Homo sapiens (human): 2058
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Entry
2058 CDS
T01001
Symbol
EPRS1, EARS, EPRS, GLUPRORS, HLD15, PARS, PIG32, QARS, QPRS
Name
(RefSeq) glutamyl-prolyl-tRNA synthetase 1
KO
K14163
bifunctional glutamyl/prolyl-tRNA synthetase [EC:
6.1.1.17
6.1.1.15
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00860
Porphyrin metabolism
hsa00970
Aminoacyl-tRNA biosynthesis
hsa01100
Metabolic pathways
hsa01240
Biosynthesis of cofactors
Disease
H00679
Hypomyelinating leukodystrophy
Drug target
Bersiporocin (
DG03294
):
D12794
D12795
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
2058 (EPRS1)
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
2058 (EPRS1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
2058 (EPRS1)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
2058 (EPRS1)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.15 proline---tRNA ligase
2058 (EPRS1)
6.1.1.17 glutamate---tRNA ligase
2058 (EPRS1)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class I (A)
2058 (EPRS1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Multi-aminoacyl-tRNA synthetase complex (MSC)
2058 (EPRS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_1c
WHEP-TRS
ProRS-C_1
tRNA-synt_2b
HGTP_anticodon
tRNA-synt_1c_C
tRNA-synt_1c_C2
Arc1p_N_like
GST_C
tRNA-synt_1e
GST_C_2
GST_C_3
Motif
Other DBs
NCBI-GeneID:
2058
NCBI-ProteinID:
NP_004437
OMIM:
138295
HGNC:
3418
Ensembl:
ENSG00000136628
UniProt:
P07814
Structure
PDB
PDBj
LinkDB
All DBs
Position
1:complement(219968600..220046505)
Genome browser
AA seq
1512 aa
AA seq
DB search
MATLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENILHVSENVIFTDVNSILRYLAR
VATTAGLYGSNLMEHTEIDHWLEFSATKLSSCDSFTSTINELNHCLSLRTYLVGNSLSLA
DLCVWATLKGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQSVGTKWDVSTTKARVAPEK
KQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTN
PEKEKEDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMK
AEREQRIDSKHRKNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCK
IQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYI
WEYSRLNLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGS
SRSVVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVG
LKPVWYSPKVFIEGADAETFSEGEMVTFINWGNLNITKIHKNADGKIISLDAKLNLENKD
YKKTTKVTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFKQYVNKNSKHEELMLGDPC
LKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLIYIPDGHTKEMPTSGSKEKTK
VEATKNETSAPFKERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELKAKKAPKEDVDAA
VKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILESKSLYDEVAAQGEVVRKL
KAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPGQPPLSQSSDSSPTRNSEPAGLETPE
AKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKPVSATGAED
KDKKKKEKENKSEKQNKPQKQNDGQRKDPSKNQGGGLSSSGAGEGQGPKKQTRLGLEAKK
EENLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPM
FVSQSALEKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDL
PIKLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEEL
LAIPVVKGRKTEKEKFAGGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPK
IPGEKQFAYQNSWGLTTRTIGVMTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDK
EALIAKCNDYRRRLLSVNIRVRADLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFV
AVRRDTGEKLTVAENEAETKLQAILEDIQVTLFTRASEDLKTHMVVANTMEDFQKILDSG
KIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAKSLCIPFKPLCELQPGAKCVCGKN
PAKYYTLFGRSY
NT seq
4539 nt
NT seq
+upstream
nt +downstream
nt
atggcgacgctctctctgaccgtgaattcaggagaccctccgctaggagctttgctggca
gtagaacacgtgaaagacgatgtcagcatttccgttgaagaagggaaagagaatattctt
catgtttctgaaaatgtgatattcacagatgtgaattctatacttcgctacttggctaga
gttgcaactacagctgggttatatggctctaatctgatggaacatactgagattgatcac
tggttggagttcagtgctacaaaattatcttcatgtgattcctttacttctacaattaat
gaactcaatcattgcctgtctctgagaacatacttagttggaaactccttgagtttagca
gatttatgtgtttgggccaccctaaaaggaaatgctgcctggcaagaacagttgaaacag
aagaaagctccagttcatgtaaaacgttggtttggctttcttgaagcccagcaggccttc
cagtcagtaggtaccaagtgggatgtttcaacaaccaaagctcgagtggcacctgagaaa
aagcaagatgttgggaaatttgttgagcttccaggtgcggagatgggaaaggttaccgtc
agatttcctccagaggccagtggttacttacacattgggcatgcaaaagctgctcttctg
aaccagcactaccaggttaactttaaagggaaactgatcatgagatttgatgacacaaat
cctgaaaaagaaaaggaagattttgagaaggttatcttggaagatgttgcaatgttgcat
atcaaaccagatcaatttacttatacttcggatcattttgaaactataatgaagtatgca
gagaagctaattcaagaagggaaggcttatgtggatgatactcctgctgaacagatgaaa
gcagaacgtgagcagaggatagactctaaacatagaaaaaaccctattgagaagaatcta
caaatgtgggaagaaatgaaaaaagggagccagtttggtcagtcctgttgtttgcgagca
aaaattgacatgagtagtaacaatggatgcatgagagatccaaccctttatcgctgcaaa
attcaaccacatccaagaactggaaataaatacaatgtttatccaacatatgattttgcc
tgccccatagttgacagcatcgaaggtgttacacatgccctgagaacaacagaataccat
gacagagatgagcagttttactggattattgaagctttaggcataagaaaaccatatatt
tgggaatatagtcggctaaatctcaacaacacagtgctatccaaaagaaaactcacatgg
tttgtcaatgaaggactagtagatggatgggatgacccaagatttcctacggttcgtggt
gtactgagaagagggatgacagttgaaggactgaaacagtttattgctgctcagggctcc
tcacgttcagtcgtgaacatggagtgggacaaaatctgggcgtttaacaaaaaggttatt
gacccagtggctccacgatatgttgcattactgaagaaagaagtgatcccagtgaatgta
cctgaagctcaggaggagatgaaagaagtagccaaacacccaaagaatcctgaggttggc
ttgaagcctgtgtggtatagtcccaaagttttcattgaaggtgctgatgcagagactttt
tcggagggtgagatggttacatttataaattggggcaacctcaacattacaaaaatacac
aaaaatgcagatggaaaaatcatatctcttgatgcaaagttgaatttggaaaacaaagac
tacaagaaaaccactaaggtcacttggcttgcagagactacacatgctcttcctattcca
gtaatctgtgtcacttatgagcacttgatcacaaagccagtgctaggaaaagacgaggac
tttaagcagtatgtcaacaagaacagtaagcatgaagagctaatgctaggggatccctgc
cttaaggatttgaaaaaaggagatattatacaactccagagaagaggattcttcatatgt
gatcaaccttatgaacctgttagcccatatagttgcaaggaagccccgtgtgttttgata
tacattcctgatgggcacacaaaggaaatgccaacatcagggtcaaaggaaaagaccaaa
gtagaagccacaaaaaatgagacctctgctccttttaaggaaagaccaacaccttctctg
aataataattgtactacatctgaggattccttggtcctttacaatagagtggctgttcaa
ggagatgtggttcgtgaattaaaagccaagaaagcaccaaaggaagatgtagatgcagct
gtaaaacagcttttgtctttgaaagctgaatataaggagaaaactggccaggaatataaa
cctggaaaccctcctgctgaaataggacagaatatttcttctaattcctcagcaagtatt
ctggaaagtaaatctctgtatgatgaagttgctgcacaaggggaggtggttcgtaagcta
aaagctgaaaaatcccctaaggctaaaataaatgaagctgtagaatgcttactgtccctg
aaggctcagtataaagaaaaaactgggaaggagtacatacctggtcagcccccattatct
caaagttcggattcaagcccaaccagaaattctgaacctgctggtttagaaacaccagaa
gcgaaagtactttttgacaaagtagcttctcaaggggaagtagttcggaaacttaaaact
gaaaaagcccctaaggatcaagtagatatagctgttcaagaactccttcagctaaaggca
cagtacaagtctttgataggagtagagtataagcctgtgtcggccactggagctgaggac
aaagataagaagaagaaagaaaaagaaaataaatctgaaaagcagaataagcctcagaaa
caaaatgatggccaaaggaaagacccttctaaaaaccaaggaggtgggctctcatcaagt
ggagcaggagaagggcaggggcctaagaaacagaccaggttgggtcttgaggcaaaaaaa
gaagaaaatcttgctgattggtattctcaggtcatcacaaagtcagaaatgattgaatac
catgacataagtggctgttatattcttcgtccctgggcctatgccatttgggaagccatc
aaggacttttttgatgctgagatcaagaaacttggtgttgaaaactgctacttccccatg
tttgtgtctcaaagtgcattagagaaagagaagactcatgttgctgactttgccccagag
gttgcttgggttacaagatctggcaaaaccgagctggcagaaccaattgccattcgtcct
actagtgaaacagtaatgtatcctgcatatgcaaaatgggtacagtcacacagagacctg
cccatcaagctcaatcagtggtgcaatgtggtgcgttgggaattcaagcatcctcagcct
ttcctacgtactcgtgaatttctttggcaggaagggcacagtgcttttgctaccatggaa
gaggcagcggaagaggtcttgcagatacttgacttatatgctcaggtatatgaagaactc
ctggcaattcctgttgttaaaggaagaaagacggaaaaggaaaaatttgcaggaggagac
tatacaactacaatagaagcatttatatctgctagtggaagagctatccagggaggaaca
tcacatcatttagggcagaatttttccaaaatgtttgaaatcgtttttgaagatccaaag
ataccaggagagaagcaatttgcctatcaaaactcctggggcctgacaactcgaactatt
ggtgttatgaccatggttcatggggacaacatgggtttagtattaccaccccgtgtagca
tgtgttcaggtggtgattattccttgtggcattaccaatgcactttctgaagaagacaaa
gaagcgctgattgcaaaatgcaatgattatcgaaggcgattactcagtgttaacatccgc
gttagagctgatttacgagataattattctccaggttggaaattcaatcactgggagctc
aagggagttcccattagacttgaagttgggccacgtgatatgaagagctgtcagtttgta
gccgtcagacgagatactggagaaaagctgacagttgctgaaaatgaggcagagactaaa
cttcaagctattttggaagacatccaggtcacccttttcacaagggcttctgaagacctt
aagactcatatggttgtggctaatacaatggaagactttcagaagatactagattctgga
aagattgttcagattccattctgtggggaaattgactgtgaggactggatcaaaaagacc
actgccagggatcaagatcttgaacctggtgctccatccatgggagctaaaagcctttgc
atccccttcaaaccactctgtgaactgcagcctggagccaaatgtgtctgtggcaagaac
cctgccaagtactacaccttatttggtcgcagctactga
DBGET
integrated database retrieval system
