Homo sapiens (human): 2720
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Entry
2720 CDS
T01001
Symbol
GLB1, EBP, ELNR1, MPS4B
Name
(RefSeq) galactosidase beta 1
KO
K12309
beta-galactosidase [EC:
3.2.1.23
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00052
Galactose metabolism
hsa00511
Other glycan degradation
hsa00531
Glycosaminoglycan degradation
hsa00600
Sphingolipid metabolism
hsa00604
Glycosphingolipid biosynthesis - ganglio series
hsa01100
Metabolic pathways
hsa04142
Lysosome
Module
hsa_M00079
Keratan sulfate degradation
Network
nt06012
Glycosaminoglycan degradation
nt06014
Sphingolipid degradation
Element
N00623
Keratan sulfate degradation
N00640
Hydrolysis of lactosylceramide
N01710
Hydrolysis of ganglioside
N01711
Hydrolysis of GA1
Disease
H00123
Mucopolysaccharidosis type IV
H00281
GM1 gangliosidosis
H00421
Mucopolysaccharidosis
H00422
Glycoproteinoses
H00423
Sphingolipidosis
H00426
Gangliosidosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00052 Galactose metabolism
2720 (GLB1)
09103 Lipid metabolism
00600 Sphingolipid metabolism
2720 (GLB1)
09107 Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
2720 (GLB1)
00604 Glycosphingolipid biosynthesis - ganglio series
2720 (GLB1)
00511 Other glycan degradation
2720 (GLB1)
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
2720 (GLB1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
2720 (GLB1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.23 beta-galactosidase
2720 (GLB1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
2720 (GLB1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Glyco_hydro_35
BetaGal_ABD_1
BetaGal_gal-bd
BetaGal_ABD2
Glyco_hydro_42
Motif
Other DBs
NCBI-GeneID:
2720
NCBI-ProteinID:
NP_000395
OMIM:
611458
HGNC:
4298
Ensembl:
ENSG00000170266
UniProt:
P16278
Structure
PDB
LinkDB
All DBs
Position
3:complement(32961108..33097146)
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AA seq
677 aa
AA seq
DB search
MPGFLVRILPLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRV
PRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVIL
RPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPV
ITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTV
DFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARG
ASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKV
PEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRT
TLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENM
GRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWA
HNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLT
LFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKR
LMPPPPQKNKDSWLDHV
NT seq
2034 nt
NT seq
+upstream
nt +downstream
nt
atgccggggttcctggttcgcatcctccctctgttgctggttctgctgcttctgggccct
acgcgcggcttgcgcaatgccacccagaggatgtttgaaattgactatagccgggactcc
ttcctcaaggatggccagccatttcgctacatctcaggaagcattcactactcccgtgtg
ccccgcttctactggaaggaccggctgctgaagatgaagatggctgggctgaacgccatc
cagacgtatgtgccctggaactttcatgagccctggccaggacagtaccagttttctgag
gaccatgatgtggaatattttcttcggctggctcatgagctgggactgctggttatcctg
aggcccgggccctacatctgtgcagagtgggaaatgggaggattacctgcttggctgcta
gagaaagagtctattcttctccgctcctccgacccagattacctggcagctgtggacaag
tggttgggagtccttctgcccaagatgaagcctctcctctatcagaatggagggccagtt
ataacagtgcaggttgaaaatgaatatggcagctactttgcctgtgattttgactacctg
cgcttcctgcagaagcgctttcgccaccatctgggggatgatgtggttctgtttaccact
gatggagcacataaaacattcctgaaatgtggggccctgcagggcctctacaccacggtg
gactttggaacaggcagcaacatcacagatgctttcctaagccagaggaagtgtgagccc
aaaggacccttgatcaattctgaattctatactggctggctagatcactggggccaacct
cactccacaatcaagaccgaagcagtggcttcctccctctatgatatacttgcccgtggg
gcgagtgtgaacttgtacatgtttataggtgggaccaattttgcctattggaatggggcc
aactcaccctatgcagcacagcccaccagctacgactatgatgccccactgagtgaggct
ggggacctcactgagaagtattttgctctgcgaaacatcatccagaagtttgaaaaagta
ccagaaggtcctatccctccatctacaccaaagtttgcatatggaaaggtcactttggaa
aagttaaagacagtgggagcagctctggacattctgtgtccctctgggcccatcaaaagc
ctttatcccttgacatttatccaggtgaaacagcattatgggtttgtgctgtaccggaca
acacttcctcaagattgcagcaacccagcacctctctcttcacccctcaatggagtccac
gatcgagcatatgttgctgtggatgggatcccccagggagtccttgagcgaaacaatgtg
atcactctgaacataacagggaaagctggagccactctggaccttctggtagagaacatg
ggacgtgtgaactatggtgcatatatcaacgattttaagggtttggtttctaacctgact
ctcagttccaatatcctcacggactggacgatctttccactggacactgaggatgcagtg
tgcagccacctggggggctggggacaccgtgacagtggccaccatgatgaagcctgggcc
cacaactcatccaactacacgctcccggccttttatatggggaacttctccattcccagt
gggatcccagacttgccccaggacacctttatccagtttcctggatggaccaagggccag
gtctggattaatggctttaaccttggccgctattggccagcccggggccctcagttgacc
ttgtttgtgccccagcacatcctgatgacctcggccccaaacaccatcaccgtgctggaa
ctggagtgggcaccctgcagcagtgatgatccagaactatgtgctgtgacgttcgtggac
aggccagttattggctcatctgtgacctacgatcatccctccaaacctgttgaaaaaaga
ctcatgcccccacccccgcaaaaaaacaaagattcatggctggaccatgtatga
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