Homo sapiens (human): 1906 Help Entry 1906              CDS       T01001                                  Symbol EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME Name (RefSeq) endothelin 1   KO K16366   endothelin-1 Organism hsa  Homo sapiens (human) Pathway hsa04024   cAMP signaling pathway hsa04066   HIF-1 signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa04668   TNF signaling pathway hsa04916   Melanogenesis hsa04924   Renin secretion hsa04926   Relaxin signaling pathway hsa04933   AGE-RAGE signaling pathway in diabetic complications hsa05200   Pathways in cancer hsa05410   Hypertrophic cardiomyopathy hsa05418   Fluid shear stress and atherosclerosis Network nt06325  Hormone/cytokine signaling   Element N01792   EDN-EDNR signaling pathway Disease H01884   Auriculocondylar syndrome Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04668 TNF signaling pathway     1906 (EDN1)    04066 HIF-1 signaling pathway     1906 (EDN1)    04024 cAMP signaling pathway     1906 (EDN1)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1906 (EDN1)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     1906 (EDN1)    04924 Renin secretion     1906 (EDN1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     1906 (EDN1)   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     1906 (EDN1)    05410 Hypertrophic cardiomyopathy     1906 (EDN1)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     1906 (EDN1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:hsa04052]     1906 (EDN1) Cytokines and neuropeptides [BR:hsa04052]  Neuropeptides   Neuropeptides (GPCR binding)    1906 (EDN1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Endothelin Motif Other DBs NCBI-GeneID:  1906 NCBI-ProteinID:  NP_001946 OMIM:  131240 HGNC:  3176 Ensembl:  ENSG00000078401 CPD:  C16009 C16010 UniProt:  P05305 Q6FH53 Structure PDBPDBj LinkDB All DBs Position 6:12230516..12297194 Genome browser AA seq 212 aa AA seqDB search MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW NT seq 639 nt NT seq  +upstreamnt  +downstreamnt atggattatttgctcatgattttctctctgctgtttgtggcttgccaaggagctccagaa acagcagtcttaggcgctgagctcagcgcggtgggtgagaacggcggggagaaacccact cccagtccaccctggcggctccgccggtccaagcgctgctcctgctcgtccctgatggat aaagagtgtgtctacttctgccacctggacatcatttgggtcaacactcccgagcacgtt gttccgtatggacttggaagccctaggtccaagagagccttggagaatttacttcccaca aaggcaacagaccgtgaaaatagatgccaatgtgctagccaaaaagacaagaagtgctgg aatttttgccaagcaggaaaagaactcagggctgaagacattatggagaaagactggaat aatcataagaaaggaaaagactgttccaagcttgggaaaaagtgtatttatcagcagtta gtgagaggaagaaaaatcagaagaagttcagaggaacacctaagacaaaccaggtcggag accatgagaaacagcgtcaaatcatcttttcatgatcccaagctgaaaggcaagccctcc agagagcgttatgtgacccacaaccgagcacattggtga

Homo sapiens (human): 1907 Help Entry 1907              CDS       T01001                                  Symbol EDN2, ET-2, ET2, PPET2 Name (RefSeq) endothelin 2   KO K16367   endothelin-2 Organism hsa  Homo sapiens (human) Pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa04924   Renin secretion Network nt06325  Hormone/cytokine signaling   Element N01792   EDN-EDNR signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     1907 (EDN2)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1907 (EDN2)  09150 Organismal Systems   09152 Endocrine system    04924 Renin secretion     1907 (EDN2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:hsa04052]     1907 (EDN2) Cytokines and neuropeptides [BR:hsa04052]  Neuropeptides   Neuropeptides (GPCR binding)    1907 (EDN2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Endothelin Motif Other DBs NCBI-GeneID:  1907 NCBI-ProteinID:  NP_001947 OMIM:  131241 HGNC:  3177 Ensembl:  ENSG00000127129 CPD:  C16012 UniProt:  P20800 LinkDB All DBs Position 1:complement(41478775..41484683) Genome browser AA seq 178 aa AA seqDB search MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGA VPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR NT seq 537 nt NT seq  +upstreamnt  +downstreamnt atggtctccgtgcctaccacctggtgctccgttgcgctagccctgctcgtggccctgcat gaagggaagggccaggctgctgccaccctggagcagccagcgtcctcatctcatgcccaa ggcacccaccttcggcttcgccgttgctcctgcagctcctggctcgacaaggagtgcgtc tacttctgccacttggacatcatctgggtgaacactcctgaacagacagctccttacggc ctgggaaacccgccaagacgccggcgccgctccctgccaaggcgctgtcagtgctccagt gccagggaccccgcctgtgccaccttctgccttcgaaggccctggactgaagccggggca gtcccaagccggaagtcccctgcagacgtgttccagactggcaagacaggggccactaca ggagagcttctccaaaggctgagggacatttccacagtcaagagcctctttgccaagcga caacaggaggccatgcgggagcctcggtccacacattccaggtggaggaagagatag

Homo sapiens (human): 1908 Help Entry 1908              CDS       T01001                                  Symbol EDN3, ET-3, ET3, HSCR4, PPET3, WS4B Name (RefSeq) endothelin 3   KO K05227   endothelin-3 Organism hsa  Homo sapiens (human) Pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa04924   Renin secretion Network nt06325  Hormone/cytokine signaling   Element N01792   EDN-EDNR signaling pathway Disease H00759   Waardenburg syndrome H00910   Hirschsprung disease Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     1908 (EDN3)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     1908 (EDN3)  09150 Organismal Systems   09152 Endocrine system    04924 Renin secretion     1908 (EDN3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04052 Cytokines and neuropeptides [BR:hsa04052]     1908 (EDN3) Cytokines and neuropeptides [BR:hsa04052]  Neuropeptides   Neuropeptides (GPCR binding)    1908 (EDN3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Endothelin Motif Other DBs NCBI-GeneID:  1908 NCBI-ProteinID:  NP_996917 OMIM:  131242 HGNC:  3178 Ensembl:  ENSG00000124205 CPD:  C16013 UniProt:  P14138 Structure PDBPDBj LinkDB All DBs Position 20:59300611..59325992 Genome browser AA seq 238 aa AA seqDB search MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP NT seq 717 nt NT seq  +upstreamnt  +downstreamnt atggagccggggctgtggctccttttcgggctcacagtgacctccgccgcaggattcgtg ccttgctcccagtctggggatgctggcaggcgcggcgtgtcccaggcccccactgcagcc agatctgagggggactgtgaagagactgtggctggccctggcgaggagactgtggctggc cctggcgaggggactgtggccccgacagcactgcagggtccaagccctggaagccctggg caggagcaggcggccgagggggcccctgagcaccaccgatccaggcgctgcacgtgcttc acctacaaggacaaggagtgtgtctactattgccacctggacatcatttggatcaacact cccgaacagacggtgccctatggactgtccaactacagaggaagcttccggggcaagagg tctgcggggccacttccagggaatctgcagctctcacatcggccacacttgcgctgcgct tgtgtggggagatatgacaaggcctgcctgcacttttgcacccaaactctggacgtcagc agtaattcaaggacggcagaaaaaacagacaaagaagaggaagggaaggttgaagtcaag gaccaacaaagcaagcaggctttagacctccaccatccaaagctcatgcccggcagtgga ctcgccctcgctccatctacctgcccccgctgcctctttcaggaaggagccccttag

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