Homo sapiens (human): 23239
Help
Entry
23239 CDS
T01001
Symbol
PHLPP1, PHLPP, PLEKHE1, PPM3A, SCOP
Name
(RefSeq) PH domain and leucine rich repeat protein phosphatase 1
KO
K16340
PH domain and leucine-rich repeat-containing protein phosphatase [EC:
3.1.3.16
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04151
PI3K-Akt signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
23239 (PHLPP1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:
hsa01009
]
23239 (PHLPP1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.16 protein-serine/threonine phosphatase
23239 (PHLPP1)
Protein phosphatases and associated proteins [BR:
hsa01009
]
Protein serine/threonine phosphatases
Mg2+- or Mn2+- dependent protein phosphatases (PPMs)
PPM1 phosphatases (PP2C)
23239 (PHLPP1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
LRR_8
PP2C
LRR_4
RA_3
LRR_14
LRR_6
LRR_LRWD1
PH
Motif
Other DBs
NCBI-GeneID:
23239
NCBI-ProteinID:
NP_919431
OMIM:
609396
HGNC:
20610
Ensembl:
ENSG00000081913
UniProt:
O60346
LinkDB
All DBs
Position
18:62715541..62980433
Genome browser
AA seq
1717 aa
AA seq
DB search
MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP
SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL
LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK
HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK
GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA
DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS
DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP
RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT
RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS
GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH
CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ
DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN
VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE
KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD
NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD
VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE
RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT
NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM
NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR
LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK
LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK
QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL
SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV
PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP
GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG
SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR
RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH
HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL
NT seq
5154 nt
NT seq
+upstream
nt +downstream
nt
atggagcccgccgccgcggccacggtacagcgactccccgagctcggcagggaggaccga
gcttcggctccggcggccgccgctgcggcagcagcagcagcagcggcggccgcggcggct
ctggcggcggcggccgggggcggccggagtccggagcccgcgctgaccccggcggccccg
agcggcgggaacggcagcggcagcggggcgcgggaagaggccccaggcgaggcgccgccg
gggccgctgccgggcagagcggggggtgccgggcgcaggaggcggcgcggggcgccccag
cccattgccggcggggctgcccccgtacccggggccggcggcggcgccaactccctcctg
ctgaggagagggcggctgaagaggaatctgtccgcggccgccgcggccgcctcctcgtcg
tcgtcgtcctcggccgctgctgcctcgcactcccccggcgctgccggcctccccgcctcc
tgctcggcctcggcgtcgctgtgcacccggagcctggacaggaagacgctgcttctgaag
caccggcagacgctgcagctgcagccgtcggaccgggactgggtgaggcaccagctccag
cgcggctgcgtgcacgtcttcgaccgccacatggcctcgacctacctgcgcccggtgctc
tgcacactggacaccacggccggcgaggtggccgcccgcctgctgcagctgggccacaaa
ggcggcggcgtggtgaaggtgctgggccaggggcccggagccgccgccgcccgggagccc
gctgaaccgccccccgaggccggcccccggctggcgcccccggagccgcgggactcggag
gtaccgcccgcgaggagcgcgccgggtgccttcggggggcctccgcgcgcgccccccgcc
gacctacccctgcccgtcggcggcccgggcgggtggtcgcgccgcgccagcccagcgccc
tcggactccagccccggcgagccgttcgttgggggccctgtctcttcgccccgcgcccca
cggcctgtggtctccgacaccgagagcttcagtctgagtcccagcgccgagagcgtgtct
gaccggttggacccctacagcagcggcggcggctcctcgtcgtcgtcggaagagctcgag
gccgacgcagcctcggccccgacgggggtcccgggccagccccgccgtcccggccacccc
gcgcagcccctcccgcttccccagacggcttcctcgcctcagccgcagcagaaagccccg
agggccattgacagcccgggcggggccgtccgcgaggggtcgtgcgaggagaaggcagcg
gcagccgtggccccgggaggcctccagtctacccccgggaggagcggggtgaccgcggag
aaggcgcctccgccgcccccgccgcccaccctgtacgtgcagctccacggagagaccacc
cggcgcttggaggcggaggagaagccattgcagatccaaaatgactacctcttccaactg
ggatttggggagctgtggagggtgcaggaggaaggcatggactcggagattggctgcctc
atccgcttctatgcaggaaaacctcacagcacgggtagctctgaacggattcagctctca
ggaatgtataatgtccgtaaaggcaagatgcagttgccagtgaaccgatggacaagacgc
caagtcatcctatgtgggacctgcctgatagtatcatctgtgaaagacagcttgaccgga
aagatgcatgttctgccactaattggtggaaaagtagaagaagtgaaaaagcaccaacac
tgtttagcatttagctcctctggaccccaaagccagacttactacatttgctttgatact
ttcacagaatacttaaggtggctgcgacaagtctccaaggttgcatcccagcgcattagc
tcagtggacctctcgtgttgtagcctggaacatctgcctgccaacctcttctacagccaa
gacctcactcatctcaatttaaaacaaaacttcctaaggcagaaccctagccttccagct
gccagggggcttaatgaactgcaaaggttcaccaagttgaagagtcttaacctttccaat
aatcatttaggggacttcccactggcagtctgcagtattccaaccctggcagagctgaac
gtgtcctgcaatgccctgcgatcagtcccggcagccgttggagtgatgcacaacttacag
acatttttgttggatggaaactttctccaatcccttcctgctgagttggagaacatgaag
cagcttagttatctgggtctttctttcaatgaatttactgacattcccgaagtattggag
aaattgactgctgtggataaactttgtatgtctggaaactgtgtggagacccttaggcta
caggctttaagaaaaatgcctcacattaaacatgtggatctaaggttgaacgtaattagg
aagctgatagcagatgaagtggactttctacagcatgttactcagcttgacctacgagac
aataagcttggtgatctagatgctatgattttcaacaacattgaagttttacactgtgaa
aggaatcaactggtcacattagacatctgtggctatttcctaaaagcgctctatgcctct
tctaatgaacttgttcaacttgatgtttacccagttccaaattatctgtcctacatggat
gtttcaaggaaccgcttagaaaatgtgcctgagtgggtatgtgaaagccgaaagctagaa
gttttggatattggccataatcaaatatgtgaacttcctgcccgcttattttgtaatagc
agtctccggaaactactggcaggacacaaccagttggcaaggctgcctgaaaggctagaa
agaacctcggtggaggtcttggatgtgcaacacaaccagctccttgagctcccacctaac
cttctgatgaaggctgacagcctgagattcctgaacgcctctgcgaacaaactggaaagc
cttcctccagccacgctttccgaagagacaaacagtatcttacaagagttgtatttgaca
aataacagcctcacagacaaatgtgtgcccttgttaacgggacacccccatttgaagatc
cttcacatggcctataaccgacttcagagttttccagcaagtaaaatggcgaaactggag
gaacttgaagaaattgatctcagtgggaataagctgaaagccatcccaacaacgatcatg
aattgcaggcgcatgcacaccgtgattgctcactccaactgcatcgaggtctttcccgaa
gttatgcagctcccagagatcaagtgtgtggacctgagctgtaatgagctaagtgaagtc
acattaccagaaaacctgcctcccaaactgcaggagctagacctgactggaaacccgcgc
cttgtccttgatcacaaaaccctggaactactgaataatatccgctgtttcaagattgat
cagccttctacaggagacgcttccggagccccagctgtatggagtcatggttacactgaa
gcttcgggggtaaaaaacaagttgtgtgtcgcagccctgtcggtgaataacttctgtgac
aaccgcgaagccctgtatggtgtgtttgacggagaccggaatgtggaggtgccctacctt
ctccagtgcactatgagtgacattttggctgaagagctgcaaaaaacaaaaaacgaagaa
gaatacatggtcaatacattcattgtcatgcaaaggaaacttggaactgctgggcagaag
cttggtggtgccgctgtcctttgtcatatcaagcatgaccctgtggatccaggaggatcc
ttcaccttgacctctgctaatgtgggcaagtgccaaacagttctctgtcgaaatggaaag
ccgctgcctctgtccagatcttacatcatgagctgtgaagaagagctgaagaggattaaa
cagcacaaggccattatcactgaggatggcaaggtgaacggagtgactgagtccacgcgc
atcctgggctacaccttcctccatcccagtgtggtgcctcgcccccacgtgcagtccgtg
ctcctgactccccaggatgagttcttcatcctaggcagtaaggggttgtgggacagcctg
tccgtcgaggaggccgtggaagccgtgcgcaacgtgcccgatgccctggctgctgccaag
aagctgtgtaccctggcccagagctacggctgccacgacagcatcagcgctgtggtggtg
cagctcagtgtcactgaggacagcttctgctgctgcgagctcagcgccggtggggctgtg
ccaccacccagtcctggcatctttcctccctcagtgaacatggtgatcaaggatcggccc
tcagatgggctgggcgtgccgtcctccagcagcggcatggcttccgagattagcagtgag
ctctccacttctgagatgagcagcgaggtggggtcaacagcctccgatgagcccccgccc
ggagccctaagcgagaacagccctgcctaccccagtgagcagcgctgcatgctccacccc
atctgtctgtccaactccttccagcgccagctatccagcgccacgttctctagcgccttc
tccgacaacggccttgacagtgacgatgaggagcccatcgagggcgtcttcaccaacggc
agccgggtggaggtggaggtggacatccactgcagccgggccaaggagaaggagaaacag
cagcacctgcttcaggtgccagcagaggccagtgatgagggcattgtcatcagcgccaac
gaggatgagccaggtctgcccaggaaggcagacttctctgccgttgggaccattgggcgc
cggagggccaatggctctgttgcgccccaggaaaggagccacaatgtgatagaggtggct
acagacgcacctcttcgaaagcctggaggctattttgctgccccggctcagccggatcct
gatgatcagtttatcatacccccggagctggaagaggaggtcaaagaaatcatgaagcat
caccaggagcaacagcagcagcagcagccgccaccaccccctcagctccagccgcagctg
ccgcggcactaccagctggaccagctgccagattattacgacacgccactatga
DBGET
integrated database retrieval system
