Homo sapiens (human): 27330
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Entry
27330 CDS
T01001
Symbol
RPS6KA6, PP90RSK4, RSK-4, RSK4, S6K-alpha-6, p90RSK6
Name
(RefSeq) ribosomal protein S6 kinase A6
KO
K04373
ribosomal protein S6 kinase alpha-1/2/3/6 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04114
Oocyte meiosis
hsa04150
mTOR signaling pathway
hsa04714
Thermogenesis
hsa04720
Long-term potentiation
hsa04722
Neurotrophin signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04931
Insulin resistance
hsa05135
Yersinia infection
hsa05207
Chemical carcinogenesis - receptor activation
Network
nt06526
MAPK signaling
Element
N01601
ERK-RSK signaling
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04150 mTOR signaling pathway
27330 (RPS6KA6)
09150 Organismal Systems
09156 Nervous system
04720 Long-term potentiation
27330 (RPS6KA6)
04722 Neurotrophin signaling pathway
27330 (RPS6KA6)
09159 Environmental adaptation
04714 Thermogenesis
27330 (RPS6KA6)
09160 Human Diseases
09161 Cancer: overview
05207 Chemical carcinogenesis - receptor activation
27330 (RPS6KA6)
09171 Infectious disease: bacterial
05135 Yersinia infection
27330 (RPS6KA6)
09167 Endocrine and metabolic disease
04931 Insulin resistance
27330 (RPS6KA6)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
27330 (RPS6KA6)
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
27330 (RPS6KA6)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
27330 (RPS6KA6)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
RSK family [OT]
27330 (RPS6KA6)
Messenger RNA biogenesis [BR:
hsa03019
]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
Stress granule specific factors
27330 (RPS6KA6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
ABC1
Kdo
Pkinase_fungal
Pkinase_C
YrbL-PhoP_reg
FTA2
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
27330
NCBI-ProteinID:
NP_001317441
OMIM:
300303
HGNC:
10435
Ensembl:
ENSG00000072133
UniProt:
Q9UK32
A0AAU7BN28
Structure
PDB
PDBj
LinkDB
All DBs
Position
X:complement(84058346..84188499)
Genome browser
AA seq
745 aa
AA seq
DB search
MGLSTSAIWKNTRVEIVNPYEVKRKVKVNGLKMVDEPMEEGEADSCHDEGVVKEIPITHH
VKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRT
KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLA
ELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYM
APEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEA
QSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCF
DPEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAA
QFGEVYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNI
ITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVV
HRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYD
AACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLL
SHMLHMDPHQRYTAEQILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQ
PVLEPVAASSLAQRRSMKKRTSTGL
NT seq
2238 nt
NT seq
+upstream
nt +downstream
nt
atgggtctctctacctcagcaatttggaaaaatactcgagtggaaattgttaatccctat
gaagtaaaacgaaaggtgaaggtaaatggtcttaaaatggttgatgagccaatggaagag
ggagaagcagattcttgtcatgatgaaggagttgttaaagaaatccctattactcatcat
gttaaggaaggctatgagaaagcagatcctgcacagtttgagttgctcaaggttcttggt
caggggtcatttggaaaggtttttcttgttagaaagaagaccggtcctgatgctgggcag
ctctatgcaatgaaggtgttaaaaaaagcctctttaaaagttcgagacagagttcggaca
aagatggagagggatatactggtggaagtaaatcatccatttattgtcaaattgcactat
gcctttcagactgaagggaaactgtacttaatactggattttctcaggggaggagatgtt
ttcacaagattatccaaagaggttctgtttacagaggaagatgtgaaattctacctcgca
gaactggcccttgctttggatcatctgcaccaattaggaattgtttatagagacctgaag
ccagaaaacattttgcttgatgaaataggacatatcaaattaacagattttggactcagc
aaggagtcagtagatcaagaaaagaaggcttactcattttgtggtacagtagagtatatg
gctcctgaagtagtaaataggagaggccattcccagagtgctgattggtggtcatatggt
gttcttatgtttgaaatgcttactggtactctgccatttcaaggtaaagacagaaatgag
accatgaatatgatattaaaagcaaaacttggaatgcctcaatttcttagtgctgaagca
caaagtcttctaaggatgttattcaaaaggaatccagcaaatagattgggatcagaagga
gttgaagaaatcaaaagacatctgttttttgcaaatattgactgggataaattatataaa
agagaagttcaacctcctttcaaacctgcttctggaaaaccagatgatactttttgtttt
gatcctgaatttactgcaaaaacacctaaagattctcccggtttgccagccagtgcaaat
gctcatcagctcttcaaaggattcagctttgttgcaacttctattgcagaagaatataaa
atcactcctatcacaagtgcaaatgtattaccaattgttcagataaatggaaatgctgca
caatttggtgaagtatatgaattgaaggaggatattggtgttggctcctactctgtttgc
aagcgatgcatacatgcaactaccaacatggaatttgcagtgaagatcattgacaaaagt
aagcgagacccttcagaagagattgaaatattgatgcgctatggacaacatcccaacatt
attactttgaaggatgtctttgatgatggtagatatgtttaccttgttacggatttaatg
aaaggaggagagttacttgaccgtattctcaaacaaaaatgtttctcggaacgggaggct
agtgatatactatatgtaataagtaagacagttgactatcttcattgtcaaggagttgtt
catcgtgatcttaaacctagtaatattttatacatggatgaatcagccagtgcagattca
atcaggatatgtgattttgggtttgcaaaacaacttcgaggagaaaatggacttctctta
actccatgctacactgcaaactttgttgcacctgaggttcttatgcaacagggatatgat
gctgcttgtgatatctggagtttaggagtccttttttacacaatgttggctggctacact
ccatttgctaatggccccaatgatactcctgaagagatactgctgcgtataggcaatgga
aaattctctttgagtggtggaaactgggacaatatttcagacggagcaaaggatttgctt
tcccatatgcttcatatggacccacatcagcggtatactgctgaacaaatattaaagcac
tcatggataactcacagagaccagttgccaaatgatcagccaaagagaaatgatgtgtca
catgttgttaagggagcaatggttgcaacatactctgccctgactcacaagacctttcaa
ccagtcctagagcctgtagctgcttcaagcttagcccagcgacggagcatgaaaaagcga
acatcaactggcctgtaa
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