KEGG   Homo sapiens (human): 27019
Entry
27019             CDS       T01001                                 
Symbol
DNAI1, CILD1, DIC1, ICS1, PCD, oda6
Name
(RefSeq) dynein axonemal intermediate chain 1
  KO
K10409  dynein axonemal intermediate chain 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04814  Motor proteins
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
  Element
N00976  Retrograde axonal transport
N00977  Mutation-caused aberrant Htt to retrograde axonal transport
N01159  Mutation-caused aberrant TUBA4A to retrograde axonal transport
N01160  Mutation-caused aberrant SOD1 to retrograde axonal transport
Disease
H00564  Primary ciliary dyskinesia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    27019 (DNAI1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    27019 (DNAI1)
   05016 Huntington disease
    27019 (DNAI1)
   05022 Pathways of neurodegeneration - multiple diseases
    27019 (DNAI1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    27019 (DNAI1)
   04812 Cytoskeleton proteins [BR:hsa04812]
    27019 (DNAI1)
Cilium and associated proteins [BR:hsa03037]
 Motile cilia and associated proteins
  Dynein arm
   27019 (DNAI1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     27019 (DNAI1)
SSDB
Motif
Pfam: WD40
Other DBs
NCBI-GeneID: 27019
NCBI-ProteinID: NP_036276
OMIM: 604366
HGNC: 2954
Ensembl: ENSG00000122735
Pharos: Q9UI46(Tbio)
UniProt: Q9UI46 A0A140VJI0
Structure
LinkDB
Position
9:34458805..34520984
AA seq 699 aa
MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDA
ELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRR
QHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTP
KQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEK
QEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ
DFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQ
SRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQP
SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKV
EGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHN
MSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAA
VTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSP
NLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT
NT seq 2100 nt   +upstreamnt  +downstreamnt
atgattcctgcttctgcgaaggctccccataaacagcctcataagcagagcatcagcata
ggcagaggaaccaggaagagagatgaagattcagggactgaagtgggagaaggcacagat
gaatgggcccaatccaaagccacagttagaccccctgaccagctggagttgaccgatgcg
gagttaaaggaggagttcactcggattttgacagccaacaacccacacgcaccccagaac
attgtcaggtacagcttcaaagaaggcacatataagcctattggctttgtgaaccaactg
gcagttcactacacccaggttgggaacctgatccccaaagactcagatgaaggacggcgg
cagcattaccgcgatgaattagtggcaggttctcaggagtctgtcaaggtgatttcagaa
acaggaaacctcgaagaagacgaagagcccaaggagttagaaactgagcctgggagtcaa
acagatgtgcctgcagctggggcagctgaaaaagtgactgaagaagaattgatgactcct
aagcagcccaaggagagaaagctcactaaccagttcaacttcagtgagagggcctcacag
acctacaacaaccctgtccgggatcgagaatgccagacggagcctcctcccaggacaaac
ttttcagccacagccaatcagtgggagatctatgatgcctatgtagaggaacttgagaag
caggaaaagaccaaagagaaggagaaggcaaagaccccagtggctaaaaaatcagggaag
atggccatgaggaagctgacatctatggagtctcagactgatgatctcatcaaattgtcc
caagctgctaagatcatggagcggatggtcaaccagaatacatatgatgacattgctcaa
gattttaagtactatgacgatgctgctgatgaataccgggaccaggtgggtaccctgctg
ccgctctggaagttccaaaatgacaaagccaagcgcctgtccgtcactgccctctgctgg
aatccaaagtacagggatctgtttgcagtgggatatggctcttatgacttcatgaagcag
agccggggcatgctgctgctctacagcctgaagaaccccagcttccctgagtacatgttc
agcagcaacagcggcgtcatgtgtctcgacatccacgtggaccacccctacctggtggca
gtaggccactatgacggcaacgtggccatttacaacctcaagaagccccactcccagccc
tccttctgcagctcagccaagtctggcaagcactcagaccctgtgtggcaggtcaagtgg
cagaaggatgacatggaccaaaaccttaacttcttctctgtgtcatctgacggcaggatt
gtgtcttggactctcgtgaagagaaagctggttcacatagatgtcatcaagctgaaggtg
gaaggcagcaccacggaagttcctgaggggttgcagctgcacccagtgggttgtggcact
gcctttgacttccacaaagagattgactacatgttcctagtgggcacagaggagggaaaa
atctacaagtgctctaaatcctactccagccaattcctcgacacctatgacgcccacaac
atgtcagtggacactgtgtcctggaacccataccacaccaaggtcttcatgtcctgcagc
tccgactggacagtgaagatctgggaccacaccatcaagaccccgatgttcatctatgac
ctgaactcagccgtgggtgatgtggcctgggcgccatactcttctactgtgttcgcagca
gtcaccacagatgggaaggcccacatatttgacttagccatcaacaagtatgaggccatc
tgcaaccagcctgtggcggccaaaaagaacaggctcacccacgtgcagttcaatctcatc
caccccatcatcattgtgggcgatgaccgtgggcacatcatcagcctcaagctctcaccc
aatttgcgcaagatgccaaaggaaaagaaggggcaggaggtgcagaagggtccagctgtg
gagattgcgaaactggacaaactgctgaacctggtgagggaagtgaaaatcaagacctga

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