Homo sapiens (human): 23517
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Entry
23517 CDS
T01001
Symbol
MTREX, Dob1, KIAA0052, Mtr4, SKIV2L2, fSAP118
Name
(RefSeq) Mtr4 exosome RNA helicase
KO
K12598
ATP-dependent RNA helicase DOB1 [EC:
5.6.2.6
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03018
RNA degradation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03018 RNA degradation
23517 (MTREX)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
23517 (MTREX)
03041 Spliceosome [BR:
hsa03041
]
23517 (MTREX)
03009 Ribosome biogenesis [BR:
hsa03009
]
23517 (MTREX)
03016 Transfer RNA biogenesis [BR:
hsa03016
]
23517 (MTREX)
Enzymes [BR:
hsa01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.6 RNA 3'-5' helicase
23517 (MTREX)
Messenger RNA biogenesis [BR:
hsa03019
]
Eukaryotic type
mRNA degradation factors
3'-5' decay
TRAMP complex
23517 (MTREX)
Spliceosome [BR:
hsa03041
]
Complex B
U4/U6.U5 tri-snRNP components
U4/U6.U5 tri-snRNP related factors
23517 (MTREX)
Complex C
U4/U6.U5 tri-SnRNP related factors
23517 (MTREX)
Ribosome biogenesis [BR:
hsa03009
]
Eukaryotic type
Pre-60S particles
Helicases
23517 (MTREX)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
tRNA degradation factors
TRAMP complex
23517 (MTREX)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
MTR4_beta-barrel
DSHCT
DEAD
MTR4-like_stalk
Helicase_C
DEXQc_Suv3
ResIII
nSTAND3
AAA_22
Motif
Other DBs
NCBI-GeneID:
23517
NCBI-ProteinID:
NP_056175
OMIM:
618122
HGNC:
18734
Ensembl:
ENSG00000039123
UniProt:
P42285
Q3MHC9
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:55307989..55425579
Genome browser
AA seq
1042 aa
AA seq
DB search
MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGKRFDGKLQSESTNNG
KNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQSVETVEGCTHEVALPAEE
DYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALR
EKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGS
EVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLH
KQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNTAMQVLRDAGDLAKGD
QKGRKGGTKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFNTDEEKKMV
EEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLIKALF
ATETFAMGINMPARTVLFTNARKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVD
EKMSPTIGKQLLKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPG
VVEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLV
KVKNEGDDFGWGVVVNFSKKSNVKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKP
DEKGEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPI
DDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELK
KARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDL
SAEQATALLSCFVFQENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLS
SFKPHLMDVVYTWATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELE
NKFAEGITKIKRDIVFAASLYL
NT seq
3129 nt
NT seq
+upstream
nt +downstream
nt
atggcggacgcattcggagatgagctgttcagcgtgttcgagggcgactcgaccactgcg
gcgggaaccaaaaaagacaaggaaaaggacaaggggaaatggaaggggcctccagggtct
gcagacaaggcagggaaacgttttgatggtaaattacaatcagaatcaactaataatgga
aaaaataagagagatgtagatttcgaaggtacagatgaacccatttttggaaagaagccc
aggatagaagagtcaataactgaagacttaagtttggcagacctgatgcccagagtcaag
gtacaatcagttgaaactgttgaagggtgtacacatgaggttgcacttcctgcagaagag
gattatttaccacttaaaccacgagttggaaaagctgctaaggaatacccgttcattctt
gatgcttttcaaagagaggccattcagtgtgttgacaataatcagtctgttctagtatct
gcacatacctcagcgggaaaaacagtatgcgccgagtatgccattgcattggccttaagg
gaaaagcagcgtgtaatatttaccagcccaattaaggctctgagtaaccaaaaataccgt
gaaatgtatgaagaatttcaagatgttggtttgatgactggtgatgttactattaatcct
acggcatcttgtcttgttatgaccacagagattttgagaagtatgctttacagaggttcc
gaagttatgagagaagttgcttgggttatatttgatgaaattcattatatgagagattca
gaacgtggtgtagtatgggaagaaactattattttgcttcctgataacgtccactatgtc
tttctttcggctactattccaaatgcccgacagtttgctgaatggatttgccatttacat
aaacagccttgtcatgttatttacacagattatcggcccactccattgcaacactacatt
tttccagcagggggagatggcctgcatcttgtggttgatgaaaatggtgacttcagagaa
gataattttaatactgcaatgcaagtgcttcgagatgcaggtgatttggccaaaggagac
cagaaagggcggaaaggaggaacaaaaggaccatcaaatgttttcaaaattgtgaagatg
attatggaaagaaatttccaacctgtgattattttcagttttagtaagaaagattgtgaa
gcctatgcacttcaaatgaccaaattagatttcaacacagatgaagaaaagaagatggtt
gaagaagtattcagtaatgcaattgattgcttatccgatgaagataaaaaactccctcag
gtagaacatgtacttcctcttttgaagaggggaattggtattcaccatggtggtttactt
cctattttgaaagaaactatagaaattctcttttctgaaggattgataaaggccttattt
gccacggagacctttgctatgggaattaacatgccagctagaactgttttatttacaaat
gcccgcaaatttgatgggaaggatttccgatggatttcttctggtgaatacattcagatg
tctggtcgtgctggaaggagaggaatggatgatagaggaattgtaattcttatggtagat
gaaaagatgagcccaacaattggaaaacaattacttaagggctccgctgatcctctaaat
agtgctttccatttgacctacaacatggttttgaacttactacgtgtagaagaaattaat
cctgagtacatgttggaaaaatccttctaccagtttcagcattatagagcaattccagga
gtagtagagaaggtaaagaattcagaagaacagtataataaaatagtaattcccaatgaa
gaaagtgtggttatctattataagattagacagcagcttgccaaattgggtaaagaaatt
gaagaatatattcacaaaccaaaatactgcttaccttttctacaaccaggtcgtttggta
aaggtaaagaatgaaggagatgactttggctggggagtagtggtgaatttctcaaaaaag
tcaaatgttaagcctaactctggtgaactggatcctttgtatgtagtagaagtacttctg
cgctgtagcaaagagagcttgaaaaattcagctacagaagctgcaaaaccagctaaacct
gatgagaaaggagagatgcaggttgtcccagttttggtgcatctcctgtctgctatcagc
agtgttaggctttacattcctaaagaccttcggccggtggacaatagacagagtgtttta
aaatcaatacaggaagttcagaaacgttttcctgacggcatccccttattagaccctatt
gatgatatgggcattcaagatcaagggctgaaaaaagtcattcagaaagtagaagctttt
gagcatcgaatgtattctcatccacttcacaatgatccaaatttggaaactgtgtatacg
ctttgtgaaaaaaaagcacagattgcaatagatattaaatctgcaaagcgagaactgaag
aaagcaagaacagtcctacaaatggatgaactcaaatgtcgcaaacgtgttttaagaagg
ttgggatttgctacttcttctgatgtaatagagatgaaaggacgagtggcttgtgagata
agcagtgctgatgagctccttctaactgagatgatgtttaatggccttttcaatgacctt
tctgcagaacaggcaacagcattattaagctgctttgtgtttcaagagaattctagtgag
atgcccaaattaacagaacaattagcaggaccacttcgtcaaatgcaggaatgtgctaaa
agaattgcaaaagtttcagcagaagccaaattggaaattgatgaggaaacttatctaagc
tcatttaaacctcacttaatggatgtagtatatacctgggcaactggagctacatttgcc
catatctgcaaaatgacagatgtctttgaaggcagcataattcgttgtatgaggcgcctg
gaagaattgcttcgacaaatgtgtcaagcagcaaaagccattggaaacactgagctggaa
aataaatttgcagaaggaatcaccaaaatcaagagagatattgtgtttgctgccagcctc
tacttgtag
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