KEGG   Homo sapiens (human): 2356
Entry
2356              CDS       T01001                                 
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase
  KO
K01930  folylpolyglutamate synthase [EC:6.3.2.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa01523  Antifolate resistance
hsa04981  Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    2356 (FPGS)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    2356 (FPGS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    2356 (FPGS)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.17  tetrahydrofolate synthase
     2356 (FPGS)
SSDB
Motif
Pfam: Mur_ligase_C
Other DBs
NCBI-GeneID: 2356
NCBI-ProteinID: NP_004948
OMIM: 136510
HGNC: 3824
Ensembl: ENSG00000136877
UniProt: Q05932
LinkDB
Position
9:127802858..127814506
AA seq 587 aa
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq 1764 nt   +upstreamnt  +downstreamnt
atgtcgcgggcgcggagccacctgcgcgccgctctattcctggcagcggcgtctgcgcgc
ggcataacgacccaggtcgcggcgcggcggggcttgagcgcgtggccggtgccgcaggag
ccgagcatggagtaccaggatgccgtgcgcatgctcaataccctgcagaccaatgccggc
tacctggagcaggtgaagcgccagcggggtgaccctcagacacagttggaagccatggaa
ctgtacctggcacggagtgggctgcaggtggaggacttggaccggctgaacatcatccac
gtcactgggacgaaggggaagggctccacctgtgccttcacggaatgtatcctccgaagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggttcgggagcggatc
cgcatcaatgggcagcccatcagtcctgagctcttcaccaagtacttctggcgcctctac
caccggctggaggagaccaaggatggcagctgtgtctccatgcccccctacttccgcttc
ctgacactcatggccttccacgtcttcctccaagagaaggtggacctggcagtggtggag
gtgggcattggcggggcttatgactgcaccaacatcatcaggaagcctgtggtgtgcgga
gtctcctctcttggcatcgaccacaccagcctcctgggggatacggtggagaagatcgca
tggcagaaagggggcatctttaagcaaggtgtccctgccttcactgtgctccaacctgaa
ggtcccctggcagtgctgagggaccgagcccagcagatctcatgtcctctatacctgtgt
ccgatgctggaggccctcgaggaaggggggccgccgctgaccctgggcctggagggggag
caccagcggtccaacgccgccttggccttgcagctggcccactgctggctgcagcggcag
gaccgccatggtgctggggagccaaaggcatccaggccagggctcctgtggcagctgccc
ctggcacctgtgttccagcccacatcccacatgcggctcgggcttcggaacacggagtgg
ccgggccggacgcaggtgctgcggcgcgggcccctcacctggtacctggacggtgcgcac
accgccagcagcgcgcaggcctgcgtgcgctggttccgccaggcgctgcagggccgcgag
aggccgagcggtggccccgaggttcgagtcttgctcttcaatgctaccggggaccgggac
ccggcggccctgctgaagctgctgcagccctgccagtttgactatgccgtcttctgccct
aacctgacagaggtgtcatccacaggcaacgcagaccaacagaacttcacagtgacactg
gaccaggtcctgctccgctgcctggaacaccagcagcactggaaccacctggacgaagag
caggccagcccggacctctggagtgcccccagcccagagcccggtgggtccgcatccctg
cttctggcgccccacccaccccacacctgcagtgccagctccctcgtcttcagctgcatt
tcacatgccttgcaatggatcagccaaggccgagaccccatcttccagccacctagtccc
ccaaagggcctcctcacccaccctgtggctcacagtggggccagcatactccgtgaggct
gctgccatccatgtgctagtcactggcagcctgcacctggtgggtggtgtcctgaagctg
ctggagcccgcactgtcccagtag

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