| Entry |
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| Symbol |
ATP2A1, ATP2A, SERCA1
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| Name |
(RefSeq) ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
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| KO |
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| Organism |
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04919 | Thyroid hormone signaling pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy |
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| Network |
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| Element |
| N01645 | Cytosolic Ca2+ removal, SERCA |
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| Disease |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
487 (ATP2A1)
04024 cAMP signaling pathway
487 (ATP2A1)
04022 cGMP-PKG signaling pathway
487 (ATP2A1)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
487 (ATP2A1)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
487 (ATP2A1)
09153 Circulatory system
04260 Cardiac muscle contraction
487 (ATP2A1)
04261 Adrenergic signaling in cardiomyocytes
487 (ATP2A1)
09154 Digestive system
04972 Pancreatic secretion
487 (ATP2A1)
09158 Development and regeneration
04380 Osteoclast differentiation
487 (ATP2A1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
487 (ATP2A1)
05017 Spinocerebellar ataxia
487 (ATP2A1)
05022 Pathways of neurodegeneration - multiple diseases
487 (ATP2A1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
487 (ATP2A1)
05412 Arrhythmogenic right ventricular cardiomyopathy
487 (ATP2A1)
05414 Dilated cardiomyopathy
487 (ATP2A1)
05415 Diabetic cardiomyopathy
487 (ATP2A1)
Enzymes [BR:hsa01000]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
487 (ATP2A1)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
16:28878488..28904466
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| AA seq |
1001 aa
MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSIL
TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALC
NDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGP
VKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGML
DPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDD
LPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI
GGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMA
LSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLR
ALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERRK |
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| NT seq |
3006 nt +upstreamnt +downstreamnt
atggaggccgctcatgctaaaaccacggaggaatgtttggcctattttggggtgagtgag
accacgggcctcaccccggaccaagttaagcggaatctggagaaatacggcctcaatgag
ctccctgctgaggaagggaagaccctgtgggagctggtgatagagcagtttgaagacctc
ctggtgcggattctcctcctggccgcatgcatttccttcgtgctggcctggtttgaggaa
ggtgaagagaccatcactgcctttgttgaaccctttgtcatcctcttgatcctcattgcc
aatgccatcgtgggggtttggcaggagcggaacgcagagaacgccatcgaggccctgaag
gagtatgagccagagatggggaaggtctaccgggctgaccgcaagtcagtgcaaaggatc
aaggctcgggacatcgtccctggggacatcgtggaggtggctgtgggggacaaagtccct
gcagacatccgaatcctcgccatcaaatccaccacgctgcgggttgaccagtccatcctg
acaggcgagtctgtatctgtcatcaaacacacggagcccgttcctgacccccgagctgtc
aaccaggacaagaagaacatgcttttctcgggcaccaacattgcagccggcaaggccttg
ggcatcgtggccaccactggtgtgggcaccgagattgggaagatccgagaccaaatggct
gccacagaacaggacaagacccccttgcagcagaagctggatgagtttggggagcagctc
tccaaggtcatctccctcatctgtgtggctgtctggcttatcaacattggccacttcaac
gaccccgtccatgggggctcctggttccgcggggccatctactactttaagattgccgtg
gccttggctgtggctgccatccccgaaggtcttcctgcagtcatcaccacctgcctggcc
ctgggtacccgtcggatggcaaagaagaatgccattgtaagaagcttgccctccgtagag
accctgggctgcacctctgtcatctgttccgacaagacaggcaccctcaccaccaaccag
atgtctgtctgcaagatgtttatcattgacaaggtggatggggacatctgcctcctgaat
gagttctccatcaccggctccacttacgctccagagggagaggtcttgaagaatgataag
ccagtccggccagggcagtatgacgggctggtggagctggccaccatctgtgccctctgc
aatgactcctccttggacttcaacgaggccaaaggtgtctatgagaaggtcggcgaggcc
accgagacagcactcaccaccctggtggagaagatgaatgtgttcaacacggatgtgaga
agcctctcgaaggtggagagagccaacgcctgcaactcggtgatccgccagctaatgaag
aaggaattcaccctggagttctcccgagacagaaagtccatgtctgtctattgctcccca
gccaaatcttcccgggctgctgtgggcaacaagatgtttgtcaagggtgcccctgagggc
gtcatcgaccgctgtaactatgtgcgagttggcaccacccgggtgccactgacggggccg
gtgaaggaaaagatcatggcggtgatcaaggagtggggcactggccgggacaccctgcgc
tgcttggccctggccacccgggacacccccccgaagcgagaggaaatggtcctggatgac
tctgccaggttcctggagtatgagacggacctgacattcgtgggtgtagtgggcatgctg
gaccctccgcgcaaggaggtcacgggctccatccagctgtgccgtgacgccgggatccgg
gtgatcatgatcactggggacaacaagggcacagccattgccatctgccggcgaattggc
atctttggggagaacgaggaggtggccgatcgcgcctacacgggccgagagttcgacgac
ctgcccctggctgaacagcgggaagcctgccgacgtgcctgctgcttcgcccgtgtggag
ccctcgcacaagtccaagattgtggagtacctgcagtcctacgatgagatcacagccatg
acaggtgatggcgtcaatgacgcccctgccctgaagaaggctgagattggcattgccatg
ggatctggcactgccgtggccaagactgcctctgagatggtgctggctgacgacaacttc
tccaccatcgtagctgctgtggaggagggccgcgccatctacaacaacatgaagcagttc
atccgctacctcatttcctccaacgtgggcgaggtggtctgtatcttcctgaccgctgcc
ctggggctgcctgaggccctgatcccggtgcagctgctatgggtgaacttggtgaccgac
gggctcccagccacagccctgggcttcaacccaccagacctggacatcatggaccgcccc
ccccggagccccaaggagcccctcatcagtggctggctcttcttccgctacatggcaatc
gggggctatgtgggtgcagccaccgtgggagcagctgcctggtggttcctgtacgctgag
gatgggcctcatgtcaactacagccagctgactcacttcatgcagtgcaccgaggacaac
acccactttgagggcatagactgtgaggtcttcgaggcccccgagcccatgaccatggcc
ctgtccgtgctggtgaccatcgagatgtgcaatgcactgaacagcctgtccgagaaccag
tccctgctgcggatgccaccctgggtgaacatctggctgctgggctccatctgcctctcc
atgtccctgcacttcctcatcctctatgttgaccccctgccgatgatcttcaagctccgg
gccctggacctcacccagtggctcatggtcctcaagatctcactgccagtcattgggctc
gacgaaatcctcaagttcgttgctcggaactacctagaggatccagaagatgaaagaagg
aagtga |
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