KEGG   Homo sapiens (human): 4035
Entry
4035              CDS       T01001                                 
Symbol
LRP1, A2MR, APOER, APR, CD91, DDH3, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5
Name
(RefSeq) LDL receptor related protein 1
  KO
K04550  low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04148  Efferocytosis
hsa04979  Cholesterol metabolism
hsa05010  Alzheimer disease
hsa05144  Malaria
Network
nt06535  Efferocytosis
  Element
N01764  Calreticulin-LRP1 mediated recognition and engulfment
Disease
H00750  Keratosis pilaris atrophicans
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    4035 (LRP1)
 09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    4035 (LRP1)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05144 Malaria
    4035 (LRP1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4035 (LRP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4035 (LRP1)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    4035 (LRP1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    4035 (LRP1)
CD molecules [BR:hsa04090]
 Proteins
  4035 (LRP1)
SSDB
Motif
Pfam: Ldl_recept_a Ldl_recept_b FXa_inhibition DUF5050 cEGF SGL EGF_CA EGF
Other DBs
NCBI-GeneID: 4035
NCBI-ProteinID: NP_002323
OMIM: 107770
HGNC: 6692
Ensembl: ENSG00000123384
UniProt: Q07954 Q59FG2
Structure
LinkDB
Position
12:57128483..57213361
AA seq 4544 aa
MLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA
PEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGC
QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYL
LQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANE
TVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDI
DDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTK
LVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFE
NYLYATNSDNANAQQKTSVIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACEN
DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG
MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDG
IHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNG
WMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFY
DRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVT
LLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGV
TCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRF
KCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD
CGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQF
KCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRW
RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC
ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAP
GEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGES
CRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDK
IYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTT
LLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLT
VDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNT
LAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT
VSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVL
DYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTN
KKQINVARLDGSFKNAVVQGLEQPHGLVVHPLRGKLYWTDGDNISMANMDGSNRTLLFSG
QKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLW
WADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQL
CLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG
TSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNIY
WTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDG
TERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMFS
VSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCA
VANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERNL
NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVE
NVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLD
ECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDK
IERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDI
PQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAV
NSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVS
NMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS
ATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNY
FACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG
DGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDD
REFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDG
ENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCH
INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH
GSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV
ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCD
KGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSR
SVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLF
EDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGG
CSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCG
DHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC
TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV
DGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ
FRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDC
ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQ
CNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTD
NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP
KLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNN
TKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESV
RIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMP
RGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDW
GNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPI
VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYH
QHKQPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPRPGTC
NLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPT
GFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQM
AADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGH
CSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQPGHIASILIPLLLLLLLVLVAGV
VFWYKRRVQGAKGFQHQRMTNGAMNVEIGNPTYKMYEGGEPDDVGGLLDADFALDPDKPT
NFTNPVYATLYMGGHGSRHSLASTDEKRELLGRGPEDEIGDPLA
NT seq 13635 nt   +upstreamnt  +downstreamnt
atgctgaccccgccgttgctcctgctgctgcccctgctctcagctctggtcgcggcggct
atcgacgcccctaagacttgcagccccaagcagtttgcctgcagagatcaaataacctgt
atctcaaagggctggcggtgcgacggtgagagggactgcccagacggatctgacgaggcc
cctgagatttgtccacagagtaaggcccagcgatgccagccaaacgagcataactgcctg
ggtactgagctgtgtgttcccatgtcccgcctctgcaatggggtccaggactgcatggac
ggctcagatgaggggccccactgccgagagctccaaggcaactgctctcgcctgggctgc
cagcaccattgtgtccccacactcgatgggcccacctgctactgcaacagcagctttcag
cttcaggcagatggcaagacctgcaaagattttgatgagtgctcagtgtacggcacctgc
agccagctatgcaccaacacagacggctccttcatatgtggctgtgttgaaggatacctc
ctgcagccggataaccgctcctgcaaggccaagaacgagccagtagaccggccccctgtg
ctgttgatagccaactcccagaacatcttggccacgtacctgagtggggcccaggtgtct
accatcacacctacgagcacgcggcagaccacagccatggacttcagctatgccaacgag
accgtatgctgggtgcatgttggggacagtgctgctcagacgcagctcaagtgtgcccgc
atgcctggcctaaagggcttcgtggatgagcacaccatcaacatctccctcagtctgcac
cacgtggaacagatggccatcgactggctgacaggcaacttctactttgtggatgacatc
gatgataggatctttgtctgcaacagaaatggggacacatgtgtcacattgctagacctg
gaactctacaaccccaagggcattgccctggaccctgccatggggaaggtgtttttcact
gactatgggcagatcccaaaggtggaacgctgtgacatggatgggcagaaccgcaccaag
ctcgtcgacagcaagattgtgtttcctcatggcatcacgctggacctggtcagccgcctt
gtctactgggcagatgcctatctggactatattgaagtggtggactatgagggcaagggc
cgccagaccatcatccagggcatcctgattgagcacctgtacggcctgactgtgtttgag
aattatctctatgccaccaactcggacaatgccaatgcccagcagaagacgagtgtgatc
cgtgtgaaccgctttaacagcaccgagtaccaggttgtcacccgggtggacaagggtggt
gccctccacatctaccaccagaggcgtcagccccgagtgaggagccatgcctgtgaaaac
gaccagtatgggaagccgggtggctgctctgacatctgcctgctggccaacagccacaag
gcgcggacctgccgctgccgttccggcttcagcctgggcagtgacgggaagtcatgcaag
aagccggagcatgagctgttcctcgtgtatggcaagggccggccaggcatcatccggggc
atggatatgggggccaaggtcccggatgagcacatgatccccattgaaaacctcatgaac
ccccgagccctggacttccacgctgagaccggcttcatctactttgccgacaccaccagc
tacctcattggccgccagaagattgatggcactgagcgggagaccatcctgaaggacggc
atccacaatgtggagggtgtggccgtggactggatgggagacaatctgtactggacggac
gatgggcccaaaaagacaatcagcgtggccaggctggagaaagctgctcagacccgcaag
actttaatcgagggcaaaatgacacaccccagggctattgtggtggatccactcaatggg
tggatgtactggacagactgggaggaggaccccaaggacagtcggcgtgggcggctggag
agggcgtggatggatggctcacaccgagacatctttgtcacctccaagacagtgctttgg
cccaatgggctaagcctggacatcccggctgggcgcctctactgggtggatgccttctac
gaccgcatcgagacgatactgctcaatggcacagaccggaagattgtgtatgaaggtcct
gagctgaaccacgcctttggcctgtgtcaccatggcaactacctcttctggactgagtat
cggagtggcagtgtctaccgcttggaacggggtgtaggaggcgcaccccccactgtgacc
cttctgcgcagtgagcggccccccatctttgagatccgaatgtatgatgcccagcagcag
caagttggcaccaacaaatgccgggtgaacaatggcggctgcagcagcctgtgcttggcc
acccctgggagccgccagtgcgcctgtgctgaggaccaggtgttggacgcagacggcgtc
acttgcttggcgaacccatcctacgtgcctccaccccagtgccagccaggcgagtttgcc
tgtgccaacagccgctgcatccaggagcgctggaagtgtgacggagacaacgattgcctg
gacaacagtgatgaggccccagccctctgccatcagcacacctgcccctcggaccgattc
aagtgcgagaacaaccggtgcatccccaaccgctggctctgcgacggggacaatgactgt
gggaacagtgaagatgagtccaatgccacttgttcagcccgcacctgcccccccaaccag
ttctcctgtgccagtggccgctgcatccccatctcctggacgtgtgatctggatgacgac
tgtggggaccgctctgatgagtctgcttcgtgtgcctatcccacctgcttccccctgact
cagtttacctgcaacaatggcagatgtatcaacatcaactggagatgcgacaatgacaat
gactgtggggacaacagtgacgaagccggctgcagccactcctgttctagcacccagttc
aagtgcaacagcgggcgttgcatccccgagcactggacctgcgatggggacaatgactgc
ggagactacagtgatgagacacacgccaactgcaccaaccaggccacgaggccccctggt
ggctgccacactgatgagttccagtgccggctggatggactatgcatccccctgcggtgg
cgctgcgatggggacactgactgcatggactccagcgatgagaagagctgtgagggagtg
acccacgtctgcgatcccagtgtcaagtttggctgcaaggactcagctcggtgcatcagc
aaagcgtgggtgtgtgatggcgacaatgactgtgaggataactcggacgaggagaactgc
gagtccctggcctgcaggccaccctcgcacccttgtgccaacaacacctcagtctgcctg
ccccctgacaagctgtgtgatggcaacgacgactgtggcgacggctcagatgagggcgag
ctctgcgaccagtgctctctgaataacggtggctgcagccacaactgctcagtggcacct
ggcgaaggcattgtgtgttcctgccctctgggcatggagctggggcccgacaaccacacc
tgccagatccagagctactgtgccaagcatctcaaatgcagccaaaagtgcgaccagaac
aagttcagcgtgaagtgctcctgctacgagggctgggtcctggaacctgacggcgagagc
tgccgcagcctggaccccttcaagccgttcatcattttctccaaccgccatgaaatccgg
cgcatcgatcttcacaaaggagactacagcgtcctggtgcccggcctgcgcaacaccatc
gccctggacttccacctcagccagagcgccctctactggaccgacgtggtggaggacaag
atctaccgcgggaagctgctggacaacggagccctgactagtttcgaggtggtgattcag
tatggcctggccacacccgagggcctggctgtagactggattgcaggcaacatctactgg
gtggagagtaacctggatcagatcgaggtggccaagctggatgggaccctccggaccacc
ctgctggccggtgacattgagcacccaagggcaatcgcactggatccccgggatgggatc
ctgttttggacagactgggatgccagcctgccccgcattgaggcagcctccatgagtggg
gctgggcgccgcaccgtgcaccgggagaccggctctgggggctggcccaacgggctcacc
gtggactacctggagaagcgcatcctttggattgacgccaggtcagatgccatttactca
gcccgttacgacggctctggccacatggaggtgcttcggggacacgagttcctgtcgcac
ccgtttgcagtgacgctgtacgggggggaggtctactggactgactggcgaacaaacaca
ctggctaaggccaacaagtggaccggccacaatgtcaccgtggtacagaggaccaacacc
cagccctttgacctgcaggtgtaccacccctcccgccagcccatggctcccaatccctgt
gaggccaatgggggccagggcccctgctcccacctgtgtctcatcaactacaaccggacc
gtgtcctgcgcctgcccccacctcatgaagctccacaaggacaacaccacctgctatgag
tttaagaagttcctgctgtacgcacgtcagatggagatccgaggtgtggacctggatgct
ccctactacaactacatcatctccttcacggtgcccgacatcgacaacgtcacagtgcta
gactacgatgcccgcgagcagcgtgtgtactggtctgacgtgcggacacaggccatcaag
cgggccttcatcaacggcacaggcgtggagacagtcgtctctgcagacttgccaaatgcc
cacgggctggctgtggactgggtctcccgaaacctgttctggacaagctatgacaccaat
aagaagcagatcaatgtggcccggctggatggctccttcaagaacgcagtggtgcagggc
ctggagcagccccatggccttgtcgtccaccctctgcgtgggaagctctactggaccgat
ggtgacaacatcagcatggccaacatggatggcagcaatcgcaccctgctcttcagtggc
cagaagggccccgtgggcctggctattgacttccctgaaagcaaactctactggatcagc
tccgggaaccataccatcaaccgctgcaacctggatgggagtgggctggaggtcatcgat
gccatgcggagccagctgggcaaggccaccgccctggccatcatgggggacaagctgtgg
tgggctgatcaggtgtcggaaaagatgggcacatgcagcaaggctgacggctcgggctcc
gtggtccttcggaacagcaccaccctggtgatgcacatgaaggtctatgacgagagcatc
cagctggaccataagggcaccaacccctgcagtgtcaacaacggtgactgctcccagctc
tgcctgcccacgtcagagacgacccgctcctgcatgtgcacagccggctatagcctccgg
agtggccagcaggcctgcgagggcgtaggttcctttctcctgtactctgtgcatgaggga
atcaggggaattcccctggatcccaatgacaagtcagatgccctggtcccagtgtccggg
acctcgctggctgtcggcatcgacttccacgctgaaaatgacaccatctactgggtggac
atgggcctgagcacgatcagccgggccaagcgggaccagacgtggcgtgaagacgtggtg
accaatggcattggccgtgtggagggcattgcagtggactggatcgcaggcaacatctac
tggacagaccagggctttgatgtcatcgaggtcgcccggctcaatggctccttccgctac
gtggtgatctcccagggtctagacaagccccgggccatcaccgtccacccggagaaaggg
tacttgttctggactgagtggggtcagtatccgcgtattgagcggtctcggctagatggc
acggagcgtgtggtgctggtcaacgtcagcatcagctggcccaacggcatctcagtggac
taccaggatgggaagctgtactggtgcgatgcacggacagacaagattgaacggatcgac
ctggagacaggtgagaaccgcgaggtggttctgtccagcaacaacatggacatgttttca
gtgtctgtgtttgaggatttcatctactggagtgacaggactcatgccaacggctctatc
aagcgcgggagcaaagacaatgccacagactccgtgcccctgcgaaccggcatcggcgtc
cagcttaaagacatcaaagtcttcaaccgggaccggcagaaaggcaccaacgtgtgcgcg
gtggccaatggcgggtgccagcagctgtgcctgtaccggggccgtgggcagcgggcctgc
gcctgtgcccacgggatgctggctgaagacggagcatcgtgccgcgagtatgccggctac
ctgctctactcagagcgcaccattctcaagagtatccacctgtcggatgagcgcaacctc
aatgcgcccgtgcagcccttcgaggaccctgagcacatgaagaacgtcatcgccctggcc
tttgactaccgggcaggcacctctccgggcacccccaatcgcatcttcttcagcgacatc
cactttgggaacatccaacagatcaacgacgatggctccaggaggatcaccattgtggaa
aacgtgggctccgtggaaggcctggcctatcaccgtggctgggacactctctattggaca
agctacacgacatccaccatcacgcgccacacagtggaccagacccgcccaggggccttc
gagcgtgagaccgtcatcactatgtctggagatgaccacccacgggccttcgttttggac
gagtgccagaacctcatgttctggaccaactggaatgagcagcatcccagcatcatgcgg
gcggcgctctcgggagccaatgtcctgacccttatcgagaaggacatccgtacccccaat
ggcctggccatcgaccaccgtgccgagaagctctacttctctgacgccaccctggacaag
atcgagcggtgcgagtatgacggctcccaccgctatgtgatcctaaagtcagagcctgtc
caccccttcgggctggccgtgtatggggagcacattttctggactgactgggtgcggcgg
gcagtgcagcgggccaacaagcacgtgggcagcaacatgaagctgctgcgcgtggacatc
ccccagcagcccatgggcatcatcgccgtggccaacgacaccaacagctgtgaactctct
ccatgccgaatcaacaacggtggctgccaggacctgtgtctgctcactcaccagggccat
gtcaactgctcatgccgagggggccgaatcctccaggatgacctcacctgccgagcggtg
aattcctcttgccgagcacaagatgagtttgagtgtgccaatggcgagtgcatcaacttc
agcctgacctgcgacggcgtcccccactgcaaggacaagtccgatgagaagccatcctac
tgcaactcccgccgctgcaagaagactttccggcagtgcagcaatgggcgctgtgtgtcc
aacatgctgtggtgcaacggggccgacgactgtggggatggctctgacgagatcccttgc
aacaagacagcctgtggtgtgggcgagttccgctgccgggacgggacctgcatcgggaac
tccagccgctgcaaccagtttgtggattgtgaggacgcctcagatgagatgaactgcagt
gccaccgactgcagcagctacttccgcctgggcgtgaagggcgtgctcttccagccctgc
gagcggacctcactctgctacgcacccagctgggtgtgtgatggcgccaatgactgtggg
gactacagtgatgagcgcgactgcccaggtgtgaaacgccccagatgccctctgaattac
ttcgcctgccctagtgggcgctgcatccccatgagctggacgtgtgacaaagaggatgac
tgtgaacatggcgaggacgagacccactgcaacaagttctgctcagaggcccagtttgag
tgccagaaccatcgctgcatctccaagcagtggctgtgtgacggcagcgatgactgtggg
gatggctcagacgaggctgctcactgtgaaggcaagacgtgcggcccctcctccttctcc
tgccctggcacccacgtgtgcgtccccgagcgctggctctgtgacggtgacaaagactgt
gctgatggtgcagacgagagcatcgcagctggttgcttgtacaacagcacttgtgacgac
cgtgagttcatgtgccagaaccgccagtgcatccccaagcacttcgtgtgtgaccacgac
cgtgactgtgcagatggctctgatgagtcccccgagtgtgagtacccgacctgcggcccc
agtgagttccgctgtgccaatgggcgctgtctgagctcccgccagtgggagtgtgatggc
gagaatgactgccacgaccagagtgacgaggctcccaagaacccacactgcaccagccaa
gagcacaagtgcaatgcctcgtcacagttcctgtgcagcagtgggcgctgtgtggctgag
gcactgctctgcaacggccaggatgactgtggcgacagctcggacgagcgtggctgccac
atcaatgagtgtctcagccgcaagctcagtggctgcagccaggactgtgaggacctcaag
atcggcttcaagtgccgctgtcgccctggcttccggctgaaggacgacggccggacgtgt
gctgatgtggacgagtgcagcaccaccttcccctgcagccagcgctgcatcaacactcat
ggcagctataagtgtctgtgtgtggagggctatgcaccccgcggcggcgacccccacagc
tgcaaggctgtgactgacgaggaaccgtttctgatcttcgccaaccggtactacctgcgc
aagctcaacctggacgggtccaactacacgttacttaagcagggcctgaacaacgccgtt
gccttggattttgactaccgagagcagatgatctactggacagatgtgaccacccagggc
agcatgatccgaaggatgcaccttaacgggagcaatgtgcaggtcctacaccgtacaggc
ctcagcaaccccgatgggctggctgtggactgggtgggtggcaacctgtactggtgcgac
aaaggccgggacaccatcgaggtgtccaagctcaatggggcctatcggacggtgctggtc
agctctggcctccgtgagcccagggctctggtggtggatgtgcagaatgggtacctgtac
tggacagactggggtgaccattcactgatcggccgcatcggcatggatgggtccagccgc
agcgtcatcgtggacaccaagatcacatggcccaatggcctgacgctggactatgtcact
gagcgcatctactgggccgacgcccgcgaggactacattgaatttgccagcctggatggc
tccaatcgccacgttgtgctgagccaggacatcccgcacatctttgcactgaccctgttt
gaggactacgtctactggaccgactgggaaacaaagtccattaaccgagcccacaagacc
acgggcaccaacaaaacgctcctcatcagcacgctgcaccggcccatggacctgcatgtc
ttccatgccctgcgccagccagacgtgcccaatcacccctgcaaggtcaacaatggtggc
tgcagcaacctgtgcctgctgtcccccgggggagggcacaaatgtgcctgccccaccaac
ttctacctgggcagcgatgggcgcacctgtgtgtccaactgcacggctagccagtttgta
tgcaagaacgacaagtgcatccccttctggtggaagtgtgacaccgaggacgactgcggg
gaccactcagacgagcccccggactgccctgagttcaagtgccggcccggacagttccag
tgctccacaggtatctgcacaaaccctgccttcatctgcgatggcgacaatgactgccag
gacaacagtgacgaggccaactgtgacatccacgtctgcttgcccagtcagttcaaatgc
accaacaccaaccgctgtattcccggcatcttccgctgcaatgggcaggacaactgcgga
gatggggaggatgagagggactgccccgaggtgacctgcgcccccaaccagttccagtgc
tccattaccaaacggtgcatcccccgggtctgggtctgcgaccgggacaatgactgtgtg
gatggcagtgatgagcccgccaactgcacccagatgacctgtggtgtggacgagttccgc
tgcaaggattcgggccgctgcatcccagcgcgttggaagtgtgacggagaggatgactgt
ggggatggctcggatgagcccaaggaagagtgtgatgaacgcacctgtgagccataccag
ttccgctgcaagaacaaccgctgcgtgcccggccgctggcagtgcgactacgacaacgat
tgcggtgacaactccgatgaagagagctgcacccctcggccctgctccgagagtgagttc
tcctgtgccaacggccgctgcatcgcggggcgctggaaatgcgatggagaccacgactgc
gcggacggctcggacgagaaagactgcaccccccgctgtgacatggaccagttccagtgc
aagagcggccactgcatccccctgcgctggcgctgtgacgcagacgccgactgcatggac
ggcagcgacgaggaggcctgcggcactggcgtgcggacctgccccctggacgagttccag
tgcaacaacaccttgtgcaagccgctggcctggaagtgcgatggcgaggatgactgtggg
gacaactcagatgagaaccccgaggagtgtgcccggttcgtgtgccctcccaaccggccc
ttccgttgcaagaatgaccgcgtctgtctgtggatcgggcgccaatgcgatggcacggac
aactgtggggatgggactgatgaagaggactgtgagccccccacagcccacaccacccac
tgcaaagacaagaaggagtttctgtgccggaaccagcgctgcctctcctcctccctgcgc
tgcaacatgttcgatgactgcggggacggctctgacgaggaggactgcagcatcgacccc
aagctgaccagctgcgccaccaatgccagcatctgtggggacgaggcacgctgcgtgcgc
accgagaaagcggcctactgtgcctgccgctcgggcttccacaccgtgcccggccagccc
ggatgccaagacatcaacgagtgcctgcgcttcggcacctgctcccagctctgcaacaac
accaagggcggccacctctgcagctgcgctcggaacttcatgaagacgcacaacacctgc
aaggccgaaggctctgagtaccaggtcctgtacatcgctgatgacaatgagatccgcagc
ctgttccccggccacccccattcggcttacgagcaggcattccagggtgacgagagtgtc
cgcattgatgctatggatgtccatgtcaaggctggccgtgtctattggaccaactggcac
acgggcaccatctcctaccgcagcctgccacctgctgcgcctcctaccacttccaaccgc
caccggcgacagattgaccggggtgtcacccacctcaacatttcagggctgaagatgccc
agaggcatcgccatcgactgggtggccggaaacgtgtactggaccgactcgggccgagat
gtgattgaggtggcgcagatgaagggcgagaaccgcaagacgctcatctcgggcatgatt
gacgagccccacgccattgtggtggacccactgagggggaccatgtactggtcagactgg
ggcaaccaccccaagattgagacggcagcgatggatgggacgcttcgggagacactggtg
caggacaacattcagtggcccacaggcctggccgtggattatcacaatgagcggctgtac
tgggcagacgccaagctttcagtcatcggcagcatccggctcaatggcacggaccccatt
gtggctgctgacagcaaacgaggcctaagtcaccccttcagcatcgacgtctttgaggat
tacatctatggtgtcacctacatcaataatcgtgtcttcaagatccataagtttggccac
agccccttggtcaacctgacagggggcctgagccacgcctctgacgtggtcctttaccat
cagcacaagcagcccgaagtgaccaacccatgtgaccgcaagaaatgcgagtggctctgc
ctgctgagccccagtgggcctgtctgcacctgtcccaatgggaagcggctggacaacggc
acatgcgtgcctgtgccctctccaacgccccccccagatgctccccggcctggaacctgt
aacctgcagtgcttcaacggtggcagctgtttcctcaatgcacggaggcagcccaagtgc
cgctgccaaccccgctacacgggtgacaagtgtgaactggaccagtgctgggagcactgt
cgcaatgggggcacctgtgctgcctccccctctggcatgcccacgtgccggtgccccacg
ggcttcacgggccccaaatgcacccagcaggtgtgtgcgggctactgtgccaacaacagc
acctgcactgtcaaccagggcaaccagccccagtgccgatgcctacccggcttcctgggc
gaccgctgccagtaccggcagtgctctggctactgtgagaactttggcacatgccagatg
gctgctgatggctcccgacaatgccgctgcactgcctactttgagggatcgaggtgtgag
gtgaacaagtgcagccgctgtctcgaaggggcctgtgtggtcaacaagcagagtggggat
gtcacctgcaactgcacggatggccgggtggcccccagctgtctgacctgcgtcggccac
tgcagcaatggcggctcctgtaccatgaacagcaaaatgatgcctgagtgccagtgccca
ccccacatgacagggccccggtgtgaggagcacgtcttcagccagcagcagccaggacat
atagcctccatcctaatccctctgctgttgctgctgctgctggttctggtggccggagtg
gtattctggtataagcggcgagtccaaggggctaagggcttccagcaccaacggatgacc
aacggggccatgaacgtggagattggaaaccccacctacaagatgtacgaaggcggagag
cctgatgatgtgggaggcctactggacgctgactttgccctggaccctgacaagcccacc
aacttcaccaaccccgtgtatgccacactctacatggggggccatggcagtcgccactcc
ctggccagcacggacgagaagcgagaactcctgggccggggccctgaggacgagataggg
gaccccttggcatag

KEGG   Homo sapiens (human): 4036
Entry
4036              CDS       T01001                                 
Symbol
LRP2, DBS, GP330, LRP-2
Name
(RefSeq) LDL receptor related protein 2
  KO
K06233  low density lipoprotein-related protein 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04340  Hedgehog signaling pathway
hsa04918  Thyroid hormone synthesis
hsa04979  Cholesterol metabolism
Network
nt06501  HH signaling
  Element
N01538  Hedgehog signaling pathway, PTCH coreceptor
Disease
H00886  Donnai-Barrow syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    4036 (LRP2)
 09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    4036 (LRP2)
  09154 Digestive system
   04979 Cholesterol metabolism
    4036 (LRP2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4036 (LRP2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    4036 (LRP2)
SSDB
Motif
Pfam: Ldl_recept_a Ldl_recept_b FXa_inhibition cEGF DUF5050 EGF_CA
Other DBs
NCBI-GeneID: 4036
NCBI-ProteinID: NP_004516
OMIM: 600073
HGNC: 6694
Ensembl: ENSG00000081479
UniProt: P98164 Q7Z5C0 Q7Z5C1
Structure
LinkDB
Position
2:complement(169127109..169362534)
AA seq 4655 aa
MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI
GCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQC
IPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT
EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWV
CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN
TSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQ
KCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVES
QNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNK
IYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLER
AFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSL
IPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYAT
NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIR
GIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA
NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYL
FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD
GLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHL
KSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNE
PPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECI
PAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDE
KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC
IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS
DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCL
GHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFL
LANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLV
ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDR
RVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALD
PRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD
YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVM
YNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC
LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE
IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTL
IANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEH
LECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQY
EVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGL
FSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHV
DVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLY
FTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFL
DCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTP
YGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAE
VNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS
LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTV
IASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGY
LYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTL
TGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGI
NTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERC
GASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRC
DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDR
TCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQH
WYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKR
HQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTC
GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDG
SDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSIS
GCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP
GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKR
LYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLN
GGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVII
STKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTI
YWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLC
LIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSD
GSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQ
CANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDC
GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCH
PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDH
YNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGA
YCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSH
EVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL
GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQH
CRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQD
EEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKY
VMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMF
WTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYD
GTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRI
FHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPP
CRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGAL
AIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAI
DRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSE
IVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLP
AKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV
NT seq 13968 nt   +upstreamnt  +downstreamnt
atggatcgcgggccggcagcagtggcgtgcacgctgctcctggctctcgtcgcctgccta
gcgccggccagtggccaagaatgtgacagtgcgcattttcgctgtggaagtgggcattgc
atccctgcagactggaggtgtgatgggaccaaagactgttcagatgacgcggatgaaatt
ggctgcgctgttgtgacctgccagcagggctatttcaagtgccagagtgagggacaatgc
atccccaactcctgggtgtgtgaccaagatcaagactgtgatgatggctcagatgaacgt
caagattgctcacaaagtacatgctcaagtcatcagataacatgctccaatggtcagtgt
atcccaagtgaatacaggtgcgaccacgtcagagactgccccgatggagctgatgagaat
gactgccagtacccaacatgtgagcagcttacttgtgacaatggggcctgctataacacc
agtcagaagtgtgattggaaagttgattgcagggactcctcagatgaaatcaactgcact
gagatatgcttgcacaatgagttttcatgtggcaatggagagtgtatccctcgtgcttat
gtctgtgaccatgacaatgattgccaagacggcagtgacgaacatgcttgcaactatccg
acctgcggtggttaccagttcacttgccccagtggccgatgcatttatcaaaactgggtt
tgtgatggagaagatgactgtaaagataatggagatgaagatggatgtgaaagcggtcct
catgatgttcataaatgttccccaagagaatggtcttgcccagagtcgggacgatgcatc
tccatttataaagtttgtgatgggattttagattgcccaggaagagaagatgaaaacaac
actagtaccggaaaatactgtagtatgactctgtgctctgccttgaactgccagtaccag
tgccatgagacgccgtatggaggagcgtgtttttgtcccccaggttatatcatcaaccac
aatgacagccgtacctgtgttgagtttgatgattgccagatatggggaatttgtgaccag
aagtgtgaaagccgacctggccgtcacctgtgccactgtgaagaagggtatatcttggag
cgtggacagtattgcaaagctaatgattcctttggcgaggcctccattatcttctccaat
ggtcgggatttgttaattggtgatattcatggaaggagcttccggatcctagtggagtct
cagaatcgtggagtggccgtgggtgtggctttccactatcacctgcaaagagttttttgg
acagacaccgtgcaaaataaggttttttcagttgacattaatggtttaaatatccaagag
gttctcaatgtttctgttgaaaccccagagaacctggctgtggactgggttaataataaa
atctatctagtggaaaccaaggtcaaccgcatagatatggtaaatttggatggaagctat
cgggttacccttataactgaaaacttggggcatcctagaggaattgccgtggacccaact
gttggttatttatttttctcagattgggagagcctttctggggaacctaagctggaaagg
gcattcatggatggcagcaaccgtaaagacttggtgaaaacaaagctgggatggcctgct
ggggtaactctggatatgatatcgaagcgtgtttactgggttgactctcggtttgattac
attgaaactgtaacttatgatggaattcaaaggaagactgtagttcatggaggctccctc
attcctcatccctttggagtaagcttatttgaaggtcaggtgttctttacagattggaca
aagatggccgtgctgaaggcaaacaagttcacagagaccaacccacaagtgtactaccag
gcttccctgaggccctatggagtgactgtttaccattccctcagacagccctatgctacc
aatccgtgtaaagataacaatgggggctgtgagcaggtctgtgtcctcagccacagaaca
gataatgatggtttgggtttccgttgcaagtgcacattcggcttccaactggatacagat
gagcgccactgcattgctgttcagaatttcctcattttttcatcccaagttgctattcgt
gggatcccgttcaccttgtctacccaggaagatgtcatggttccagtttcggggaatcct
tctttctttgtcgggattgattttgacgcccaggacagcactatctttttttcagatatg
tcaaaacacatgatttttaagcaaaagattgatggcacaggaagagaaattctcgcagct
aacagggtggaaaatgttgaaagtttggcttttgattggatttcaaagaatctctattgg
acagactctcattacaagagtatcagtgtcatgaggctagctgataaaacgagacgcaca
gtagttcagtatttaaataacccacggtcggtggtagttcatccttttgccgggtatcta
ttcttcactgattggttccgtcctgctaaaattatgagagcatggagtgacggatctcac
ctcttgcctgtaataaacactactcttggatggcccaatggcttggccatcgattgggct
gcttcacgattgtactgggtagatgcctattttgataaaattgagcacagcacctttgat
ggtttagacagaagaagactgggccatatagagcagatgacacatccgtttggacttgcc
atctttggagagcatttattttttactgactggagactgggtgccattattcgagtcagg
aaagcagatggtggagaaatgacagttatccgaagtggcattgcttacatactgcatttg
aaatcgtatgatgtcaacatccagactggttctaacgcctgtaatcaacccacgcatcct
aacggtgactgcagccacttctgcttcccggtgccaaatttccagcgagtgtgtgggtgc
ccttatggaatgaggctggcttccaatcacttgacatgcgagggggacccaaccaatgaa
ccacccacagagcagtgtggcttattttccttcccctgtaaaaatggcagatgtgtgccc
aattactatctctgtgatggagtcgatgattgtcatgataacagtgatgagcaactatgt
ggcacacttaataatacctgttcatcttcggcgttcacctgtggccatggggagtgcatt
cctgcacactggcgctgtgacaaacgcaacgactgtgtggatggcagtgatgagcacaac
tgccccacccacgcacctgcttcctgccttgacacccaatacacctgtgataatcaccag
tgtatctcaaagaactgggtctgtgacacagacaatgattgtggggatggatctgatgaa
aagaactgcaattcgacagagacatgccaacctagtcagtttaattgccccaatcatcga
tgtattgacctatcgtttgtctgtgatggtgacaaggattgtgttgatggatctgatgag
gttggttgtgtattaaactgtactgcttctcaattcaagtgtgccagtggggataaatgt
attggcgtcacaaatcgttgtgatggtgtttttgattgcagtgacaactcggatgaagca
ggctgtccaaccaggcctcctggtatgtgccactcagatgaatttcagtgccaagaagat
ggtatctgcatcccgaacttctgggaatgtgatgggcatccagactgcctctatggatct
gatgagcacaatgcctgtgtccccaagacttgcccttcatcatatttccactgtgacaac
ggaaactgcatccacagggcatggctctgtgatcgggacaatgactgcggggatatgagt
gatgagaaggactgccctactcagccctttcgctgtcctagttggcaatggcagtgtctt
ggccataacatctgtgtgaatctgagtgtagtgtgtgatggcatctttgactgccccaat
gggacagatgagtccccactttgcaatgggaacagctgctcagatttcaatggtggttgt
actcacgagtgtgttcaagagccctttggggctaaatgcctatgtccattgggattctta
cttgccaatgattctaagacctgtgaagacatagatgaatgtgatattctaggctcttgt
agccagcactgttacaatatgagaggttctttccggtgctcgtgtgatacaggctacatg
ttagaaagtgatgggaggacttgcaaagttacagcatctgagagtctgctgttacttgtg
gcaagtcagaacaaaattattgccgacagtgtcacctcccaggtccacaatatctattca
ttggtcgagaatggttcttacattgtagctgttgattttgattcaattagtggtcgtatc
ttttggtctgatgcaactcagggtaaaacctggagtgcgtttcaaaatggaacggacaga
agagtggtatttgacagtagcatcatcttgactgaaactattgcaatagattgggtaggt
cgtaatctttactggacagactatgctctggaaacaattgaagtctccaaaattgatggg
agccacaggactgtgctgattagtaaaaacctaacaaatccaagaggactagcattagat
cccagaatgaatgagcatctactgttctggtctgactggggccaccaccctcgcatcgag
cgagccagcatggacggcagcatgcgcactgtcattgtccaggacaagatcttctggccc
tgcggcttaactattgactaccccaacagactgctctacttcatggactcctatcttgat
tacatggacttttgtgattataatggacaccatcggagacaggtgatagccagtgatttg
attatacggcacccctatgccctaactctctttgaagactctgtgtactggactgaccgt
gctactcgtcgggttatgcgagccaacaagtggcatggagggaaccagtcagttgtaatg
tataatattcaatggccccttgggattgttgcggttcatccttcgaaacaaccaaattcc
gtgaatccatgtgccttttcccgctgcagccatctctgcctgctttcctcacaggggcct
catttttactcctgtgtttgtccttcaggatggagtctgtctcctgatctcctgaattgc
ttgagagatgatcaacctttcttaataactgtaaggcaacatataatttttggaatctcc
cttaatcctgaggtgaagagcaatgatgctatggtccccatagcagggatacagaatggt
ttagatgttgaatttgatgatgctgagcaatacatctattgggttgaaaatccaggtgaa
attcacagagtgaagacagatggcaccaacaggacagtatttgcttctatatctatggtg
gggccttctatgaacctggccttagattggatttcaagaaacctttattctaccaatcct
agaactcagtcaatcgaggttttgacactccacggagatatcagatacagaaaaacattg
attgccaatgatgggacagctcttggagttggctttccaattggcataactgttgatcct
gctcgtgggaagctgtactggtcagaccaaggaactgacagtggggttcctgccaagatc
gccagtgctaacatggatggcacatctgtgaaaactctctttactgggaacctcgaacac
ctggagtgtgtcactcttgacatcgaagagcagaaactctactgggcagtcactggaaga
ggagtgattgaaagaggaaacgtggatggaacagatcgaatgatcctggtacaccagctt
tcccacccctggggaattgcagtccatgattctttcctttattatactgatgaacagtat
gaggtcattgaaagagttgataaggccactggggccaacaaaatagtcttgagagataat
gttccaaatctgaggggtcttcaagtttatcacagacgcaatgccgccgaatcctcaaat
ggctgtagcaacaacatgaatgcctgtcagcagatttgcctgcctgtaccaggaggattg
ttttcctgcgcctgtgccactggatttaaactcaatcctgataatcggtcctgctctcca
tataactctttcattgttgtttcaatgctgtctgcaatcagaggctttagcttggaattg
tcagatcattcagaaaccatggtgccggtggcaggccaaggacgaaacgcactgcatgtg
gatgtggatgtgtcctctggctttatttattggtgtgattttagcagctcagtggcatct
gataatgcgatccgtagaattaaaccagatggatcttctctgatgaacattgtgacacat
ggaataggagaaaatggagtccggggtattgcagtggattgggtagcaggaaatctttat
ttcaccaatgcctttgtttctgaaacactgatagaagttctgcggatcaatactacttac
cgccgtgttcttcttaaagtcacagtggacatgcctaggcatattgttgtagatcccaag
aacagatacctcttctgggctgactatgggcagagaccaaagattgagcgttctttcctt
gactgtaccaatcgaacagtgcttgtgtcagagggcattgtcacaccacggggcttggca
gtggaccgaagtgatggctacgtttattgggttgatgattctttagatataattgcaagg
attcgtatcaatggagagaactctgaagtgattcgttatggcagtcgttacccaactcct
tatggcatcactgtttttgaaaattctatcatatgggtagataggaatttgaaaaagatc
ttccaagccagcaaggaaccagagaacacagagccacccacagtgataagagacaatatc
aactggctaagagatgtgaccatctttgacaagcaagtccagccccggtcaccagcagag
gtcaacaacaacccttgcttggaaaacaatggtgggtgctctcatctctgctttgctctg
cctggattgcacaccccaaaatgtgactgtgcctttgggaccctgcaaagtgatggcaag
aattgtgccatttcaacagaaaatttcctcatctttgccttgtctaattccttgagaagc
ttacacttggaccctgaaaaccatagcccacctttccaaacaataaatgtggaaagaact
gtcatgtctctagactatgacagtgtaagtgatagaatctacttcacacaaaatttagcc
tctggagttggacagatttcctatgccaccctgtcttcagggatccatactccaactgtc
attgcttcaggtatagggactgctgatggcattgcctttgactggattactagaagaatt
tattacagtgactacctcaaccagatgattaattccatggctgaagatgggtctaaccgc
actgtgatagcccgcgttccaaaaccaagagcaattgtgttagatccctgccaagggtac
ctgtactgggctgactgggatacacatgccaaaatcgagagagccacattgggaggaaac
ttccgcgtacccattgtgaacagcagtctggtcatgcccagtgggctgactctggactat
gaagaggaccttctctactgggtggatgctagtctgcagaggattgaacgcagcactctg
acgggcgtggatcgtgaagtcattgtcaatgcagccgttcatgcttttggcttgactctc
tatggccagtatatttactggactgacttgtacacacaaagaatttaccgagctaacaaa
tatgacgggtcaggtcagattgcaatgaccacaaatttgctctcccagcccaggggaatc
aacactgttgtgaagaaccagaaacaacagtgtaacaatccttgtgaacagtttaatggg
ggctgcagccatatctgtgcaccaggtccaaatggtgccgagtgccagtgtccacatgag
ggcaactggtatttggccaacaacaggaagcactgcattgtggacaatggtgaacgatgt
ggtgcatcttccttcacctgctccaatgggcgctgcatctcggaagagtggaagtgtgat
aatgacaacgactgtggggatggcagtgatgagatggaaagtgtctgtgcacttcacacc
tgctcaccgacagccttcacctgtgccaatgggcgatgtgtccaatactcttaccgctgt
gattactacaatgactgtggtgatggcagtgatgaggcagggtgcctgttcagggactgc
aatgccaccacggagtttatgtgcaataacagaaggtgcatacctcgtgagtttatctgc
aatggtgtagacaactgccatgataataacacttcagatgagaaaaattgccctgatcgc
acttgccagtctggatacacaaaatgtcataattcaaatatttgtattcctcgcgtttat
ttgtgtgacggagacaatgactgtggagataacagtgatgaaaaccctacttattgcacc
actcacacgtgcagcagcagtgagttccaatgcgcatctgggcgctgtattcctcaacat
tggtattgtgatcaagaaacagattgttttgatgcctctgatgaacctgcctcttgtggt
cactctgagcgaacatgcctagctgatgagttcaagtgtgatggtgggaggtgcatccca
agcgaatggatctgtgacggtgataatgactgtggggatatgagtgacgaggataaaagg
caccagtgtcagaatcaaaactgctcggattccgagtttctctgtgtaaatgacagacct
ccggacaggaggtgcattccccagtcttgggtctgtgatggcgatgtggattgtactgac
ggctacgatgagaatcagaattgcaccaggagaacttgctctgaaaatgaattcacctgt
ggttacggactgtgtatcccaaagatattcaggtgtgaccggcacaatgactgtggtgac
tatagcgacgagaggggctgcttataccagacttgccaacagaatcagtttacctgtcag
aacgggcgctgcattagtaaaaccttcgtctgtgatgaggataatgactgtggagacgga
tctgatgagctgatgcacctgtgccacaccccagaacccacgtgtccacctcacgagttc
aagtgtgacaatgggcgctgcatcgagatgatgaaactctgcaaccacctagatgactgt
ttggacaacagcgatgagaaaggctgtggcattaatgaatgccatgacccttcaatcagt
ggctgcgatcacaactgcacagacaccttaaccagtttctattgttcctgtcgtcctggt
tacaagctcatgtctgacaagcggacttgtgttgatattgatgaatgcacagagatgcct
tttgtctgtagccagaagtgtgagaatgtaataggctcctacatctgtaagtgtgcccca
ggctacctccgagaaccagatggaaagacctgccggcaaaacagtaacatcgaaccctat
ctcatttttagcaaccgttactatttgagaaatttaactatagatggctatttttactcc
ctcatcttggaaggactggacaatgttgtggcattagattttgaccgagtagagaagaga
ttgtattggattgatacacagaggcaagtcattgagagaatgtttctgaataagacaaac
aaggagacaatcataaaccacagactaccagctgcagaaagtctggctgtagactgggtt
tccagaaagctctactggttggatgcccgcctggatggcctctttgtctctgacctcaat
ggtggacaccgccgcatgctggcccagcactgtgtggatgccaacaacaccttctgcttt
gataatcccagaggacttgcccttcaccctcaatatgggtacctctactgggcagactgg
ggtcaccgcgcatacattgggagagtaggcatggatggaaccaacaagtctgtgataatc
tccaccaagttagagtggcctaatggcatcaccattgattacaccaatgatctactctac
tgggcagatgcccacctgggttacatagagtactctgatttggagggccaccatcgacac
acggtgtatgatggggcactgcctcaccctttcgctattaccatttttgaagacactatt
tattggacagattggaatacaaggacagtggaaaagggaaacaaatatgatggatcaaat
agacagacactggtgaacacaacacacagaccatttgacatccatgtgtaccatccatat
aggcagcccattgtgagcaatccctgtggtaccaacaatggtggctgttctcatctctgc
ctcatcaagccaggaggaaaagggttcacttgcgagtgtccagatgacttccgcaccctt
cagctgagtggcagcacctactgcatgcccatgtgctccagcacccagttcctgtgcgct
aacaatgaaaagtgcattcctatctggtggaaatgtgatggacagaaagactgctcagat
ggctctgatgaactggccctttgcccgcagcgcttctgccgactgggacagttccagtgc
agtgacggcaactgcaccagcccgcagactttatgcaatgctcaccaaaattgccctgat
gggtctgatgaagaccgtcttctttgtgagaatcaccactgtgactccaatgaatggcag
tgcgccaacaaacgttgcatcccagaatcctggcagtgtgacacatttaacgactgtgag
gataactcagatgaagacagttcccactgtgccagcaggacctgccggccgggccagttt
cggtgtgctaatggccgctgcatcccgcaggcctggaagtgtgatgtggataatgattgt
ggagaccactcggatgagcccattgaagaatgcatgagctctgcccatctctgtgacaac
ttcacagaattcagctgcaaaacaaattaccgctgcatcccaaagtgggccgtgtgcaat
ggtgtagatgactgcagggacaacagtgatgagcaaggctgtgaggagaggacatgccat
cctgtgggggatttccgctgtaaaaatcaccactgcatccctcttcgttggcagtgtgat
gggcaaaatgactgtggagataactcagatgaggaaaactgtgctccccgggagtgcaca
gagagcgagtttcgatgtgtcaatcagcagtgcattccctcgcgatggatctgtgaccat
tacaacgactgtggggacaactcagatgaacgggactgtgagatgaggacctgccatcct
gaatattttcagtgtacaagtggacattgtgtacacagtgaactgaaatgcgatggatcc
gctgactgtttggatgcgtctgatgaagctgattgtcccacacgctttcctgatggtgca
tactgccaggctactatgttcgaatgcaaaaaccatgtttgtatcccgccatattggaaa
tgtgatggcgatgatgactgtggcgatggttcagatgaagaacttcacctgtgcttggat
gttccctgtaattcaccaaaccgtttccggtgtgacaacaatcgctgcatttatagtcat
gaggtgtgcaatggtgtggatgactgtggagatggaactgatgagacagaggagcactgt
agaaaaccgacccctaaaccttgtacagaatatgaatataagtgtggcaatgggcattgc
attccacatgacaatgtgtgtgatgatgccgatgactgtggtgactggtccgatgaactg
ggttgcaataaaggaaaagaaagaacatgtgctgaaaatatatgcgagcaaaattgtacc
caattaaatgaaggaggatttatctgctcctgtacagctgggttcgaaaccaatgttttt
gacagaacctcctgtctagatatcaatgaatgtgaacaatttgggacttgtccccagcac
tgcagaaataccaaaggaagttatgagtgtgtctgtgctgatggcttcacgtctatgagt
gaccgccctggaaaacgatgtgcagctgagggtagctctcctttgttgctactgcctgac
aatgtccgaattcgaaaatataatctctcatctgagaggttctcagagtatcttcaagat
gaggaatatatccaagctgttgattatgattgggatcccaaggacataggcctcagtgtt
gtgtattacactgtgcgaggggagggctctaggtttggtgctatcaaacgtgcctacatc
cccaactttgaatccggccgcaataatcttgtgcaggaagttgacctgaaactgaaatac
gtaatgcagccagatggaatagcagtggactgggttggaaggcatatttactggtcagat
gtcaagaataaacgcattgaggtggctaaacttgatggaaggtacagaaagtggctgatt
tccactgacctggaccaaccagctgctattgctgtgaatcccaaactagggcttatgttc
tggactgactggggaaaggaacctaaaatcgagtctgcctggatgaatggagaggaccgc
aacatcctggttttcgaggaccttggttggccaactggcctttctatcgattatttgaac
aatgaccgaatctactggagtgacttcaaggaggacgttattgaaaccataaaatatgat
gggactgataggagagtcattgcaaaggaagcaatgaacccttacagcctggacatcttt
gaagaccagttatactggatatctaaggaaaagggagaagtatggaaacaaaataaattt
gggcaaggaaagaaagagaaaacgctggtagtgaacccttggctcactcaagttcgaatc
tttcatcaactcagatacaataagtcagtgcccaacctttgcaaacagatctgcagccac
ctctgccttctgagacctggaggatacagctgtgcctgtccccaaggctccagctttata
gaggggagcaccactgagtgtgatgcagccatcgaactgcctatcaacctgcccccccca
tgcaggtgcatgcacggaggaaattgctattttgatgagactgacctccccaaatgcaag
tgtcctagcggctacaccggaaaatattgtgaaatggcgttttcaaaaggcatctctcca
ggaacaaccgcagtagctgtgctgttgacaatcctcttgatcgtcgtaattggagctctg
gcaattgcaggattcttccactatagaaggaccggctcccttttgcctgctctgcccaag
ctgccaagcttaagcagtctcgtcaagccctctgaaaatgggaatggggtgaccttcaga
tcaggggcagatcttaacatggatattggagtgtctggttttggacctgagactgctatt
gacaggtcaatggcaatgagtgaagactttgtcatggaaatggggaagcagcccataata
tttgaaaacccaatgtactcagccagagacagtgctgtcaaagtggttcagccaatccag
gtgactgtatctgaaaatgtggataataagaattatggaagtcccataaacccttctgag
atagttccagagacaaacccaacttcaccagctgctgatggaactcaggtgacaaaatgg
aatctcttcaaacgaaaatctaaacaaactaccaactttgaaaatccaatctatgcacag
atggagaacgagcaaaaggaaagtgttgctgcgacaccacctccatcaccttcgctccct
gctaagcctaagcctccttcgagaagagacccaactccaacctattctgcaacagaagac
acttttaaagacaccgcaaatcttgttaaagaagactctgaagtatag

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