Homo sapiens (human): 490
Help
Entry
490 CDS
T01001
Symbol
ATP2B1, MRD66, PMCA1, PMCA1kb
Name
(RefSeq) ATPase plasma membrane Ca2+ transporting 1
KO
K05850
P-type Ca2+ transporter type 2B [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04925
Aldosterone synthesis and secretion
hsa04961
Endocrine and other factor-regulated calcium reabsorption
hsa04970
Salivary secretion
hsa04972
Pancreatic secretion
hsa04978
Mineral absorption
Network
nt06528
Calcium signaling
Element
N01429
Cytosolic Ca2+ removal, PMCA
Disease
H00773
Autosomal dominant intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
490 (ATP2B1)
04024 cAMP signaling pathway
490 (ATP2B1)
04022 cGMP-PKG signaling pathway
490 (ATP2B1)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
490 (ATP2B1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
490 (ATP2B1)
09154 Digestive system
04970 Salivary secretion
490 (ATP2B1)
04972 Pancreatic secretion
490 (ATP2B1)
04978 Mineral absorption
490 (ATP2B1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
490 (ATP2B1)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
490 (ATP2B1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Cation_ATPase_C
E1-E2_ATPase
ATP_Ca_trans_C
Cation_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
Motif
Other DBs
NCBI-GeneID:
490
NCBI-ProteinID:
NP_001673
OMIM:
108731
HGNC:
814
Ensembl:
ENSG00000070961
UniProt:
P20020
Structure
PDB
LinkDB
All DBs
Position
12:complement(89588049..89709366)
Genome browser
AA seq
1220 aa
AA seq
DB search
MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGIC
TKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIV
SLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQ
FRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDE
SSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEK
KDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKS
VLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFF
IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL
TMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRH
VGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFS
KGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEP
EPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIAT
KCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGI
IDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVK
AVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASL
ALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGR
NAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQ
IIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEE
IPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSS
IHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEM
NKSATSSSPGSPLHSLETSL
NT seq
3663 nt
NT seq
+upstream
nt +downstream
nt
atgggcgacatggcaaacaactcagttgcttacagtggtgtgaaaaactctttgaaggaa
gctaatcatgatggagactttggaattacgctcgcagagctgcgggctctcatggagctc
aggtccacagatgcattacgaaaaatacaggaaagctatggagatgtctatggaatttgc
accaaattgaaaacatctcccaatgaaggtttaagtggaaaccctgcagatttagaaaga
agagaagcagtgtttggaaagaattttatacctcctaaaaagccaaaaacctttcttcaa
ttagtatgggaagcattacaagatgtcactttaattatattagaaattgcagccatagta
tcattgggcctttctttttatcagcctccagaaggggataatgcactttgtggagaagtt
tctgttggggaggaagaaggtgaaggtgaaactggttggattgaaggagctgcaatcctc
ttgtctgtagtgtgtgtggtgttagtaacagctttcaatgactggagtaaggaaaaacag
tttagaggtttgcagagccgaattgaacaagaacagaagttcactgtcatcaggggtggt
caggtcattcagatacctgtagctgacattactgttggagatattgctcaagtgaaatat
ggtgatcttcttccagctgacggcatacttattcaaggcaacgatcttaaaattgatgaa
agctcattgactggtgaatcagatcatgttaaaaagtctttagataaggatcccttactt
ctatcaggtactcatgtaatggaaggctctggaagaatggtagttacagctgtaggtgta
aattctcaaactggaattatctttaccttacttggagctggaggtgaagaggaagagaag
aaagatgagaagaaaaaggaaaagaaaaataagaaacaagatggagctattgagaatcgc
aacaaagcaaaagcccaggatggtgcagccatggaaatgcagccattgaagagtgaagaa
ggtggagatggtgatgaaaaagataaaaagaaagcaaatttgccaaaaaaggaaaaatct
gttttacaagggaaacttacaaaactggctgttcagattggcaaagcaggtctgttgatg
tctgccatcacagttatcattctagtattatattttgtcattgacaccttctgggttcag
aaaagaccatggcttgctgagtgcacaccaatttatatacaatactttgtgaagttcttc
attattggagttacagttttagtggtcgcagtgccagaaggtcttccacttgcagtcacg
atctcactggcttattcagtcaaaaaaatgatgaaagataataacttagtaaggcatctg
gatgcttgtgaaaccatgggaaatgctacagctatttgttcagataaaacaggaactttg
acaatgaacagaatgacagtcgttcaagcttacataaatgaaaaacattataaaaaggtt
cctgaaccagaagctattccaccaaatattttgtcctatcttgtaacaggaatttctgtg
aattgtgcttatacatcaaaaatattgccaccagagaaagagggtggattacctcgtcac
gttggtaataaaactgaatgtgccttgttgggacttcttttggatttaaaacgggattat
caggatgttagaaatgaaataccagaagaagcactgtacaaagtctacaccttcaattct
gttaggaagtccatgagtactgtcctgaaaaattcagatggaagttatcgaatattcagc
aagggtgcatctgagataattctgaaaaagtgtttcaaaatcttgagtgctaatggtgag
gcaaaagtattcagaccaagggaccgtgatgatattgtaaaaactgtgattgaaccgatg
gcatcagaaggcttgagaaccatatgtcttgcattcagagattttccagcaggagaacca
gaaccagagtgggataatgaaaatgatattgtcaccggccttacatgcattgctgttgtg
gggattgaagatcctgtgagacctgaggtgccagatgcaattaaaaagtgtcagagggct
ggaattactgtgcggatggtcactggtgataatattaatactgctcgggccattgctacc
aaatgtggtattttacatcctggggaagattttctgtgcctagaaggtaaagattttaac
agaagaatacgaaatgaaaaaggagagattgagcaagagaggatagacaagatttggcca
aaacttcgagtacttgcaagatcatctcctactgataagcatacactggttaaaggtata
attgacagcactgtctcagaccaacgccaggttgtagctgtaactggtgatggtacaaat
gatggcccagcactaaagaaagcagatgttggatttgcaatgggtattgctggaactgat
gtagctaaagaagcatccgatattattctcacagatgacaactttacaagcattgttaaa
gcagttatgtggggacgaaatgtctatgacagcatctcaaaattccttcagttccaactt
actgttaatgtagtagcagtgattgttgcttttacgggcgcctgcattactcaagactca
ccgcttaaggctgtgcagatgctgtgggtaaacctcataatggatacactcgcttccctg
gctctggcaacggaaccacccactgagtctctcttgcttcggaaaccttatggtagaaat
aagcctctcatctcacgtacaatgatgaagaatattttgggtcatgcattctatcaactt
gtagtagtctttacactcttatttgctggagaaaagttttttgacattgatagtggaaga
aatgctcctttgcatgctcctccttcagaacattatactattgtttttaatacctttgtg
ctgatgcaacttttcaacgaaataaatgcccggaaaattcatggtgaaagaaatgtattc
gaaggaatctttaacaatgccatcttctgcacaattgttttaggcacttttgtggtacag
ataataattgtgcagtttggtggaaaacctttcagttgttcagaactttcaatagaacag
tggctatggtcaatattcctaggaatgggaacattactctggggccagcttatttcaaca
attccaactagccgtttaaaattcctcaaagaagctggtcatggaacacaaaaggaagaa
atacctgaggaggaattagcagaggatgttgaagagattgatcacgctgaaagggagttg
cggcgtggccaaatcttgtggtttagaggtctgaacagaatccaaacacagattcgagtg
gtgaatgcatttcgtagttctttatatgaagggttagaaaaaccggaatcaagaagttcg
attcacaactttatgacacatcctgagtttaggatagaagattcagagcctcatatcccc
cttattgatgacactgatgccgaagatgatgctcctacaaaacgtaactccagtcctcca
ccctctcccaacaaaaataacaatgctgttgacagtggaattcaccttacaatagaaatg
aacaagtctgctacctcttcatccccaggaagcccactacatagtttggaaacatcactc
tga
Homo sapiens (human): 491
Help
Entry
491 CDS
T01001
Symbol
ATP2B2, DFNA82, PMCA2, PMCA2a, PMCA2i
Name
(RefSeq) ATPase plasma membrane Ca2+ transporting 2
KO
K05850
P-type Ca2+ transporter type 2B [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04925
Aldosterone synthesis and secretion
hsa04961
Endocrine and other factor-regulated calcium reabsorption
hsa04970
Salivary secretion
hsa04972
Pancreatic secretion
hsa04978
Mineral absorption
Network
nt06528
Calcium signaling
Element
N01429
Cytosolic Ca2+ removal, PMCA
Disease
H00604
Deafness, autosomal dominant
H00605
Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
491 (ATP2B2)
04024 cAMP signaling pathway
491 (ATP2B2)
04022 cGMP-PKG signaling pathway
491 (ATP2B2)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
491 (ATP2B2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
491 (ATP2B2)
09154 Digestive system
04970 Salivary secretion
491 (ATP2B2)
04972 Pancreatic secretion
491 (ATP2B2)
04978 Mineral absorption
491 (ATP2B2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
491 (ATP2B2)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
491 (ATP2B2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Cation_ATPase_C
E1-E2_ATPase
ATP_Ca_trans_C
Cation_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
EMC3_TMCO1
Motif
Other DBs
NCBI-GeneID:
491
NCBI-ProteinID:
NP_001001331
OMIM:
108733
HGNC:
815
Ensembl:
ENSG00000157087
UniProt:
Q01814
LinkDB
All DBs
Position
3:complement(10324023..10708007)
Genome browser
AA seq
1243 aa
AA seq
DB search
MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRL
KTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLG
LSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFR
GLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESS
LTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEEEEKKD
KKGVKKGDGLQLPAADGAAASNAADSANASLVNGKMQDGNVDASQSKAKQQDGAAAMEMQ
PLKSAEGGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDT
FVVNKKPWLPECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL
VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLIN
AIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVY
TFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKV
IEPMACDGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKC
QRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDK
IWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIA
GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT
QDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAV
YQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGER
NVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQV
IATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRGLNRIQTQ
IRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLEEDAALKQNS
SPPSSLNKNNSAIDSGINLTTDTSKSATSSSPGSPIHSLETSL
NT seq
3732 nt
NT seq
+upstream
nt +downstream
nt
atgggtgacatgaccaacagcgacttttactccaaaaaccaaagaaatgagtcgagccat
gggggcgagttcgggtgcacaatggaggagctccgctccctcatggagctgcggggcact
gaggctgtggtcaagatcaaggagacttatggggacaccgaagccatctgccggcgcctc
aaaacctcacctgttgaaggtttgccgggcaccgctccagacctggaaaagagaaagcaa
atttttgggcaaaactttatacctccaaagaagccaaaaaccttcctgcagctcgtgtgg
gaggcgctgcaggacgtgacgctcatcatcctggagattgccgccatcatctccctgggg
ctgtccttctaccacccgcccggcgagggcaacgaaggatgtgcgacggcccagggtggg
gcagaggatgaaggagaggcagaggcaggttggatcgagggggccgccattctcctctca
gttatctgtgtggtcctggtcacggccttcaatgactggagcaaagagaaacagttccgg
ggcctgcagagccgcatcgagcaggaacagaaatttaccgtggtccgggctggccaggtg
gtccagatccctgtggctgagatcgtggttggggacatagcccaggtcaaatatggtgac
ctcctccctgccgacggcctcttcatccagggcaatgacctcaagattgatgaaagctcc
ctaactggagagtctgaccaggtgcgcaagtccgtggacaaggaccccatgctgctgtca
ggaacccacgtgatggagggctcaggacggatgttggtgactgctgtgggtgtgaactct
cagactggcatcatctttaccctcctgggggctggtggtgaagaggaagagaagaaagac
aaaaaaggtgtgaagaagggggatggccttcagctaccagcagcagacggtgcggcagct
tcaaatgctgcagatagtgcgaatgccagcctagtcaatggtaaaatgcaggatggcaat
gtggacgccagccagagcaaagccaaacaacaggacggggcagccgccatggagatgcag
cccctcaagagtgccgagggcggcgacgctgacgacaggaagaaggccagcatgcacaag
aaggagaagtccgtgctgcagggcaagctcaccaagctggctgtgcagatcgggaaggcg
ggcttggtgatgtcagccatcacggtgatcatcctggtgctctacttcactgtggacacc
ttcgtggtcaacaagaagccgtggctgcctgagtgcacgcccgtctacgtgcagtacttt
gtcaagttcttcatcattggcgtgacggtgctggtggtcgccgtgcccgaggggctccct
ctggccgtcaccatctcgttggcctattcggtgaagaaaatgatgaaggacaacaacctg
gtacgccacctggatgcctgtgagaccatgggcaatgccacagccatctgctcagacaag
acaggcacgctgaccaccaatcgcatgacagtggtacaggcctatgtcggcgacgtccac
tataaagagatccccgaccccagctccatcaacaccaagaccatggagctgctgatcaat
gccatcgccatcaacagcgcctacaccaccaagattctgcccccagagaaggagggcgcc
ctgcctcggcaggtgggcaacaagacggagtgcggcctgctgggcttcgtgctggacctg
aagcaggactacgagcccgtgcgcagccagatgccagaggagaagttgtacaaagtgtac
accttcaactccgtgcgcaagtccatgagcactgtcatcaagctgcccgacgagagcttc
cgcatgtacagcaagggggcttctgagatcgtgctcaagaagtgctgcaaaatcctcaat
ggggcgggagagcctcgtgtcttccggccccgcgaccgggacgagatggtaaagaaggtg
attgagcccatggcttgcgatgggctccgcactatctgcgtggcctaccgcgacttcccc
agcagcccggagccggactgggacaatgagaatgacatcctcaacgaactcacctgcatc
tgcgtggtgggcatcgaggacccggtgcggccagaggtcccagaagccatccgcaagtgc
cagcgggcaggcatcacggtccgcatggtcactggcgacaatatcaacacggctcgggcc
atcgccatcaagtgtggcatcatccatcctggggaggactttctgtgcctcgagggcaag
gagttcaacaggaggatccgcaacgagaagggggagattgagcaggagcgaattgacaag
atctggccaaagctgcgggtgctggctcgctcctccccaacggacaagcataccctggtt
aaaggcatcatcgacagcacacacactgagcagcggcaggtggtggccgtgacgggggac
gggaccaacgacgggcctgcactcaagaaggccgacgtgggcttcgccatgggcatcgca
ggcactgacgtggccaaggaggcctcagacatcatcctgacagacgacaatttcagcagc
atcgtcaaggcagtgatgtggggccgcaacgtctatgacagcatctccaaattcttgcag
ttccagctcaccgtcaacgtggtggccgtgattgtggccttcacaggcgcctgcatcacg
caggactcccctctgaaggccgtgcagatgctctgggtgaacctcatcatggacacgttt
gcctcgctggcactggccactgagccgcccacggagaccctgctgctgaggaagccgtac
ggccgcaacaagccgctcatctccaggaccatgatgaagaacatcctgggccatgctgtc
taccagcttgccctcatcttcaccctgctctttgttggcgagaagatgttccagatcgac
agcgggaggaacgcgcccctgcattcgccaccctcagaacattacaccatcatcttcaac
accttcgtcatgatgcagctcttcaacgagatcaacgcccgcaagatccacggcgagcgc
aatgtctttgacggcatcttccggaaccccatcttctgcaccatcgtgctgggcaccttt
gccatccagatagtgatcgtgcagtttggagggaagccattcagctgctctccactgcag
ctggaccagtggatgtggtgcatattcattgggttaggagagctcgtttggggccaggtc
atcgccaccatcccgaccagcagactcaagttcctcaaggaggcaggcaggctcacacag
aaggaggagatcccggaggaggagctcaacgaggacgtggaggagatcgaccacgcggag
cgggagctgcggcggggccagatcctgtggttccgaggcctgaatcggatccagacacag
atccgcgtcgtgaaggcgttccgtagctctctctatgaaggtttagaaaagcctgaatct
cgaacctccatccataacttcatggctcatcctgaattccggatcgaagattcccagccc
cacatccccctcattgatgacaccgacctggaagaagatgccgcgctcaagcagaactcg
agcccgccgtcatccctcaacaagaacaacagcgccatcgacagtgggatcaacctgacg
accgacacaagcaaatcagctacctcttcaagtccagggagccccatccacagcctggag
acgtcgctttag
Homo sapiens (human): 492
Help
Entry
492 CDS
T01001
Symbol
ATP2B3, CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1
Name
(RefSeq) ATPase plasma membrane Ca2+ transporting 3
KO
K05850
P-type Ca2+ transporter type 2B [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04925
Aldosterone synthesis and secretion
hsa04961
Endocrine and other factor-regulated calcium reabsorption
hsa04970
Salivary secretion
hsa04972
Pancreatic secretion
hsa04978
Mineral absorption
Network
nt06316
Renin-angiotensin-aldosterone signaling
nt06528
Calcium signaling
Element
N00305
Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N01429
Cytosolic Ca2+ removal, PMCA
Disease
H01603
Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
492 (ATP2B3)
04024 cAMP signaling pathway
492 (ATP2B3)
04022 cGMP-PKG signaling pathway
492 (ATP2B3)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
492 (ATP2B3)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
492 (ATP2B3)
09154 Digestive system
04970 Salivary secretion
492 (ATP2B3)
04972 Pancreatic secretion
492 (ATP2B3)
04978 Mineral absorption
492 (ATP2B3)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
492 (ATP2B3)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
492 (ATP2B3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Cation_ATPase_C
E1-E2_ATPase
ATP_Ca_trans_C
Cation_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
Motif
Other DBs
NCBI-GeneID:
492
NCBI-ProteinID:
NP_001001344
OMIM:
300014
HGNC:
816
Ensembl:
ENSG00000067842
UniProt:
Q16720
LinkDB
All DBs
Position
X:153517642..153582929
Genome browser
AA seq
1220 aa
AA seq
DB search
MGDMANSSIEFHPKPQQQRDVPQAGGFGCTLAELRTLMELRGAEALQKIEEAYGDVSGLC
RRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIV
SLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEK
QFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQANDLKID
ESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEE
KKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANAPKKEKSVL
QGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVEGRTWLAECTPVYVQYFVKFFII
GVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT
NRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVG
NKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKG
ASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEPMACDGLRTICIAYRDFSAGQEPD
WDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCG
IIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDS
TTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVM
WGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALA
TEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAP
LHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVI
VQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTD
EELAEGEEEIDHAERELRRGQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESKTSIHN
FMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPSPNQNNNAIDSGIYLTTHVTKSA
TSSVFSSSPGSPLHSVETSL
NT seq
3663 nt
NT seq
+upstream
nt +downstream
nt
atgggcgacatggccaatagttccatcgagttccaccccaagccccagcagcagcgggat
gtcccccaggctggaggctttgggtgcacgctggcggagctgcgcaccctcatggagctg
cgaggggccgaggcgctgcagaagatcgaggaggcctacggggatgtcagcgggctctgc
cggaggctgaagacctcacccacagagggcctggcggacaacaccaatgacctggagaag
cgcaggcagatctacgggcagaacttcatccccccaaagcaacccaagaccttcctgcag
ctggtgtgggaggccctgcaggacgtgaccctcatcatcctggaggtggctgccatcgtc
tctctgggcctctcgttctatgcgccgccaggagaggagagtgaagcctgtgggaatgtg
tcgggaggcgcagaagatgagggcgaggccgaagctggctggatcgagggggctgccatc
ctgctgtccgtcatctgtgtggtgctggtcacggccttcaatgactggagcaaggagaag
cagttccgaggcctgcagagccgaattgagcaggagcagaagttcacggtcatccggaac
gggcagctcctccaggtccccgtggctgcgctggtggtgggggacattgcccaggtcaag
tacggcgacctgctgccagccgacggcgtgctcatccaggccaatgacctcaagatcgac
gagagctccctgacgggcgagtctgaccacgtgcgcaagtcagctgacaaagatcccatg
ctgctctcaggcactcatgtcatggaaggttctggaagaatggtggtgaccgccgttggc
gtgaattcccagacaggcatcatcttcacgctgcttggagctggcggagaggaggaagag
aagaaagataagaaaggcaagcagcaggatggggccatggagagtagccagaccaaagct
aagaagcaggatggtgcagtggccatggagatgcagcccctgaagagcgcggagggtggg
gagatggaggagcgggagaagaagaaagccaacgcacccaaaaaggagaagtctgtcctt
caggggaagctcacaaagctagccgtgcagatcgggaaagcagggctggtgatgtctgcc
atcaccgtcatcatcctggtcctctactttgtgattgagacgtttgtcgtggaaggccgg
acatggctggcagagtgcacgccggtctatgtacaatacttcgtgaagttcttcatcatt
ggtgtcactgtgctggtcgtggctgtcccagagggcctgcctcttgctgtcaccatctcc
ttagcttactctgtcaagaaaatgatgaaagacaacaacctggtgcgccacctggatgcc
tgcgagaccatgggcaacgccacagccatctgctccgacaagacgggcacgctcaccacc
aaccgtatgaccgtggtccagtcctacctaggagacacccactacaaagagattccggcc
cccagcgccctgacccctaagatcctcgacctcctggtccatgccatctccatcaacagt
gcctataccaccaaaatactacctcctgagaaggaaggcgccctcccacgccaggtgggc
aataagacggagtgcgccctgctgggcttcgtcttggacctgaagcgggacttccagccc
gtgcgcgagcagatcccggaagacaagctttacaaagtgtacaccttcaactcggtccgc
aagtccatgagcacagtcatccgcatgcccgacggtggcttccgcctcttcagcaagggg
gcctcagagatcctcttgaaaaagtgcaccaacatcttgaacagcaatggcgaactccgg
ggctttcggcctcgggaccgggacgacatggtgaggaagatcatcgagccgatggcttgc
gatggcctccgcaccatctgcatcgcctaccgggacttctctgcaggccaggagcccgac
tgggacaacgagaatgaggtcgtgggtgacctcacctgcatagctgtcgtgggcattgag
gaccctgtgcggcccgaggtccctgaagctatccgaaaatgccagcgtgctggcatcaca
gtccgcatggtgactggggacaacatcaacacggcccgggccatcgcagccaaatgcggc
atcatccagcccggggaggacttcctgtgcctagaagggaaggagttcaaccggcggatc
cgcaatgagaaaggcgagatagaacaggagcggctggacaaggtgtggcccaagctgagg
gtgctggcccggtcgtctcccaccgacaagcacacactggtcaaagggattatcgacagc
accactggtgagcagcggcaggtggtggctgtgacaggggatggcaccaacgatgggccg
gccctcaagaaggcggacgtgggcttcgccatgggcatcgcagggaccgacgtggccaag
gaggcctccgacatcatcctgaccgatgacaacttcaccagcatcgtcaaggcagtcatg
tggggccgtaacgtctatgacagcatctccaagttcctgcagtttcaactgacggtcaat
gtggtggctgtgatcgtggccttcacaggtgcctgcattactcaggactctcctctcaaa
gccgtgcagatgttgtgggtgaacttgatcatggacacatttgcctctctggccctggcg
acggagccacccacagagtcgctgctgctgcggaagccgtacggccgcgacaagcccctc
atctcccgcaccatgatgaagaacattctgggccacgccgtgtaccagctcgccatcatc
ttcaccctgctgtttgtcggggagctcttcttcgacatcgacagcgggaggaatgcgccc
ctgcactcgccaccctcagagcactacaccatcatcttcaacacgttcgtcatgatgcag
ctctttaacgagatcaacgcccgcaagatccacggcgagaggaacgtgttcgacggcatc
ttcagcaaccccatcttctgcaccatcgttttgggcactttcgggattcagattgtcatc
gtccagtttggcgggaagcccttcagctgctccccactatccacagaacagtggctctgg
tgcctgtttgttggtgttggggagctggtctggggacaggtcattgccaccatccccacc
agccagctcaagtgcctgaaggaagccgggcacgggcccgggaaggacgagatgaccgac
gaggagctggccgaaggcgaggaagagatcgaccatgccgagcgggagctccgcaggggc
cagatcctctggttccggggcctgaaccggattcagacgcagatccgggtggtgaaagcg
ttccgtagctcgctctatgaaggcctggagaaaccagaatccaagacctccattcacaac
ttcatggccacgcccgagtttctgatcaatgactacacccacaacatcccgctcattgac
gacacggacgtggacgagaacgaggagcgcctccgggcccccccgcccccgtcccccaac
cagaacaacaacgccatagacagcggcatctacctgaccacgcatgtcaccaagtcagct
acctcttcagtgttttcctccagtcccgggagcccgctccacagcgtggagacgtccctc
taa
Homo sapiens (human): 493
Help
Entry
493 CDS
T01001
Symbol
ATP2B4, ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
Name
(RefSeq) ATPase plasma membrane Ca2+ transporting 4
KO
K05850
P-type Ca2+ transporter type 2B [EC:
7.2.2.10
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04925
Aldosterone synthesis and secretion
hsa04961
Endocrine and other factor-regulated calcium reabsorption
hsa04970
Salivary secretion
hsa04972
Pancreatic secretion
hsa04978
Mineral absorption
Network
nt06528
Calcium signaling
Element
N01429
Cytosolic Ca2+ removal, PMCA
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
493 (ATP2B4)
04024 cAMP signaling pathway
493 (ATP2B4)
04022 cGMP-PKG signaling pathway
493 (ATP2B4)
09150 Organismal Systems
09152 Endocrine system
04925 Aldosterone synthesis and secretion
493 (ATP2B4)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
493 (ATP2B4)
09154 Digestive system
04970 Salivary secretion
493 (ATP2B4)
04972 Pancreatic secretion
493 (ATP2B4)
04978 Mineral absorption
493 (ATP2B4)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
493 (ATP2B4)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.10 P-type Ca2+ transporter
493 (ATP2B4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Cation_ATPase_C
E1-E2_ATPase
ATP_Ca_trans_C
Cation_ATPase_N
Cation_ATPase
Hydrolase
Hydrolase_3
Motif
Other DBs
NCBI-GeneID:
493
NCBI-ProteinID:
NP_001675
OMIM:
108732
HGNC:
817
Ensembl:
ENSG00000058668
UniProt:
P23634
Structure
PDB
LinkDB
All DBs
Position
1:203626832..203744081
Genome browser
AA seq
1205 aa
AA seq
DB search
MTNPSDRVLPANSMAESREGDFGCTVMELRKLMELRSRDALTQINVHYGGVQNLCSRLKT
SPVEGLSGNPADLEKRRQVFGHNVIPPKKPKTFLELVWEALQDVTLIILEIAAIISLVLS
FYRPAGEENELCGQVATTPEDENEAQAGWIEGAAILFSVIIVVLVTAFNDWSKEKQFRGL
QCRIEQEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDLKIDESSLT
GESDHVKKSLDKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKK
GKKQGVPENRNKAKTQDGVALEIQPLNSQEGIDNEEKDKKAVKVPKKEKSVLQGKLTRLA
VQIGKAGLLMSALTVFILILYFVIDNFVINRRPWLPECTPIYIQYFVKFFIIGITVLVVA
VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQA
YIGGIHYRQIPSPDVFLPKVLDLIVNGISINSAYTSKILPPEKEGGLPRQVGNKTECALL
GFVTDLKQDYQAVRNEVPEEKLYKVYTFNSVRKSMSTVIRNPNGGFRMYSKGASEIILRK
CNRILDRKGEAVPFKNKDRDDMVRTVIEPMACDGLRTICIAYRDFDDTEPSWDNENEILT
ELTCIAVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFL
CLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVV
AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSI
SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLL
KRRPYGRNKPLISRTMMKNILGHAFYQLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHY
TIVFNTFVLMQLFNEINSRKIHGEKNVFSGIYRNIIFCSVVLGTFICQIFIVEFGGKPFS
CTSLSLSQWLWCLFIGIGELLWGQFISAIPTRSLKFLKEAGHGTTKEEITKDAEGLDEID
HAEMELRRGQILWFRGLNRIQTQIKVVKAFHSSLHESIQKPYNQKSIHSFMTHPEFAIEE
ELPRTPLLDEEEEENPDKASKFGTRVLLLDGEVTPYANTNNNAVDCNQVQLPQSDSSLQS
LETSV
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgacgaacccatcagaccgtgtcttgcctgccaactcgatggccgagagccgtgaaggg
gactttggctgcacagtaatggaactgaggaagctcatggagctgcgttcaagggatgca
ctgacccagattaatgtccactatggaggtgtacagaatctctgcagtagactgaaaacc
tcccctgtggaaggtctgtctgggaaccctgcagatctggagaaacgtaggcaggtgttt
ggacacaacgtgatcccccccaaaaagcccaagactttcttagaattagtgtgggaagct
cttcaagatgtcacgcttatcatcctggagattgcagccatcatctccctggtcctgtcc
ttttatcgccctgctggtgaagaaaatgaactgtgtggtcaagtcgcaactaccccagaa
gatgaaaatgaggcacaagctggctggattgagggggcagccatccttttctcagtgatc
atcgtggtgttagtgactgcctttaatgattggagcaaagagaagcaattccgggggctg
cagtgccgcattgaacaggagcaaaagttctccatcatccgaaacggtcaactcatccag
ctccctgtggctgagattgtggttggtgatattgcccaagtcaaatacggtgatctgctg
cctgcagatggaatcctgatccaagggaatgatctgaagattgatgagagctctctgaca
ggggaatctgaccatgtcaagaagtccctggacaaagaccccatgttgctctcagggacc
catgtcatggaaggttctggccggatggtggtgacagctgttggtgtcaactctcagact
ggaatcatccttactctcttgggggtcaatgaggatgacgaaggggagaaaaagaagaaa
ggtaaaaaacaaggagtccctgaaaatcgcaacaaagcaaagacccaagacggagtggcc
ctggaaatccagccactcaacagccaggagggaatcgacaatgaggaaaaggacaagaag
gcagtcaaggtgcctaaaaaggagaagtcagtgctgcagggcaagctgactcgcctggct
gttcagattgggaaagccggtctgctcatgtctgctctcacggttttcatcctgattcta
tactttgtgattgacaactttgtgataaatcgcagaccatggctccctgagtgtactccc
atctacatccagtactttgtcaagttcttcatcatcggcatcactgtactggtggtggct
gtgccagaggggctgcctctggctgtcaccatctcactggcctactctgtgaagaaaatg
atgaaagacaataacctagtacggcacttggatgcttgtgagaccatgggcaacgccacc
gccatctgctctgataagacaggcacgttgaccatgaaccgcatgactgtggtacaagct
tatattgggggcatccattaccgtcaaatcccaagccctgatgtcttcctgcccaaagtc
ctggacctcattgtcaatggcatttctatcaacagtgcttatacctccaagattctgcct
ccagagaaggagggaggcctgcctcggcaggtgggcaacaagaccgagtgtgctctgcta
ggctttgtcacagatctgaagcaggattatcaggctgtgcgtaatgaagtgcccgaggag
aagctctacaaggtgtacacctttaactcagtgcgcaagtcaatgagcaccgtcatcagg
aatcccaacggtggcttccgtatgtacagcaagggcgcctctgagatcatcttgcgcaag
tgtaatcgaatcctggaccggaaaggggaagcagtgccattcaagaataaagacagagat
gatatggtacgcactgtcatcgagcccatggcctgtgatggactccggactatctgcata
gcttaccgggacttcgatgacacagagccctcttgggacaatgagaatgagatcctcacc
gaactgacctgtatcgcggtggtgggcattgaggaccctgtgcgcccagaggtgccagat
gctattgccaaatgcaaacaagctggcattactgtcagaatggtgacaggtgacaacatc
aacacagcccgggccattgccaccaaatgtggcattctgacacctggggatgacttcctg
tgcttagaaggcaaagaattcaaccggctcatccgcaacgagaaaggcgaggtagagcaa
gaaaagctggacaagatctggcctaagcttcgggtcctggcgcgatcttctcccactgac
aagcacaccctggtgaaaggcataattgacagcactgttggggaacaccggcaggtcgtg
gctgtcactggtgatggcacaaatgacgggcctgctctgaagaaagcggatgttggtttt
gccatgggcatcgcaggcacagatgtagcaaaggaggcttcagacatcatcctaacagat
gacaacttcaccagcattgtgaaggcagtgatgtggggacgaaatgtctatgacagcatc
tccaagttcctgcagttccagctcactgtcaatgtggtggccgtgattgtagccttcact
ggagcctgtatcactcaggattccccattgaaagctgtgcagatgttgtgggttaatctg
atcatggacacttttgcttcattggccctggccacagagccccctacggaatctctgttg
aagcggcgcccctatggccgaaataagcctctgatctcacgcactatgatgaagaacatc
ttgggccatgcattctatcagctcattgtcatctttatccttgtctttgcgggtgagaaa
ttctttgatattgatagtgggaggaaggcacctctacattcaccacccagccagcactat
accattgtttttaacaccttcgtgctgatgcagctcttcaatgaaatcaactcccgaaag
atccatggagagaagaacgtcttttcaggcatctaccgcaacattatcttctgctctgta
gtcttgggcacattcatctgccagattttcatcgtggaatttgggggtaaacccttcagt
tgtacaagcctcagcctgtctcagtggctgtggtgtctcttcattgggattggagaactt
ctgtggggccagttcatctccgcaatacctacccgatccctgaagttcctgaaggaggct
gggcatggcaccaccaaagaggagatcaccaaggatgccgagggactggatgagattgac
catgctgagatggagctgcgccgaggccagatcctctggttccggggcctgaaccgtatc
cagactcagatcaaagtggtcaaagcgttccatagttccctccacgaaagcattcagaaa
ccctacaaccaaaagtccatccacagcttcatgacccaccctgaattcgccatagaggag
gagttgccacgaacaccactcctggatgaggaagaggaggaaaatcctgacaaggcttct
aagtttgggactagggtgctcctgttggatggtgaggtcactccatatgccaatacaaac
aacaatgcggtggattgcaaccaagtgcagctcccccagtcggacagctctctacagagc
ctagagacatcagtttga
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integrated database retrieval system
