Homo sapiens (human): 23152
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Entry
23152 CDS
T01001
Symbol
CIC, MRD45
Name
(RefSeq) capicua transcriptional repressor
KO
K20225
capicua transcriptional repressor
Organism
hsa
Homo sapiens (human)
Pathway
hsa05017
Spinocerebellar ataxia
Disease
H00773
Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05017 Spinocerebellar ataxia
23152 (CIC)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
23152 (CIC)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
HMG SOX
23152 (CIC)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DUF4819
HMG_box
HMG_box_2
Zf_WRKY19
Motif
Other DBs
NCBI-GeneID:
23152
NCBI-ProteinID:
NP_001291744
OMIM:
612082
HGNC:
14214
Ensembl:
ENSG00000079432
UniProt:
Q96RK0
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:42268530..42295796
Genome browser
AA seq
2517 aa
AA seq
DB search
MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAE
EGEEEEAERGPGAEGPPLELHPGDPAPGPAEDPKGDGEAGRWEPSLSRKTATFKSRAPKK
KYVEEHGAGSSGVAGAPEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPA
EACGPGPWPPGSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRAL
TFYEGVPGAGVDVVLDATPPPGALVVGTAVCTCVEPGVAAYREGVVVEVATKPAAYKVRL
SPGPSSQPGLPGSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQ
AEPGATLPPCPAALDPKQPEDAEVSKISFGGNLGTHCEEGEEKHPPALGTPALLPLPPPQ
LLSPPPKSPAFVGPGRPGEQPSPCQEGSQGGSRSSSVASLEKGTAPAARARTPLTAAQQK
YKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGP
GGAGRPAAVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAA
VMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPLFGFRPANFSPINASPVIQRTAVRS
RHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLP
HPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPS
PLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEVRAGGPG
RGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHP
SPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDP
SVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPP
HPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRT
QSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVS
KILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGG
HKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSAR
PRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPFAAPGEGGALA
ATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERV
TDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSA
PSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFL
PMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAP
APSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGARTEM
GTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYG
APAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPT
LPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQS
VPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSV
PVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAG
GHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVG
VSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAA
TILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGS
FEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPP
PAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSS
GRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVL
PSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAK
CEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATA
AFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPVPPPTGTAAAPAPTP
SPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATGR
NT seq
7554 nt
NT seq
+upstream
nt +downstream
nt
atgaagccaatgaagaaggcatgcactggcctttcaggtcctggcagtggcagcaagtcc
cccccagccaccagggccaaggctctgaggcggcgaggggctggggagggtgacaagcca
gaggaggaggatgacgaggcacagcagccgcaaccacagtccgggcccgaagaggctgag
gaaggggaggaggaggaggctgagcggggccctggggctgaaggtcctccactggagctg
caccctggcgacccggctccaggcccagcagaggaccccaaaggggatggggaggcaggc
cgctgggagccctcactcagccgcaagacagccacgttcaagtctcgagcgcccaagaag
aagtatgtggaggagcacggagctggcagcagtggggtggctggggcccctgaagagcgg
gtgcggacccctgaggaggccagtggcctgggggtgcctccacggccacccacctccact
cgttcctcctccactgacacagccagcgagcactcggcggacctggaggatgagccggct
gaggcttgtggtccaggcccttggccccctggcagcaccagtggcagctatgacctgcgg
cagctgcggtcccagcgggtgctggctcggcgtggtgatggccttttcctgccggctgtg
gtgcgccaggtgcgccgaagccaggacctgggcgtgcagttccctggtgaccgagccctg
actttctatgagggggtgccaggcgctggtgtggatgtagttttggatgccacaccccca
ccaggtgccctggtggtgggcacagctgtctgtacctgtgtggagcccggcgtggctgcc
taccgggaaggtgtggtggtggaggtggccaccaagccagctgcctacaaggtccgtctc
agccctggccccagctcccagccaggcctaccaggcagcctcccgcagcccccacagcca
ctgcaccgtgagccagaggaggctgtgtgggtggcccgctccagcctacgcctgctgcgc
cccccctgggaacctgagaccatgctgaggaagccccctacaggccctgaggaagagcag
gcagagcctggggccaccctgccaccctgccctgctgccctggaccccaaacagcccgag
gatgctgaggtctctaagatcagctttggtggcaacctgggtactcactgtgaggagggc
gaggagaagcaccctccagccctgggtaccccagccctgctcccactgcccccaccccag
ctcctgtcaccaccacccaagtctccagcctttgtgggccccggccgccctggcgagcag
ccctcgccctgccaggaggggagccagggcggcagccgcagcagcagcgtggcctccctg
gaaaaggggacagcaccggcagcccgggcccgcacgccactgacagccgcccagcagaag
tacaagaagggcgatgtggtctgcacacccagcggaatacgaaagaagttcaacggcaag
cagtggcgccggctgtgctcacgagatggctgcatgaaggagtcacagcggcgaggctac
tgctcacgccacctgtccatgcgaaccaaagagatggaaggcctggcagacagtgggcct
ggcggggcgggccggcccgcggccgtggcagcccgtgagggcagcacggagtttgactgg
ggtgatgagacgtcgagggacagtgaggccagcagtgtggcggctcgtggagactcacgg
ccacgcctggtggcccctgctgacttgtcacgctttgagttcgacgagtgtgaggcggcc
gtgatgctggtgtcgctgggcagctcgcgctcaggcacgccctccttctcacccgtctcc
actcaatcgcccttctcgccagccccatcaccctcaccctcaccactcttcggcttccgc
cctgccaactttagccccatcaatgcctcaccagtcatccagcgcactgcagtccgcagt
cgccacctgagcgccagcacccctaaggcaggcgtgctgacgccaccagacctgggcccc
cacccaccgccacctgccccccgagagcgccactcctctggaatcctacccaccttccag
accaacctgaccttcaccgtgcccatcagccctgggcgacggaagacagagctgttgccg
catccaggggccttgggggcccctggcgcagggggtggaggagccgccccagactttccc
aagagtgacagcttagactctggtgtggactcagtgtcccacacacctacaccctccacg
ccggctggcttccgggccgtgtcccctgctgtgcccttctctcgctcccgccagccctca
ccattgctgctgttgccaccccctgccggcctgacctcggatccagggccctctgtgcgc
agggtgcctgctgtgcagcgggactcacctgttattgtccgcaaccctgatgtgccactg
ccctccaaattccctggggaggtgggcactgctggtgaggtgcgggctgggggacctggg
cggggctgccgtgaaaccccagtgccccctggggtggccagtgggaagcctggcctgccc
ccacctctgccagcccccgtgcccatcaccgtgcctccagctgcaccaactgccgtggcc
cagccgatgcccgcctttggcctggcttcttcaccctttcagcctgtggccttccacccc
tcacctgctgccctgttgcccgttttggtgcccagcagctataccagccaccctgccccc
aagaaggaagtcatcatgggccggcctggaacagtgtggacgaatgtggaacctcgctct
gtggctgtgttcccttggcactccttagtccccttcctggcacccagccagcctgacccc
tccgtgcagccgagcgaggcccagcaacctgccagccacccagtggcctccaaccagagc
aaagaacctgctgagtcggcagctgttgctcatgaacggccaccaggtgggacagggagt
gctgaccctgagcggccccctggagccacatgccctgagagcccaggacccggaccccca
caccctttgggggtggtggaatctggtaagggtccgcctcccaccacggaggaggaggcc
tccggccccccaggagagccccggctggacagtgagacagagagtgaccatgatgatgcc
ttcctctccatcatgtctcctgagatccagttgcctctaccgcccggaaaacgtcggacc
cagtccctcagtgccctacccaaggaacgggactcatcttctgagaaggatggacgcagc
cccaacaagcgggagaaggaccacatccggcggcccatgaatgccttcatgatcttcagc
aagcggcaccgggccctggtccaccagcgtcatcccaaccaggacaaccggaccgtcagc
aagatcctgggcgagtggtggtatgccctggggcccaaggagaagcagaagtaccacgac
ctggccttccaggtgaaggaggcccacttcaaggcccacccagattggaagtggtgcaac
aaggaccgaaagaagtccagctcagaggccaagcccacgagcctggggctggcaggaggg
cacaaggagacgcgggagcggagcatgtcggagacgggcactgctgctgcccctggggtg
tcctctgagctcctgtccgttgcagcccagacactcctgagctcagacaccaaggctccg
gggagcagctcctgtggggcagaacggctacacacagttgggggacctggctcagcccgg
ccccgagctttctcccacagcggggtacacagcctggacggcggagaagtagacagtcag
gcgctacaggaactgacgcagatggtgtctggccctgcatcgtactctggcccaaagcct
tctacccagtatggagctccaggaccctttgcagcccctggtgagggaggtgccttggcg
gccactgggcggcccccgctgctgcccacccgagcttctcgttctcagcgtgcggccagt
gaggacatgacgagtgatgaggagcgcatggtcatctgtgaggaggaaggggatgatgat
gtcattgctgacgatggcttcggcaccactgacattgatctcaagtgcaaggagcgggtg
accgacagcgagagtggggacagctctggggaggacccagagggcaacaagggctttggt
cggaaggtgttttcacctgtgatccgttcctcctttacccactgccgccccccactggac
cctgagcccccagggcccccggatcctcctgtagcctttggcaaaggctatggttccgcc
ccatcctcctctgcgtcctcgcctgcttcctcctcagcctcggcagccacctccttctca
ctgggctcaggaaccttcaaggcccaggagtctggtcagggcagcacagcgggcccccta
cggcccccaccccctggggctgggggtccagcgacaccttccaaggcaacccggttcctc
ccaatggatcctgccaccttccggcgcaagagacccgaaagtgtgggtggcctggagcca
ccaggcccctcagtcatcgcggcccctcccagcggaggaggaaacatcctgcagacactg
gtgctgcccccaaacaaggaggagcaagagggcggcggagccagagtgccctccgccccc
gccccatcactggcctatggggccccagcagctcccctgtcccgtcctgccgccaccatg
gtcaccaatgtggtgcggcctgtcagcagcactcctgtgcccatcgcctctaagcccttc
cccacctctggccgggctgaggcgtctccaaatgacacagcaggtgccaggactgaaatg
ggcactgggtctcgggtgcctgggggctccccgctgggtgtcagcttagtgtattcggac
aagaagtcggcagcagccacctcaccagccccacacttggtggctggacccctgctgggc
actgtggggaaggcgcctgccactgtcactaacctactggtgggcaccccggggtatggg
gcccctgcgccccctgctgtccagttcattgcccagggggcccctggtggtgggaccact
gcgggctcaggagcaggtgctgggagtggccccaatgggccagtacccctgggcatcctg
caaccaggtgccctgggcaaggctgggggaatcacccaggtacagtacatcctgcccacg
ctgccccagcagcttcaggtggcacctgccccagcaccagcccctgggaccaaggcagcg
gctcccagcggccctgcacccaccaccagcatccgtttcaccctcccaccgggcacttcc
accaacggcaaagtcctggctgccactgcacccactcctggcatccccatcctgcagtct
gtaccctccgccccaccccccaaagcccagtcagtttctcccgtgcaggccccgcccccg
ggtggctcagcccagctgctgcctgggaaggtcctagtgcctctggccgcccctagcatg
tcagtgcggggtggaggggccggccagccactgccactggtgagcccgcccttctcagta
cctgtgcagaatggtgcccagccccccagcaagatcatccagctgaccccggtgcctgtg
agcacacccagcggcctggtgccgcccctgagcccagccacactccctggacccacctct
cagcctcagaaggtcctgttgccctcctccaccagaatcacctatgtgcagtcagcgggc
gggcacgcgctgcccctgggtaccagccctgcgtccagccaggctggaacagtcacctcg
tacgggcccacgagctctgtagctctaggcttcacctcgctggggcccagcggccccgcc
ttcgtgcagcccctgctctcagcaggccaagccccactgctggctcccggtcaggtgggc
gtgtcacctgtgcccagtccccagctgccgcctgcctgtgcagcccccggaggtcctgtc
ataacagcattttactctggcagccctgcacccacctcctcagcacccctggcccagcca
tcccaggcccccccaagcctggtctacactgtggccaccagcacaaccccacctgcagcc
accattctgcccaagggcccgccagcccctgccactgccaccccagccccgactagccct
ttccccagcgccacagcaggttccatgacctacagcttagtggcccccaaggcccagcgg
cccagcccgaaggccccccagaaagtgaaggcagccatcgccagcattcccgtggggtcc
tttgaggcaggtgcctctgggcggcctggccctgcaccccggcagcctctggagcctggc
ccagtccgagagccaactgccccagagtctgagcttgaggggcagcccacaccaccagcc
cctccacccctgccagagacctggactcccacggcccggagcagccccccactgccccca
cctgctgaggagcggaccagcgccaagggccctgagaccatggccagcaaattccccagc
tcatcttcagactggcgcgtccctgggcagggcctggagaatcgtggggagcctcccact
cctcccagcccggccccagctccagctgtagcccctggtggcagcagcgagagcagcagt
gggcgggcagccggggacaccccggagcgcaaggaggcggctggtactggcaagaaggtg
aaggtgcggcccccgcccctgaagaagacctttgactctgtggacaacagggtcctgtca
gaagtggacttcgaagagcgctttgctgagttgcctgagtttcggcctgaggaggtgctg
ccctcccccaccctgcagtctctggccacctcaccccgggccatcctgggctcttaccgc
aagaagaggaagaactccacggacctggattcagcacccgaggaccccacctcgcccaag
cgcaagatgagaagacgctccagctgcagctcggagcccaacacccccaagagtgccaag
tgcgagggggacatcttcacctttgaccgtacaggtacagaagccgaggacgtgcttggg
gagctagagtatgacaaggtgccatactcctccctgcggcgcaccctggaccagcgccgg
gccctggtcatgcagctctttcaggaccatggcttcttcccgtcagcccaggccacagcc
gccttccaggcccgctatgcagacatctttccctccaaggtttgtctgcagttgaagatc
cgtgaggtgcgccagaagatcatgcaggctgccactcccacggagcagccccctggagct
gaggctcctctccctgtaccgccccccactggcaccgctgctgcccctgcccccactccc
agccccgcagggggccctgaccccacctcacccagctcggactctggcacggcccaggct
gccccgccactgcctccacccccagagtcggggcctggacagcctggctgggagggggct
ccccagccctcccccccacccccaggtccctccacagctgccacaggcaggtga
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integrated database retrieval system
