Homo sapiens (human): 3309
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Entry
3309 CDS
T01001
Symbol
HSPA5, BIP, GRP78, HEL-S-89n
Name
(RefSeq) heat shock protein family A (Hsp70) member 5
KO
K09490
endoplasmic reticulum chaperone BiP [EC:
3.6.4.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03060
Protein export
hsa04141
Protein processing in endoplasmic reticulum
hsa04612
Antigen processing and presentation
hsa04918
Thyroid hormone synthesis
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05417
Lipid and atherosclerosis
Network
nt06412
Unfolded protein response (UPR) signaling
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
Element
N01015
ATF6-mediated transcription
N01033
Mutation-caused aberrant SNCA to ATF6-mediated transcription
N01034
Mutation-caused aberrant SNCA to IRE1a-XBP1 signaling pathway
N01035
Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway
N01147
Mutation-caused aberrant SOD1 to ATF6-mediated transcription
N01148
Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway
N01149
Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway
N01198
Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03060 Protein export
3309 (HSPA5)
04141 Protein processing in endoplasmic reticulum
3309 (HSPA5)
09150 Organismal Systems
09151 Immune system
04612 Antigen processing and presentation
3309 (HSPA5)
09152 Endocrine system
04918 Thyroid hormone synthesis
3309 (HSPA5)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
3309 (HSPA5)
05014 Amyotrophic lateral sclerosis
3309 (HSPA5)
05020 Prion disease
3309 (HSPA5)
05022 Pathways of neurodegeneration - multiple diseases
3309 (HSPA5)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3309 (HSPA5)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
3309 (HSPA5)
04131 Membrane trafficking [BR:
hsa04131
]
3309 (HSPA5)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
3309 (HSPA5)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.6 Acting on acid anhydrides
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.4.10 non-chaperonin molecular chaperone ATPase
3309 (HSPA5)
Chaperones and folding catalysts [BR:
hsa03110
]
Heat shock proteins
HSP70 / DNAK
3309 (HSPA5)
Membrane trafficking [BR:
hsa04131
]
Endoplasmic reticulum (ER) - Golgi transport
Forward pathways
ER-Golgi intermediate compartment (ERGIC) proteins
3309 (HSPA5)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3309 (HSPA5)
Exosomal proteins of other body fluids (saliva and urine)
3309 (HSPA5)
Exosomal proteins of colorectal cancer cells
3309 (HSPA5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HSP70
MreB_Mbl
FtsA
Hydantoinase_A
DUF4795
FGGY_C
DDR
RNB
Motif
Other DBs
NCBI-GeneID:
3309
NCBI-ProteinID:
NP_005338
OMIM:
138120
HGNC:
5238
Ensembl:
ENSG00000044574
Pharos:
P11021
(Tchem)
UniProt:
P11021
V9HWB4
Structure
PDB
LinkDB
All DBs
Position
9:complement(125234853..125241343)
Genome browser
AA seq
654 aa
AA seq
DB search
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
NT seq
1965 nt
NT seq
+upstream
nt +downstream
nt
atgaagctctccctggtggccgcgatgctgctgctgctcagcgcggcgcgggccgaggag
gaggacaagaaggaggacgtgggcacggtggtcggcatcgacctggggaccacctactcc
tgcgtcggcgtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgc
atcacgccgtcctatgtcgccttcactcctgaaggggaacgtctgattggcgatgccgcc
aagaaccagctcacctccaaccccgagaacacggtctttgacgccaagcggctcatcggc
cgcacgtggaatgacccgtctgtgcagcaggacatcaagttcttgccgttcaaggtggtt
gaaaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacattt
gctcctgaagaaatttctgccatggttctcactaaaatgaaagaaaccgctgaggcttat
ttgggaaagaaggttacccatgcagttgttactgtaccagcctattttaatgatgcccaa
cgccaagcaaccaaagacgctggaactattgctggcctaaatgttatgaggatcatcaac
gagcctacggcagctgctattgcttatggcctggataagagggagggggagaagaacatc
ctggtgtttgacctgggtggcggaaccttcgatgtgtctcttctcaccattgacaatggt
gtcttcgaagttgtggccactaatggagatactcatctgggtggagaagactttgaccag
cgtgtcatggaacacttcatcaaactgtacaaaaagaagacgggcaaagatgtcaggaaa
gacaatagagctgtgcagaaactccggcgcgaggtagaaaaggccaaacgggccctgtct
tctcagcatcaagcaagaattgaaattgagtccttctatgaaggagaagacttttctgag
accctgactcgggccaaatttgaagagctcaacatggatctgttccggtctactatgaag
cccgtccagaaagtgttggaagattctgatttgaagaagtctgatattgatgaaattgtt
cttgttggtggctcgactcgaattccaaagattcagcaactggttaaagagttcttcaat
ggcaaggaaccatcccgtggcataaacccagatgaagctgtagcgtatggtgctgctgtc
caggctggtgtgctctctggtgatcaagatacaggtgacctggtactgcttgatgtatgt
ccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaac
acagtggtgcctaccaagaagtctcagatcttttctacagcttctgataatcaaccaact
gttacaatcaaggtctatgaaggtgaaagacccctgacaaaagacaatcatcttctgggt
acatttgatctgactggaattcctcctgctcctcgtggggtcccacagattgaagtcacc
tttgagatagatgtgaatggtattcttcgagtgacagctgaagacaagggtacagggaac
aaaaataagatcacaatcaccaatgaccagaatcgcctgacacctgaagaaatcgaaagg
atggttaatgatgctgagaagtttgctgaggaagacaaaaagctcaaggagcgcattgat
actagaaatgagttggaaagctatgcctattctctaaagaatcagattggagataaagaa
aagctgggaggtaaactttcctctgaagataaggagaccatggaaaaagctgtagaagaa
aagattgaatggctggaaagccaccaagatgctgacattgaagacttcaaagctaagaag
aaggaactggaagaaattgttcaaccaattatcagcaaactctatggaagtgcaggccct
cccccaactggtgaagaggatacagcagaaaaagatgagttgtag
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