Homo sapiens (human): 4321
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Entry
4321 CDS
T01001
Symbol
MMP12, HME, ME, MME, MMP-12
Name
(RefSeq) matrix metallopeptidase 12
KO
K01413
matrix metalloproteinase-12 (macrophage elastase) [EC:
3.4.24.65
]
Organism
hsa
Homo sapiens (human)
Drug target
Aderamastat:
D12909
Marimastat:
D03795
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
4321 (MMP12)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.65 macrophage elastase
4321 (MMP12)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M10
4321 (MMP12)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_M10
Hemopexin
PG_binding_1
Reprolysin_3
Astacin
Metallopep
Peptidase_M54
Peptidase_M66
Reprolysin_5
Reprolysin_4
Motif
Other DBs
NCBI-GeneID:
4321
NCBI-ProteinID:
NP_002417
OMIM:
601046
HGNC:
7158
Ensembl:
ENSG00000262406
UniProt:
P39900
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(102862736..102874982)
Genome browser
AA seq
470 aa
AA seq
DB search
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
NT seq
1413 nt
NT seq
+upstream
nt +downstream
nt
atgaagtttcttctaatactgctcctgcaggccactgcttctggagctcttcccctgaac
agctctacaagcctggaaaaaaataatgtgctatttggtgaaagatacttagaaaaattt
tatggccttgagataaacaaacttccagtgacaaaaatgaaatatagtggaaacttaatg
aaggaaaaaatccaagaaatgcagcacttcttgggtctgaaagtgaccgggcaactggac
acatctaccctggagatgatgcacgcacctcgatgtggagtccccgatgtccatcatttc
agggaaatgccaggggggcccgtatggaggaaacattatatcacctacagaatcaataat
tacacacctgacatgaaccgtgaggatgttgactacgcaatccggaaagctttccaagta
tggagtaatgttacccccttgaaattcagcaagattaacacaggcatggctgacattttg
gtggtttttgcccgtggagctcatggagacttccatgcttttgatggcaaaggtggaatc
ctagcccatgcttttggacctggatctggcattggaggggatgcacatttcgatgaggac
gaattctggactacacattcaggaggcacaaacttgttcctcactgctgttcacgagatt
ggccattccttaggtcttggccattctagtgatccaaaggccgtaatgttccccacctac
aaatatgttgacatcaacacatttcgcctctctgctgatgacatacgtggcattcagtcc
ctgtatggagacccaaaagagaaccaacgcttgccaaatcctgacaattcagaaccagct
ctctgtgaccccaatttgagttttgatgctgtcactaccgtgggaaataagatctttttc
ttcaaagacaggttcttctggctgaaggtttctgagagaccaaagaccagtgttaattta
atttcttccttatggccaaccttgccatctggcattgaagctgcttatgaaattgaagcc
agaaatcaagtttttctttttaaagatgacaaatactggttaattagcaatttaagacca
gagccaaattatcccaagagcatacattcttttggttttcctaactttgtgaaaaaaatt
gatgcagctgtttttaacccacgtttttataggacctacttctttgtagataaccagtat
tggaggtatgatgaaaggagacagatgatggaccctggttatcccaaactgattaccaag
aacttccaaggaatcgggcctaaaattgatgcagtcttctactctaaaaacaaatactac
tatttcttccaaggatctaaccaatttgaatatgacttcctactccaacgtatcaccaaa
acactgaaaagcaatagctggtttggttgttag
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