| Entry |
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| Symbol |
UBR4, RBAF600, ZUBR1, p600
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| Name |
(RefSeq) ubiquitin protein ligase E3 component n-recognin 4
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| KO |
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| Organism |
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| Pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
23352 (UBR4)
09172 Infectious disease: viral
05165 Human papillomavirus infection
23352 (UBR4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system [BR:hsa04121]
23352 (UBR4)
Enzymes [BR:hsa01000]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
23352 (UBR4)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
Single Ring-finger type E3
UBR box proteins
23352 (UBR4)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
1:complement(19074510..19210266)
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| AA seq |
5183 aa
MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESE
SEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDE
ACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPV
SPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFI
AQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFH
SLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRT
GSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFL
ILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHA
IKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLST
SYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETIS
PSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITS
SMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTS
DLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECL
KVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQEL
SVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNS
RRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKL
VKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYI
NQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKC
SSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFS
KMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAA
VLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSES
YISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLE
SSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEEC
LQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEK
SPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIV
RENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAA
VDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSH
LSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCH
TCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTM
KESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQ
NQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMV
PTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGK
ITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTF
SSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFL
LPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLK
DSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKT
SPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHT
ACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTR
TSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEI
SNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKK
LNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTG
DSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPAS
VQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSI
AIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNA
FLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQA
LIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQS
EVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAI
ALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGS
TLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAI
STTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYM
QVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLS
VFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVA
TSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSR
IPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGI
KKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSV
LYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQAT
TQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESN
SSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTP
QTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEV
PFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQ
AIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQC
PRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPC
CAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSG
TAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAAT
KSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHIL
VSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWA
NPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRIL
QKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGI
DGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQA
ARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYL
AARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKS
RLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRY
NLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIG
PLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRI
VYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQ
GRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAE
QVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRII
PYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKD
LILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLI
GTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMR
QKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTK
RVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLL
PVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGG
GGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTV
LALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALV
DLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLD
VAGLLSEITDPESFLKDLLNSVP |
|---|
| NT seq |
15552 nt +upstreamnt +downstreamnt
atggcgacgagcggcggcgaagaggcggcggcagcggctccggcgccggggaccccggca
acgggggcggacacgaccccgggctgggaggtggctgtgcggcccctgctgtccgcgtcc
tactccgccttcgagatgaaggagttgccgcagctggtggcctcagtcatcgagagtgaa
tcagaaatcctgcaccatgagaagcagtacgagccattctactcatcttttgttgcactt
tccacacactatattacaacagtttgcagtctcattccccggaaccaacttcagtcagtg
gcagcagcctgtaaagttctaattgagttttctctcctgcgtctggagaatccagatgag
gcttgtgctgtgtcccagaaacacttgattctcctaatcaagggcctgtgcactggctgt
agccgactagatagaactgaaattatcacatttacagcaatgatgaaatccgccaagctg
ccccaaacagtgaagacactttcagacgtggaagatcagaaagagctggcctcaccagta
agccctgagttgaggcaaaaggaggtacagatgaattttttgaaccagctgacctcagtt
tttaaccctagaactgtagcatcacaacctatcagtacacagactctggtggaaggagaa
aatgatgagcagtcatctacagatcaagcctcagctatcaaaaccaagaatgtgttcata
gctcagaacgtggctagtcttcaagagcttggtggctcggagaagctactgcgtgtatgt
ttgaacctgccatatttcctacgctatatcaatcggttccaagatgcagttttagctaat
tccttcttcataatgcctgcaacagtagcagatgccactgctgttcgtaatggctttcat
tcattggtgattgatgtaactatggcattggataccctttctctacctgtgttggaacct
ctcaatccttctcgtctacaagatgtgacagtcctcagcctaagttgtctgtatgcaggt
gtgagtgtggcaacgtgcatggccatcctccatgtgggtagtgcccagcaagtgcggaca
gggtccacgagctccaaagaagatgactatgaaagtgacgcagctacaattgtccagaaa
tgtctcgaaatctatgacatgattggacaagcaatcagcagttctcgccgggctggtggt
gagcactatcagaatttccaattgctgggtgcttggtgcttgttaaacagccttttcctc
atactgaacctcagtcctactgcgttggctgataaggggaaagagaaggacccactggct
gccctccgagtcagagacatcctttctcgtactaaagagggagtgggctcccctaaactg
gggcctggaaaagggcatcagggatttggggtactctcagtaatattggcaaaccatgcc
atcaaactgctaacgtctctctttcaagacctacaagtggaggcccttcacaagggttgg
gagacagatggcccccctgcagccttgagcattatggcccagagcacctccatacagagg
attcaacggctgattgactctgtcccactgatgaacctgctcttgacgttactttcaact
tcctacagaaaggcatgtgtcctgcagcggcagaggaagggctccatgagcagcgatgcc
agcgcctccaccgactccaatacttactatgaggacgatttcagtagcacggaggaggac
agcagccaagacgatgacagtgagcctattttggggcaatggtttgaggagactatttct
cccagtaaagagaaagcagcacctccgcctcctcccccacctcctccactggaaagctct
cctcgggttaaaagccccagtaagcaggcccctggtgagaagggcaacattctggcgagt
cgcaaagatcctgagttgttcttaggtctggcttccaacattttgaacttcatcacctct
tccatgctgaactctcggaacaattttatccgaaactatctgagtgtatctctttcagaa
caccatatggccaccctagccagtatcatcaaggaggtggacaaagatggactcaagggt
tcatcagatgaagagtttgctgcagctctctatcacttcaaccactcactggtaacctct
gaccttcagtcacctaacctgcagaacacactgttgcagcagctaggagtggctcctttt
tctgagggcccttggcccttgtacattcaccctcaaagcctctctgtgctttcacgcctc
ctgctcatctggcaacataaagccagtgctcaaggtgaccctgacgtcccagaatgcctt
aaagtttgggacaggtttttgtctacaatgaagcagaatgccctgcaaggtgtggtgccc
agtgagacagaggatctgaatgtagaacacctgcagatgctcctcctcattttccacaat
ttcaccgagacaggccggcgggccatattgtcgctttttgtccagatcatccaggagttg
agcgtcaacatggatgctcagatgcgcttcgtgccgcttatcttggctcgcctccttctc
atctttgattatctgcttcatcagtactccaaagcccctgtgtatctatttgagcaggta
cagcataacctgctaagtcctccctttgggtgggcaagtggatcccaggacagcaacagc
cgccgggcaaccactcctctctatcatggattcaaagaagtagaagaaaactggtctaag
catttctcatcagatgctgtcccacaccccagattctactgtgtcctgtccccagaagcc
tcagaggatgatttgaaccgacttgattctgtggcatgtgacgtccttttctccaagctt
gtcaagtatgatgagctttatgctgcactgacagccctgcttgcagctgggtcccagctt
gatacagttaggagaaaggaaaacaagaatgtaacagccttggaggcctgtgcccttcaa
tattacttcttgatactgtggaggatcctaggaattttaccaccatcaaagacttacatt
aaccagctatccatgaactcacctgagatgagcgaatgtgacatcttgcacactctgcga
tggtcttctcggctccggatcagctcctatgtcaactggataaaggatcaccttatcaaa
cagggaatgaaggctgagcatgctagctcgcttctagaactggcatccaccactaagtgt
agctcagtgaaatatgatgttgaaatagtagaggaatacttcgctcgacagatctcatcc
ttctgtagtatcgactgtaccaccatcttgcagctgcatgaaattcccagtctgcagtcc
atctacacccttgatgccgcgatctcaaaggtccaggtctctttggatgagcatttttct
aagatggctgctgagactgatcctcataagtcgtctgagattaccaagaacctacttcca
gccacgctgcaactcattgacacctatgcatcgttcaccagagcctatttgctgcaaaac
tttaatgaagagggaacaactgagaaaccttccaaggagaaactgcaaggctttgctgct
gttttggctattggctctagcaggtgcaaggcaaatactctgggtccgacactggttcag
aatttgccatcgtcagtgcagactgtgtgtgagtcctggaacaacatcaataccaatgaa
tttcccaatattggatcctggcgcaatgcctttgccaatgacaccatcccttcagagagt
tatattagtgcagtgcaggctgcacacctggggactctctgtagccaaagtctgcccctg
gctgcttccctgaagcataccctcctctcactggtcaggttgactggagatcttattgtt
tggtcagatgagatgaacccaccacaggtaattcggacactgctacctcttcttttggaa
tcaagcactgagagtgttgccgagatcagtagcaactccctggaacgcatcttgggccct
gctgagtctgatgagttcttggctcgtgtttatgagaagctgatcactggttgttacaac
attctggccaatcatgcagatcctaacagtggactggatgaatccatcctggaggaatgt
ctccagtacttggaaaagcagctggaaagtagccaggctcgtaaagctatggaggagttt
ttctctgacagtggagaacttgtacagatcatgatggcaacagccaatgagaacctctct
gctaaattctgtaaccgagttttgaaattcttcaccaaactcttccagctgactgagaag
agccctaacccgagcctgttgcatctctgtggctccctggcacaactggcctgtgtggaa
cctgtgcgcctgcaggcctggctcacccgcatgactacatcgcccccaaaagattctgat
cagctggatgtaattcaggagaaccggcagctgctgcagttactgaccacatacattgtt
cgggaaaacagccaagttggggaaggtgtgtgtgctgttcttctgggcaccctgactccc
atggcaacagagatgctggccaacggtgatgggactggcttccctgaacttatggttgtg
atggccactctggccagtgcaggtcaaggtgctggtcaccttcagcttcataatgctgct
gtggattggctgagcagatgcaagaaatacctgtcacagaagaatgtagttgaaaaactg
aatgccaatgtaatgcatggaaagcatgtgatgatcttggagtgcacatgccatatcatg
tcttacttggctgatgtcacgaatgccctgagccagagtaatggtcaaggcccaagtcat
ctctcagtggatggggaagagcgggccattgaagtagactcagactgggtggaggagttg
gcggtggaagaggaagattcccaggctgaggattcagatgaagattctctttgcaataaa
ctctgcacttttacgatcacacagaaagaattcatgaaccagcattggtaccactgtcac
acctgtaaaatggtggatggcgtgggtgtctgcacagtgtgtgctaaggtgtgccacaag
gatcatgagatttcctatgccaagtatggatccttcttctgtgactgtggagccaaggaa
gatggcagctgtttggctctggtgaagagaactcctagcagtggcatgagctctaccatg
aaggagtcggcatttcagagtgaacccaggatttcagagagtctagtgcgtcatgccagc
acctcctcgccagctgacaaagccaaggttaccatcagtgatggaaaggttgctgacgaa
gagaagcccaagaagagcagcctctgccgcacagtagagggctgccgggaggaattacag
aaccaggccaatttctccttcgctcctctcgtgttagacatgcttaatttccttatggat
gccattcagaccaacttccagcaagcttcagccgtcgggagcagcagccgtgctcagcaa
gccctcagtgagctacacactgtggagaaggcagtggagatgacagaccagctgatggtt
cccaccttagggtcccaggaaggtgcctttgagaatgtgcggatgaattacagtggagac
cagggccagaccatccggcagctgatcagtgctcatgtgctcaggcgggtggctatgtgt
gtgctctcctctccccatgggcgccgccaacatttggctgtcagccatgagaagggcaag
atcaccgttctgcagctctctgcactcctgaagcaagcagattccagcaaaaggaagtta
actctgacccgcttggcttctgccccagttccttttactgtgttgagcctcacaggaaat
ccctgcaaggaagactacttggcggtttgtgggctaaaggactgtcatgtgctcaccttt
agtagctcaggctctgtttcggatcacttggttttgcaccctcagttggcaacggggaac
ttcatcatcaaagccgtgtggttacctggttcacagaccgagttagcaattgtcaccgca
gactttgttaagatttatgacctgtgtgttgatgccttgagtccaaccttctattttctc
ctgccaagctcaaagataagagatgttaccttccttttcaatgaggagggaaagaacatc
attgttataatgtcttcggctgggtacatctatactcagcttatggaagaggccagcagt
gcccagcagggacccttctatgtcactaatgtgttggaaatcaatcatgaggacctgaag
gacagtaacagccaggtggcgggcggtggtgtgtccgtgtactactcccacgtgttgcag
atgttgttcttcagctattgtcaaggcaaatcattcgcagccaccatcagcaggacaacc
ctggaggtgttgcaactcttccccatcaacatcaaaagttccaatggtggcagtaagact
tctcctgctctttgccagtggtctgaggtgatgaaccaccctggcttggtgtgctgtgtc
cagcaaactacaggggtgccgctggtagttatggtgaaaccagacacttttcttatccag
gagattaagactcttcctgctaaagcgaagatccaagacatggttgctattaggcacacg
gcctgcaatgagcagcagcggacaacaatgattctgctgtgtgaggatggcagcctgcgc
atttacatggccaacgtggagaacacctcctactggctgcagccatccctgcagcccagc
agtgtcatcagcatcatgaagcctgttcgaaagcgcaaaacagctacaatcacaacccgc
acgtctagccaggtgactttccccattgacttttttgaacacaaccagcagctgacagat
gtggagtttggtggtaacgacctcctacaggtctataatgcacaacagataaaacaccgg
ctgaattccactggcatgtatgtggccaacaccaagcccggaggcttcaccattgagatt
agtaacaacaatagcactatggtgatgacaggcatgcggatccagattgggactcaagca
atagaacgggccccgtcatatatcgagatcttcggcagaactatgcagctcaacctgagt
cgctcacgctggtttgacttccccttcaccagagaagaagccctgcaggctgataagaag
ctgaacctcttcattggggcctcggtggatccagcaggtgtcaccatgatagatgctgta
aaaatttatggcaagactaaggagcagtttggctggcctgatgagcccccagaagaattc
ccttctgcctctgtcagcaacatctgcccttcaaatctgaaccagagcaacggcactgga
gatagcgactcagctgcccccactacgaccagtggaactgtcctggagaggctggttgtg
agttctttagaagccctggaaagctgctttgccgttggcccaatcatcgagaaggagaga
aacaagaatgctgctcaggagctggccactttgctgttgtccctgccagcacctgccagt
gtccagcagcagtccaagagccttctggccagcctgcacaccagccgctcggcctaccac
agccacaaggatcaggccttgctgagcaaagctgtgcagtgtctcaacacatctagcaaa
gagggcaaggatttggaccctgaggtgttccagaggctagtgatcacagctcgctccatt
gccatcatgcgccccaacaaccttgtccactttacggagtcaaagctgccccagatggaa
acagaaggaatggatgaagggaaggaaccgcagaagcagttggaaggagattgctgtagt
ttcatcacccagcttgtgaaccacttctggaaactccatgcatccaaacccaagaatgcc
ttcttggcacctgcctgccttccaggactaactcatattgaagctactgtcaatgctctg
gtggacatcatccatggctactgtacctgtgagctggattgtattaacacagcatccaag
atctacatgcagatgctcttgtgtcctgatcctgctgtgagcttctcttgtaaacaagct
ctaattcgagtcctaaggcccaggaacaaacggagacatgtgactttaccctcttcccct
cgaagcaacactccaatgggagacaaggatgatgatgacgatgatgatgcagatgagaaa
atgcagtcatcagggatcccgaatggtggtcacatccgtcaggaaagccaggaacagagt
gaggtggaccatggagattttgagatggtgtctgagtcgatggtcctggagacagctgaa
aatgtcaacaatggcaacccctctcccctggaggccctgctggcaggcgcagagggcttc
ccccccatgctggacatcccacctgatgcagatgacgagaccatggttgaactagccatt
gccctgagcctgcagcaggaccaacaaggcagcagcagcagtgccctgggcctgcagagc
ctgggactgtccggccaggcacccagctcttcctctctggacgcaggaaccctctctgac
accacagcatcagctccagcctcagacgacgagggcagtacagcagcgacagatggttct
acccttcggacctctcctgctgaccacggtggtagtgtgggctcggagagcgggggcagt
gcagtggactcagtggctggcgagcacagtgtatctggccggagcagtgcttatggcgat
gctacagctgaggggcatccggctggaccaggaagtgtcagctcaagcactggagccatc
agcaccaccactgggcaccaggagggagatggctccgagggagaaggagaaggagaaact
gaaggagatgtccacactagcaacaggctgcacatggtccgtctaatgctgttggagaga
ttactgcagaccctgcctcaattacgaaacgttggcggtgtccgggccatcccatacatg
caggtcattctaatgctcactacagatctggatggagaagatgagaaagacaagggggcc
ctagacaacctgctctcccagcttattgctgagttgggtatggataaaaaggatgtctcc
aagaagaatgagcgcagcgccctgaatgaagtccatctggtagtaatgagactcctgagt
gtcttcatgtcccgcaccaaatctggatccaagtcttccatatgtgagtcatcttccctc
atctccagtgccacagcagcagctctactgagctctggggctgtggactactgcctgcac
gtgctcaaatcactgctggaatattggaagagccaacagaatgacgaggagcctgtggct
accagccagttgctgaaaccacatactacctcctccccacctgacatgagcccattcttt
ctccgccagtatgtgaagggtcatgctgctgatgtgtttgaggcctatactcagcttcta
acagaaatggtactgaggcttccttaccaaatcaaaaagattactgacaccaattctcga
atcccacctcctgtctttgaccactcgtggttttactttctctccgagtacctcatgatc
cagcagactccatttgtgcgccgtcaagtccgcaaacttctgctcttcatctgtggatcc
aaagagaagtaccgccagctccgggatttgcacaccctggactctcacgtgcgtgggatc
aagaagctgctagaagagcaggggatattcctccgggcaagtgtggttacagccagctca
ggctccgccttgcaatatgacacactcatcagcctgatggagcacctgaaagcctgtgca
gagattgccgcccagcgaaccatcaactggcagaaattctgcatcaaagatgactccgtc
ctgtacttcctcctccaagtcagtttccttgtggatgagggcgtgtccccagtgctgctg
caactgctctcctgtgctctgtgcggcagcaaggtgctcgctgcactggcagcctcttcg
ggatcctccagtgcttcttcctcctcagcccctgtggctgccagttctggacaagccaca
acacagtccaagtcttccactaaaaagagcaagaaagaagaaaaagaaaaggagaaagat
ggtgagacctctggcagccaggaggaccagctgtgcacagctctggtgaaccagctgaac
aaatttgccgataaggaaaccctgatccagttcctgcgttgtttcctgttagagtccaat
tcttcctcggtgcgctggcaggcccactgtctgacactgcacatctacagaaattccagc
aaatctcaacaggagctcctgctagatctgatgtggtccatctggccagaactcccagcc
tatggtcgtaaggctgcccagtttgtggacctactaggatatttctccctgaaaactcca
caaacagagaagaagttgaaggagtattcacagaaggctgtggagattctgcggactcaa
aaccatattcttaccaaccaccccaactcgaacatttataacactttgtctggcttagtg
gagtttgatggctattacctggagagcgatccctgcctggtgtgtaataacccggaagta
ccgttctgttatatcaagctgtcttccattaaagtggacacgcggtacaccaccacccag
caggttgtgaagctcattggcagtcacaccatcagcaaagtgacagtgaaaatcggggat
ctgaaacggaccaagatggtgcggaccatcaacctgtattataacaaccgaaccgtgcag
gccatcgtggagttgaaaaacaagccagctcgctggcacaaagccaagaaggttcagctg
acccctggacagacagaggtgaagattgacctgccgttgcccattgtggcctccaatctg
atgattgagtttgcagacttctatgaaaactaccaggcctccacagagaccctgcagtgc
cctcgctgtagtgcctcggtccctgccaacccaggagtctgtggcaactgtggagagaat
gtgtaccagtgtcacaaatgcagatccatcaactacgatgaaaaggatcccttcctctgc
aatgcctgtggcttctgtaaatatgcccgcttcgacttcatgctctatgccaagccttgc
tgtgcagtggatcccattgagaatgaagaagaccggaagaaggctgtatccaacatcaat
acacttttggacaaagctgatcgagtgtatcatcagctgatgggacaccggccacagctg
gagaacctgctctgcaaagtgaatgaggcagctccagaaaagccacaggatgactcagga
acagcagggggcatcagctccacttctgccagtgtgaatcgttacatcctgcagttggct
caggagtattgtggagactgcaagaactcttttgatgaactctccaaaatcatccagaaa
gtctttgcttcgcgcaaagagttgttggaatatgacctacagcagagggaagcagccact
aaatcatcccggacctccgtgcagcccacattcactgccagccagtaccgtgccttatcc
gtcctgggctgtggccacacatcctccaccaagtgctatggctgcgcctcggctgtcaca
gaacattgtatcacactacttcgggccctggccaccaacccagccttgaggcacatcctt
gtctcccagggccttatccgggagctctttgattataatcttcgccgaggggctgcggcc
atgcgggaggaggtccgccagctcatgtgcctcctaactcgagacaacccagaagccacc
caacagatgaatgacctgattattggcaaggtctccacagccctgaagggccactgggcc
aaccccgatctggcaagtagcctgcagtatgaaatgctgctgctgacggattctatctcc
aaggaggacagctgctgggagctccggttacgctgtgctctcagccttttcctcatggct
gtgaacattaagactcctgtggtggttgaaaacattaccctcatgtgcctgaggatcttg
cagaagctgataaaaccacctgctcccactagcaagaagaacaaggatgtccccgttgag
gccctcaccacggtgaagccatactgcaatgagatccatgcccaggctcaactgtggctc
aagagagaccccaaggcatcctatgatgcctggaagaagtgtcttcctatcagagggata
gatggcaatgggaaagcccccagcaaatcagagctccgccatctctatttgactgagaag
tatgtgtggaggtggaaacagttcctgagtcgtcgggggaagaggacctcccccttggat
ctcaaactggggcataacaactggctgcgacaagtgcttttcactccagcaacgcaggcc
gcacggcaggcagcctgtaccattgtggaagctctagccaccattcccagccgcaagcag
caggtcctggacctgcttaccagttacctggatgagctgagcatagctggggagtgtgca
gctgagtacctggctctctaccagaagctcatcacttctgcgcactggaaagtctacttg
gcagctcggggagtcctaccctatgtgggcaacctcatcaccaaggaaatagctcgtctg
ctggccctggaggaggctaccctgagtaccgatctgcagcagggttatgcccttaaaagt
ctcacaggccttctctcctcctttgttgaggtggaatccatcaaaagacattttaaaagt
cgcttggtgggtactgtgctgaatggatacctgtgcttgcggaagctggtggtgcagagg
accaagctgatcgatgagacgcaggacatgctgctggagatgctggaggacatgaccaca
ggtacagaatcagaaaccaaggccttcatggctgtgtgcattgagacagccaagcgctac
aatctggatgactaccggaccccggtgttcatcttcgagaggctctgcagcatcatttat
cctgaggagaatgaagtcactgagttctttgtgaccctggagaaggatccccaacaagaa
gacttcttacagggcaggatgcctgggaacccgtatagcagcaatgagccaggcatcggg
ccgctgatgagggatataaagaacaagatttgccaggactgtgacttagtggccctcctg
gaagatgacagtggcatggagcttctagtgaacaataaaatcattagtttggaccttcct
gtggctgaagtttacaagaaagtctggtgtaccacgaatgagggagagcccatgaggatt
gtttatcgtatgcgggggctgctgggcgatgccacagaggagttcattgagtccctggac
tctactacagatgaagaagaagatgaagaagaagtgtataaaatggctggtgtgatggcc
cagtgtgggggcctggaatgcatgcttaacagactcgcagggatcagagatttcaagcag
ggacgccaccttctaacagtgctactgaaattgttcagttactgcgtgaaggtgaaagtc
aaccggcagcaactggtcaaactggaaatgaacaccttgaacgtcatgctggggacccta
aacctggcccttgtagctgaacaagaaagcaaggacagtgggggtgcagctgtggctgag
caggtgcttagcatcatggagatcattctagatgagtccaatgctgagcccctgagtgag
gacaagggcaacctcctcctgacaggtgacaaggatcaactggtgatgctcttggaccag
atcaacagcacctttgttcgctccaaccccagtgtgctccagggcctgcttcgcatcatc
ccgtacctttcctttggagaggtggagaaaatgcagatcttggtggagcgattcaaacca
tactgcaactttgataaatatgatgaagatcacagtggtgatgataaagtcttcctggac
tgcttctgtaaaatagctgctggcatcaagaacaacagcaatgggcaccagctgaaggat
ctgattctccagaaggggatcacccagaatgcacttgactacatgaaaaagcacatccct
agcgccaagaatttggatgccgacatctggaaaaagtttttgtctcgcccagccttgcca
tttatcctaaggctgcttcggggcctggccatccagcaccctggcacccaggttctgatt
ggaactgattccatcccgaacctgcataagctggagcaggtgtccagtgatgagggcatt
gggaccttggcagagaacctgctggaagccctgcgggaacaccctgacgtaaacaagaag
attgacgcagcccgcagggagacccgggcagagaagaagcgcatggccatggcaatgagg
cagaaggccctgggcaccctgggcatgacgacaaatgaaaagggccaggtcgtgaccaag
acagcactcctgaagcagatggaagagctgatcgaggagcctggcctcacgtgctgcatc
tgcagggagggatacaagttccagcccacaaaggtcctgggcatttataccttcacgaag
cgggtagccttggaggagatggagaataagccccggaaacagcagggctacagcaccgtg
tcccacttcaacattgtgcactacgactgccatctggctgccgtcaggttggctcgaggc
cgggaagagtgggagagtgccgccctgcagaatgccaacaccaagtgcaacgggctcctt
ccggtctggggacctcatgtccctgaatcagcttttgccacttgcttggcaagacacaac
acttacctccaggaatgtacaggccagcgggagcccacgtatcagctcaacatccatgac
atcaaactgctcttcctgcgcttcgccatggagcagtcgttcagcgcagacactggcggg
ggcggccgggagagcaacatccacctgatcccgtacatcattcacactgtgctttacgtc
ctgaacacaacccgagcaacttcccgagaagagaagaacctccaaggctttctggaacag
cccaaggagaagtgggtggagagtgcctttgaagtggacgggccctactatttcacagtc
ttggcccttcacatcctgccccctgagcagtggagagccacacgtgtggaaatcttgcgg
aggctgttggtgacctcgcaggctcgggcagtggctccaggtggagccaccaggctgaca
gataaggcagtgaaggactattccgcttaccgttcttcccttctcttttgggccctcgtc
gatctcatttacaacatgtttaagaaggtgcctaccagtaacacagagggaggctggtcc
tgctctctcgctgagtacatccgccacaacgacatgcccatctacgaagctgccgacaaa
gccctgaaaaccttccaggaggagttcatgccagtggagaccttctcagagttcctcgat
gtggccggtcttttatcagaaatcaccgatccagagagcttcctgaaggacctgttgaac
tcagtcccctga |
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