KEGG   Homo sapiens (human): 4539
Entry
4539              CDS       T01001                                 
Symbol
ND4L, MTND4L, MT-ND4L
Name
(RefSeq) NADH dehydrogenase subunit 4L
  KO
K03882  NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04714  Thermogenesis
hsa04723  Retrograde endocannabinoid signaling
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00142  NADH:ubiquinone oxidoreductase, mitochondria
Disease
H00068  Leber hereditary optic atrophy
H00473  Mitochondrial complex I deficiency
H01355  Kearns-Sayre syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4539 (ND4L)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    4539 (ND4L)
  09159 Environmental adaptation
   04714 Thermogenesis
    4539 (ND4L)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4539 (ND4L)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4539 (ND4L)
   05012 Parkinson disease
    4539 (ND4L)
   05014 Amyotrophic lateral sclerosis
    4539 (ND4L)
   05016 Huntington disease
    4539 (ND4L)
   05020 Prion disease
    4539 (ND4L)
   05022 Pathways of neurodegeneration - multiple diseases
    4539 (ND4L)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4539 (ND4L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4539 (ND4L)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     4539 (ND4L)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    4539 (ND4L)
SSDB
Motif
Pfam: Oxidored_q2
Other DBs
NCBI-GeneID: 4539
NCBI-ProteinID: YP_003024034
OMIM: 516004
HGNC: 7460
Pharos: P03901(Tclin)
UniProt: P03901 Q7GXZ4
Structure
LinkDB
Position
MT:10470..10766
AA seq 98 aa
MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVP
IAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
NT seq 297 nt   +upstreamnt  +downstreamnt
atgcccctcatttacataaatattatactagcatttaccatctcacttctaggaatacta
gtatatcgctcacacctcatatcctccctactatgcctagaaggaataatactatcgctg
ttcattatagctactctcataaccctcaacacccactccctcttagccaatattgtgcct
attgccatactagtctttgccgcctgcgaagcagcggtgggcctagccctactagtctca
atctccaacacatatggcctagactacgtacataacctaaacctactccaatgctaa

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