Homo sapiens (human): 3776
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Entry
3776 CDS
T01001
Symbol
KCNK2, K2p2.1, TPKC1, TREK, TREK-1, TREK1, hTREK-1c, hTREK-1e
Name
(RefSeq) potassium two pore domain channel subfamily K member 2
KO
K04913
potassium channel subfamily K member 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04024
cAMP signaling pathway
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04927
Cortisol synthesis and secretion
hsa04934
Cushing syndrome
hsa04971
Gastric acid secretion
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
3776 (KCNK2)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
3776 (KCNK2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
3776 (KCNK2)
09154 Digestive system
04971 Gastric acid secretion
3776 (KCNK2)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
3776 (KCNK2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
3776 (KCNK2)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Potassium channel, two-pore domain (K2P)
3776 (KCNK2)
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Gene cluster
GFIT
Motif
Pfam:
Ion_trans_2
Ion_trans
bZIP_Maf
Derepression
VG15
Motif
Other DBs
NCBI-GeneID:
3776
NCBI-ProteinID:
NP_001017425
OMIM:
603219
HGNC:
6277
Ensembl:
ENSG00000082482
UniProt:
O95069
Q6ZW95
Structure
PDB
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All DBs
Position
1:215005542..215237090
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AA seq
426 aa
AA seq
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MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWK
TVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQ
IVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALL
GIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVAL
PAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYF
AAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATS
IKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIA
VIENIK
NT seq
1281 nt
NT seq
+upstream
nt +downstream
nt
atgcttcccagcgcctcgcgggagagacccggctatagagcaggagtggcggcacctgac
ttgctggatcctaaatctgccgctcagaactccaaaccgaggctctcgttttccacgaaa
cccacagtgcttgcttcccgggtggagagtgacacgaccattaatgttatgaaatggaag
acggtctccacgatattcctggtggttgtcctctatctgatcatcggagccaccgtgttc
aaagcattggagcagcctcatgagatttcacagaggaccaccattgtgatccagaagcaa
acattcatatcccaacattcctgtgtcaattcgacggagctggatgaactcattcagcaa
atagtggcagcaataaatgcagggattataccgttaggaaacacctccaatcaaatcagt
cactgggatttgggaagttccttcttctttgctggcactgttattacaaccataggattt
ggaaacatctcaccacgcacagaaggcggcaaaatattctgtatcatctatgccttactg
ggaattcccctctttggttttctcttggctggagttggagatcagctaggcaccatattt
ggaaaaggaattgccaaagtggaagatacgtttattaagtggaatgttagtcagaccaag
attcgcatcatctcaacaatcatatttatactatttggctgtgtactctttgtggctctg
cctgcgatcatattcaaacacatagaaggctggagtgccctggacgccatttattttgtg
gttatcactctaacaactattggatttggtgactacgttgcaggtggatccgatattgaa
tatctggacttctataagcctgtcgtgtggttctggatccttgtagggcttgcttacttt
gctgctgtcctgagcatgattggagattggctccgagtgatatctaaaaagacaaaagaa
gaggtgggagagttcagagcacacgctgctgagtggacagccaacgtcacagccgaattc
aaagaaaccaggaggcgactgagtgtggagatttatgacaagttccagcgggccacctcc
atcaagcggaagctctcggcagaactggctggaaaccacaatcaggagctgactccttgt
aggaggaccctgtcagtgaaccacctgaccagcgagagggatgtcttgcctcccttactg
aagactgagagtatctatctgaatggtttgacgccacactgtgctggtgaagagattgct
gtgattgagaacatcaaatag
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