Homo sapiens (human): 3735
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Entry
3735 CDS
T01001
Symbol
KARS1, CMTRIB, DEAPLE, DFNB89, KARS, KARS2, KRS, LEPID
Name
(RefSeq) lysyl-tRNA synthetase 1
KO
K04567
lysyl-tRNA synthetase, class II [EC:
6.1.1.6
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00970
Aminoacyl-tRNA biosynthesis
Disease
H00264
Charcot-Marie-Tooth disease
H00605
Deafness, autosomal recessive
H02687
Congenital deafness and adult-onset progressive leukoencephalopathy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
00970 Aminoacyl-tRNA biosynthesis
3735 (KARS1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01007 Amino acid related enzymes [BR:
hsa01007
]
3735 (KARS1)
09182 Protein families: genetic information processing
03016 Transfer RNA biogenesis [BR:
hsa03016
]
3735 (KARS1)
Enzymes [BR:
hsa01000
]
6. Ligases
6.1 Forming carbon-oxygen bonds
6.1.1 Ligases forming aminoacyl-tRNA and related compounds
6.1.1.6 lysine---tRNA ligase
3735 (KARS1)
Amino acid related enzymes [BR:
hsa01007
]
Aminoacyl-tRNA synthetase
Class II (A)
3735 (KARS1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
Aminoacyl-tRNA synthetases (AARSs)
Multi-aminoacyl-tRNA synthetase complex (MSC)
3735 (KARS1)
Prokaryotic type
Other AARSs
3735 (KARS1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
tRNA-synt_2
tRNA_anti-codon
tRNA-synt_2d
Dec-1
Motif
Other DBs
NCBI-GeneID:
3735
NCBI-ProteinID:
NP_005539
OMIM:
601421
HGNC:
6215
Ensembl:
ENSG00000065427
UniProt:
Q15046
Structure
PDB
PDBj
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All DBs
Position
16:complement(75627724..75647665)
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AA seq
597 aa
AA seq
DB search
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
NT seq
1794 nt
NT seq
+upstream
nt +downstream
nt
atggcggccgtgcaggcggccgaggtgaaagtggatggcagcgagccgaaactgagcaag
aatgagctgaagagacgcctgaaagctgagaagaaagtagcagagaaggaggccaaacag
aaagagctcagtgagaaacagctaagccaagccactgctgctgccaccaaccacaccact
gataatggtgtgggtcctgaggaagagagcgtggacccaaatcaatactacaaaatccgc
agtcaagcaattcatcagctgaaggtcaatggggaagacccatacccacacaagttccat
gtagacatctcactcactgacttcatccaaaaatatagtcacctgcagcctggggatcac
ctgactgacatcaccttaaaggtggcaggtaggatccatgccaaaagagcttctggggga
aagctcatcttctatgatcttcgaggagagggggtgaagttgcaagtcatggccaattcc
agaaattataaatcagaagaagaatttattcatattaataacaaactgcgtcggggagac
ataattggagttcaggggaatcctggtaaaaccaagaagggtgagctgagcatcattccg
tatgagatcacactgctgtctccctgtttgcatatgttacctcatcttcactttggcctc
aaagacaaggaaacaaggtatcgccagagatacttggacttgatcctgaatgactttgtg
aggcagaaatttatcatccgctctaagatcatcacatatataagaagtttcttagatgag
ctgggattcctagagattgaaactcccatgatgaacatcatcccagggggagccgtggcc
aagcctttcatcacttatcacaacgagctggacatgaacttatatatgagaattgctcca
gaactctatcataagatgcttgtggttggtggcatcgaccgggtttatgaaattggacgc
cagttccggaatgaggggattgatttgacgcacaatcctgagttcaccacctgtgagttc
tacatggcctatgcagactatcacgatctcatggaaatcacggagaagatggtttcaggg
atggtgaagcatattacaggcagttacaaggtcacctaccacccagatggcccagagggc
caagcctacgatgttgacttcaccccacccttccggcgaatcaacatggtagaagagctt
gagaaagccctggggatgaagctgccagaaacgaacctctttgaaactgaagaaactcgc
aaaattcttgatgatatctgtgtggcaaaagctgttgaatgccctccacctcggaccaca
gccaggctccttgacaagcttgttggggagttcctggaagtgacttgcatcaatcctaca
ttcatctgtgatcacccacagataatgagccctttggctaaatggcaccgctctaaagag
ggtctgactgagcgctttgagctgtttgtcatgaagaaagagatatgcaatgcgtatact
gagctgaatgatcccatgcggcagcggcagctttttgaagaacaggccaaggccaaggct
gcaggtgatgatgaggccatgttcatagatgaaaacttctgtactgccctggaatatggg
ctgccccccacagctggctggggcatgggcattgatcgagtcgccatgtttctcacggac
tccaacaacatcaaggaagtacttctgtttcctgccatgaaacccgaagacaagaaggag
aatgtagcaaccactgatacactggaaagcacaacagttggcacttctgtctag
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