KEGG   Homo sapiens (human): 2023
Entry
2023              CDS       T01001                                 
Symbol
ENO1, ENO1L1, HEL-S-17, MPB1, NNE, PPH
Name
(RefSeq) enolase 1
  KO
K01689  enolase [EC:4.2.1.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
hsa03018  RNA degradation
hsa04066  HIF-1 signaling pathway
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00002  Glycolysis, core module involving three-carbon compounds
hsa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P
Network
nt06017  Glycogen metabolism
  Element
N00731  Glycolysis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    2023 (ENO1)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    2023 (ENO1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    2023 (ENO1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    2023 (ENO1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2023 (ENO1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.11  phosphopyruvate hydratase
     2023 (ENO1)
Messenger RNA biogenesis [BR:hsa03019]
 Prokaryotic type
  Bacterial mRNA degradation factors
   RNA degradosome components
    Other RNA degradosome components
     2023 (ENO1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   2023 (ENO1)
SSDB
Motif
Pfam: Enolase_C Enolase_N MR_MLE_C MAAL_C
Other DBs
NCBI-GeneID: 2023
NCBI-ProteinID: NP_001419
OMIM: 172430
HGNC: 3350
Ensembl: ENSG00000074800
Pharos: P06733(Tchem)
UniProt: P06733 A0A024R4F1
Structure
LinkDB
Position
1:complement(8861000..8878686)
AA seq 434 aa
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGK
GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCK
AGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFRE
AMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKV
VIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDD
WGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLA
QANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSK
AKFAGRNFRNPLAK
NT seq 1305 nt   +upstreamnt  +downstreamnt
atgtctattctcaagatccatgccagggagatctttgactctcgcgggaatcccactgtt
gaggttgatctcttcacctcaaaaggtctcttcagagctgctgtgcccagtggtgcttca
actggtatctatgaggccctagagctccgggacaatgataagactcgctatatggggaag
ggtgtctcaaaggctgttgagcacatcaataaaactattgcgcctgccctggttagcaag
aaactgaacgtcacagaacaagagaagattgacaaactgatgatcgagatggatggaaca
gaaaataaatctaagtttggtgcgaacgccattctgggggtgtcccttgccgtctgcaaa
gctggtgccgttgagaagggggtccccctgtaccgccacatcgctgacttggctggcaac
tctgaagtcatcctgccagtcccggcgttcaatgtcatcaatggcggttctcatgctggc
aacaagctggccatgcaggagttcatgatcctcccagtcggtgcagcaaacttcagggaa
gccatgcgcattggagcagaggtttaccacaacctgaagaatgtcatcaaggagaaatat
gggaaagatgccaccaatgtgggggatgaaggcgggtttgctcccaacatcctggagaat
aaagaaggcctggagctgctgaagactgctattgggaaagctggctacactgataaggtg
gtcatcggcatggacgtagcggcctccgagttcttcaggtctgggaagtatgacctggac
ttcaagtctcccgatgaccccagcaggtacatctcgcctgaccagctggctgacctgtac
aagtccttcatcaaggactacccagtggtgtctatcgaagatccctttgaccaggatgac
tggggagcttggcagaagttcacagccagtgcaggaatccaggtagtgggggatgatctc
acagtgaccaacccaaagaggatcgccaaggccgtgaacgagaagtcctgcaactgcctc
ctgctcaaagtcaaccagattggctccgtgaccgagtctcttcaggcgtgcaagctggcc
caggccaatggttggggcgtcatggtgtctcatcgttcgggggagactgaagataccttc
atcgctgacctggttgtggggctgtgcactgggcagatcaagactggtgccccttgccga
tctgagcgcttggccaagtacaaccagctcctcagaattgaagaggagctgggcagcaag
gctaagtttgccggcaggaacttcagaaaccccttggccaagtaa

KEGG   Homo sapiens (human): 2026
Entry
2026              CDS       T01001                                 
Symbol
ENO2, HEL-S-279, NSE
Name
(RefSeq) enolase 2
  KO
K01689  enolase [EC:4.2.1.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
hsa03018  RNA degradation
hsa04066  HIF-1 signaling pathway
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00002  Glycolysis, core module involving three-carbon compounds
hsa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P
Network
nt06017  Glycogen metabolism
  Element
N00731  Glycolysis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    2026 (ENO2)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    2026 (ENO2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    2026 (ENO2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    2026 (ENO2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2026 (ENO2)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.11  phosphopyruvate hydratase
     2026 (ENO2)
Messenger RNA biogenesis [BR:hsa03019]
 Prokaryotic type
  Bacterial mRNA degradation factors
   RNA degradosome components
    Other RNA degradosome components
     2026 (ENO2)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   2026 (ENO2)
SSDB
Motif
Pfam: Enolase_C Enolase_N MR_MLE_C MAAL_C
Other DBs
NCBI-GeneID: 2026
NCBI-ProteinID: NP_001966
OMIM: 131360
HGNC: 3353
Ensembl: ENSG00000111674
Pharos: P09104(Tbio)
UniProt: P09104 Q6FHV6
Structure
LinkDB
Position
12:6914580..6923697
AA seq 434 aa
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGK
GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCK
AGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRD
AMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKI
VIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDD
WAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLA
QENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDE
ARFAGHNFRNPSVL
NT seq 1305 nt   +upstreamnt  +downstreamnt
atgtccatagagaagatctgggcccgggagatcctggactcccgcgggaaccccacagtg
gaggtggatctctatactgccaaaggtcttttccgggctgcagtgcccagtggagcctct
acgggcatctatgaggccctggagctgagggatggagacaaacagcgttacttaggcaaa
ggtgtcctgaaggcagtggaccacatcaactccaccatcgcgccagccctcatcagctca
ggtctctctgtggtggagcaagagaaactggacaacctgatgctggagttggatgggact
gagaacaaatccaagtttggggccaatgccatcctgggtgtgtctctggccgtgtgtaag
gcaggggcagctgagcgggaactgcccctgtatcgccacattgctcagctggccgggaac
tcagacctcatcctgcctgtgccggccttcaacgtgatcaatggtggctctcatgctggc
aacaagctggccatgcaggagttcatgatcctcccagtgggagctgagagctttcgggat
gccatgcgactaggtgcagaggtctaccatacactcaagggagtcatcaaggacaaatac
ggcaaggatgccaccaatgtgggggatgaaggtggctttgcccccaatatcctggagaac
agtgaagccttggagctggtgaaggaagccatcgacaaggctggctacacggaaaagatc
gttattggcatggatgttgctgcctcagagttttatcgtgatggcaaatatgacttggac
ttcaagtctcccactgatccttcccgatacatcactggggaccagctgggggcactctac
caggactttgtcagggactatcctgtggtctccattgaggacccatttgaccaggatgat
tgggctgcctggtccaagttcacagccaatgtagggatccagattgtgggtgatgacctg
acagtgaccaacccaaaacgtattgagcgggcagtggaagaaaaggcctgcaactgtctg
ctgctcaaggtcaaccagatcggctcggtcactgaagccatccaagcgtgcaagctggcc
caggagaatggctggggggtcatggtgagtcatcgctcaggagagactgaggacacattc
attgctgacctggtggtggggctgtgcacaggccagatcaagactggtgccccgtgccgt
tctgaacgtctggctaaatacaaccagctcatgagaattgaggaagagctgggggatgaa
gctcgctttgccggacataacttccgtaatcccagtgtgctgtga

KEGG   Homo sapiens (human): 2027
Entry
2027              CDS       T01001                                 
Symbol
ENO3, GSD13, MSE
Name
(RefSeq) enolase 3
  KO
K01689  enolase [EC:4.2.1.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
hsa03018  RNA degradation
hsa04066  HIF-1 signaling pathway
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00002  Glycolysis, core module involving three-carbon compounds
hsa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P
Network
nt06017  Glycogen metabolism
  Element
N00731  Glycolysis
Disease
H00069  Glycogen storage disease
H01762  Muscle glycogen storage disease
H01953  Glycogen storage disease type XIII
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    2027 (ENO3)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    2027 (ENO3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    2027 (ENO3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    2027 (ENO3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    2027 (ENO3)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.11  phosphopyruvate hydratase
     2027 (ENO3)
Messenger RNA biogenesis [BR:hsa03019]
 Prokaryotic type
  Bacterial mRNA degradation factors
   RNA degradosome components
    Other RNA degradosome components
     2027 (ENO3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   2027 (ENO3)
SSDB
Motif
Pfam: Enolase_C Enolase_N MR_MLE_C MAAL_C
Other DBs
NCBI-GeneID: 2027
NCBI-ProteinID: NP_001967
OMIM: 131370
HGNC: 3354
Ensembl: ENSG00000108515
Pharos: P13929(Tbio)
UniProt: P13929
Structure
LinkDB
Position
17:4948710..4957129
AA seq 434 aa
MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGK
GVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCK
AGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKE
AMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKV
VIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDD
WATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLA
QSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDK
AIFAGRKFRNPKAK
NT seq 1305 nt   +upstreamnt  +downstreamnt
atggccatgcagaaaatctttgcccgggaaatcttggactccaggggcaaccccacggtg
gaggtggacctgcacacggccaagggccgattccgagcagctgtgcccagtggggcttcc
acgggtatctatgaggctctggaactaagagacggagacaaaggccgctacctggggaaa
ggagtcctgaaggctgtggagaacatcaacaatactctgggccctgctctgctgcaaaag
aaactaagcgttgtggatcaagaaaaagttgacaaatttatgattgagctagatgggacc
gagaataagtccaagtttggggccaatgccatcctgggcgtgtccttggccgtgtgtaag
gcgggagcagctgagaagggggtccccctgtaccgccacatcgcagatctcgctgggaac
cctgacctcatactcccagtgccagccttcaatgtgatcaacgggggctcccatgctgga
aacaagctggccatgcaggagttcatgattctgcctgtgggagccagctccttcaaggaa
gccatgcgcattggcgccgaggtctaccaccacctcaagggggtcatcaaggccaagtat
gggaaggatgccaccaatgtgggtgatgaaggtggcttcgcacccaacatcctggagaac
aatgaggccctggagctgctgaagacggccatccaggcggctggttacccagacaaggtg
gtgatcggcatggatgtggcagcatctgagttctatcgcaatgggaagtacgatcttgac
ttcaagtcgcctgatgatcccgcacggcacatcactggggagaagctcggagagctgtat
aagagctttatcaagaactatcctgtggtctccatcgaagacccctttgaccaggatgac
tgggccacttggacctccttcctctcgggggtgaacatccagattgtgggggatgacttg
acagtcaccaaccccaagaggattgcccaggccgttgagaagaaggcctgcaactgtctg
ctgctgaaggtcaaccagatcggctcggtgaccgaatcgatccaggcgtgcaaactggct
cagtctaatggctggggggtgatggtgagccaccgctctggggagactgaggacacattc
attgctgaccttgtggtggggctctgcacaggacagatcaagactggcgccccctgccgc
tcggagcgtctggccaaatacaaccaactcatgaggatcgaggaggctcttggggacaag
gcaatctttgctggacgcaagttccgtaacccgaaggccaagtga

KEGG   Homo sapiens (human): 387712
Entry
387712            CDS       T01001                                 
Symbol
ENO4, C10orf134, ENOS
Name
(RefSeq) enolase 4
  KO
K01689  enolase [EC:4.2.1.11]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01230  Biosynthesis of amino acids
hsa03018  RNA degradation
hsa04066  HIF-1 signaling pathway
Module
hsa_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa_M00002  Glycolysis, core module involving three-carbon compounds
hsa_M00003  Gluconeogenesis, oxaloacetate => fructose-6P
Network
nt06017  Glycogen metabolism
  Element
N00731  Glycolysis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    387712 (ENO4)
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    387712 (ENO4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    387712 (ENO4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    387712 (ENO4)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    387712 (ENO4)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.11  phosphopyruvate hydratase
     387712 (ENO4)
Messenger RNA biogenesis [BR:hsa03019]
 Prokaryotic type
  Bacterial mRNA degradation factors
   RNA degradosome components
    Other RNA degradosome components
     387712 (ENO4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   387712 (ENO4)
SSDB
Motif
Pfam: Enolase_C Enolase_N Porin_2 PRIMA1
Other DBs
NCBI-GeneID: 387712
NCBI-ProteinID: NP_001229628
OMIM: 131375
HGNC: 31670
Ensembl: ENSG00000188316
UniProt: A6NNW6
LinkDB
Position
10:116849499..116912375
AA seq 625 aa
MEEEGGGRSCGTTRELQKLKQQAMEYYRENDVPRRLEELLNSTFYLQPADVYGHLANCFS
KLAKPPTICKIVGKDVLDGLGLPTLQVDIFCTIQNFPKNVCSVVISTHFEVHENALPELA
KAEEAERASAVSTAVQWVNSTITHELQGMAPSDQAEVDHLLRIFFASKVQEDKGRKELEK
SLEYSTVPTPLPPVPPPPPPPPPTKKKGQKPGRKDTITEKPIAPAEPVEPVLSGSMAIGA
VSLAVAKACAMLLNKPLYLNIALLKHNQEQPTTLSMPLLMVSLVSCGKSSSGKLNLMKEV
ICIPHPELTTKQGVEMLMEMQKHINKIIEMPSPPKAETKKGHDGSKRGQQQITGKMSHLG
CLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNKGKYEVIMGTYKNA
AEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQ
GNISIPKSNGLIIKHTNQTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLG
VRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLGFKEEHTFFYFNEEAEKAAEALEAAA
AREPLVPTFPTQGVEESAETGASSG
NT seq 1878 nt   +upstreamnt  +downstreamnt
atggaggaagaaggcggcggccgcagctgtgggaccactagggagctgcagaagctgaag
cagcaggcgatggagtactaccgggagaacgacgttccgcgcaggctggaagagctgctc
aactccaccttctacctccagcctgccgacgtctacgggcacctggcaaactgcttttct
aaacttgcaaagcctcccaccatatgcaaaatagtggggaaagacgtactagatggactg
gggcttccaaccctgcaagtggacatattctgcaccattcaaaactttcccaagaacgta
tgttctgtggtgatctcgactcattttgaagtccatgagaatgctctgcccgagctggcc
aaggcggaggaggcagagagggccagcgcggtgagcaccgccgtgcagtgggtcaacagc
accatcacgcacgagctccaggggatggcaccctctgaccaggcagaggtggatcaccta
ctcaggatattcttcgcaagtaaagtacaagaagataaggggagaaaagaattggaaaag
agcctggaatactcaacagtgcctacacctctacctccagtaccaccaccaccaccccct
ccacctcctaccaaaaaaaaggggcaaaagccagggaggaaggatactattacagagaaa
cctattgcgcctgcagagcctgttgagcctgtactcagtggcagtatggccataggggcc
gtgtcactagctgttgccaaagcctgtgccatgctgcttaataaacctctgtacttaaat
atcgctctactgaagcacaatcaggaacagccaacaacgctatctatgcctttgctgatg
gtatcgctggtcagctgtgggaagtcatcatctgggaagctaaatttaatgaaagaagtg
atttgtataccccatcctgaattaacaaccaaacaaggtgtcgagatgcttatggaaatg
cagaaacatatcaacaaaataattgaaatgccctctcctccaaaagcagagacaaaaaaa
gggcacgatggaagcaaaagaggtcaacagcagatcactggcaagatgtctcatcttggc
tgtttaaccattaactgtgactccatagaacagccactgcttctaatacaggaaatctgt
gccaacctggggctagaactgggaacaaatctgcatctagctatcaactgtgctggacat
gagctgatggactacaataaaggaaagtatgaagtgatcatgggcacatacaaaaatgca
gcggagatggttgacctgtatgtggatctgatcaacaagtacccttcaattattgcctta
attgatcctttcaggaaggaggactctgaacagtgggacagcatctatcacgcacttggt
tccaggtgttacataattgcaggaactgcttccaaaagcatttctaaacttctagagcaa
ggaaacatcagcatccccaaatccaatgggctgatcataaaacacacaaaccaaactaca
atgtctgacttggtggaaataaccaatctgattgacagtaagaagcacatcactgtcttt
ggaagtacagaaggagaatcatctgatgacagccttgtcgatttggctgttgggcttggt
gtccggttcatcaagttggggggtctttcccgtggtgaacgagtgactaaatacaaccgc
cttctcactatagaggaagaacttgtccagaatggaacactgggtttcaaagaagaacac
acttttttttactttaatgaggaagctgaaaaggctgcggaggcacttgaggctgctgcg
gctagggagccgctggtgcccaccttccccacacaaggtgtagaggaatcagccgaaaca
ggagcatcctctggatag

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