Homo sapiens (human): 23077 Help Entry 23077             CDS       T01001                                  Symbol MYCBP2, Myc-bp2, PAM, PHR1, Phr Name (RefSeq) MYC binding protein 2   KO K10693   RCR-type E3 ubiquitin transferase [EC:2.3.2.33] Organism hsa  Homo sapiens (human) Brite KEGG Orthology (KO) [BR:hsa00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hsa04121]     23077 (MYCBP2) Enzymes [BR:hsa01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.33  RCR-type E3 ubiquitin transferase      23077 (MYCBP2) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    Other single Ring-finger type E3     23077 (MYCBP2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PHR RCC1_2 RCC1 SH3_3 ANAPC10 zf-RING_2 Filamin Nup98_GLEBS zf-RING_11 Motif Other DBs NCBI-GeneID:  23077 NCBI-ProteinID:  NP_055872 OMIM:  610392 HGNC:  23386 Ensembl:  ENSG00000005810 UniProt:  O75592 Structure PDBPDBj LinkDB All DBs Position 13:complement(77044657..77327094) Genome browser AA seq 4678 aa AA seqDB search MMMCAATASPAAASSGLGGDGFYPAATFSSSPAPGALFMPVPDGSVAAAGLGLGLPAADS RGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHPASRNKKILNKKKLKRKQKSKSK VKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCVLEWQKKEISLAAASKNSVQSGE SDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSHPSLCLRSLQALLNVLQGQQPEG LQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALSCACLFSLVASWGETGRTLQAIS AILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQDWFSNGIKKAALMHKWPLKEIS VDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGHIYNSTSRIRNRKEKKSWLGYAQ GYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEGQNILFTDGEYINQIAASRDDGF VVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEKDLHIISTGFDEESAILGAGREF ALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAED GSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELY MFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAM NQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGA SCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDL LLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSH PAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGD VYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSK GQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEALINSHVLATSEI FASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRF RPNTRELWCYNAVVADARLPSAADMQSRCSILSPELALPTGSRALTTRSHAALHILGCLD TLAAMQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFESHGGGWGYSAHSVEAIRFSADT DILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFD EPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIP QLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVECFESLLSILHWSWTTLVLGVEE LRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIYPVSATGKAVVEETSKLAECIGK TRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAVLQECHNTFTACFHSFYPTPALQ WACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHTSVKLTSIFPIAYDGEVLLRSIV KQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSFREVLEKMLVIVVLPVRNSLRRE NELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSLHSVKASANRFTKTSQGRSWNTG NGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLVDDSEHAGDSTHSHRWTSLELVK GTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTANGDGGMTTVQCPDGVTFTF STCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSKANEEDKNCSRALSVVSTVVRAS KDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGPVAAAIPKVAVEVFGLVQQLLPS VAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSSHYAVIESEHPYKPACVMHYKVT FPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSGYGPKLTSVHENLNSWIELKKFS GSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGFKCFAIGYEFSPGPDEGVIQLEK ELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAALQVCKTHSGILGKGLALSHSPTI LEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARWLQPDSYADPQKTSLILNKDDIR CGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKMSLQQDQAKKPQRIPGSPAVTAA SSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKVYENYSFEELRFASPTPKRPSEN MLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGLEVKVKDPPKGMIPPGTQLVKPK SEPQPNKVRKFVAKDSAGLRIRSHPSLQSEQIGIVKVNGTITFIDEIHNDDGVWLRLNDE TIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTNTDDFFKDINSCCPQEATMQEQD MPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLVLGNKVKAVGEVTNSEGTWVQLD QNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPFSVQAFNKGASC SAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRG TESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLS SPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDT LRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSST LKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTRPK KEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFLKFHPE LSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALNMFNIAPHGPDISKMGSINKNKV LSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPLTLQHLVAFWEDISLATIKAASQ NMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVRPRGNLFGEMAQLAVGGPEKDTI CELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGWAGNCGDGGIGGSTWYLVC DRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTMEAHQVIKANALFLLSLSSAAEP SILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTLARHHHENFVGYQDDNLFQDEMR YLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLETSPITDTDLAKRTVFQRSYSVV ASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHPSPELSRLISAHSSLSKGERNFQ WPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFNWLLCNVIQTTSLHDILWHFVAS LTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSDIVIAGEAAHPLPHTFHRLLQTI SDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNVFHHINNILSKSDDGDSEESFSI SIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIGSLTDGSTETFWESGDEDKNKTK NITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGKAVEDLCRIKQVDLDSRHIGWVT SELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGESTKIAGQISASVAQQRNCEAETLR VFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEKVYNATSDADLKEHMVGIIFSRS KLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENANSQPNDEDASSDAYCFELLSMV LALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQVTSLLRRVLPEVTPSRLASIIGV KSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALTVQLKAKGTTITGTAGTTVGKGV TTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIKLIKDMAAGHLSEAWSRVTKNAIA ETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQDHVDRLSSGRWMGKDGQQKQMPM CDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTHQRQVFKEEEEAIKVDLHEGCGR TKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRFCGSRSGTELSAVGSVCSDADCQ EYAKIACSKTHPCGHPCGGVKNEEHCLPCLHGCDKSATSLKQDADDMCMICFTEALSAAP AIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPICKNKINHIVLKDLLDPIKELYED VRRKALMRLEYEGLHKSEAITTPGVRFYNDPAGYAMNRYAYYVCYKCRKAYFGGEARCDA EAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYKCRYCCSVAVFFCFGTTHFCNAC HDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVHPPTGEEFALGCGVCRNAHTF NT seq 14037 nt NT seq  +upstreamnt  +downstreamnt atgatgatgtgcgcagcgactgcctcccccgccgccgcctcctcggggctcggcggggac ggattctacccagccgccaccttctcttcctccccggcgccgggggcgctgttcatgccg gttcccgacggctccgtggctgctgcggggctggggctggggctacccgccgcggactcc cggggtcactaccagctgctgctgtcaggccgggccctggccgaccgctaccggaggatt tataccgctgcgctcaatgacagggaccaggggggcggcagcgctggacacccagcctcc aggaataagaaaattttaaataagaagaaattgaaaagaaaacagaagagcaaatcaaaa gtgaagacaagaagcaagtctgaaaacttagagaatacagtaatcataccagatatcaaa ctacatagcaatccttctgctttcaatatttactgtaatgtacgccattgcgttctggaa tggcagaaaaaggaaatatcattggcagccgcatctaagaactctgtgcagagtggagaa tcagatagtgatgaagaagaggaatccaaagagccccctatcaagcttccaaagattatt gaggttggcctttgtgaagtttttgaattgatcaaagagacacgattttctcatccatcc ctgtgtctcaggagtctccaagccctgctcaacgtgctgcagggccagcagccagaaggc ctccagtctgagccacctgaggtcctagagtctctcttccagcttcttttggaaatcacc gttcgaagtactgggatgaatgacagcacaggacagtccttaacagcactttcctgtgct tgcctctttagtctggtggcttcttggggagaaacaggaaggacacttcaggccatctct gctatcctcaccaacaatggaagccatgcttgccaaactattcaggtgccaacaattcta aattcgctacagagaagtgtacaagcagttttggtgggaaaaattcaaattcaggactgg tttagtaatggcattaagaaagcagctttaatgcacaagtggccattaaaagaaatatct gttgatgaagatgaccaatgtctacttcagaatgatggattttttctttatctattatgc aaggatggattatataaaataggctctggatacagtggaacagttaggggccatatatac aattctacatcccgtattagaaacagaaaagaaaaaaagtcttggttagggtatgctcag ggttatttattatatagagatgtgaataaccacagcatgacagccataaggataagccct gaaacactggagcaagatggtactgtgatgttaccagattgccacactgaaggtcaaaat attttattcactgatggagaatatattaatcagatagctgcttcaagagatgatggcttt gttgtcagaatatttgccacaagcactgaacctgttctacagcaagaattgcaacttaaa ctggctagaaaatgcttacatgcctgtggtatctcactattcgatctggaaaaggacttg catattataagtacaggatttgatgaggagtcagcaattcttggtgcaggacgagagttt gcgctaatgaaaacagcaaatggaaagatatattacactggcaaataccagagtcttgga atcaaacaaggtggtccttcagcaggaaaatgggttgagctaccaattacaaaatctcca aagatagtacacttctcagttggacacgatggctctcacgcccttttagttgcagaagat gggagcatattctttacaggatctgctagtaaaggagaagatggagaatcaactaagagc agacggcaatccaaaccttataaacctaaaaagataattaagatggaaggaaagattgtg gtatatacagcctgcaataatggaagtagttctgttatttctaaagatggagaactctac atgtttggaaaagatgccatttactctgatagttcaagtttggtaactgatttgaagggc cattttgtaactcaggtagctatgggcaaagctcacacttgtgttttaatgaagaatgga gaggtgtggacatttggtgtaaataataaaggacagtgtggacgagatactggtgccatg aaccaaggtgggaaagggtttggagttgaaaatatggcaacagcaatggatgaagacctg gaagaagaactagatgaaaaagatgagaagtctatgatgtgccctccaggcatgcacaaa tggaagctggagcagtgcatggtttgcactgtctgtggagactgtacaggttatggagcc agctgtgtcagtagtggacggccagacagagtccccggagggatctgtggttgtggttcc ggagaatctggttgtgctgtgtgtggatgttgcaaggcctgtgcaagagagttagatggt caagaggcaagacaaagaggaattcttgatgcagtgaaagaaatgatacctttagatctt cttttagctgtcccagtgcccggggttaacattgaagaacaccttcagttacgacaagaa gaaaaacggcaacgtgtaatcagaaggcacagattagaggaaggaagaggcccccttgta tttgctggtcctatttttatgaaccatcgagaacaggctctagccagactcagatcccat ccagcacagctaaagcataaacgggacaagcacaaagatggaagtggagaaagaggcgaa aaggatgcaagcaaaatcacaacataccctccaggctctgtgcgatttgactgtgagctc cgggcagtccaagtcagctgtggatttcaccattcagtggttttaatggaaaatggagat gtctatacatttggttatgggcagcatgggcagctaggacatggagatgtcaactccagg ggatgtcccactcttgttcaagcattgccaggccctagcacacaagtcactgcaggcagc aaccatacggcagtacttttaatggatggacaggtcttcacatttggaagtttttctaaa ggacaactgggcagaccaattttggatgtgccatattggaatgcaaagccagctcccatg cctaacattggatcaaaatatggaagaaaagctacttggataggtgcaagtggggaccaa acttttttacgaattgatgaagcacttattaattctcatgtacttgctacatcagaaatt tttgccagtaaacacataataggcttggtacctgcttctatatcagaacctcctccattt aaatgccttctgataaataaagtggatgggagttgtaaaacttttaatgactcagaacaa gaggatctgcaaggatttggtgtgtgtcttgatcctgtatatgatgtaatttggaggttt cgaccaaatactagagagctgtggtgttacaatgcggtggttgctgatgccaggcttccc tctgcagcagacatgcagtccagatgtagtatcctaagtcctgaacttgccttaccaaca ggatcaagggccctcactacccgatctcatgcagctttgcacattttaggttgtcttgat accttggcagctatgcaggacttaaaaatgggtgttgcaagtacagaggaagagactcaa gcagtaatgaaggtttattctaaagaagattatagtgtggtaaacaggtttgaaagtcat ggaggaggctggggttattctgcccattcagtagaagctatacgtttcagtgccgacact gatattttacttggtggtcttggtctgtttggaggtagaggagaatatactgctaaaatt aagctgtttgaattgggtcctgatggaggagatcatgaaactgatggtgaccttcttgca gagactgatgtattggcttatgactgtgctgctagagaaaaatatgcaatgatgtttgat gagcctgttctcctgcaagctgggtggtggtatgtggcatgggcccgagtgtcaggaccc agcagtgactgtggatctcatggacaggcatctattaccacagatgatggggttgttttc cagttcaagagttcaaagaaatcaaataatggtacagatgttaatgcgggtcagatacct cagttattatacagacttccaaccagtgatggcagtgcttcaaaaggcaaacagcaaacc agtgaacctgtacacattttaaagaggtcttttgcaagaactgtctcagtggaatgtttt gagtcattgttgagtattcttcactggagctggaccaccttagtcttaggagttgaagaa cttagaggattaaaaggattccagttcacagctacactcctagatttagagagactgcgc tttgtgggtacctgttgtctgaggttattgcgtgtctatacctgtgaaatttacccagtg tcagctacaggaaaagcagttgtagaagaaactagcaaattagcagagtgtattggaaaa accagaactttgttaagaaaaattttatcagaaggagttgatcactgcatggtgaaattg gataatgatcctcaaggatatctcagtcaacccttgagtcttctagaagctgtccttcag gaatgtcataatactttcactgcctgctttcattctttctacccaactcctgccttacag tgggcttgcctttgtgatctgctgaattgtttggatcaggatatccaagaagcaaacttc aagacatcaagtagccgactccttgcagctgttatgtcagctctgtgtcacacgtctgtt aagctgacttccatcttcccgattgcgtatgatggagaagtattactacgatcaattgtt aaacaagttagtacagagaacgactcaacactagttcatcgttttccccttttggtggca catatggaaaaactcagccagagtgaagagaatatctcagggatgacaagcttccgtgaa gttctggagaaaatgctggtcattgttgtgctaccagtcaggaacagcctgaggagagaa aatgaactcttctcctcccacctcgtctctaacacctgtggattactggccagcattgtc agtgaactgacagcgtcagccctgggatctgaggttgatggacttaattctcttcactct gtaaaagctagtgctaaccgatttacaaaaacaagtcagggcagaagttggaacactggg aacgggtcccctgatgcaatctgtttttcagtagacaaacctggaatagttgtggttggt ttctctgtctatggaggaggtggaattcatgaatatgaattagaggtgttggttgatgat agtgaacatgcaggagattcaactcattcccacagatggacatctctggaattagtgaaa ggaacgtacacaacggatgactcacccagtgatatagctgagatcagacttgacaaagtg gttcctttaaaggaaaatgttaaatatgctgtgcgcttgaggaactatggaagccgtaca gccaatggagatggaggaatgaccacagttcagtgccctgatggtgtgacattcacattc agcacgtgcagcttgagcagtaacggcacaaaccaaaccagaggacagatcccacagata ctctactataggagtgaatttgatggagatttacaatcccaacttctgagtaaagccaat gaagaagataaaaactgtagcagagcattgtctgttgtaagcactgtcgttcgagcctct aaggacctcctgcacagagctcttgctgtggatgctgatgacattccagaactgctgagt tcttccagtctgttttccatgctgctcccccttattatagcctacataggaccagtagct gctgctattcccaaggtggctgtagaagtctttggccttgtccaacaattgcttccgtca gttgccattttgaatcagaagtatgcaccgcctgccttcaaccctaatcagtcgacagat agcaccacaggaaaccagcctgaacagggcctctctgcttgtacaacctccagtcactat gctgtcatagagagtgagcacccgtataaacctgcctgtgtgatgcattacaaggtgaca ttcccagaatgtgtgaggtggatgacaatcgaatttgaccctcagtgtggtactgcacag tcagaagatgtccttcgtttgttgattcctgtcagaactgttcagaattcaggatatgga ccaaaattgacatctgttcatgaaaatcttaattcatggatagaattaaagaaattttca ggatcctctgggtggcctactatggttttggtgttgccaggaaatgaggcccttttttca ttggagactgcatcagattatgtgaaagatgacaaagcttctttctatggttttaagtgt tttgcaattggatatgaatttagccctggacctgatgagggagtcatccaattggaaaaa gaattagccaatcttggtggggtttgtgcagcagctctgatgaagaaggacctagcactt cctattggtaatgaattagaagaagaccttgaaattcttgaggaggctgcattgcaggtg tgcaaaacccattctggaattcttggaaagggtctagctctttctcattcaccaactata ttagaagcacttgagggaaatttaccactccaaatccaaagcaatgaacagtcttttctg gatgattttattgcctgtgtcccaggatcaagtggtggaaggcttgcaaggtggcttcag ccagattcatatgcggatcctcagaaaacatctttgatcctgaataaggatgatattcgt tgtggttggcctaccaccataactgttcaaacaaaagaccagtatggggatgtggtacat gttcccaatatgaaggtggaagtgaaagctgtccctgtttctcagaaaaaaatgtcttta caacaagatcaagcaaagaaacctcaaaggattcctggcagtcctgcagtaacagctgca tcttctaatactgacatgacttatggagggctggcatcaccaaagctagatgtttcatat gaaccaatgatagtgaaggaagctcgatatattgccataacaatgatgaaggtttatgaa aattattcatttgaagaactacgttttgcatcaccaactcctaagagacccagtgagaat atgctgatccgtgtcaataatgatgggacttattgtgcaaattggactccaggggctatt ggactctacactcttcatgttaccattgatggcattgaaatcgatgctggtctggaagta aaagtaaaagacccaccaaaagggatgataccaccaggaactcagttggtcaaaccaaag tctgaacctcagcctaataaggttcgaaaatttgtggccaaggacagtgcggggcttcgc atccgtagccacccttcccttcagagtgagcagataggcatagtgaaagtcaatggaact atcacttttattgatgagatccataatgatgatggtgtgtggctgaggctgaatgatgag acaataaagaagtatgtccctaacatgaatggttacactgaagcctggtgcctctctttt aatcaacatcttggcaagagtcttctggtccctgttgacgaatctaaaactaatactgat gactttttcaaagacataaactcctgctgcccacaggaagcaacaatgcaagaacaagat atgccattcttgcgaggagggccaggcatgtacaaggtagtgaagacgggaccttcaggt cacaacatcagaagctgccctaaccttagaggtatcccaattggaatgttagttctggga aacaaagtcaaagcagtgggagaggtaaccaattctgaagggacatgggtgcaactggat cagaacagcatggtagagttctgtgagagtgatgaaggagaggcatggtccttagctaga gacagaggcggaaaccagtacctccgacatgaagatgaacaagctcttctggatcagaat tctcaaactcctcctccaagccctttctcagtgcaagcttttaataaaggggcaagttgc agtgcccaaggatttgattatggactcggaaatagcaaaggtgatcgaggaaacatctca acatcttctaaaccagcctctacatcaggaaaatcagagctgtcctctaaacacagcaga tcgcttaaacctgatggacgtatgagccggactactgctgatcagaagaagccaaggggc acagaaagtttatctgctagtgaatccctcatcttaaaatctgatgctgcaaagttgagg tcagattcccacagtaggtcattatcccccaaccataacaccttgcagacattgaaatct gatgggaggatgccttctagctccagagctgaatccccaggaccaggttctcggttgtca tctcctaagccaaagactctcccagccaataggtctagcccatcgggtgctagttctcca cgctcctcctcaccacatgataaaaatctacctcaaaaaagtactgctcctgttaagaca aagcttgatcctcctcgggaacgttctaaatcagactcttacacacttgatccagatacc ctccgcaagaagaaaatgcccctcacagaacctttgagaggacggtcaacgtcaccaaaa ccaaaatcagtaccaaaggattctacagattcccctggatctgaaaatagagctccctct ccccatgtggtacaggaaaacctccacagtgaggtggtcgaagtctgcacctcaagtact ttaaaaacaaatagtctaacagacagcacctgcgatgacagcagtgaatttaagagtgtg gatgaaggttcaaataaagttcattttagcattggaaaagcaccactgaaagatgaacag gaaatgagagcatctcccaaaataagtcgaaaatgtgctaatagacacaccaggcccaaa aaagaaaaatcgagttttcttttcaaaggagatggatccaagcctttagagccagccaag caagccatgtctccttctgtggccgaatgtgccagagctgtgtttgcttccttcctctgg catgaaggcatagtacatgatgcaatggcttgttcttctttcctaaagtttcatcctgaa ctttccaaagaacatgctcctataaggagtagtttaaatagccaacaacctacagaggaa aaagaaaccaagttaaaaaatagacattcattagaaatatcatctgcactgaatatgttt aatattgcaccccatggaccagatatatctaagatgggtagcatcaacaaaaacaaggta ttgtctatgcttaaggaaccacctctgcatgaaaaatgtgaggatgggaaaaccgagacc acttttgaaatgtccatgcataacacaatgaagtctaagtctcctcttcccttaacttta caacatttagtggctttttgggaagacatctctttggctactatcaaagctgcttcccag aatatgatttttccaagtcctggttcctgtgcagttcttaaaaagaaagagtgtgagaaa gagaataagaagtccaaaaaggaaaaaaagaaaaaagaaaaggcagaagttaggcccagg ggtaatttgtttggagagatggcccagctggcagtaggaggaccagagaaagataccatc tgtgaactgtgtggggagtcacatccatacccggtgacctatcacatgagacaagctcac ccaggttgtggccgatatgctggtggacaaggttacaatagcattgggcatttttgtgga ggatgggctggtaactgtggtgatggtggcataggaggaagcacttggtatctggtatgt gatcgctgtagagaaaaatacctccgcgaaaaacaggctgctgcaagggagaaggtcaaa caatctaggagaaaaccaatgcaagtcaagacccctcgtgccttgcccaccatggaagct caccaggtgattaaagccaatgcactcttcctgctgtccctgagcagtgcagcagaaccg agcattctgtgttaccatcctgcaaagccattccaatctcagttgcccagtgtaaaagaa ggcatttctgaggatcttcctgtgaaaatgccttgtctctacctgcagacattagctagg catcatcatgaaaattttgtgggctatcaagatgacaatctattccaggatgaaatgaga tatctacgttcaacatctgtacctgccccgtatatatcagtaactcctgatgcaagtcct aatgtatttgaagagccagagagcaatatgaagtctatgccaccaagtttagaaaccagt cccataactgatactgatcttgcaaagagaactgtcttccaaagatcatactcagttgtt gcttccgaatatgataaacaacactccattttacctgcacgagttaaagctattcctaga agaagagttaacagtggagacactgaagttggttcttcccttttgagacatccgtctcct gagctttctcggctaatctcagcccacagctctctttctaaaggagaacgaaatttccag tggccagttttagcttttgttatacaacatcatgatctagaaggtcttgaaatagcaatg aaacaggccctaaggaaatctgcttgtcgagtttttgctatggaggctttcaactggctt ctgtgtaatgtcatccaaaccacttctctccatgatattctgtggcattttgtggcatca ctgactcctgcaccagtggaaccagaggaagaagaggatgaagaaaataaaacaagcaaa gaaaattcagaacaagagaaagatacaagagtatgtgaacatccactctcagacatagtg attgccggggaagctgctcatcctttaccacacacctttcaccgcttgctgcagaccatc tcagaccttatgatgtctctccccagcggcagttcattacagcaaatggccctgaggtgc tggagtctcaaattcaagcaatctgatcaccagttccttcatcagagcaacgtctttcat cacattaacaatattttgtcaaagtcagatgatggcgatagtgaagagagttttagcatc agtatacagtctggctttgaagctatgagtcaggaattatgcatagtaatgtgcttaaag gacttaaccagcattgttgacataaaaacttcaagccgacctgccatgattggcagtttg acagacggctccacagaaaccttttgggaatcaggagatgaagataaaaacaaaactaag aacatcaccatcaactgtgtaaaaggaatcaatgcccgctatgtgtctgttcacgtggac aattcccgagatcttgggaataaagttacctcaatgaccttcttaactggcaaagcagta gaagatttgtgcagaataaagcaggttgatctggattccaggcacattggctgggtaaca agtgaacttccaggaggggataatcacatcataaaaattgaattaaaaggcccagaaaat acactgagagttcgacaagtcaaagtcctgggctggaaagatggtgaaagcacaaaaata gctggccagatttcagccagtgtggcccagcagaggaactgtgaagctgagactctgcga gtattcagactgattacgtctcaagtatttggaaagctcatctctggagatgctgaacct acaccagaacaagaggaaaaagcactattgtcatcacctgaaggagaagaaaaagtatac aatgcaacatcagatgctgacctgaaagaacatatggttggaatcatattcagcaggagt aagctgactaacttacaaaaacaggtgtgtgctcatattgtccaagctattcgcatggaa gctaccagagtccgtgaagaatgggaacatgctatatcaagcaaagaaaatgccaattct cagccaaatgatgaagatgcctcctctgatgcctactgctttgagctgctctctatggtt ttagcactgagtggctctaacgttggccggcaatatctggctcaacagctaaccctgctt caggatctcttctcgctgcttcacacagcctctcctagagtccagagacaggtaacctct ttactaagaagagttttgcctgaagtaacccctagtcgtctggccagcatcataggagtg aaatccctccccccagcagatatcagtgatatcattcactcaacagagaaaggagactgg aataagctgggtatcttggacatgtttctaggatgcattgccaaagcactcactgtacag ctaaaagccaaaggaaccaccatcactggaacagctggtaccactgtgggcaaaggagtt acaacagttactcttccgatgattttcaattccagttatctccgacgaggtgaaagtcat tggtggatgaagggctcaacccctacccagatctcagagatcatcattaaacttatcaag gatatggcagcaggtcatctgtcagaagcttggtcccgagtgacaaaaaatgctattgca gaaaccatcattgccttgaccaagatggaagaagaatttaggtctccagtgagatgtatt gcaacaactagactctggcttgctctcgcatccctatgtgttcttgatcaggaccacgta gatcgtctctcctcggggagatggatgggaaaggatggacaacaaaaacaaatgcctatg tgtgataaccatgatgatggtgaaactgcagcaatcattttatgcaatgtctgtggaaat ttatgtacagactgtgacagattccttcaccttcatcgaagaaccaaaactcatcaaaga caggtcttcaaagaagaagaagaagctataaaggttgaccttcatgaaggttgtggtaga accaaattgttctggttgatggcactggcagattctaaaacaatgaaggcaatggtggaa ttccgagaacacacaggcaaacccaccacgagtagctcagaagcatgtcgcttctgtggt tccaggagtggaacagagttatctgctgttggcagtgtttgttctgatgcagattgccag gaatacgctaagatagcctgtagtaagacgcatccttgtggccatccatgcgggggtgtt aaaaacgaagagcactgtctgccctgtctacacggctgtgacaaaagtgccacaagcctg aagcaagacgccgatgacatgtgcatgatatgtttcaccgaagcgctctcggcagcacca gccattcagctggattgtagtcacatattccacttacagtgctgtcggcgagtattagaa aatcgatggcttggcccaaggataacatttggatttatatcttgtcccatttgcaagaac aaaattaatcacatagtactaaaagacctacttgatccaataaaagaactctatgaggat gtcagaagaaaagccttaatgagattggaatatgaaggtctgcataagagtgaagctatc acaactcctggtgtgaggttttataatgacccagctggctatgcaatgaatagatatgca tattatgtgtgctacaaatgcagaaaggcatattttggtggtgaagctcgctgcgatgct gaggctggacggggagatgattatgatcccagagagctcatttgtggtgcctgttctgat gtttccagggctcagatgtgtcccaaacatggcacagactttttggaatataaatgtcgc tactgctgttcagtggctgtttttttctgttttggaacaacacatttttgtaatgcttgt catgatgattttcaaagaatgactagcattcctaaggaagaactaccacactgtcctgca ggtcccaaaggcaagcagttagaaggaactgaatgtccactccatgttgttcatccaccc actggggaagagtttgctctgggatgtggagtgtgcagaaatgcccacactttttag

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