KEGG   Homo sapiens (human): 4191
Entry
4191              CDS       T01001                                 
Symbol
MDH2, DEE51, EIEE51, M-MDH, MDH, MGC:3559, MOR1
Name
(RefSeq) malate dehydrogenase 2
  KO
K00026  malate dehydrogenase [EC:1.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00270  Cysteine and methionine metabolism
hsa00620  Pyruvate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01605  Gluconeogenesis
N01617  Citrate cycle, second carbon oxidation 2
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    4191 (MDH2)
   00620 Pyruvate metabolism
    4191 (MDH2)
   00630 Glyoxylate and dicarboxylate metabolism
    4191 (MDH2)
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    4191 (MDH2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     4191 (MDH2)
SSDB
Motif
Pfam: Ldh_1_C Ldh_1_N Semialdhyde_dh NAD_binding_10 THF_DHG_CYH_C 3Beta_HSD DapB_N
Other DBs
NCBI-GeneID: 4191
NCBI-ProteinID: NP_005909
OMIM: 154100
HGNC: 6971
Ensembl: ENSG00000146701
UniProt: P40926 A0A024R4K3 B3KTM1
Structure
LinkDB
Position
7:76048106..76067508
AA seq 338 aa
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
NT seq 1017 nt   +upstreamnt  +downstreamnt
atgctctccgccctcgcccggcctgccagcgctgctctccgccgcagcttcagcacctcg
gcccagaacaatgctaaagtagctgtgctaggggcctctggaggcatcgggcagccactt
tcacttctcctgaagaacagccccttggtgagccgcctgaccctctatgatatcgcgcac
acacccggagtggccgcagatctgagccacatcgagaccaaagccgctgtgaaaggctac
ctcggacctgaacagctgcctgactgcctgaaaggttgtgatgtggtagttattccggct
ggagtccccagaaagccaggcatgacccgggacgacctgttcaacaccaatgccacgatt
gtggccaccctgaccgctgcctgtgcccagcactgcccggaagccatgatctgcgtcatt
gccaatccggttaattccaccatccccatcacagcagaagttttcaagaagcatggagtg
tacaaccccaacaaaatcttcggcgtgacgaccctggacatcgtcagagccaacaccttt
gttgcagagctgaagggtttggatccagctcgagtcaacgtccctgtcattggtggccat
gctgggaagaccatcatccccctgatctctcagtgcacccccaaggtggactttccccag
gaccagctgacagcactcactgggcggatccaggaggccggcacggaggtggtcaaggct
aaagccggagcaggctctgccaccctctccatggcgtatgccggcgcccgctttgtcttc
tcccttgtggatgcaatgaatggaaaggaaggtgttgtggaatgttccttcgttaagtca
caggaaacggaatgtacctacttctccacaccgctgctgcttgggaaaaagggcatcgag
aagaacctgggcatcggcaaagtctcctcttttgaggagaagatgatctcggatgccatc
cccgagctgaaggcctccatcaagaagggggaagatttcgtgaagaccctgaagtga

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