Homo sapiens (human): 2869
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Entry
2869 CDS
T01001
Symbol
GRK5, FP2025, GPRK5
Name
(RefSeq) G protein-coupled receptor kinase 5
KO
K08291
G protein-coupled receptor kinase [EC:
2.7.11.16
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04062
Chemokine signaling pathway
hsa04144
Endocytosis
hsa05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
2869 (GRK5)
09150 Organismal Systems
09151 Immune system
04062 Chemokine signaling pathway
2869 (GRK5)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
2869 (GRK5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2869 (GRK5)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.16 G-protein-coupled receptor kinase
2869 (GRK5)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
GRK family [OT]
2869 (GRK5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
RGS
Kinase-like
Pkinase_fungal
Sulfakinin
Motif
Other DBs
NCBI-GeneID:
2869
NCBI-ProteinID:
NP_005299
OMIM:
600870
HGNC:
4544
Ensembl:
ENSG00000198873
UniProt:
P34947
Structure
PDB
PDBj
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All DBs
Position
10:119207571..119459745
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AA seq
590 aa
AA seq
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MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
NT seq
1773 nt
NT seq
+upstream
nt +downstream
nt
atggagctggaaaacatcgtggccaacacggtcttgctgaaagccagggaagggggcgga
ggaaagcgcaaagggaaaagcaagaagtggaaagaaatcctgaagttccctcacattagc
cagtgtgaagacctccgaaggaccatagacagagattactgcagtttatgtgacaagcag
ccaatcgggaggctgcttttccggcagttttgtgaaaccaggcctgggctggagtgttac
attcagttcctggactccgtggcagaatatgaagttactccagatgaaaaactgggagag
aaagggaaggaaattatgaccaagtacctcaccccaaagtcccctgttttcatagcccaa
gttggccaagacctggtctcccagacggaggagaagctcctacagaagccgtgcaaagaa
ctcttttctgcctgtgcacagtctgtccacgagtacctgaggggagaaccattccacgaa
tatctggacagcatgttttttgaccgctttctccagtggaagtggttggaaaggcaaccg
gtgaccaaaaacactttcaggcagtatcgagtgctaggaaaagggggcttcggggaggtc
tgtgcctgccaggttcgggccacgggtaaaatgtatgcctgcaagcgcttggagaagaag
aggatcaaaaagaggaaaggggagtccatggccctcaatgagaagcagatcctcgagaag
gtcaacagtcagtttgtggtcaacctggcctatgcctacgagaccaaggatgcactgtgc
ttggtcctgaccatcatgaatgggggtgacctgaagttccacatctacaacatgggcaac
cctggcttcgaggaggagcgggccttgttttatgcggcagagatcctctgcggcttagaa
gacctccaccgtgagaacaccgtctaccgagatctgaaacctgaaaacatcctgttagat
gattatggccacattaggatctcagacctgggcttggctgtgaagatccccgagggagac
ctgatccgcggccgggtgggcactgttggctacatggctccagaggtcctgaacaaccag
aggtacggcctgagccccgactactggggccttggctgcctcatctatgagatgatcgag
ggccagtcgccgttccgcggccgcaaggagaaggtgaagcgggaggaggtggaccgccgg
gtcctggagacggaggaggtgtactcccacaagttctccgaggaggccaagtccatctgc
aagatgctgctcacgaaagatgcgaagcagaggctgggctgccaggaggagggggctgca
gaggtcaagagacaccccttcttcaggaacatgaacttcaagcgcttagaagccgggatg
ttggaccctcccttcgttccagacccccgcgctgtgtactgtaaggacgtgctggacatc
gagcagttctccactgtgaagggcgtcaatctggaccacacagacgacgacttctactcc
aagttctccacgggctctgtgtccatcccatggcaaaacgagatgatagaaacagaatgc
tttaaggagctgaacgtgtttggacctaatggtaccctcccgccagatctgaacagaaac
caccctccggaaccgcccaagaaagggctgctccagagactcttcaagcggcagcatcag
aacaattccaagagttcgcccagctccaagaccagttttaaccaccacataaactcaaac
catgtcagctcgaactccaccggaagcagctag
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