Homo sapiens (human): 23152
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Entry
23152 CDS
T01001
Symbol
CIC, MRD45
Name
(RefSeq) protein capicua homolog isoform CIC-L
KO
K20225
capicua transcriptional repressor
Organism
hsa
Homo sapiens (human)
Pathway
hsa05017
Spinocerebellar ataxia
Disease
H00773
Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05017 Spinocerebellar ataxia
23152 (CIC)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
23152 (CIC)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
HMG SOX
23152 (CIC)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
HTH_Cic_C
Cic
HMG_box
HMG_box_2
Zf_WRKY19
Motif
Other DBs
NCBI-GeneID:
23152
NCBI-ProteinID:
NP_001291744
OMIM:
612082
HGNC:
14214
UniProt:
Q96RK0
Structure
PDB
PDBj
LinkDB
All DBs
Position
19:42268530..42295796
Genome browser
AA seq
2517 aa
AA seq
DB search
MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAE
EGEEEEAERGPGAEGPPLELHPGDPAPGPAEDPKGDGEAGRWEPSLSRKTATFKSRAPKK
KYVEEHGAGSSGVAGAPEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPA
EACGPGPWPPGSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRSQDLGVQFPGDRAL
TFYEGVPGAGVDVVLDATPPPGALVVGTAVCTCVEPGVAAYREGVVVEVATKPAAYKVRL
SPGPSSQPGLPGSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQ
AEPGATLPPCPAALDPKQPEDAEVSKISFGGNLGTHCEEGEEKHPPALGTPALLPLPPPQ
LLSPPPKSPAFVGPGRPGEQPSPCQEGSQGGSRSSSVASLEKGTAPAARARTPLTAAQQK
YKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSRHLSMRTKEMEGLADSGP
GGAGRPAAVAAREGSTEFDWGDETSRDSEASSVAARGDSRPRLVAPADLSRFEFDECEAA
VMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPLFGFRPANFSPINASPVIQRTAVRS
RHLSASTPKAGVLTPPDLGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLP
HPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPS
PLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEVRAGGPG
RGCRETPVPPGVASGKPGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHP
SPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDP
SVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPP
HPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRT
QSLSALPKERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVS
KILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGG
HKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSAR
PRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPFAAPGEGGALA
ATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERV
TDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSA
PSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFL
PMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAP
APSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPNDTAGARTEM
GTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYG
APAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPT
LPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQS
VPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSV
PVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTSQPQKVLLPSSTRITYVQSAG
GHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVG
VSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPAA
TILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGS
FEAGASGRPGPAPRQPLEPGPVREPTAPESELEGQPTPPAPPPLPETWTPTARSSPPLPP
PAEERTSAKGPETMASKFPSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSS
GRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDSVDNRVLSEVDFEERFAELPEFRPEEVL
PSPTLQSLATSPRAILGSYRKKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAK
CEGDIFTFDRTGTEAEDVLGELEYDKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATA
AFQARYADIFPSKVCLQLKIREVRQKIMQAATPTEQPPGAEAPLPVPPPTGTAAAPAPTP
SPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATGR
NT seq
7554 nt
NT seq
+upstream
nt +downstream
nt
atgaagccaatgaagaaggcatgcactggcctttcaggtcctggcagtggcagcaagtcc
cccccagccaccagggccaaggctctgaggcggcgaggggctggggagggtgacaagcca
gaggaggaggatgacgaggcacagcagccgcaaccacagtccgggcccgaagaggctgag
gaaggggaggaggaggaggctgagcggggccctggggctgaaggtcctccactggagctg
caccctggcgacccggctccaggcccagcagaggaccccaaaggggatggggaggcaggc
cgctgggagccctcactcagccgcaagacagccacgttcaagtctcgagcgcccaagaag
aagtatgtggaggagcacggagctggcagcagtggggtggctggggcccctgaagagcgg
gtgcggacccctgaggaggccagtggcctgggggtgcctccacggccacccacctccact
cgttcctcctccactgacacagccagcgagcactcggcggacctggaggatgagccggct
gaggcttgtggtccaggcccttggccccctggcagcaccagtggcagctatgacctgcgg
cagctgcggtcccagcgggtgctggctcggcgtggtgatggccttttcctgccggctgtg
gtgcgccaggtgcgccgaagccaggacctgggcgtgcagttccctggtgaccgagccctg
actttctatgagggggtgccaggcgctggtgtggatgtagttttggatgccacaccccca
ccaggtgccctggtggtgggcacagctgtctgtacctgtgtggagcccggcgtggctgcc
taccgggaaggtgtggtggtggaggtggccaccaagccagctgcctacaaggtccgtctc
agccctggccccagctcccagccaggcctaccaggcagcctcccgcagcccccacagcca
ctgcaccgtgagccagaggaggctgtgtgggtggcccgctccagcctacgcctgctgcgc
cccccctgggaacctgagaccatgctgaggaagccccctacaggccctgaggaagagcag
gcagagcctggggccaccctgccaccctgccctgctgccctggaccccaaacagcccgag
gatgctgaggtctctaagatcagctttggtggcaacctgggtactcactgtgaggagggc
gaggagaagcaccctccagccctgggtaccccagccctgctcccactgcccccaccccag
ctcctgtcaccaccacccaagtctccagcctttgtgggccccggccgccctggcgagcag
ccctcgccctgccaggaggggagccagggcggcagccgcagcagcagcgtggcctccctg
gaaaaggggacagcaccggcagcccgggcccgcacgccactgacagccgcccagcagaag
tacaagaagggcgatgtggtctgcacacccagcggaatacgaaagaagttcaacggcaag
cagtggcgccggctgtgctcacgagatggctgcatgaaggagtcacagcggcgaggctac
tgctcacgccacctgtccatgcgaaccaaagagatggaaggcctggcagacagtgggcct
ggcggggcgggccggcccgcggccgtggcagcccgtgagggcagcacggagtttgactgg
ggtgatgagacgtcgagggacagtgaggccagcagtgtggcggctcgtggagactcacgg
ccacgcctggtggcccctgctgacttgtcacgctttgagttcgacgagtgtgaggcggcc
gtgatgctggtgtcgctgggcagctcgcgctcaggcacgccctccttctcacccgtctcc
actcaatcgcccttctcgccagccccatcaccctcaccctcaccactcttcggcttccgc
cctgccaactttagccccatcaatgcctcaccagtcatccagcgcactgcagtccgcagt
cgccacctgagcgccagcacccctaaggcaggcgtgctgacgccaccagacctgggcccc
cacccaccgccacctgccccccgagagcgccactcctctggaatcctacccaccttccag
accaacctgaccttcaccgtgcccatcagccctgggcgacggaagacagagctgttgccg
catccaggggccttgggggcccctggcgcagggggtggaggagccgccccagactttccc
aagagtgacagcttagactctggtgtggactcagtgtcccacacacctacaccctccacg
ccggctggcttccgggccgtgtcccctgctgtgcccttctctcgctcccgccagccctca
ccattgctgctgttgccaccccctgccggcctgacctcggatccagggccctctgtgcgc
agggtgcctgctgtgcagcgggactcacctgttattgtccgcaaccctgatgtgccactg
ccctccaaattccctggggaggtgggcactgctggtgaggtgcgggctgggggacctggg
cggggctgccgtgaaaccccagtgccccctggggtggccagtgggaagcctggcctgccc
ccacctctgccagcccccgtgcccatcaccgtgcctccagctgcaccaactgccgtggcc
cagccgatgcccgcctttggcctggcttcttcaccctttcagcctgtggccttccacccc
tcacctgctgccctgttgcccgttttggtgcccagcagctataccagccaccctgccccc
aagaaggaagtcatcatgggccggcctggaacagtgtggacgaatgtggaacctcgctct
gtggctgtgttcccttggcactccttagtccccttcctggcacccagccagcctgacccc
tccgtgcagccgagcgaggcccagcaacctgccagccacccagtggcctccaaccagagc
aaagaacctgctgagtcggcagctgttgctcatgaacggccaccaggtgggacagggagt
gctgaccctgagcggccccctggagccacatgccctgagagcccaggacccggaccccca
caccctttgggggtggtggaatctggtaagggtccgcctcccaccacggaggaggaggcc
tccggccccccaggagagccccggctggacagtgagacagagagtgaccatgatgatgcc
ttcctctccatcatgtctcctgagatccagttgcctctaccgcccggaaaacgtcggacc
cagtccctcagtgccctacccaaggaacgggactcatcttctgagaaggatggacgcagc
cccaacaagcgggagaaggaccacatccggcggcccatgaatgccttcatgatcttcagc
aagcggcaccgggccctggtccaccagcgtcatcccaaccaggacaaccggaccgtcagc
aagatcctgggcgagtggtggtatgccctggggcccaaggagaagcagaagtaccacgac
ctggccttccaggtgaaggaggcccacttcaaggcccacccagattggaagtggtgcaac
aaggaccgaaagaagtccagctcagaggccaagcccacgagcctggggctggcaggaggg
cacaaggagacgcgggagcggagcatgtcggagacgggcactgctgctgcccctggggtg
tcctctgagctcctgtccgttgcagcccagacactcctgagctcagacaccaaggctccg
gggagcagctcctgtggggcagaacggctacacacagttgggggacctggctcagcccgg
ccccgagctttctcccacagcggggtacacagcctggacggcggagaagtagacagtcag
gcgctacaggaactgacgcagatggtgtctggccctgcatcgtactctggcccaaagcct
tctacccagtatggagctccaggaccctttgcagcccctggtgagggaggtgccttggcg
gccactgggcggcccccgctgctgcccacccgagcttctcgttctcagcgtgcggccagt
gaggacatgacgagtgatgaggagcgcatggtcatctgtgaggaggaaggggatgatgat
gtcattgctgacgatggcttcggcaccactgacattgatctcaagtgcaaggagcgggtg
accgacagcgagagtggggacagctctggggaggacccagagggcaacaagggctttggt
cggaaggtgttttcacctgtgatccgttcctcctttacccactgccgccccccactggac
cctgagcccccagggcccccggatcctcctgtagcctttggcaaaggctatggttccgcc
ccatcctcctctgcgtcctcgcctgcttcctcctcagcctcggcagccacctccttctca
ctgggctcaggaaccttcaaggcccaggagtctggtcagggcagcacagcgggcccccta
cggcccccaccccctggggctgggggtccagcgacaccttccaaggcaacccggttcctc
ccaatggatcctgccaccttccggcgcaagagacccgaaagtgtgggtggcctggagcca
ccaggcccctcagtcatcgcggcccctcccagcggaggaggaaacatcctgcagacactg
gtgctgcccccaaacaaggaggagcaagagggcggcggagccagagtgccctccgccccc
gccccatcactggcctatggggccccagcagctcccctgtcccgtcctgccgccaccatg
gtcaccaatgtggtgcggcctgtcagcagcactcctgtgcccatcgcctctaagcccttc
cccacctctggccgggctgaggcgtctccaaatgacacagcaggtgccaggactgaaatg
ggcactgggtctcgggtgcctgggggctccccgctgggtgtcagcttagtgtattcggac
aagaagtcggcagcagccacctcaccagccccacacttggtggctggacccctgctgggc
actgtggggaaggcgcctgccactgtcactaacctactggtgggcaccccggggtatggg
gcccctgcgccccctgctgtccagttcattgcccagggggcccctggtggtgggaccact
gcgggctcaggagcaggtgctgggagtggccccaatgggccagtacccctgggcatcctg
caaccaggtgccctgggcaaggctgggggaatcacccaggtacagtacatcctgcccacg
ctgccccagcagcttcaggtggcacctgccccagcaccagcccctgggaccaaggcagcg
gctcccagcggccctgcacccaccaccagcatccgtttcaccctcccaccgggcacttcc
accaacggcaaagtcctggctgccactgcacccactcctggcatccccatcctgcagtct
gtaccctccgccccaccccccaaagcccagtcagtttctcccgtgcaggccccgcccccg
ggtggctcagcccagctgctgcctgggaaggtcctagtgcctctggccgcccctagcatg
tcagtgcggggtggaggggccggccagccactgccactggtgagcccgcccttctcagta
cctgtgcagaatggtgcccagccccccagcaagatcatccagctgaccccggtgcctgtg
agcacacccagcggcctggtgccgcccctgagcccagccacactccctggacccacctct
cagcctcagaaggtcctgttgccctcctccaccagaatcacctatgtgcagtcagcgggc
gggcacgcgctgcccctgggtaccagccctgcgtccagccaggctggaacagtcacctcg
tacgggcccacgagctctgtagctctaggcttcacctcgctggggcccagcggccccgcc
ttcgtgcagcccctgctctcagcaggccaagccccactgctggctcccggtcaggtgggc
gtgtcacctgtgcccagtccccagctgccgcctgcctgtgcagcccccggaggtcctgtc
ataacagcattttactctggcagccctgcacccacctcctcagcacccctggcccagcca
tcccaggcccccccaagcctggtctacactgtggccaccagcacaaccccacctgcagcc
accattctgcccaagggcccgccagcccctgccactgccaccccagccccgactagccct
ttccccagcgccacagcaggttccatgacctacagcttagtggcccccaaggcccagcgg
cccagcccgaaggccccccagaaagtgaaggcagccatcgccagcattcccgtggggtcc
tttgaggcaggtgcctctgggcggcctggccctgcaccccggcagcctctggagcctggc
ccagtccgagagccaactgccccagagtctgagcttgaggggcagcccacaccaccagcc
cctccacccctgccagagacctggactcccacggcccggagcagccccccactgccccca
cctgctgaggagcggaccagcgccaagggccctgagaccatggccagcaaattccccagc
tcatcttcagactggcgcgtccctgggcagggcctggagaatcgtggggagcctcccact
cctcccagcccggccccagctccagctgtagcccctggtggcagcagcgagagcagcagt
gggcgggcagccggggacaccccggagcgcaaggaggcggctggtactggcaagaaggtg
aaggtgcggcccccgcccctgaagaagacctttgactctgtggacaacagggtcctgtca
gaagtggacttcgaagagcgctttgctgagttgcctgagtttcggcctgaggaggtgctg
ccctcccccaccctgcagtctctggccacctcaccccgggccatcctgggctcttaccgc
aagaagaggaagaactccacggacctggattcagcacccgaggaccccacctcgcccaag
cgcaagatgagaagacgctccagctgcagctcggagcccaacacccccaagagtgccaag
tgcgagggggacatcttcacctttgaccgtacaggtacagaagccgaggacgtgcttggg
gagctagagtatgacaaggtgccatactcctccctgcggcgcaccctggaccagcgccgg
gccctggtcatgcagctctttcaggaccatggcttcttcccgtcagcccaggccacagcc
gccttccaggcccgctatgcagacatctttccctccaaggtttgtctgcagttgaagatc
cgtgaggtgcgccagaagatcatgcaggctgccactcccacggagcagccccctggagct
gaggctcctctccctgtaccgccccccactggcaccgctgctgcccctgcccccactccc
agccccgcagggggccctgaccccacctcacccagctcggactctggcacggcccaggct
gccccgccactgcctccacccccagagtcggggcctggacagcctggctgggagggggct
ccccagccctcccccccacccccaggtccctccacagctgccacaggcaggtga
DBGET
integrated database retrieval system
