Homo sapiens (human): 2181
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Entry
2181 CDS
T01001
Symbol
ACSL3, ACS3, FACL3, LACS_3, LACS3, PRO2194
Name
(RefSeq) acyl-CoA synthetase long chain family member 3
KO
K01897
long-chain-fatty-acid---CoA ligase [EC:
6.2.1.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00061
Fatty acid biosynthesis
hsa00071
Fatty acid degradation
hsa01100
Metabolic pathways
hsa01212
Fatty acid metabolism
hsa03320
PPAR signaling pathway
hsa04146
Peroxisome
hsa04216
Ferroptosis
hsa04714
Thermogenesis
hsa04920
Adipocytokine signaling pathway
Module
hsa_M00086
beta-Oxidation, acyl-CoA synthesis
Network
nt06020
beta-Oxidation in mitochondria
Element
N00765
beta-Oxidation, acyl-CoA synthesis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00061 Fatty acid biosynthesis
2181 (ACSL3)
00071 Fatty acid degradation
2181 (ACSL3)
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
2181 (ACSL3)
09143 Cell growth and death
04216 Ferroptosis
2181 (ACSL3)
09150 Organismal Systems
09152 Endocrine system
04920 Adipocytokine signaling pathway
2181 (ACSL3)
03320 PPAR signaling pathway
2181 (ACSL3)
09159 Environmental adaptation
04714 Thermogenesis
2181 (ACSL3)
09180 Brite Hierarchies
09181 Protein families: metabolism
01004 Lipid biosynthesis proteins [BR:
hsa01004
]
2181 (ACSL3)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
2181 (ACSL3)
Enzymes [BR:
hsa01000
]
6. Ligases
6.2 Forming carbon-sulfur bonds
6.2.1 Acid-thiol ligases
6.2.1.3 long-chain-fatty-acid---CoA ligase
2181 (ACSL3)
Lipid biosynthesis proteins [BR:
hsa01004
]
Acyl-CoA ligase
Long/very long chain acyl-CoA ligase
2181 (ACSL3)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of breast milk
2181 (ACSL3)
Exosomal proteins of breast cancer cells
2181 (ACSL3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
AMP-binding
AMP-binding_C
Motif
Other DBs
NCBI-GeneID:
2181
NCBI-ProteinID:
NP_004448
OMIM:
602371
HGNC:
3570
Ensembl:
ENSG00000123983
UniProt:
O95573
LinkDB
All DBs
Position
2:222861036..222944639
Genome browser
AA seq
720 aa
AA seq
DB search
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPV
NSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPN
GKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACF
MYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGK
PPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMIS
HSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQ
SSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQI
SKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTES
AGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYY
KNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAA
LKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLK
VLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
NT seq
2163 nt
NT seq
+upstream
nt +downstream
nt
atgaataaccacgtgtcttcaaaaccatctaccatgaagctaaaacataccatcaaccct
attcttttatattttatacattttctaatatcactttatactattttaacatacattccg
ttttattttttctccgagtcaagacaagaaaaatcaaaccgaattaaagcaaagcctgta
aattcaaaacctgattctgcatacagatctgttaatagtttggatggtttggcttcagta
ttataccctggatgtgatactttagataaagtttttacatatgcaaaaaacaaatttaag
aacaaaagactcttgggaacacgtgaagttttaaatgaggaagatgaagtacaaccaaat
ggaaaaatttttaaaaaggttattcttggacagtataattggctttcctatgaagatgtc
tttgttcgagcctttaattttggaaatggattacagatgttgggtcagaaaccaaagacc
aacatcgccatcttctgtgagaccagggccgagtggatgatagctgcacaggcgtgtttt
atgtataattttcagcttgttacattatatgccactctaggaggtccagccattgttcat
gcattaaatgaaacagaggtgaccaacatcattactagtaaagaactcttacaaacaaag
ttgaaggatatagtttctttggtcccacgcctgcggcacatcatcactgttgatggaaag
ccaccgacctggtccgagttccccaagggcatcattgtgcataccatggctgcagtggag
gccctgggagccaaggccagcatggaaaaccaacctcatagcaaaccattgccctcagat
attgcagtaatcatgtacacaagtggatccacaggacttccaaagggagtcatgatctca
catagtaacattattgctggtataactgggatggcagaaaggattccagaactaggagag
gaagatgtctacattggatatttgcctctggcccatgttctagaattaagtgctgagctt
gtctgtctttctcacggatgccgcattggttactcttcaccacagactttagcagatcag
tcttcaaaaattaaaaaaggaagcaaaggggatacatccatgttgaaaccaacactgatg
gcagcagttccggaaatcatggatcggatctacaaaaatgtcatgaataaagtcagtgaa
atgagtagttttcaacgtaatctgtttattctggcctataattacaaaatggaacagatt
tcaaaaggacgtaatactccactgtgcgacagctttgttttccggaaagttcgaagcttg
ctagggggaaatattcgtctcctgttgtgtggtggcgctccactttctgcaaccacgcag
cgattcatgaacatctgtttctgctgtcctgttggtcagggatacgggctcactgaatct
gctggggctggaacaatttccgaagtgtgggactacaatactggcagagtgggagcacca
ttagtttgctgtgaaatcaaattaaaaaactgggaggaaggtggatactttaatactgat
aagccacaccccaggggtgaaattcttattgggggccaaagtgtgacaatggggtactac
aaaaatgaagcaaaaacaaaagctgatttctttgaagatgaaaatggacaaaggtggctc
tgtactggggatattggagagtttgaacccgatggatgcttaaagattattgatcgtaaa
aaggaccttgtaaaactacaggcaggggaatatgtttctcttgggaaagtagaggcagct
ttgaagaatcttccactagtagataacatttgtgcatatgcaaacagttatcattcttat
gtcattggatttgttgtgccaaatcaaaaggaactaactgaactagctcgaaagaaagga
cttaaagggacttgggaggagctgtgtaacagttgtgaaatggaaaatgaggtacttaaa
gtgctttccgaagctgctatttcagcaagtctggaaaagtttgaaattccagtaaaaatt
cgtttgagtcctgaaccgtggacccctgaaactggtctggtgacagatgccttcaagctg
aaacgcaaagagcttaaaacacattaccaggcggacattgagcgaatgtatggaagaaaa
taa
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