Homo sapiens (human): 23621 Help Entry 23621             CDS       T01001                                  Symbol BACE1, ASP2, BACE, HSPC104 Name (RefSeq) beta-secretase 1   KO K04521   beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46] Organism hsa  Homo sapiens (human) Pathway hsa05010   Alzheimer disease Drug target Atabecestat:  D11456 Elenbecestat:  D11509 Lanabecestat (DG02834):  D10946 D10947 Umibecestat:  D11690 Verubecestat:  D10739 Brite KEGG Orthology (KO) [BR:hsa00001]  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     23621 (BACE1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01002 Peptidases and inhibitors [BR:hsa01002]     23621 (BACE1) Enzymes [BR:hsa01000]  3. Hydrolases   3.4  Acting on peptide bonds (peptidases)    3.4.23  Aspartic endopeptidases     3.4.23.46  memapsin 2      23621 (BACE1) Peptidases and inhibitors [BR:hsa01002]  Aspartic peptidases   Family A1: pepsin family    23621 (BACE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Asp TAXi_C TAXi_N Motif Other DBs NCBI-GeneID:  23621 NCBI-ProteinID:  NP_036236 OMIM:  604252 HGNC:  933 Ensembl:  ENSG00000186318 UniProt:  P56817 Structure PDBPDBj LinkDB All DBs Position 11:complement(117285698..117316256) Genome browser AA seq 501 aa AA seqDB search MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW RCLRCLRQQHDDFADDISLLK NT seq 1506 nt NT seq  +upstreamnt  +downstreamnt atggcccaagccctgccctggctcctgctgtggatgggcgcgggagtgctgcctgcccac ggcacccagcacggcatccggctgcccctgcgcagcggcctggggggcgcccccctgggg ctgcggctgccccgggagaccgacgaagagcccgaggagcccggccggaggggcagcttt gtggagatggtggacaacctgaggggcaagtcggggcagggctactacgtggagatgacc gtgggcagccccccgcagacgctcaacatcctggtggatacaggcagcagtaactttgca gtgggtgctgccccccaccccttcctgcatcgctactaccagaggcagctgtccagcaca taccgggacctccggaagggtgtgtatgtgccctacacccagggcaagtgggaaggggag ctgggcaccgacctggtaagcatcccccatggccccaacgtcactgtgcgtgccaacatt gctgccatcactgaatcagacaagttcttcatcaacggctccaactgggaaggcatcctg gggctggcctatgctgagattgccaggcctgacgactccctggagcctttctttgactct ctggtaaagcagacccacgttcccaacctcttctccctgcagctttgtggtgctggcttc cccctcaaccagtctgaagtgctggcctctgtcggagggagcatgatcattggaggtatc gaccactcgctgtacacaggcagtctctggtatacacccatccggcgggagtggtattat gaggtgatcattgtgcgggtggagatcaatggacaggatctgaaaatggactgcaaggag tacaactatgacaagagcattgtggacagtggcaccaccaaccttcgtttgcccaagaaa gtgtttgaagctgcagtcaaatccatcaaggcagcctcctccacggagaagttccctgat ggtttctggctaggagagcagctggtgtgctggcaagcaggcaccaccccttggaacatt ttcccagtcatctcactctacctaatgggtgaggttaccaaccagtccttccgcatcacc atccttccgcagcaatacctgcggccagtggaagatgtggccacgtcccaagacgactgt tacaagtttgccatctcacagtcatccacgggcactgttatgggagctgttatcatggag ggcttctacgttgtctttgatcgggcccgaaaacgaattggctttgctgtcagcgcttgc catgtgcacgatgagttcaggacggcagcggtggaaggcccttttgtcaccttggacatg gaagactgtggctacaacattccacagacagatgagtcaaccctcatgaccatagcctat gtcatggctgccatctgcgccctcttcatgctgccactctgcctcatggtgtgtcagtgg cgctgcctccgctgcctgcgccagcagcatgatgactttgctgatgacatctccctgctg aagtga

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