Dynein_AAA_lid AAA_5 AAA_lid_1 DYN_lid AAA_22 AAA_16 DUF6739
Other DBs
NCBI-GeneID: 1769
NCBI-ProteinID: NP_001193856
OMIM: 603337
HGNC: 2952
Ensembl: ENSG00000124721
Pharos: Q96JB1(Tdark)
UniProt: Q96JB1 Q8IU65 A0A075B6F3
LinkDB
Position
6:38715311..39030792
AA seq 4707 aa
MEKDAEDGAPSEGAEAPPSTEEAAPPRSEEEEAPRPPTVEAPAEDGFSPSAEDAVSSVVD
YRDLIPSEEGIVLPDDHEADLNRVRQRLAPRPVQSVISEVLSLPSSRRSSRYRRSMSGLP
NLQETLKERQARFREARESRRLKIDPSYKYIFEILAENLGLDIVTVEELILDCPSLEAFT
NFFAKDGCKTLKFLYQEGDVPGIECGRTIAGATKGAKMMKLYIDNAAPDKLKGLCIFFVR
CRNDVAINVKTIQEEALFTVLDASKGLLNGIRDMLANIFLPAVLATNNWGALNQSKQGES
EKHIFTETINRYLSFLDGARISIEGTVKLKTIDNVNFSKLHTFEEVTAAASNSETVHQLE
EVLMVWYKQIEQVLIESEQMRKEAGDSGPLTELEHWKRMSAKFNYIIEQIKGPSCKAVIN
VLNVAHSKLLKNWRDLDARITDTANESKDNVRYLYTLEKVCQPLYNHDLVSMAHGIQNLI
NAIRMIHGVSRYYNTSERMTSLFIKVTNQMVTACKAYITDGGLNHVWDQETPVVLKKIQD
CIFLFKEYQASFHKTRKLISESSGEKSFEVSEMYIFGKFEAFCKRLEKITEMITVVQTYS
TLSNSTIEGIDIMAIKFRNIYQGVKKKQYDILDPRRTEFDTDFLDFMTKINGLEVQIQAF
MNSSFGKILSSQQALQLLQRFQKLNIPCLGLEINHTIERILQYYVAELDATKKLYHSQKD
DPPLARNMPPIAGKILWVRQLYRRISEPINYFFKNSDILSSPDGKAVIRQYNKISYVLVE
FEVVYHTAWIREISQLHYALQATLFVRHPETGKLLVNFDPKILEVVRETKCMIKMKLDVP
EQAKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSVFVNLMTPKMKKVESVLRQGLTVL
TWSSLTLESFFQEVELVLDMFNQLLKKISDLCEMHIDTVLKEIAKTVLISLPESGATKVE
DMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQIYEVKYTGKVGKQSEQRKHVVFG
SETGEGENNDYEANIVNEFDTHDKEDEFKKECKEVFAFFSHQLLDSLQKATRLSLDTMKR
RIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIPSLDDIQQAINRMIQLTLEVSRGVAH
WGQQQIRPIKSVIPSPTTTDVTHQNTGKLLKKEERSFEEAIPARKLKNFYPGVAEHKDIS
KLVLLLSSSVNSLRKAAHEALQDFQKYKTLWTEDRDVKVKEFLANNPSLTEIRSEILHYA
TFEQEIDELKPIIVVGALELHTEPMKLALSIEAKAWKMLLCRYLNEEYKKKMSYMIAFIN
EYLKKLSRPIRDLDDVRFAMEALSCIRDNEIQMDMTLGPIEEAYAILNRFEVEVTKEESE
AVDTLRYSFNKLQSKAVSVQEDLVQVQPKFKSNLLESVEVFREDVINFAEAYELEGPMVP
NIPPQEASNRLQIFQASFDDLWRKFVTYSSGEQLFGLPVTDYEVLHKTRKELNLLQKLYG
LYDTVMSSISGYYEILWGDVDIEKINAELLEFQNRCRKLPKGLKDWQAFLDLKKRIDDFS
ESCPLLEMMTNKAMKQRHWDRISELTGTPFDVESDSFCLRNIMEAPLLKHKDDIEDICIS
AIKEKDIEAKLTQVIENWTNQNLSFAAFKGKGELLLKGTESGEIITLMEDSLMVLGSLLS
NRYNAPFKKNIQNWVYKLSTSSDIIEEWLVVQNLWVYLEAVFVGGDIAKQLPQEAKRFQN
IDKSWIKIMQRAHENPNVINCCVGDETMGQLLPHLHEQLEVCQKSLTGYLEKKRLLFPRF
FFVSDPVLLEILGQASDSHTIQPHLPAVSDNINEVTFHAKDYDRIMAVISREGEKIVLDN
SVMAKGPVEIWLLDLLKMQMSSLHNIIRSAFYQISDSGFQLLPFLSHFPAQVGLLGIQML
WTHDSEEALRNAKDDRKIMQVTNQKFLDILNTLISQTTHDLSKFDRVKFETLITIHVHQR
DIFDDLVKMHIKSPTDFEWLKQSRFYFKEDLDQTVVSITDVDFIYQNEFLGCTDRLVITP
LTDRCYITLAQALGMNMGGAPAGPAGTGKTETTKDMGRCLGKYVVVFNCSDQMDFRGLGR
IFKGLAQSGSWGCFDEFNRIELPVLSVAAQQIYIVLTARKERKKQFIFSDGDCVDLNPEF
GIFLTMNPGYAGRQELPENLKIQFRTVAMMVPDRQIIMRVKLASCGFLENVILAQKFYVL
YKLCEEQLTKQVHYDFGLRNILSVLRTLGSQKRARPEDSELSIVMRGLRDMNLSKLVDED
EPLFLSLINDLFPGLQLDSNTYAELQNAVAHQVQIEGLINHPPWNLKLVQLYETSLVRHG
LMTLGPSGSGKTTVITILMKAQTECGRPHREMRMNPKAITAPQMFGRLDTATNDWTDGIF
STLWRKTLKAKKGENIFLILDGPVDAIWIENLNSVLDDNKTLTLANGDRIPMAPSCKLLF
EVHNIENASPATVSRMGMVYISSSALSWRPILQAWLKKRTAQEAAVFLTLYEKVFEDTYT
YMKLNLNPKMQLLECNYIVQSLNLLEGLIPSKEEGGVSCVEHLHKLFVFGLMWSLGALLE
LESREKLEAFLRQHESKLDLPEIPKGSNQTMYEFYVTDYGDWEHWNKKLQPYYYPTDSIP
EYSSILVPNVDNIRTNFLIDTIAKQHKAVLLTGEQGTAKTVMVKAYLKKYDPEVQLSKSL
NFSSATEPMMFQRTIESYVDKRIGSTYGPPGGRKMTVFIDDINMPVINEWGDQITNEIVR
QMMEMEGMYSLDKPGDFTTIVDVQLIAAMIHPGGGRNDIPQRLKRQFTVFNCTLPSNASI
DKIFGIIGCGYFDPCRSFKPQICEMIVNLVSVGRVLWQWTKVKMLPTPSKFHYIFNLRDL
SRIWQGMLTIKAEECASIPTLLSLFKHECSRVIADRFITPEDEQWFNAHLTRAVEENIGS
DAASCILPEPYFVDFLREMPEPTGDEPEDSVFEVPKIYELMPSFDFLAEKLQFYQRQFNE
IIRGTSLDLVFFKDAMTHLIKISRIIRTSCGNALLVGVGGSGKQSLSRLASFIAGYQIFQ
ITLTRSYNVTNLTDDLKALYKVAGADGKGITFIFTDSEIKDEAFLEYLNNLLSSGEISNL
FARDEMDEITQGLISVMKRELPRHPPTFDNLYEYFISRSRKNLHVVLCFSPVGEKFRARS
LKFPGLISGCTMDWFSRWPREALIAVASYFLSDYNIVCSSEIKRQVVETMGLFHDMVSES
CESYFQRYRRRAHVTPKSYLSFINGYKNIYAEKVKFINEQAERMNIGLDKLMEASESVAK
LSQDLAVKEKELAVASIKADEVLAEVTVSAQASAKIKNEVQEVKDKAQKIVDEIDSEKVK
AESKLEAAKPALEEAEAALNTIKPNDIATVRKLAKPPHLIMRIMDCVLLLFQKKIDPVTM
DPEKSCCKPSWGESLKLMSATGFLWSLQQFPKDTINEETVELLQPYFNMDDYTFESAKKV
CGNVAGLLSWTLAMAIFYGINREVLPLKANLAKQEGRLAVANAELGKAQALLDEKQAELD
KVQAKFDAAMNEKMDLLNDADTCRKKMQAASTLIDGLSGEKIRWTQQSKEFKAQINRLVG
DILLCTGFLSYLGPFNQIFRNYLLKDQWEMELRARKIPFTENLNLISMLVDPPTIGEWGL
QGLPGDDLSIQNGIIVTKATRYPLLIDPQTQGKTWIKSKEKENDLQVTSLNHKYFRTHLE
DSLSLGRPLLIEDIHEELDPALDNVLEKNFIKSGTTFKVKVGDKECDIMDTFKLYITTKL
PNPAFTPEINAKTSVIDFTVTMKGLENQLLRRVILTEKQELEAERVKLLEDVTFNKRKMK
ELEDNLLYKLSATKGSLVDDESLIGVLRTTKQTAAEVSEKLHVAAETEIKINAAQEEFRP
AATRGSILYFLITEMSMVNIMYQTSLAQFLKLFDQSMARSEKSPLPQKRITNIIEYLTYE
VFTYSVRGLYENHKFLFVLLMTLKIDLQRGTVKHREFQALIKGGAALDLKACPPKPYRWI
LDMTWLNLVELSKLPQFAEIMNQISRNEKGWKSWFDKDAPEEEIIPDGYNDSLDTCHKLL
LIRSWCPDRTVFQARKYIADSLEEKYTEPVILNLEKTWEESDTRTPLICFLSMGSDPTNQ
IDALAKKLKLECRTISMGQGQEVHARKLIQMSMQQGGWVLLQNCHLGLEFMEELLETLIT
TEASDDSFRVWITTEPHDRFPITLLQTSLKFTNEPPQGVRAGLKRTFAGINQDLLDISNL
PMWKPMLYTVAFLHSTVQERRKFGPLGWNIPYEFNSADFSASVQFIQNHLDECDIKKGVS
WNTVRYMIGEVQYGGRVTDDFDKRLLNCFARVWFSEKMFEPSFCFYTGYKIPLCKTLDQY
FEYIQSLPSLDNPEVFGLHPNADITYQSNTASAVLETITNIQPKESGGGVGETREAIVYR
LSEDMLSKLPPDYIPHEVKSRLIKMGHLNSMNIFLRQEIDRMQRVISILRSSLSDLKLAI
EGTIIMSENLRDALDNMYDARIPQLWKRVSWDSSTLGFWFTELLERNAQFSTWIFEGRPN
VFWMTGFFNPQGFLTAMRQEVTRAHKGWALDTVTIHNEVLRQTKEEITSPPGEGVYIYGL
YMDGAAWDRRNGKLMESTPKVLFTQLPVLHIFAINSTAPKDPKLYVCPIYKKPRRTDLTF
ITVVYLRTVLSPDHWILRGVALLCDIK
NT seq 14124 nt   +upstreamnt  +downstreamnt
atggagaaggatgctgaagatggcgccccttctgagggagcagaggctcctccctctacg
gaagaggctgcccctccccgttcagaagaggaagaggccccgcgccctccgacagtggag
gccccggcagaagatggtttctctccttccgcagaagatgctgtttcttctgtggtggat
tatcgggatctcattccttctgaagaagggatagttcttccagatgatcatgaagcggat
ctgaatagagttcgacagaggcttgcaccgcgaccggttcagtcagtgatttcggaagtg
ctgtccttgccgtcttcccggaggtcctccagataccgccggagtatgagtggccttccc
aatctacaggaaacattaaaagagagacaggcaagatttagagaggcaagggaaagccga
agactgaaaattgacccttcatacaaatatatatttgaaattctagcagaaaatcttggc
ctggacatagtaactgttgaagaattaattttggattgcccatctctggaagcatttact
aatttttttgcgaaagatggttgtaagacactgaaatttttgtaccaagaaggagatgta
cctggtattgaatgtggtcgaactattgctggagcaactaaaggggcaaaaatgatgaaa
ttgtatatagacaatgcagccccggataaactaaaaggactgtgcatattttttgttcgt
tgccgtaatgatgttgctataaatgttaaaactattcaagaggaagcgctctttactgtt
ctggatgcgtcgaaaggactcttaaatggaattagggatatgttggcaaatatatttcta
ccagctgttcttgcaacaaacaactggggtgctttaaaccagtccaagcagggagaatct
gaaaaacatattttcactgaaaccatcaacagatatctttcatttttagatggtgctaga
ataagtattgagggaacagtgaagttaaagacaatagacaatgttaatttttccaaactg
cacacctttgaagaagtaactgctgcagccagcaactcagaaactgttcatcagctggag
gaagtgctgatggtatggtacaaacagatcgaacaggtacttattgagagtgagcagatg
agaaaagaagctggtgattcaggtccactcactgaattggaacactggaaacgcatgtca
gccaagttcaactatatcattgagcagattaaagggccaagttgtaaggctgtcataaat
gtgctaaatgttgcacactccaaactgctaaagaattggcgtgatttggatgcaagaatc
actgatacagcaaatgaatccaaagataatgtcagatatttgtatactttggaaaaagtg
tgtcaacctctctataaccatgacctagtttccatggcacatggaatacaaaatttgatt
aatgccatcagaatgattcacggtgtgtcaaggtattataatacctcagagagaatgacc
tcattgtttatcaaggtaacaaatcaaatggtaacagcatgtaaagcatatattactgat
ggaggattaaaccatgtatgggatcaggaaacgccagttgtactaaagaaaattcaggac
tgcatttttctattcaaggaatatcaggcatcttttcataaaacaaggaaactgatttca
gaatcctcaggggaaaaatcttttgaggtttcagaaatgtatatatttggaaaatttgaa
gctttttgcaaaagactggagaagattacagaaatgataactgttgtgcaaacatattca
accttgagtaattctaccatagaaggaatagatattatggcaataaaattcagaaatata
taccaaggggttaagaaaaagcaatatgacattctggatccaagaaggacagaatttgac
acagatttcttagatttcatgacaaaaatcaatggtttagaggtacaaatacaggcattt
atgaacagtagttttgggaaaatcttatcttctcagcaggctcttcagctacttcaaagg
tttcagaagctgaacattccctgtctgggattagaaataaaccacacaatagagcgtatt
cttcagtactatgtggctgaacttgatgctactaagaagctttatcattctcagaaagat
gacccccctcttgctcgcaacatgccccctatagcaggaaaaatactctgggtgaggcag
ctctatcgccggataagtgagcccatcaattatttctttaaaaactcagacattttatca
agtccggacggtaaagctgtcatccgtcagtataacaagatctcctatgtgctggtggaa
ttcgaggtggtctatcacacagcctggatcagagagatttcacagttgcattacgcttta
caagccacgctttttgtgcgacatccagaaacagggaagttgctggttaatttcgatccc
aaaattttggaagttgttcgggaaactaagtgtatgataaaaatgaagttggatgtacca
gaacaggcaaagagattgctaaaattggaaagtaaattgaaagcagacaaactgtatttg
cagggtcttctgcaatattatgatgagttatgtcaggaagtgccttctgtgtttgtcaat
ctgatgaccccaaaaatgaaaaaggtggaatctgtgttgaggcaaggactcacagtgtta
acatggtcgtctttaacactggaaagcttctttcaagaagtcgaattagttttggatatg
ttcaatcaacttttaaagaagatcagtgacttgtgtgaaatgcatattgatacagttctg
aaggagatagccaaaactgtgttgatttctctgcctgaaagtggtgctaccaaagtagaa
gatatgttgaccctcaatgagacatacacaaaagaatgggctgacattctaaaccacaaa
agtaagcatgtggaagaagctgtcagagaacttatatcaatatttgagcagatttatgaa
gtgaaatacactgggaaagtaggaaaacagtcagaacagcggaaacacgttgtttttgga
agtgaaacaggagagggtgaaaacaatgactatgaagctaatattgtgaatgagtttgat
actcatgataaagaagatgaatttaaaaaggagtgtaaagaggtctttgcttttttctct
catcaattactagacagtcttcaaaaagctacacggttatctctggacacaatgaaaaga
agaatatttgttgcaagcctttatgggcgaaagcagtcagaagatattatttcctttata
aaaagtgaagtacatcttgcaattcctaatgtggtgatgattcctagtttggatgacatt
caacaagccattaaccgtatgatccagttaaccctggaggtcagcagaggagtggctcac
tgggggcaacagcaaatccgtcccatcaagtctgtcattcccagccccaccactactgac
gtgacccatcaaaacacaggaaaactgctgaagaaggaagaaagatcttttgaagaagct
attcctgcgaggaagctgaagaatttttacccgggggtagcggagcacaaggatatttct
aagttggtcctgctcctttcttcctctgtaaattccctaagaaaggcagctcatgaggcc
ctgcaggactttcagaagtacaagactctctggacagaggaccgcgatgtgaaagtgaag
gaatttttggctaacaacccctctctgactgaaatcagatcagaaattctacactatgct
acttttgaacaggagattgatgagttgaagcctattattgttgtaggagcacttgaatta
catacagagccgatgaaattggccttatccatcgaggccaaggcatggaagatgttactc
tgtcgatatctgaatgaagaatacaaaaagaaaatgtcatacatgatagcatttattaat
gaatacttgaaaaagttatctagacctattcgtgatttagatgatgtcagatttgcaatg
gaagccttgtcttgcatacgtgataatgaaattcaaatggacatgactttgggaccaatt
gaagaagcctatgctattttaaacagatttgaagttgaagtaaccaaagaagaatcagaa
gcagttgataccttaagatattctttcaacaaattgcagagcaaagctgtttcagtacaa
gaggacctagttcaagtgcagccaaagtttaaaagcaatctacttgagtctgtggaagtt
tttcgtgaggacgtgataaactttgcagaagcatatgaattggaaggacctatggttcca
aatataccaccccaagaagctagcaacaggctacagatatttcaggccagtttcgatgat
ctgtggaggaaatttgttacgtattcatctggtgaacaactttttggattgcctgtgact
gattatgaggttttacacaaaaccagaaaagaactcaacttgctgcagaagctgtatgga
ttgtatgacaccgtaatgagcagtattagtggttattatgaaatactttggggagatgta
gatattgaaaaaattaatgcagaactgctggaatttcaaaacagatgtcgtaaacttcca
aaaggacttaaagattggcaagcttttttggatctcaaaaagagaattgatgatttcagt
gagtcatgtcctctactggaaatgatgaccaataaggccatgaaacagagacactgggat
agaatctccgagttaactggaaccccatttgatgtggaatctgattctttttgccttaga
aatatcatggaagcaccactccttaaacataaggatgatattgaggatatttgcatatct
gccattaaggagaaggatatcgaagccaagctgactcaggtgattgagaattggaccaac
caaaatctgagttttgcagcatttaagggaaaaggagagctcctgctcaaaggaaccgaa
tcgggagaaattatcactttgatggaggatagtttaatggtcttagggtctttactcagc
aacagatacaatgctccatttaaaaaaaatatccagaattgggtgtataaattgtccact
tcctcagatataattgaagagtggctcgtagtacagaacctttgggtttatcttgaagcc
gtctttgtaggtggagatattgccaaacagctgcctcaggaagcaaaacgttttcagaat
attgacaagtcttggataaaaataatgcagcgagctcatgagaatcccaatgtgattaat
tgctgtgttggagatgaaaccatgggacaacttttacctcatttacatgagcagttggaa
gtatgtcagaagtcactcacagggtatttggagaagaaacgattactgtttccaagattc
ttctttgtatctgatccagttctcctggaaattcttggacaagccagtgattcccacacc
atacagccgcatctccctgcagtatctgacaacatcaatgaggtgacatttcatgcaaaa
gactatgatcgcatcatggccgtcatatcaagagaaggagaaaaaattgttttggataat
tctgttatggccaaaggtcctgtggagatttggctactggatttgttaaaaatgcagatg
tcatcattacataatataattagatccgctttctatcaaatcagtgattcaggatttcaa
ctcttaccattcctcagccactttccagcacaggttggacttctgggaattcagatgttg
tggacacacgattcagaagaggctttacgtaatgcaaaagatgacaggaaaatcatgcaa
gtgaccaatcagaaatttttggatattctaaatactctcattagtcagacaacacatgat
ctaagcaagtttgatagagtgaagttcgagactctaattaccatccatgtgcatcagaga
gatatttttgatgacttggtaaaaatgcatatcaaatcacctactgactttgaatggcta
aaacagagtagattttattttaaggaagatttggatcaaactgtggtgtctattacagat
gttgattttatttaccaaaatgaatttctgggatgtactgatcgtcttgttatcactcca
ttaacagatagatgctatatcacgttagctcaggccttgggcatgaacatgggaggtgct
cccgcaggacctgctggcactggcaaaacagaaaccacaaaagacatgggaaggtgtttg
ggaaaatatgtggtcgtgttcaattgctcagatcaaatggatttcagaggcctaggaagg
attttcaaaggtcttgcacagtcgggttcctggggctgttttgatgagtttaacagaatt
gaattgcctgtattatcagtggcagcacaacaaatttatattgttttgacagcaagaaaa
gaaagaaagaaacagttcattttttctgatggtgattgtgttgatttaaatccagaattt
ggaatcttcttaacgatgaaccctggatatgctgggcgccaggaactaccagaaaaccta
aaaatccagtttagaactgttgctatgatggttcctgatagacagatcattatgagagtt
aaacttgcaagctgtggttttcttgaaaatgttatcttggctcaaaaattttacgttctt
tacaaactctgtgaagagcaacttactaaacaggttcattatgactttggattgagaaat
attctgtctgtattgaggactcttggatctcaaaaaagagccagaccagaagatagtgaa
ttaagcattgtcatgagaggactaagagatatgaacctttccaaactggttgatgaagat
gaacccctgttcctcagcttaatcaatgacctgttcccaggactgcaactggatagtaat
acttatgcagaactgcaaaacgcagtagcccatcaggttcagatagagggtttgattaac
catccaccctggaacctgaaactcgtgcagttatatgagacgtctttggtacggcatggc
ttgatgactcttgggcccagtggttctggaaagacaaccgttatcacgattctaatgaag
gcgcaaacagaatgcggaaggcctcatagagaaatgcgaatgaatccaaaagccattact
gcacctcagatgtttggcagactggacactgctaccaatgactggacagatgggattttt
tctactctgtggagaaaaacattaaaagctaaaaaaggtgaaaacattttcctcatttta
gatggtcctgtggatgccatctggattgagaacttaaattccgttttggatgacaataaa
actctgacgttagctaatggagatcgcattcccatggcccctagttgtaagcttctgttt
gaagtccacaatatcgagaacgcctctcctgccacggtttctaggatgggcatggtctat
atcagcagctctgctctcagctggaggccaatcttacaggcatggttgaagaaacgcact
gcacaggaagctgctgtattcctgacactgtatgagaaagtctttgaagatacatacaca
tatatgaagctaaatctcaatcccaaaatgcagctcttggagtgcaactatattgtgcaa
tctctcaatcttctggaagggttaattccctccaaagaagaaggcggtgtttcctgtgtc
gaacatcttcataaattatttgtgtttggcctaatgtggagtttaggagcccttctggaa
ttagaaagcagagaaaagcttgaagccttcttacggcagcatgaaagcaagttggactta
ccagaaatacctaaaggctcaaatcaaaccatgtatgagttttatgttactgattatggt
gattgggagcactggaataagaaacttcagccttattattatccaactgacagtattccg
gaatattcatcaattttggttccaaatgttgacaatattagaacaaattttttgatagac
accattgcaaaacaacataaagctgttttgctcacaggagagcagggaactgcaaaaact
gtcatggttaaggcctatttgaaaaaatatgatcctgaagtacagctatccaaaagtcta
aacttttcatctgccacagaaccaatgatgtttcagagaacaattgaaagctacgtggat
aagcgaattggaagcacatatgggccaccaggagggagaaaaatgactgtatttattgat
gatattaatatgcctgtgattaatgagtggggagatcagataactaatgagattgtgcga
cagatgatggaaatggaaggaatgtacagcttggacaagcctggagacttcactactatt
gttgatgtgcagctcatagcagcaatgatccaccctggaggtggtcgaaatgatattcca
caacgtttaaaaagacaatttactgtgtttaattgtacattgccttcaaatgcttcaata
gacaaaatttttggaattattggatgtggatactttgatccttgtagaagtttcaagcct
caaatatgtgagatgattgtgaatttagtctcagtgggtagagtgctgtggcaatggact
aaggtgaagatgctgccaactccttctaaatttcattacatcttcaatcttcgagatctt
tccagaatttggcaaggaatgttgaccataaaagctgaggagtgcgcttcaatccctact
ctcctgtcccttttcaaacacgagtgcagcagagtaattgcagacagatttataactcct
gaagatgagcagtggtttaatgcacatcttactcgtgcagttgaagaaaatattggctct
gatgcagcgtcgtgtattcttcctgaaccatactttgtggattttcttcgtgagatgcca
gaaccaactggtgatgaacctgaagactctgtgtttgaagtacccaaaatatatgaattg
atgccatcctttgactttctggctgaaaaactccagttttaccagagacagttcaatgaa
atcattagaggaacatctcttgatctggtgttttttaaagatgcaatgactcatcttatt
aagatttcacgaataattcgaacgtcgtgtggaaatgcattgctggtgggtgttggtggt
tccggaaaacaaagtctttcaagattggcctcttttattgctggctatcaaatattccag
ataacattaaccaggtcttacaatgtgactaatctaacagatgatttaaaagctttgtac
aaagttgctggtgctgatggaaaaggcatcactttcatctttactgacagtgaaataaaa
gatgaggcatttctagaataccttaacaacttgctatcttcaggggagatctccaacttg
tttgcacgagatgagatggatgaaatcacccaaggtctgatttcagtgatgaagagggag
ctacctcgccatcctcctacctttgataatttgtatgaatacttcatttcaagatcaagg
aagaacttacatgttgttctctgcttttctccagttggtgagaagttccgtgcccgttct
ttgaaatttcctggcttgatatcaggttgcactatggactggttcagccgctggccaagg
gaggctctgattgctgtggcctcctacttcctttcagactataatattgtctgctctagt
gaaattaaaagacaagttgtagaaacaatgggcctgtttcatgacatggtttcagagagc
tgtgaaagttatttccaaagataccgccgaagagcacatgtgactcccaaatcttacctc
tcatttataaatggttataaaaacatttatgctgaaaaggtgaagttcattaatgaacag
gctgaacgtatgaatattggtcttgataaactaatggaggcaagtgaatctgttgctaaa
ctctctcaggatcttgcagtcaaggagaaggagttggcagtggcttccataaaagcagac
gaagtattagcagaagtcacagtaagcgctcaggcttcagccaaaattaaaaatgaagta
caggaggtaaaggacaaagcccaaaaaattgtggatgaaattgatagtgaaaaagtgaaa
gctgaaagcaagcttgaggcagctaaacctgcactggaagaagcagaagcagccctgaat
actatcaagccaaatgatattgccacagtcaggaaacttgcaaaaccaccacatcttatt
atgagaatcatggactgtgttctgttactatttcaaaagaaaattgaccctgttactatg
gatccagaaaaatcttgctgtaagccatcatggggagagtcattaaagttgatgagtgca
acaggattcctgtggagccttcagcagttccctaaggacactataaatgaagagactgtt
gagttactacagccatattttaatatggatgattatacttttgaaagtgccaaaaaagtc
tgtgggaatgtggctggtctcctgtcttggacacttgctatggcaatattttatggcatc
aatagagaagtgttgcctctgaaggccaacctggccaagcaggaaggccggttagcagtt
gctaatgctgagttagggaaggcacaagccctgctggatgagaagcaagctgagctggat
aaagtacaggcaaaatttgatgcagcaatgaatgagaaaatggatttgcttaatgacgct
gatacgtgccggaaaaagatgcaggccgcctccactctcatcgatgggctgagtggagaa
aaaatccggtggacccagcaaagtaaagaattcaaagctcagattaatagacttgtaggt
gatattctgctgtgcacgggattcctttcctaccttggtcctttcaatcagatatttagg
aactatttgcttaaagatcaatgggaaatggagttgagagcacggaaaattcctttcaca
gaaaacctgaatcttatttcaatgttggtggatcctccaactattggtgagtgggggcta
cagggattaccaggagatgatctctcaattcagaatggcattattgtgacaaaggccacc
agatacccactcctcatagacccacaaactcaaggcaaaacttggattaaatcaaaggaa
aaagaaaatgatttacaggtgacatctctgaaccataaatattttcgcacacacttggag
gacagcctttccttgggccgaccccttctcattgaggacattcatgaagagctggatcca
gccttggataatgtattagaaaagaattttattaaatctggcaccactttcaaggtgaaa
gtcggtgataaggaatgtgatatcatggatacatttaaactttacattactacgaagtta
ccaaatcctgcctttaccccagagattaatgctaaaacgtcagtcattgatttcactgtt
acaatgaaaggacttgagaatcagttactaaggagagtcattctaacagagaaacaggag
ttagaggctgagagggttaaacttttggaggatgttacttttaataagcggaagatgaaa
gaacttgaagataacctcctctataaattaagtgctacaaaaggctcattggtagatgac
gaatctctcattggtgtacttcgaactaccaagcagacagcagctgaggtaagtgaaaag
ttgcatgtggctgcagaaactgagatcaagatcaacgcggctcaggaggagttccggccc
gcagccacccgcggaagcatcctctacttcctcatcacagagatgagcatggtcaacatc
atgtatcagacgtcattggcccagttcttgaagttatttgaccagtccatggccagatct
gaaaagtcaccactacctcaaaagagaattacaaatattatcgagtacctgacatatgaa
gtttttacatactctgtcagaggcctatacgaaaaccacaaattcctgtttgtactcctc
atgaccttaaagattgaccttcagagagggacagttaagcacagagagtttcaagctctc
attaaagggggagcagctctggacctgaaagcctgtcctcccaaaccctatcgctggatc
cttgacatgacttggctgaatcttgtggagctgagtaaacttccacaatttgcagaaatt
atgaaccagatatctcgtaatgagaaggggtggaaaagctggtttgataaagatgctcca
gaggaggaaattatccctgatggatataatgattcactagatacctgccataaactttta
cttatcaggtcttggtgcccagaccgtactgtttttcaagcaagaaagtatattgcagat
tctttggaggagaagtacacagaaccagttatcttaaatctggagaaaacttgggaagaa
agtgatacccggacacctctgatatgcttcctgtccatgggatctgaccccaccaatcaa
attgatgcattggccaagaaactgaaactggaatgtagaactatctcaatggggcaagga
caagaagtacatgctcgaaagctgattcagatgtcaatgcagcagggtggttgggtatta
ctacaaaattgccaccttggcctggaattcatggaagaattactagagacgctaattacc
actgaagccagtgatgattctttccgagtatggataactacggagccccatgatcgattt
ccaattacattgcttcagacctctctcaaattcactaatgagccaccccaaggtgtacgc
gcaggtttgaaaagaacatttgctggaattaatcaagaccttctggacatcagtaattta
cccatgtggaagccgatgctttacacagtagcatttttacactccactgtgcaggagcga
cgaaaatttggccccttaggatggaatattccctacgaattcaattctgctgacttttca
gccagtgttcagtttattcagaatcaccttgatgaatgcgatattaagaaaggtgtatca
tggaatacggttcggtacatgatcggagaagtacaatatggaggcagagtgacagatgac
tttgacaaacgtctacttaattgctttgccagagtctggttcagtgagaagatgtttgaa
ccgtcattctgcttttatactggatataaaatccccttatgcaaaaccttagaccagtat
tttgaatacatccagtcactgccatccctagataaccctgaagtctttgggcttcaccct
aatgctgatatcacgtatcagagtaacactgcttctgctgttcttgaaacaattaccaac
attcaacccaaagagagtggaggtggtgtgggagagacccgggaggctattgtttataga
ttatctgaagatatgctgagtaaactccctcctgattacattcctcatgaggtgaaatct
cgtttgataaagatgggccatcttaattcaatgaacatatttcttagacaagaaattgac
agaatgcaaagagtcatttcaatactccgcagtagcctgagtgatctaaaattggccatt
gaaggaacaatcattatgagtgagaatctgagagatgctctggacaacatgtatgatgct
cgtatacctcagctctggaaaagagtgtcttgggattcgtccacactgggcttctggttc
actgaacttttggaaagaaatgctcagttttctacgtggatatttgaagggaggcctaat
gtgttttggatgactggtttctttaatccccaaggcttcctcacagcaatgaggcaagaa
gtgacccgtgcccacaaaggctgggcactggacactgtgaccatccacaatgaagttctg
agacagaccaaggaggagatcacgtcaccccctggggaaggtgtgtatatttatgggctc
tacatggatggagcagcctgggacagacggaatgggaagctcatggaatccacccccaag
gtactcttcacgcagttacccgtgctccacatctttgccattaactccacggcacccaag
gaccccaagctgtatgtgtgtcctatttacaagaaacccaggcgaactgatttgaccttc
atcactgtggtatatttacgaacagtgttgtccccggatcactggatcctgagaggagtg
gcccttttgtgtgacatcaagtaa

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