| Entry |
|
|---|
| Symbol |
PHGDH, 3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
|
|---|
| Name |
(RefSeq) D-3-phosphoglycerate dehydrogenase
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa00260 | Glycine, serine and threonine metabolism |
| hsa00270 | Cysteine and methionine metabolism |
|
|---|
| Module |
| hsa_M00020 | Serine biosynthesis, glycerate-3P => serine |
|
|---|
| Network |
nt06033 Glycine, serine and arginine metabolism |
|---|
| Element |
|
|---|
| Disease |
| H01079 | 3-Phosphoglycerate dehydrogenase (3-PGDH) deficiency |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
26227 (PHGDH)
00270 Cysteine and methionine metabolism
26227 (PHGDH)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
26227 (PHGDH)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.95 phosphoglycerate dehydrogenase
26227 (PHGDH)
1.1.1.399 2-oxoglutarate reductase
26227 (PHGDH)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
26227 (PHGDH)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
|
|---|
| LinkDB |
|
|---|
| Position |
1:119711934..119744215
|
|---|
| AA seq |
533 aa
MAFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVT
ADVINAAEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQ
IPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISP
EVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIV
DEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFVDMVKGKSLTGVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKGTIQVITQG
TSLKNAGNCLSPAVIVGLLKEASKQADVNLVNAKLLVKEAGLNVTTSHSPAAPGEQGFGE
CLLAVALAGAPYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFRTQTSDPAMLPT
MIGLLAEAGVRLLSYQTSLVSDGETWHVMGISSLLPSLEAWKQHVTEAFQFHF |
|---|
| NT seq |
1602 nt +upstreamnt +downstreamnt
atggcttttgcaaatctgcggaaagtgctcatcagtgacagcctggacccttgctgccgg
aagatcttgcaagatggagggctgcaggtggtggaaaagcagaaccttagcaaagaggag
ctgatagcggagctgcaggactgtgaaggccttattgttcgctctgccaccaaggtgacc
gctgatgtcatcaacgcagctgagaaactccaggtggtgggcagggctggcacaggtgtg
gacaatgtggatctggaggccgcaacaaggaagggcatcttggttatgaacacccccaat
gggaacagcctcagtgccgcagaactcacttgtggaatgatcatgtgcctggccaggcag
attccccaggcgacggcttcgatgaaggacggcaaatgggagcggaagaagttcatggga
acagagctgaatggaaagaccctgggaattcttggcctgggcaggattgggagagaggta
gctacccggatgcagtcctttgggatgaagactatagggtatgaccccatcatttcccca
gaggtctcggcctcctttggtgttcagcagctgcccctggaggagatctggcctctctgt
gatttcatcactgtgcacactcctctcctgccctccacgacaggcttgctgaatgacaac
acctttgcccagtgcaagaagggggtgcgtgtggtgaactgtgcccgtggagggatcgtg
gacgaaggcgccctgctccgggccctgcagtctggccagtgtgccggggctgcactggac
gtgtttacggaagagccgccacgggaccgggccttggtggaccatgagaatgtcatcagc
tgtccccacctgggtgccagcaccaaggaggctcagagccgctgtggggaggaaattgct
gttcagttcgtggacatggtgaaggggaaatctctcacgggggttgtgaatgcccaggcc
cttaccagtgccttctctccacacaccaagccttggattggtctggcagaagctctgggg
acactgatgcgagcctgggctgggtcccccaaagggaccatccaggtgataacacaggga
acatccctgaagaatgctgggaactgcctaagccccgcagtcattgtcggcctcctgaaa
gaggcttccaagcaggcggatgtgaacttggtgaacgctaagctgctggtgaaagaggct
ggcctcaatgtcaccacctcccacagccctgctgcaccaggggagcaaggcttcggggaa
tgcctcctggccgtggccctggcaggcgccccttaccaggctgtgggcttggtccaaggc
actacgcctgtactgcaggggctcaatggagctgtcttcaggccagaagtgcctctccgc
agggacctgcccctgctcctattccggactcagacctctgaccctgcaatgctgcctacc
atgattggcctcctggcagaggcaggcgtgcggctgctgtcctaccagacttcactggtg
tcagatggggagacctggcacgtcatgggcatctcctccttgctgcccagcctggaagcg
tggaagcagcatgtgactgaagccttccagttccacttctaa |
|---|
