Homo sapiens (human): 5069
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Entry
5069 CDS
T01001
Symbol
PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Name
(RefSeq) pappalysin 1
KO
K07762
pappalysin-1 [EC:
3.4.24.79
]
Organism
hsa
Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
5069 (PAPPA)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.24 Metalloendopeptidases
3.4.24.79 pappalysin-1
5069 (PAPPA)
Peptidases and inhibitors [BR:
hsa01002
]
Metallo peptidases
Family M43: cytophagalysin family
5069 (PAPPA)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Sushi
Laminin_G_3
Peptidase_M43
DUF4215
Notch
Reprolysin_3
Peptidase_M10
Reprolysin_4
DUF4953
Motif
Other DBs
NCBI-GeneID:
5069
NCBI-ProteinID:
NP_002572
OMIM:
176385
HGNC:
8602
Ensembl:
ENSG00000182752
UniProt:
Q13219
Q7Z613
B4DTA8
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:116153791..116402321
Genome browser
AA seq
1627 aa
AA seq
DB search
MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGPATCATRAARGRRASPP
PPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFT
LQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRAR
QVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLML
GGSALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVKHAWSPM
KDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQLSSFRQPKVVRYRVVNL
YEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWELDVLEVSNSSLRRRLILANCDISKIG
DENCDPECNHTLTGHDGGDCRHLRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITN
VTQTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMH
LGGIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEPSFETGDLC
NDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYLD
LVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRILV
QYASNASSPMPCSPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQG
CYLELEFLYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLT
IRLWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVAS
ILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQC
DDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGFL
DQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLA
QTTFWLRAYFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCR
NNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSP
AEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQ
TGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQL
KGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPG
YHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRI
KCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIGS
ECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEP
FMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKD
LRGYSHG
NT seq
4884 nt
NT seq
+upstream
nt +downstream
nt
atgcggctctggagttgggtgctgcacctggggctgctgagcgccgcgctgggctgcggg
ctggccgagcgtccccgccgggcccggagagacccgcgggccggccgacccccgcgcccc
gccgccggcccggccacctgcgccacccgggcggcccgcggccgccgcgcctcgccgccg
ccgccgccgccgccgggcggtgcctgggaagccgtgcgcgtcccccggcggcggcagcag
cgggaggcgaggggcgccaccgaggagccgagcccgccgagccgggcgctctatttcagc
gggcgaggcgagcagctgcgcctccgggccgacctcgagctgccccgggacgcgttcacg
ctgcaagtgtggctgcgagcggaggggggccagaggtctccggcagtgatcacagggctg
tatgacaaatgttcttatatctcacgtgaccgaggatgggtcgtgggcattcacaccatc
agtgaccaagacaacaaagacccacgctactttttctccttgaagacagaccgagcccgg
caagtgaccaccatcaatgcccaccgcagctacctcccaggccagtgggtatacctagct
gccacctatgatgggcagttcatgaagctctatgtgaatggtgcccaggtggccacctct
ggggaacaagtgggtggcatattcagcccactgacccagaagtgcaaagtgctcatgtta
gggggcagtgccctgaatcacaactaccggggctacatcgagcacttcagtctgtggaag
gtggccaggactcagcgggagatactgtctgacatggaaacccatggcgcccacactgct
ctacctcagctcctcctccaggagaactgggacaatgtgaagcatgcctggtcccccatg
aaggatggcagcagccccaaagtggaattcagcaatgcccacggctttctgctggacacg
agtctggagcctcctctgtgcggacagacattgtgtgacaacacagaggtcattgccagc
tacaatcagctctcaagtttccgccagcccaaggtggtgcgctaccgcgtggtcaacctc
tatgaagatgatcataagaacccgacggtgacgcgcgagcaggtggacttccagcaccat
cagctggctgaggccttcaagcaatacaacatctcctgggagctggacgtgctggaggtg
agcaactcctcccttcgccgccgcctcatcctggccaactgtgacatcagcaagattggg
gatgagaactgtgaccccgagtgcaaccacacgctgacgggccacgacggcggggattgc
cgccacctgcgccaccctgccttcgtgaagaagcagcacaacggggtgtgtgacatggac
tgcaactatgaacggttcaactttgatggtggagagtgctgtgaccctgaaatcaccaat
gtcactcagacttgctttgaccccgactctccacacagagcctacttggatgttaatgag
ctgaagaacattcttaaattggatggatcaacacatctcaatattttctttgcaaaatcc
tcagaggaggagttggcaggagtagcaacttggccatgggacaaggaggccctgatgcac
ttaggtggcattgtcttgaacccatctttctatggcatgcctgggcacacccacaccatg
atccatgagattggtcacagcctgggcctctatcacgtcttccgaggcatctcagaaatc
cagtcctgcagtgacccctgcatggagacagagccctccttcgagactggagacctctgc
aatgataccaacccagcccctaaacacaagtcctgtggtgacccagggccaggaaatgac
acctgtggctttcatagcttcttcaacactccttacaacaacttcatgagctatgcagat
gacgactgtacggactccttcacgcccaatcaagtcgccagaatgcactgttacctggac
ctggtctaccagggctggcagccctccaggaaaccagcgcctgttgccctcgccccccaa
gttctgggccacacaacggactctgtgacactggagtggttcccacctatagatggccat
ttctttgaaagagaattgggatcagcatgtcatctttgcctggaagggagaatcctggtg
cagtatgcttccaacgcttcctccccaatgccctgcagcccatcaggacactggagccct
cgtgaagcagaaggtcatcctgatgttgaacagccctgtaagtccagtgtccgcacctgg
agcccaaattcagctgtcaacccacacacggttcctccagcctgccctgagcctcaaggc
tgctacctcgagctggagttcctctaccccttggtccctgagtctctgaccatttgggtg
acctttgtctccactgactgggactctagtggagctgtcaatgacatcaaactgttggct
gtcagtgggaagaacatctccctgggtcctcagaatgtcttctgtgatgtcccactgacc
atcagactctgggacgtgggcgaggaggtgtatggcatccaaatctacacgctggatgag
cacctggagatcgatgctgccatgttgacctccactgcagacaccccactctgtctacag
tgtaagcccctgaagtataaggtggtccgggaccctcctctccagatggatgtggcctcc
atcctacatctcaataggaaattcgtagacatggatctaaatcttggcagtgtgtaccag
tattgggtcataactatttcaggaactgaagagagtgagccatcacctgctgtcacatac
atccatggaagtgggtactgtggcgatggcattatacaaaaagaccaaggtgaacaatgc
gacgacatgaataagatcaatggtgatggctgctcccttttctgccgacaagaagtctcc
ttcaattgtattgatgaacccagccggtgctatttccatgatggtgatggggtatgtgag
gagtttgaacaaaaaaccagcattaaggactgtggtgtctacacgccccagggattcctg
gatcagtgggcatccaatgcttcagtatctcatcaagaccagcaatgcccaggctgggtc
atcatcggacagccagcagcatcccaggtgtgtcgaaccaaggtgatagatctcagtgaa
ggcatttcccagcatgcctggtacccttgcaccatcagctacccatattcccagctggct
cagaccactttttggctccgggcgtatttttctcaaccaatggttgccgcagctgtcatt
gtccacctggtgacggatgggacatattatggggaccaaaagcaggagaccatcagcgtg
cagctgcttgataccaaagatcagagccacgatctaggcctccatgtcctgagctgcagg
aacaatcccctgattatccctgtggtccatgacctcagccagcccttctaccacagccag
gcggtacgtgtgagcttcagttcgcccctggtcgccatctcgggggtggccctccgttcc
ttcgacaactttgaccccgtcaccctgagcagctgccagagaggggagacctacagccct
gccgagcagagctgcgtgcacttcgcatgtgagaaaactgactgtccagagctggctgtg
gagaatgcttctctcaattgctccagcagcgaccgctaccacggtgcccagtgtactgtg
agctgccggacaggctacgtgctccagatacggcgggatgatgagctgatcaagagccag
acgggacccagcgtcacagtgacctgtacagagggcaagtggaataagcaggtggcctgt
gagccagtcgactgcagcatcccagatcaccatcaagtctatgctgcctccttctcctgc
cctgagggcaccacctttggcagtcaatgttccttccagtgccgtcaccctgcacaattg
aaaggcaacaacagcctcctgacctgcatggaggatgggctgtggtccttcccagaggcc
ctgtgtgagctcatgtgcctcgctccaccccctgtgcccaatgcagacctccagaccgcc
cggtgccgagagaataagcacaaggtgggctccttctgcaaatacaaatgcaagcctgga
taccatgtgcctggatcctctcggaagtcaaagaaacgggccttcaagactcagtgtacc
caggatggcagctggcaggagggagcttgtgttcctgtgacctgtgacccacctccacca
aaattccatgggctctaccagtgtactaatggcttccagttcaacagtgagtgtaggatc
aagtgtgaagacagtgatgcctcccagggacttgggagcaatgtcattcattgccggaaa
gatggcacctggaacggctccttccatgtctgccaggagatgcaaggccagtgctcggtt
ccaaacgagctcaacagcaacctcaaactgcagtgccctgatggctatgccatagggtcg
gagtgtgccacctcgtgcctggaccacaacagcgagtccatcatcctgccaatgaacgtg
accgtgcgtgacatcccccactggctgaaccccacacgggtagagagagttgtctgcact
gctggtctcaagtggtatcctcaccctgctctgattcactgtgtcaaaggctgtgagccc
ttcatgggagacaattattgtgatgccatcaacaaccgagccttttgcaactatgacggt
ggggattgctgcacctccacagtgaagaccaaaaaggtcaccccattccctatgtcctgt
gatctacaaggtgactgtgcttgtcgggacccccaggcccaagaacacagccggaaagac
ctccggggatacagccatggctaa
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