Homo sapiens (human): 2868
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Entry
2868 CDS
T01001
Symbol
GRK4, GPRK2L, GPRK4, GRK4a, IT11
Name
(RefSeq) G protein-coupled receptor kinase 4
KO
K08291
G protein-coupled receptor kinase [EC:
2.7.11.16
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04144
Endocytosis
hsa05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
2868 (GRK4)
09150 Organismal Systems
09151 Immune system
04062 Chemokine signaling pathway
2868 (GRK4)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
2868 (GRK4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2868 (GRK4)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.16 G-protein-coupled receptor kinase
2868 (GRK4)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
GRK family [OT]
2868 (GRK4)
BRITE hierarchy
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
RGS
Kinase-like
Pkinase_fungal
ABC1
Motif
Other DBs
NCBI-GeneID:
2868
NCBI-ProteinID:
NP_892027
OMIM:
137026
HGNC:
4543
Ensembl:
ENSG00000125388
UniProt:
P32298
Structure
PDB
PDBj
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All DBs
Position
4:2963571..3040760
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AA seq
578 aa
AA seq
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MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
NT seq
1737 nt
NT seq
+upstream
nt +downstream
nt
atggagctcgagaacatcgtggccaactcgctgctgctgaaagcgcgtcaaggaggatat
ggcaaaaaaagtggtcgtagtaaaaaatggaaggagatactgacactgcctcctgtcagc
cagtgcagtgagcttagacattccattgaaaaggattatagcagtctttgtgacaagcaa
ccgataggaagacgtctcttcaggcagttctgtgataccaaacccactctaaagaggcac
attgaattcttggatgcagtggcagaatatgaagttgccgatgatgaggaccgaagtgat
tgtggactgtcaatcttagatagattcttcaatgataagttggcagcccctttaccagaa
atacctccagatgttgtgacagaatgtagattgggactgaaggaggagaacccttccaaa
aaagcctttgaggaatgtactagagttgcccataactacctaagaggggaaccatttgaa
gaataccaagaaagctcatatttttctcagtttttacaatggaaatggctggaaaggcaa
cccgtaacaaagaacacatttagacattacagagttctaggaaaaggcggatttggagag
gtttgcgcctgtcaagtgcgagccacaggaaaaatgtatgcctgcaaaaagctacaaaaa
aaaagaataaagaagaggaaaggtgaagctatggctctaaatgagaaaagaattctggag
aaagtgcaaagtagattcgtagttagtttagcctacgcttatgaaaccaaagatgccttg
tgcttggtgctcaccattatgaatggaggggatttgaagtttcacatttacaacctgggc
aatcccggctttgatgagcagagagccgttttctatgctgcagagctgtgttgcggcttg
gaagatttacagagggaaagaattgtatacagagacttgaagcctgagaatattctcctt
gatgatcgtggacacatccggatttcagacctcggtttggccacagagatcccagaagga
cagagggttcgaggaagagttggaacagtcggctacatggcacctgaagttgtcaataat
gaaaagtatacgtttagtcccgattggtggggacttggctgtctgatctatgaaatgatt
cagggacattctccattcaaaaaatacaaagagaaagtcaaatgggaggaggtcgatcaa
agaatcaagaatgataccgaggagtattctgagaagttttcagaggatgccaaatctatc
tgcaggatgttactcaccaagaatccaagcaagcggctgggctgcaggggcgagggagcg
gctggggtgaagcagcaccccgtgttcaaggacatcaacttcaggaggctggaggcaaac
atgctggagccccctttctgtcctgatcctcatgccgtttactgtaaggacgtcctggat
atcgagcagttctcggtggtgaaagggatctacctggacaccgcagatgaagacttctat
gctcggtttgctaccgggtgtgtctccatcccctggcagaatgagatgatcgaatctggg
tgtttcaaagacatcaacaaaagtgaaagtgaggaagctttgccattagatctagacaag
aacatacataccccggtttccagaccaaacagaggcttcttctatagactcttcagaaga
gggggctgcctgaccatggtccccagtgagaaggaagtggaacccaagcaatgctga
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