Homo sapiens (human): 4123
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Entry
4123 CDS
T01001
Symbol
MAN2C1, CDDG2, MAN6A8, MANA, MANA1
Name
(RefSeq) mannosidase alpha class 2C member 1
KO
K01191
alpha-mannosidase [EC:
3.2.1.24
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00511
Other glycan degradation
Disease
H02767
Congenital disorder of deglycosylation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00511 Other glycan degradation
4123 (MAN2C1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
4123 (MAN2C1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.24 alpha-mannosidase
4123 (MAN2C1)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Cytoplasm to vacuolar targeting (CVT) pathway
Selective cargos
4123 (MAN2C1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Glyco_hydro_38N
Ams1-like_1st
Glyco_hydro_38C
Alpha-mann_mid
Glyco_hydro38C2
Motif
Other DBs
NCBI-GeneID:
4123
NCBI-ProteinID:
NP_006706
OMIM:
154580
HGNC:
6827
Ensembl:
ENSG00000140400
UniProt:
Q9NTJ4
A0A140VJN9
LinkDB
All DBs
Position
15:complement(75355792..75368607)
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AA seq
1040 aa
AA seq
DB search
MAAAPALKHWRTTLERVEKFVSPLYFTDCNLRGRLFGASCPVAVLSSFLTPERLPYQEAV
QRDFRPAQVGDSFGPTWWTCWFRVELTIPEAWVGQEVHLCWESDGEGLVWRDGEPVQGLT
KEGEKTSYVLTDRLGERDPRSLTLYVEVACNGLLGAGKGSMIAAPDPEKMFQLSRAELAV
FHRDVHMLLVDLELLLGIAKGLGKDNQRSFQALYTANQMVNVCDPAQPETFPVAQALASR
FFGQHGGESQHTIHATGHCHIDTAWLWPFKETVRKCARSWVTALQLMERNPEFIFACSQA
QQLEWVKSRYPGLYSRIQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQE
FGKMCSEFWLPDTFGYSAQLPQIMHGCGIRRFLTQKLSWNLVNSFPHHTFFWEGLDGSRV
LVHFPPGDSYGMQGSVEEVLKTVANNRDKGRANHSAFLFGFGDGGGGPTQTMLDRLKRLS
NTDGLPRVQLSSPRQLFSALESDSEQLCTWVGELFLELHNGTYTTHAQIKKGNRECERIL
HDVELLSSLALARSAQFLYPAAQLQHLWRLLLLNQFHDVVTGSCIQMVAEEAMCHYEDIR
SHGNTLLSAAAAALCAGEPGPEGLLIVNTLPWKRIEVMALPKPGGAHSLALVTVPSMGYA
PVPPPTSLQPLLPQQPVFVVQETDGSVTLDNGIIRVKLDPTGRLTSLVLVASGREAIAEG
AVGNQFVLFDDVPLYWDAWDVMDYHLETRKPVLGQAGTLAVGTEGGLRGSAWFLLQISPN
SRLSQEVVLDVGCPYVRFHTEVHWHEAHKFLKVEFPARVRSSQATYEIQFGHLQRPTHYN
TSWDWARFEVWAHRWMDLSEHGFGLALLNDCKYGASVRGSILSLSLLRAPKAPDATADTG
RHEFTYALMPHKGSFQDAGVIQAAYSLNFPLLALPAPSPAPATSWSAFSVSSPAVVLETV
KQAESSPQRRSLVLRLYEAHGSHVDCWLHLSLPVQEAILCDLLERPDPAGHLTLRDNRLK
LTFSPFQVLSLLLVLQPPPH
NT seq
3123 nt
NT seq
+upstream
nt +downstream
nt
atggcggctgcgccggccttgaagcactggcgcaccacgctggagcgggtggagaagttc
gtgtcgccgctctactttaccgactgtaacctccgcggcaggctttttggggccagctgc
cctgtggctgtgctctccagcttcctgacgccggagagacttccctaccaggaggcagtc
cagcgggacttccgccccgcgcaggtcggcgacagcttcggacccacatggtggacctgc
tggttccgggtggagctgaccatcccagaggcatgggtgggccaggaagttcacctttgc
tgggaaagtgatggagaaggtctggtgtggcgtgatggagaacctgtccagggtttaacc
aaagagggtgagaagaccagctatgtcctgactgacaggctgggggaaagagacccccga
agcctcactctctatgtggaagtagcctgcaatgggctcctgggggccgggaagggaagc
atgattgcagcccctgaccctgagaagatgttccagctgagccgggctgagctagctgtg
ttccaccgggatgtccacatgctcctggtggatctggagctgctgctgggcatagccaag
ggcctcgggaaggacaaccagcgcagcttccaggccctgtacacagccaatcagatggtg
aacgtgtgtgaccctgcccagcccgagaccttcccagtggcccaggccctggcctccagg
ttctttggccaacatgggggtgaaagccaacacaccattcatgccacagggcactgccac
attgatacagcctggctttggcccttcaaagagactgtgaggaaatgtgcccggagctgg
gtgaccgccctgcagctcatggagcggaaccctgagttcatctttgcctgctcccaggcg
cagcagctggaatgggtgaagagccgctaccctggcctgtactcccgcatccaggagttt
gcgtgccgtgggcagtttgtgcctgtggggggcacctgggtggagatggatgggaacctg
cccagtggagaggccatggtgaggcagtttttgcagggccagaacttctttctgcaggag
tttgggaagatgtgctctgagttctggctgccggacacctttggctactcagcacagctc
ccccagatcatgcacggctgtggcatcaggcgctttctcacccagaaattgagctggaat
ttggtgaactccttcccacaccatacatttttctgggagggcctggatggctcccgtgta
ctggtccacttcccacctggcgactcctatgggatgcagggcagcgtggaggaggtgctg
aagaccgtggccaacaaccgggacaaggggcgggccaaccacagtgccttcctctttggc
tttggggatgggggtggtggccccacccagaccatgctggaccgcctgaagcgcctgagc
aatacggatgggctgcccagggtgcagctatcttctccaagacagctcttctcagcactg
gagagtgactcagagcagctgtgcacgtgggttggggagctcttcttggagctgcacaat
ggcacatacaccacccatgcccagatcaagaaggggaaccgggaatgtgagcggatcctg
cacgacgtggagctgctcagtagcctggccctggcccgcagtgcccagttcctataccca
gcagcccagctgcagcacctctggaggctccttcttctgaaccagttccatgatgtggtg
actggaagctgcatccagatggtggcagaggaagccatgtgccattatgaagacatccgt
tcccatggcaatacactgctcagcgctgcagccgcagccctgtgtgctggggagccaggt
cctgagggcctcctcatcgtcaacacactgccctggaagcggatcgaagtgatggccctg
cccaaaccgggcggggcccacagcctagccctggtgacagtgcccagcatgggctatgct
cctgttcctccccccacctcactgcagcccctgctgccccagcagcctgtgttcgtagtg
caagagactgatggctccgtgactctggacaatggcatcatccgagtgaagctggaccca
actggtcgcctgacgtccttggtcctggtggcctctggcagggaggccattgctgagggc
gccgtggggaaccagtttgtgctatttgatgatgtccccttgtactgggatgcatgggac
gtcatggactaccacctggagacacggaagcctgtgctgggccaggcagggaccctggca
gtgggcaccgagggcggcctgcggggcagcgcctggttcttgctacagatcagccccaac
agtcggcttagccaggaggttgtgctggacgttggctgcccctatgtccgcttccacacc
gaggtacactggcatgaggcccacaagttcctgaaggtggagttccctgctcgcgtgcgg
agttcccaggccacctatgagatccagtttgggcacctgcagcgacctacccactacaat
acctcttgggactgggctcgatttgaggtgtgggcccatcgctggatggatctgtcagaa
cacggctttgggctggccctgctcaacgactgcaagtatggcgcgtcagtgcgaggcagc
atcctcagcctctcgctcttgcgggcgcctaaagccccggacgctactgctgacacgggg
cgccacgagttcacctatgcactgatgccgcacaagggctctttccaggatgctggcgtt
atccaagctgcctacagcctaaacttccccctgttggctctgccagcccccagcccagcg
cccgccacctcctggagtgcgttttccgtgtcttcacccgcggtcgtattggagaccgtc
aagcaggcggagagcagcccccagcgccgctcgctggtcctgaggctgtatgaggcccac
ggcagccacgtggactgctggctgcacttgtcgctgccggttcaggaggccatcctctgc
gatctcttggagcgaccagaccctgctggccacttgacccttcgggacaaccgcctgaag
ctcaccttttctcccttccaagtgctgtccctgttgctcgtgcttcagcctccgccacac
tga
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