Homo sapiens (human): 3164
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Entry
3164 CDS
T01001
Symbol
NR4A1, GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
Name
(RefSeq) nuclear receptor subfamily 4 group A member 1
KO
K04465
nuclear receptor subfamily 4 group A member 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04925
Aldosterone synthesis and secretion
hsa04927
Cortisol synthesis and secretion
hsa04934
Cushing syndrome
Network
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00297
ACTH-cortisol signaling pathway
N00298
CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00320
Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321
Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322
Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323
Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04151 PI3K-Akt signaling pathway
3164 (NR4A1)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
3164 (NR4A1)
04927 Cortisol synthesis and secretion
3164 (NR4A1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
3164 (NR4A1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
3164 (NR4A1)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
3164 (NR4A1)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 nerve growth factor IB-like
3164 (NR4A1)
Nuclear receptors [BR:
hsa03310
]
4. Nerve growth factor IB like
4A. Nerve growth factor IB like receptor
3164 (NR4A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
zf-C4
Hormone_recep
Motif
Other DBs
NCBI-GeneID:
3164
NCBI-ProteinID:
NP_002126
OMIM:
139139
HGNC:
7980
Ensembl:
ENSG00000123358
UniProt:
P22736
Structure
PDB
PDBj
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All DBs
Position
12:52022832..52059503
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AA seq
598 aa
AA seq
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MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF
NT seq
1797 nt
NT seq
+upstream
nt +downstream
nt
atgccctgtatccaagcccaatatgggacaccagcaccgagtccgggaccccgtgaccac
ctggcaagcgaccccctgacccctgagttcatcaagcccaccatggacctggccagcccc
gaggcagcccccgctgcccccactgccctgcccagcttcagcaccttcatggacggctac
acaggagagtttgacaccttcctctaccagctgccaggaacagtccagccatgctcctca
gcctcctcctcggcctcctccacatcctcgtcctcagccacctcccctgcctctgcctcc
ttcaagttcgaggacttccaggtgtacggctgctaccccggccccctgagcggcccagtg
gatgaggccctgtcctccagtggctctgactactatggcagcccctgctcggccccgtcg
ccctccacgcccagcttccagccgccccagctctctccctgggatggctccttcggccac
ttctcgcccagccagacttacgaaggcctgcgggcatggacagagcagctgcccaaagcc
tctgggcccccacagcctccagccttcttttccttcagtcctcccaccggccccagcccc
agcctggcccagagccccctgaagttgttcccctcacaggccacccaccagctgggggag
ggagagagctattccatgcctacggccttcccaggtttggcacccacttctccacacctt
gagggctcggggatactggatacacccgtgacctcaaccaaggcccggagcggggcccca
ggtggaagtgaaggccgctgtgctgtgtgtggggacaacgcttcatgccagcattatggt
gtccgcacatgtgagggctgcaagggcttcttcaagcgcacagtgcagaaaaacgccaag
tacatctgcctggctaacaaggactgccctgtggacaagaggcggcgaaaccgctgccag
ttctgccgcttccagaagtgcctggcggtgggcatggtgaaggaagttgtccgaacagac
agcctgaaggggcggcggggccggctaccttcaaaacccaagcagcccccagatgcctcc
cctgccaatctcctcacttccctggtccgtgcacacctggactcagggcccagcactgcc
aaactggactactccaagttccaggagctggtgctgccccactttgggaaggaagatgct
ggggatgtacagcagttctacgacctgctctccggttctctggaggtcatccgcaagtgg
gcggagaagatccctggctttgctgagctgtcaccggctgaccaggacctgttgctggag
tcggccttcctggagctcttcatcctccgcctggcgtacaggtctaagccaggcgagggc
aagctcatcttctgctcaggcctggtgctacaccggctgcagtgtgcccgtggcttcggg
gactggattgacagtatcctggccttctcaaggtccctgcacagcttgcttgtcgatgtc
cctgccttcgcctgcctctctgcccttgtcctcatcaccgaccggcatgggctgcaggag
ccgcggcgggtggaggagctgcagaaccgcatcgccagctgcctgaaggagcacgtggca
gctgtggcgggcgagccccagccagccagctgcctgtcacgtctgttgggcaaactgccc
gagctgcggaccctgtgcacccagggcctgcagcgcatcttctacctcaagctggaggac
ttggtgccccctccacccatcattgacaagatcttcatggacacgctgcccttctga
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