Homo sapiens (human): 31
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Entry
31 CDS
T01001
Symbol
ACACA, ACAC, ACACAD, ACACalpha, ACC, ACC1, ACCA, ACCalpha, Acac1, hACC1
Name
(RefSeq) acetyl-CoA carboxylase alpha
KO
K11262
acetyl-CoA carboxylase / biotin carboxylase 1 [EC:
6.4.1.2
6.3.4.14
2.1.3.15
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00061
Fatty acid biosynthesis
hsa00620
Pyruvate metabolism
hsa00640
Propanoate metabolism
hsa01100
Metabolic pathways
hsa01212
Fatty acid metabolism
hsa04152
AMPK signaling pathway
hsa04910
Insulin signaling pathway
hsa04922
Glucagon signaling pathway
hsa04936
Alcoholic liver disease
Module
hsa_M00082
Fatty acid biosynthesis, initiation
Disease
H02711
Acetyl-CoA carboxylase-alpha deficiency
Drug target
Clesacostat (
DG03124
):
D11902
D11903
Firsocostat:
D11640
Olumacostat glasaretil:
D11186
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
31 (ACACA)
00640 Propanoate metabolism
31 (ACACA)
09103 Lipid metabolism
00061 Fatty acid biosynthesis
31 (ACACA)
09110 Biosynthesis of other secondary metabolites
00254 Aflatoxin biosynthesis
31 (ACACA)
09130 Environmental Information Processing
09132 Signal transduction
04152 AMPK signaling pathway
31 (ACACA)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
31 (ACACA)
04922 Glucagon signaling pathway
31 (ACACA)
09160 Human Diseases
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
31 (ACACA)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.3 Carboxy- and carbamoyltransferases
2.1.3.15 acetyl-CoA carboxytransferase
31 (ACACA)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.4 Other carbon-nitrogen ligases
6.3.4.14 biotin carboxylase
31 (ACACA)
6.4 Forming carbon-carbon bonds
6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
6.4.1.2 acetyl-CoA carboxylase
31 (ACACA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ACC_central
Carboxyl_trans
CPSase_L_D2
ACCA_BT
Biotin_carb_N
Biotin_carb_C
Biotin_lipoyl
ATP-grasp
Dala_Dala_lig_C
ATP-grasp_3
Motif
Other DBs
NCBI-GeneID:
31
NCBI-ProteinID:
NP_942133
OMIM:
200350
HGNC:
84
Ensembl:
ENSG00000278540
UniProt:
Q13085
Structure
PDB
PDBj
LinkDB
All DBs
Position
17:complement(37084992..37406836)
Genome browser
AA seq
2346 aa
AA seq
DB search
MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLS
DLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEK
VLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPG
GPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWAL
GDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQA
AEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEV
QILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSA
GTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMY
GVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGY
FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLET
ESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQV
LPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDG
SSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYA
EIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQ
STALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQ
DIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREV
FFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSD
MNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALR
ARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYH
SNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRM
SFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSP
PQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLV
DHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQ
LELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFE
YLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYG
SRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQA
YGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQA
FLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVI
GNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVD
PEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGS
GMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGR
EVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPID
RIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGG
IPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPL
MVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSI
NPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAE
RKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLR
RLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTE
EDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILST
MDSPST
NT seq
7041 nt
NT seq
+upstream
nt +downstream
nt
atggatgaaccatctcccttggcccaacctctggagctgaaccagcactctcgattcata
ataggttctgtgtctgaagataactcagaggatgagatcagcaacctggtgaagttggac
ctactggaggagaaggagggctccttgtcacctgcttctgttggctcagatacactctct
gatttggggatctctagcctacaggatggcttggccttgcacataaggtccagcatgtct
ggcttgcacctagtaaagcagggccgagacagaaagaaaatagattctcaacgagatttc
actgtggcttctccagcagaatttgttactcgctttgggggaaataaagtgattgagaag
gttcttattgctaacaatggcattgcagcagtgaaatgcatgcggtctatccgtaggtgg
tcttatgaaatgtttcgaaatgaacgtgcaattagattcgttgtcatggtcacacctgaa
gaccttaaagccaatgcagaatacattaagatggcagatcactatgtgccagtgcctgga
ggaccaaacaacaacaactatgcaaatgtggaattaattcttgatattgctaaaaggatc
ccagtacaagcagtgtgggctggctggggtcatgcttctgagaatcccaaactaccggaa
cttctcttgaaaaatggcattgccttcatgggtcctccaagccaggccatgtgggcttta
ggggataagattgcatcttccatagtggctcaaactgcaggtatcccaactcttccctgg
agcggcagtggtcttcgtgtggactggcaggaaaatgatttttcaaaacgtatcttaaat
gttccccaggagctatatgaaaaaggttatgtgaaagatgtggatgatgggctacaggca
gctgaggaagttggatatccagtaatgatcaaggcctcagagggaggaggagggaaggga
attagaaaagtcaacaatgcagatgacttccctaatctcttcagacaggttcaagctgaa
gttcctggatctcccatatttgtgatgagactagccaaacaatctcgtcatctggaggtg
cagatcttagcggaccaatatggcaatgctatctctttgtttggtcgtgattgctctgta
caacgcaggcatcagaagattattgaagaagcacctgctactattgctactccagcagta
tttgaacacatggaacagtgtgcggtgaaacttgccaaaatggtgggttatgtgagtgct
gggactgtggaatacctgtacagccaggatggcagcttctactttctggaattgaatcct
cggctgcaggtagagcacccttgtacagagatggtggctgatgtcaatctccctgcagca
cagctccagattgccatggggattcctctatatagaatcaaggatatccgtatgatgtat
ggggtatctccctggggtgattctcccattgattttgaagattctgcacacgttccttgt
ccaaggggccatgttattgctgctcggatcactagtgaaaatccagatgagggttttaag
cccagctcaggaacagttcaggagctaaatttccgcagcaataagaatgtttggggatat
ttcagtgttgctgctgcagggggacttcatgaatttgctgattctcagtttggtcactgc
ttttcttggggagaaaacagagaagaggcaatttcaaacatggtggtggctttgaaggag
ctgtctattcggggtgactttcgaactacagttgaatacctgatcaaattgttagagact
gaaagctttcagatgaacagaattgatactggctggctggacagactgatagcagaaaaa
gtacaggctgagcgacctgacaccatgttgggggttgtgtgtggtgccctccacgtggca
gatgtgagcctgcggaatagcgtctctaacttccttcactccttagaaaggggtcaagtc
cttcctgctcatacacttctgaatacagtagatgttgaacttatctatgagggagtcaag
tatgtacttaaggtgactcgacagtcccccaactcctatgtggtgatcatgaatggctca
tgtgtagaagtagatgtacatcggctgagtgacggtggactgctcttgtcctatgatggc
agcagttatactacgtatatgaaagaggaagtggatagatatcgcatcacaattggcaat
aaaacctgtgtgtttgagaaggaaaatgacccatcggtgatgcgctcaccttctgctggg
aagttaatccagtacattgtagaagatggaggtcatgtgtttgccggccagtgctatgct
gagattgaggtaatgaagatggtaatgaccttaacagctgtggagtctggctgtatccat
tacgtcaagcgacctggagcagctcttgaccctggctgtgtactagccaaaatgcaactg
gacaaccccagcaaggttcagcaggctgaacttcacacaggtagtctgccacggatccag
agcacggcactcagaggcgagaaactccatcgagtgttccattatgtcctggataatctg
gtcaatgtaatgaatggatactgccttccagatcctttctttagcagcaaggtaaaagac
tgggtagagcgattgatgaaaaccctcagagatccctccctgcctctcctagaattgcaa
gatattatgaccagtgtgtctggccgcattccccccaatgtggagaagtctatcaagaag
gaaatggctcagtatgctagcaacatcacatcagtcctctgtcagtttcccagccagcag
attgcaaacatcctagatagccatgcagctacattgaaccggaaatctgaacgggaagtc
ttctttatgaatactcagagcattgttcagctggtacagaggtaccgaagtggcatccga
ggccacatgaaggctgtggtgatggatctgctccggcagtacctgcgagtagagacacaa
ttccagaatggtcactatgacaaatgtgtattcgccctccgagaagagaataaaagtgac
atgaacactgtactgaactacatcttctctcacgctcaagtcaccaagaagaatcttctg
gtcacaatgcttattgatcagttgtgtggccgggaccctactctcactgatgagctgctg
aatattctcacagagctaactcaactcagtaagaccaccaatgccaaagtagcacttcga
gcacgccaggttcttattgcctcccatttgccatcatatgagcttcgccataaccaagta
gagtctatcttcctatcagctattgacatgtatggacatcaattttgcattgagaacctg
cagaaactcatcctatcagaaacatctatttttgatgtcctaccaaacttcttctatcac
agcaaccaagtagtgaggatggcagctctggaggtgtatgttcgaagggcttatattgcc
tatgaacttaacagcgtacaacaccgccagcttaaggacaacacctgtgtggtggaattc
cagttcatgctgcccacatctcatccaaacagagggaacatccctacgctaaacagaatg
tccttctcctccaacctcaaccactatggcatgacccatgtagctagtgtcagcgatgta
ctgttggacaactcattcactccaccttgtcagcggatgggcggaatggtctcttttcgg
acttttgaagattttgtcaggatctttgatgaagtgatgggctgcttctctgactcccca
ccccagagtcccacattccctgaggcaggtcacacgtctctttatgatgaggataaggtt
cccagggatgaaccaattcacattctcaatgtggctatcaagactgactgtgatattgag
gatgacaggctggcagctatgttcagagaatttacccagcaaaataaagctaccctggtt
gaccatgggatccggcgccttactttcctggttgcacaaaaggatttcagaaagcaggtc
aactatgaggtggatcggagatttcatagagaattccctaaattttttacattccgagca
agggataagtttgaggaggatcgtatctatcgtcatctggagcctgctctggctttccag
ttagagctgaaccggatgagaaattttgacctcactgccattccatgtgctaatcacaag
atgcacctgtatctcggggcagccaaggtggaagtgggcacagaagtgacagactacagg
ttctttgttcgtgcaatcatcaggcattctgatctggtcaccaaggaagcttcttttgaa
tatctgcaaaatgaaggggagcggctactcctggaagccatggatgagttggaagttgct
tttaacaatacaaatgtccgcactgactgtaaccacatcttcctcaactttgtgcccacg
gttatcatggacccatcaaagattgaggaatccgtgcggagcatggtaatgcggtatgga
agtcgcctgtggaaattgcgcgtcctccaggcagaactgaaaatcaacattcgcctgacg
ccaactggaaaagcaattcccatccgcctcttcctgacaaacgagtctggctattacttg
gatatcagcctatacaaggaagtgactgactccaggacagcacagatcatgtttcaggca
tatggagacaaacagggaccactgcatggaatgttaatcaatactccatatgtgaccaaa
gacctgctgcaatcaaagaggttccaggcacaatccttagggacaacatacatatatgat
atcccagagatgtttcggcagtccctgatcaaactctgggagtctatgtccactcaagca
tttcttccatctccccctctgccttctgacatgctgacttacactgaactggtactggat
gatcaaggtcagctggtccacatgaacaggcttccaggaggaaatgagattggcatggta
gcttggaaaatgacctttaaaagtcctgaatatccagaaggccgagatatcattgttatt
ggcaatgacatcacataccgaattgggtcctttgggcctcaagaggatttgttatttctc
agagcttccgaacttgctagggcagaaggtattccacgcatctatgtatcagccaacagt
ggagcaagaatcggactggcagaagaaattcgccatatgtttcatgtggcctgggtagat
cctgaggatccttacaagggatacaggtatttatatctgactcctcaagattataagaga
gtcagtgctctcaactctgtccattgtgaacacgtggaagatgaaggagaatccaggtac
aagataacagatattattgggaaagaagagggaattggacccgagaaccttcgaggttct
ggaatgattgctggagaatcctcattggcctataatgagatcattaccatcagcctggtg
acgtgccgggccattgggattggggcttaccttgtccggctgggacagagaaccatccag
gttgagaattctcacttaattctaacaggagctggagccctcaacaaagtcctcgggcgg
gaagtgtacacctccaataaccagctggggggcatccagattatgcacaacaatggggtg
acccactgcactgtgtgtgatgactttgaaggggttttcactgtcctgcactggctgtct
tacatgcccaagagcgtgcacagttcagttcctcttctgaactcaaaggatcctatagac
agaatcatcgagtttgttcccacaaagaccccatacgatcctcgatggatgctagcaggc
cgtcctcacccaacccaaaaaggtcagtggttgagtggcttttttgactatggatctttc
tcagagattatgcagccctgggcacagactgtggtggttggtagagccaggctaggagga
atacctgtgggagttgttgctgtagaaacccgaacagtagaactaagtatcccagctgat
ccagcaaacctggattctgaagccaagataatccagcaggctggccaggtttggttccca
gattctgcgtttaagacgtatcaggccatcaaggacttcaaccgggaagggctgcctctg
atggtctttgccaactggagaggcttctctggtggaatgaaagatatgtacgaccaagtg
ctgaagtttggtgcttacattgtggatggcttgagggagtgctgccagcctgtgctggtt
tacattcctccccaggctgagctgcggggtggctcctgggtggtgattgactcctccatc
aacccccggcacatggagatgtatgctgaccgagaaagcaggggatctgttctggagcca
gaagggacagtagaaatcaaattccgcagaaaggatctggtgaaaaccatgcgtcgggtg
gacccagtctacatccacttggctgagcgattggggaccccagagctaagcacagctgag
cggaaggagttggagaacaagttgaaggagcgggaggaattcctaattcccatttaccat
caggtagccgtgcagtttgctgacttgcacgacacaccaggccggatgcaggagaagggt
gttattagcgatatcctggattggaaaacatcccgtaccttcttctactggcggctgagg
cgtcttctgctggaggacctggtcaagaagaaaatccacaatgccaaccctgagctgact
gatggccagattcaagccatgttaaggcgctggtttgtggaagtggaaggaacagtgaag
gcttatgtttgggacaataataaggatctggcggagtggctagagaaacagctgacagag
gaggatggtgttcactcggtaatagaggaaaacatcaaatgcatcagcagagactacgtc
ctcaagcaaatccgcagcttggtccaggccaatccagaggttgccatggattccatcatc
catatgacgcagcacatatcacccactcagcgagcagaagtcatacggatcctctccaca
atggattccccttccacgtag
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integrated database retrieval system
