| Entry |
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| Symbol |
HSPA5, BIP, GRP78, HEL-S-89n
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| Name |
(RefSeq) heat shock protein family A (Hsp70) member 5
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| KO |
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| Organism |
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| Pathway |
| hsa04141 | Protein processing in endoplasmic reticulum |
| hsa04612 | Antigen processing and presentation |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
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| Network |
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| Element |
| N01015 | ATF6-mediated transcription |
| N01033 | Mutation-caused aberrant SNCA to ATF6-mediated transcription |
| N01034 | Mutation-caused aberrant SNCA to IRE1a-XBP1 signaling pathway |
| N01035 | Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway |
| N01147 | Mutation-caused aberrant SOD1 to ATF6-mediated transcription |
| N01148 | Mutation-caused aberrant SOD1 to IRE1a-XBP1 signaling pathway |
| N01149 | Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway |
| N01198 | Scrapie conformation PrPSc to PERK-ATF4 signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
03060 Protein export
3309 (HSPA5)
04141 Protein processing in endoplasmic reticulum
3309 (HSPA5)
09150 Organismal Systems
09151 Immune system
04612 Antigen processing and presentation
3309 (HSPA5)
09152 Endocrine system
04918 Thyroid hormone synthesis
3309 (HSPA5)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
3309 (HSPA5)
05014 Amyotrophic lateral sclerosis
3309 (HSPA5)
05020 Prion disease
3309 (HSPA5)
05022 Pathways of neurodegeneration - multiple diseases
3309 (HSPA5)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3309 (HSPA5)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:hsa03110]
3309 (HSPA5)
04131 Membrane trafficking [BR:hsa04131]
3309 (HSPA5)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
3309 (HSPA5)
Enzymes [BR:hsa01000]
3. Hydrolases
3.6 Acting on acid anhydrides
3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement
3.6.4.10 non-chaperonin molecular chaperone ATPase
3309 (HSPA5)
Chaperones and folding catalysts [BR:hsa03110]
Heat shock proteins
HSP70 / DNAK
3309 (HSPA5)
Membrane trafficking [BR:hsa04131]
Endoplasmic reticulum (ER) - Golgi transport
Forward pathways
ER-Golgi intermediate compartment (ERGIC) proteins
3309 (HSPA5)
Autophagy
ER-phagy
ER stress-related proteins
3309 (HSPA5)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
3309 (HSPA5)
Exosomal proteins of other body fluids (saliva and urine)
3309 (HSPA5)
Exosomal proteins of colorectal cancer cells
3309 (HSPA5)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
9:complement(125234853..125241343)
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| AA seq |
654 aa
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL |
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| NT seq |
1965 nt +upstreamnt +downstreamnt
atgaagctctccctggtggccgcgatgctgctgctgctcagcgcggcgcgggccgaggag
gaggacaagaaggaggacgtgggcacggtggtcggcatcgacctggggaccacctactcc
tgcgtcggcgtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgc
atcacgccgtcctatgtcgccttcactcctgaaggggaacgtctgattggcgatgccgcc
aagaaccagctcacctccaaccccgagaacacggtctttgacgccaagcggctcatcggc
cgcacgtggaatgacccgtctgtgcagcaggacatcaagttcttgccgttcaaggtggtt
gaaaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacattt
gctcctgaagaaatttctgccatggttctcactaaaatgaaagaaaccgctgaggcttat
ttgggaaagaaggttacccatgcagttgttactgtaccagcctattttaatgatgcccaa
cgccaagcaaccaaagacgctggaactattgctggcctaaatgttatgaggatcatcaac
gagcctacggcagctgctattgcttatggcctggataagagggagggggagaagaacatc
ctggtgtttgacctgggtggcggaaccttcgatgtgtctcttctcaccattgacaatggt
gtcttcgaagttgtggccactaatggagatactcatctgggtggagaagactttgaccag
cgtgtcatggaacacttcatcaaactgtacaaaaagaagacgggcaaagatgtcaggaaa
gacaatagagctgtgcagaaactccggcgcgaggtagaaaaggccaaacgggccctgtct
tctcagcatcaagcaagaattgaaattgagtccttctatgaaggagaagacttttctgag
accctgactcgggccaaatttgaagagctcaacatggatctgttccggtctactatgaag
cccgtccagaaagtgttggaagattctgatttgaagaagtctgatattgatgaaattgtt
cttgttggtggctcgactcgaattccaaagattcagcaactggttaaagagttcttcaat
ggcaaggaaccatcccgtggcataaacccagatgaagctgtagcgtatggtgctgctgtc
caggctggtgtgctctctggtgatcaagatacaggtgacctggtactgcttgatgtatgt
ccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaac
acagtggtgcctaccaagaagtctcagatcttttctacagcttctgataatcaaccaact
gttacaatcaaggtctatgaaggtgaaagacccctgacaaaagacaatcatcttctgggt
acatttgatctgactggaattcctcctgctcctcgtggggtcccacagattgaagtcacc
tttgagatagatgtgaatggtattcttcgagtgacagctgaagacaagggtacagggaac
aaaaataagatcacaatcaccaatgaccagaatcgcctgacacctgaagaaatcgaaagg
atggttaatgatgctgagaagtttgctgaggaagacaaaaagctcaaggagcgcattgat
actagaaatgagttggaaagctatgcctattctctaaagaatcagattggagataaagaa
aagctgggaggtaaactttcctctgaagataaggagaccatggaaaaagctgtagaagaa
aagattgaatggctggaaagccaccaagatgctgacattgaagacttcaaagctaagaag
aaggaactggaagaaattgttcaaccaattatcagcaaactctatggaagtgcaggccct
cccccaactggtgaagaggatacagcagaaaaagatgagttgtag |
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