Homo sapiens (human): 3053
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Entry
3053 CDS
T01001
Symbol
SERPIND1, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10
Name
(RefSeq) serpin family D member 1
KO
K03912
heparin cofactor II
Organism
hsa
Homo sapiens (human)
Pathway
hsa04610
Complement and coagulation cascades
Disease
H00223
Inherited thrombophilia
Drug target
Heparin (
DG00150
):
D02980
Sulodexide:
D08547
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04610 Complement and coagulation cascades
3053 (SERPIND1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
3053 (SERPIND1)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3053 (SERPIND1)
00536 Glycosaminoglycan binding proteins [BR:
hsa00536
]
3053 (SERPIND1)
Peptidases and inhibitors [BR:
hsa01002
]
Peptidase inhibitors
Family I4: serpin family
3053 (SERPIND1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other cancer cells
3053 (SERPIND1)
Glycosaminoglycan binding proteins [BR:
hsa00536
]
Heparan sulfate / Heparin
Coagulation and fibrinolysis
3053 (SERPIND1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Serpin
AAA_9
Motif
Other DBs
NCBI-GeneID:
3053
NCBI-ProteinID:
NP_000176
OMIM:
142360
HGNC:
4838
Ensembl:
ENSG00000099937
Vega:
OTTHUMG00000150755
Pharos:
P05546
(Tbio)
UniProt:
P05546
Q8IVC0
LinkDB
All DBs
Structure
PDB:
1JMO
1JMJ
6KBO
6KBV
6J12
2NCU
2NCW
2NAT
Thumbnails
Position
22q11.21
AA seq
499 aa
AA seq
DB search
MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFH
KENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGK
SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI
LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV
REYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWV
NKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVP
HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK
NGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY
EHRTSCLLFMGRVANPSRS
NT seq
1500 nt
NT seq
+upstream
nt +downstream
nt
atgaaacactcattaaacgcacttctcattttcctcatcataacatctgcgtggggtggg
agcaaaggcccgctggatcagctagagaaaggaggggaaactgctcagtctgcagatccc
cagtgggagcagttaaataacaaaaacctgagcatgcctcttctccctgccgacttccac
aaggaaaacaccgtcaccaacgactggattccagagggggaggaggacgacgactatctg
gacctggagaagatattcagtgaagacgacgactacatcgacatcgtcgacagtctgtca
gtttccccgacagactctgatgtgagtgctgggaacatcctccagctttttcatggcaag
agccggatccagcgtcttaacatcctcaacgccaagttcgctttcaacctctaccgagtg
ctgaaagaccaggtcaacactttcgataacatcttcatagcacccgttggcatttctact
gcgatgggtatgatttccttaggtctgaagggagagacccatgaacaagtgcactcgatt
ttgcattttaaagactttgttaatgccagcagcaagtatgaaatcacgaccattcataat
ctcttccgtaagctgactcatcgcctcttcaggaggaattttgggtacacactgcggtca
gtcaatgacctttatatccagaagcagtttccaatcctgcttgacttcaaaactaaagta
agagagtattactttgctgaggcccagatagctgacttctcagaccctgccttcatatca
aaaaccaacaaccacatcatgaagctcaccaagggcctcataaaagatgctctggagaat
atagaccctgctacccagatgatgattctcaactgcatctacttcaaaggatcctgggtg
aataaattcccagtggaaatgacacacaaccacaacttccggctgaatgagagagaggta
gttaaggtttccatgatgcagaccaaggggaacttcctcgcagcaaatgaccaggagctg
gactgcgacatcctccagctggaatacgtggggggcatcagcatgctaattgtggtccca
cacaagatgtctgggatgaagaccctcgaagcgcaactgacaccccgggtggtggagaga
tggcaaaaaagcatgacaaacagaactcgagaagtgcttctgccgaaattcaagctggag
aagaactacaatctagtggagtccctgaagttgatggggatcaggatgctgtttgacaaa
aatggcaacatggcaggcatctcagaccaaaggatcgccatcgacctgttcaagcaccaa
ggcacgatcacagtgaacgaggaaggcacccaagccaccactgtgaccacggtggggttc
atgccgctgtccacccaagtccgcttcactgtcgaccgcccctttcttttcctcatctac
gagcatcgcaccagctgcctgctcttcatgggaagagtggccaaccccagcaggtcctag
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integrated database retrieval system
