Homo sapiens (human): 3292
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Entry
3292 CDS
T01001
Symbol
HSD17B1, 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 1
KO
K00044
17beta-estradiol 17-dehydrogenase [EC:
1.1.1.62
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa01100
Metabolic pathways
hsa04913
Ovarian steroidogenesis
Drug target
Linustedastat:
D13078
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
3292 (HSD17B1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
3292 (HSD17B1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.62 17beta-estradiol 17-dehydrogenase
3292 (HSD17B1)
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GFIT
Motif
Pfam:
adh_short
adh_short_C2
KR
Epimerase
GDP_Man_Dehyd
DUF1776
Plexin_cytopl
Motif
Other DBs
NCBI-GeneID:
3292
NCBI-ProteinID:
NP_000404
OMIM:
109684
HGNC:
5210
Ensembl:
ENSG00000108786
UniProt:
P14061
Structure
PDB
PDBj
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All DBs
Position
17:42552923..42555214
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AA seq
328 aa
AA seq
DB search
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
NT seq
987 nt
NT seq
+upstream
nt +downstream
nt
atggcccgcaccgtggtgctcatcaccggctgttcctcgggcatcggcctgcacttggcc
gtacgtctggcttcagatccatcccagagcttcaaagtgtatgccacgttgagggacctg
aaaacacagggccggctgtgggaggcggcccgggccctggcatgccctccgggatccctg
gagacgttgcagctggacgtaagggactcaaaatccgtggccgctgcccgggaacgcgtg
actgagggccgcgtggacgtgctggtgtgtaacgcaggcctgggcctgctggggccgctg
gaggcgctgggggaggacgccgtggcctctgtgctggacgtgaatgtagtagggactgtg
cggatgctgcaggccttcctgccagacatgaagaggcgcggttcgggacgcgtgttggtg
accgggagcgtgggaggattgatggggctgcctttcaatgacgtttattgcgccagcaag
ttcgcgctcgaaggcttatgcgagagtctggcggttctgctgctgccctttggggtccac
ttgagcctgatcgagtgcggcccagtgcacaccgccttcatggagaaggtgttgggcagc
ccagaggaggtgctggaccgcacggacatccacaccttccaccgcttctaccaatacctc
gcccacagcaagcaagtctttcgcgaggcggcgcagaaccctgaggaggtggcggaggtc
ttcctcaccgctttgcgcgccccgaagccgaccctgcgctacttcaccaccgagcgcttc
ctgcccctgctgcggatgcgcctggacgaccccagcggctccaactacgtcaccgccatg
caccgggaagtgttcggcgacgttccggcaaaggccgaggctggggccgaggctgggggc
ggggccgggcctggggcagaggacgaggccgggcgcggtgcggtgggggaccctgagctc
ggcgatcctccggccgccccgcagtaa
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