| Entry |
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| Symbol |
FH, FMRD, HLRCC, HsFH, LRCC, MCL, MCUL1
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| Name |
(RefSeq) fumarate hydratase, mitochondrial
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| KO |
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| Organism |
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| Pathway |
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| Module |
| hsa_M00011 | Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate |
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| Network |
nt06031 Citrate cycle and pyruvate metabolism |
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| Element |
| N01617 | Citrate cycle, second carbon oxidation 2 |
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| Disease |
| H00804 | Multiple cutaneous and uterine leiomyomata |
| H01022 | Diseases of the tricarboxylic acid cycle |
| H01510 | Malignant paraganglioma |
| H02049 | Bilateral macronodular adrenal hyperplasia |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
2271 (FH)
00620 Pyruvate metabolism
2271 (FH)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
2271 (FH)
09162 Cancer: specific types
05211 Renal cell carcinoma
2271 (FH)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
2271 (FH)
Enzymes [BR:hsa01000]
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.2 fumarate hydratase
2271 (FH)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
1:complement(241497603..241519755)
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| AA seq |
510 aa
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK |
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| NT seq |
1533 nt +upstreamnt +downstreamnt
atgtaccgagcacttcggctcctcgcgcgctcgcgtcccctcgtgcgggctccagccgca
gccttagcttcggctcccggcttgggtggcgcggccgtgccctcgttttggcctccgaac
gcggctcgaatggcaagccaaaattccttccggatagaatatgatacctttggtgaacta
aaggtgccaaatgataagtattatggcgcccagaccgtgagatctacgatgaactttaag
attggaggtgtgacagaacgcatgccaaccccagttattaaagcttttggcatcttgaag
cgagcggccgctgaagtaaaccaggattatggtcttgatccaaagattgctaatgcaata
atgaaggcagcagatgaggtagctgaaggtaaattaaatgatcattttcctctcgtggta
tggcagactggatcaggaactcagacaaatatgaatgtaaatgaagtcattagcaataga
gcaattgaaatgttaggaggtgaacttggcagcaagatacctgtgcatcccaacgatcat
gttaataaaagccagagctcaaatgatacttttcccacagcaatgcacattgctgctgca
atagaagttcatgaagtactgttaccaggactacagaagttacatgatgctcttgatgca
aaatccaaagagtttgcacagatcatcaagattggacgtactcatactcaggatgctgtt
ccacttactcttgggcaggaatttagtggttatgttcaacaagtaaaatatgcaatgaca
agaataaaagctgccatgccaagaatctatgagctcgcagctggaggcactgctgttggt
acaggtttaaatactagaattggctttgcagaaaaggttgctgcaaaagtggctgcactt
acaggcttgccttttgtcactgctccgaataaatttgaagctctggctgctcatgacgct
ctggttgagctcagtggagccatgaacactactgcctgcagtctgatgaagatagcaaat
gatattcgatttttgggttctggtcctcggtcaggtctgggagaattgatcttgcctgaa
aatgaaccaggaagcagtatcatgccaggcaaggtgaaccctactcagtgtgaagcaatg
accatggttgcagcccaagtcatggggaaccatgttgctgtcactgtcggaggcagcaat
ggacattttgagttgaatgttttcaagccaatgatgattaaaaatgtgttacactcagcc
aggctgctgggggatgcttcagtttcctttacagaaaactgcgtggtgggaatccaggcc
aatacagaaaggatcaacaagctgatgaatgagtctctaatgttggtgacagctctcaat
cctcatatagggtatgacaaggcagcaaagattgctaagacagcacacaaaaatggatca
accttaaaggaaactgctatcgaacttggctatctcacagcagagcagtttgacgaatgg
gtaaaacctaaggacatgctgggtccaaagtga |
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