Homo sapiens (human): 4646
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Entry
4646 CDS
T01001
Symbol
MYO6, DFNA22, DFNB37
Name
(RefSeq) unconventional myosin-VI isoform 2
KO
K10358
myosin VI
Organism
hsa
Homo sapiens (human)
Pathway
hsa04814
Motor proteins
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
Network
nt06541
Cytoskeleton in neurons
Element
N01852
MYO6-mediated vesicle transport
Disease
H00604
Deafness, autosomal dominant
H00605
Deafness, autosomal recessive
H01705
Bilateral sudden sensorineural hearing loss
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09142 Cell motility
04814 Motor proteins
4646 (MYO6)
09160 Human Diseases
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
4646 (MYO6)
05132 Salmonella infection
4646 (MYO6)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
4646 (MYO6)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
4646 (MYO6)
04147 Exosome [BR:
hsa04147
]
4646 (MYO6)
Membrane trafficking [BR:
hsa04131
]
Others
Actin-binding proteins
Myosins
4646 (MYO6)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Myosins
4646 (MYO6)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
4646 (MYO6)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Myosin_head
MYO6_lever
Myosin-VI_CBD
BUD22
IQ
Myosin_N
XhlA
Fyv8
MIC21
Motif
Other DBs
NCBI-GeneID:
4646
NCBI-ProteinID:
NP_001287828
OMIM:
600970
HGNC:
7605
UniProt:
Q9UM54
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:75749239..75919537
Genome browser
AA seq
1262 aa
AA seq
DB search
MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVE
DNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSEAIKSYQGKSL
GTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDD
RIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGK
EERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEY
LKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSG
GCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVPLKVEQANNAR
DALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKL
QQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQPSD
QHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDA
LHMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRS
TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKK
YMPDKLARLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAEL
VKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL
VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYD
ALVKSSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEM
EAKRKQEEEERKKREDDEKRIQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSE
AELISDEAQADLALRRGPAVLATKAAAGTKKYDLSKWKYAELRDTINTSCDIELLAACRE
EFHRRLKVYHAWKSKNKKRNTETEQRAPKSVTDYDFAPFLNNSPQQNPAAQIPARQREIE
MNRQQRFFRIPFIRPADQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKPPILLVAGKDD
MEMCELNLEETGLTRKRGAEILPRQFEEIWERCGGIQYLQNAIESRQARPTYATAMLQSL
LK
NT seq
3789 nt
NT seq
+upstream
nt +downstream
nt
atggaggatggaaagcccgtttgggcgccacaccctacagatggatttcagatgggcaat
attgtggatattggccccgacagcttaacaattgaacccttgaatcagaaaggcaagaca
tttttggctctcataaaccaagtgtttcctgcagaagaggacagtaaaaaagatgtggaa
gataactgttcactaatgtatttaaatgaagccacactgctccataatatcaaagttcga
tatagtaaagacagaatttatacatatgtcgccaacattctgattgcagtgaatccatac
tttgacatacctaaaatatattcttcagaagcaataaagtcatatcaaggaaaatctctt
gggacaagaccacctcatgtctttgcaattgctgataaagcttttcgagacatgaaggtg
ctcaagatgagtcagtctatcattgtatctggagaatcaggagccggcaaaacagaaaat
acaaaatttgttctaagatacctgactgaatcctatggaacaggtcaagatattgatgac
agaattgttgaagctaacccactcctagaagcctttggaaatgcgaagactgttcgcaac
aataatagcagtcgatttgggaaatttgtagaaatacattttaatgaaaagagctcagtt
gttggaggatttgtttcacattatctcctagagaaatctaggatctgtgttcaaggcaaa
gaggaaagaaattatcatatcttttataggttgtgtgctggtgcttctgaagatattaga
gaaaaacttcatttgagttcaccagataattttcggtatttaaaccgaggctgcactaga
tactttgctaacaaagaaactgacaaacagattttacagaaccgcaaaagtcctgagtac
cttaaggcaggttctatgaaagatcctctgctagatgaccatggtgattttattagaatg
tgcacggctatgaaaaaaattggtttggatgatgaagaaaagcttgatctcttccgggta
gtagctggcgtcctgcaccttggaaatattgattttgaggaagctggcagcacttcaggt
ggttgtaatctgaagaataaatctgctcagtctttggaatattgtgctgaattactgggt
ttggaccaagatgatcttcgagtaagtttgaccacaagagtcatgctaacaacagcaggg
ggcaccaaaggaacagttataaaggtacctctgaaagtggagcaagcaaacaatgctcgt
gatgccctggcaaagacagtgtatagccatctttttgatcatgtggtaaacagagtaaat
cagtgttttccttttgaaacatcatcctattttattggagtcctagatattgctggtttt
gagtactttgagcataacagttttgaacaattttgcatcaactattgcaatgaaaaactt
caacaattttttaatgaaaggattctgaaggaggaacaagaactctatcaaaaagaaggt
ttaggtgttaatgaagtgcattatgtggataatcaggactgtatagatttaattgaagcc
aaattagtgggaatactggatattttggatgaagaaaatcgccttccccagccaagtgat
caacactttacatctgcagttcaccaaaagcacaaggatcattttcgactcactattccc
agaaaatctaagctggcagttcataggaatatcagagacgacgaaggcttcattatcagg
cattttgcgggggcagtgtgctatgaaacaacccagtttgtggagaaaaataatgatgct
ttacatatgtctcttgaatccttaatatgtgaatccagagataagtttatacgggaatta
tttgaatcatccacaaataacaacaaagatactaaacaaaaagcaggaaaacttagcttc
atcagcgtgggaaacaagtttaagacacagttaaatttgcttctggataaacttcgaagt
actggagcaagctttattcgttgcatcaaacctaacttaaagatgacaagccaccacttt
gaaggtgctcaaattctgtctcagcttcagtgttcagggatggtgtctgttttggacttg
atgcagggtggttacccatcacgagcttcatttcatgaactctacaacatgtacaaaaag
tatatgccagataaacttgcaagattggatccaagactattttgtaaggctttgtttaaa
gctttgggcttaaatgaaaatgactacaagtttgggttaaccaaagtattttttagacct
ggcaagtttgcagaatttgatcagatcatgaagtctgaccctgaccacttagcagagttg
gttaaaagagtcaatcactggctcacatgcagtcgctggaagaaagttcagtggtgctca
ctctcagtcatcaaattgaaaaacaaaataaaatatcgagctgaagcctgcattaaaatg
caaaaaactattcgaatgtggctttgcaagaggagacacaaacctcgcattgatggtctg
gttaaggtgggcacactgaaaaaacgacttgataaatttaatgaggtagtcagtgtgttg
aaagatggaaaacccgagatgaataaacagatcaagaatctggaaatttctattgatact
ttgatggccaaaattaagtccactatgatgacgcaggaacaaatccagaaagaatatgat
gcactggttaaaagctcagaggaactcctcagtgcattacagaaaaaaaaacagcaggaa
gaggaagcagaaaggctgaggcgtattcaagaagaaatggaaaaggaaagaaaaagacgt
gaagaagacgaaaaacgtcgaagaaaggaagaggaggaaaggcggatgaaacttgagatg
gaagcaaagagaaaacaagaagaagaagagagaaagaaaagggaagatgatgaaaaacgc
attcaagctgaagtggaggcacagctggcccgacagaaggaggaggaatcccaacagcaa
gcagttctggagcaggagcgcagggaccgggagctggccctgaggattgcccagagtgaa
gccgagctcatcagtgatgaggcccaggccgacctggcgctgcggagaggtcctgctgta
ctagccaccaaagcagctgctggtactaagaaatatgatcttagtaaatggaaatatgca
gaactacgtgataccatcaatacttcttgtgatattgagctcctggcagcttgcagagaa
gaatttcataggagactaaaagtgtatcatgcttggaaatctaagaacaagaagagaaat
actgaaacagagcaacgtgctccaaagtctgttactgattatgattttgcaccatttttg
aacaattcacctcagcaaaacccagcagctcagattcctgccaggcagcgggagattgaa
atgaaccgacagcaacgcttcttccgcatcccattcatccgccctgccgaccagtacaaa
gaccctcagagtaagaaaaaaggctggtggtatgcccattttgatggaccatggattgcc
cggcaaatggaactccatcctgacaagccacccatcctacttgtggctggtaaggacgac
atggagatgtgtgagctgaatcttgaggagactggcctgactcggaagcgtggtgctgag
atcttgccaagacagtttgaagaaatctgggaacgctgtggaggcatccagtaccttcag
aatgcgattgagagcagacaggctcggcccacctatgcaacagccatgctgcagagtctg
ttaaagtag
DBGET
integrated database retrieval system
