Homo sapiens (human): 5091
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Entry
5091 CDS
T01001
Symbol
PC, PCB
Name
(RefSeq) pyruvate carboxylase
KO
K01958
pyruvate carboxylase [EC:
6.4.1.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00020
Citrate cycle (TCA cycle)
hsa00620
Pyruvate metabolism
hsa01100
Metabolic pathways
hsa01200
Carbon metabolism
hsa01230
Biosynthesis of amino acids
Network
nt06031
Citrate cycle and pyruvate metabolism
Element
N01605
Gluconeogenesis
Disease
H00073
Pyruvate carboxylase deficiency
H01400
Secondary hyperammonemia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
5091 (PC)
00620 Pyruvate metabolism
5091 (PC)
Enzymes [BR:
hsa01000
]
6. Ligases
6.4 Forming carbon-carbon bonds
6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
6.4.1.1 pyruvate carboxylase
5091 (PC)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CPSase_L_D2
PYC_OADA
Biotin_carb_N
Biotin_carb_C
Biotin_lipoyl
HMGL-like
Dala_Dala_lig_C
Biotin_lipoyl_2
ATP-grasp_3
ATPgrasp_ST
Motif
Other DBs
NCBI-GeneID:
5091
NCBI-ProteinID:
NP_000911
OMIM:
608786
HGNC:
8636
Ensembl:
ENSG00000173599
UniProt:
P11498
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(66848420..66958383)
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AA seq
1178 aa
AA seq
DB search
MLKFRTVHGGLRLLGIRRTSTAPAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELG
IRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGF
LSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEA
HEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIE
KPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAK
QVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL
GLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISP
HYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIAFLQNVLNNQQFLAGTVDTQF
IDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAG
FRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSK
LFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVF
KFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSL
QYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGV
AAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEG
ARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQM
LGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFP
EPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHF
KDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFEL
NGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVL
SAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE
NT seq
3537 nt
NT seq
+upstream
nt +downstream
nt
atgctgaagttccgaacagtccatgggggcctgaggctcctgggaatccgccgaacctcc
accgcccccgctgcctccccaaatgtccggcgcctggagtataagcccatcaagaaagtc
atggtggccaacagaggtgagattgccatccgtgtgttccgggcctgcacggagctgggc
atccgcaccgtagccatctactctgagcaggacacgggccagatgcaccggcagaaagca
gatgaagcctatctcatcggccgcggcctggcccccgtgcaggcctacctgcacatccca
gacatcatcaaggtggccaaggagaacaacgtagatgcagtgcaccctggctacgggttc
ctctctgagcgagcggacttcgcccaggcctgccaggatgcaggggtccggtttattggg
ccaagcccagaagtggtccgcaagatgggagacaaggtggaggcccgggccatcgccatt
gctgcgggtgttcccgttgtccctggcacagatgcccccatcacgtccctgcatgaggcc
cacgagttctccaacacctacggcttccccatcatcttcaaggcggcctatgggggtgga
gggcgtggcatgagggtggtgcacagctacgaggagctggaggagaattacacccgggcc
tactcagaggctctggccgcctttgggaatggggcgctgtttgtggagaagttcatcgag
aagccacggcacatcgaggtgcagatcttgggggaccagtatgggaacatcctgcacctg
tacgagcgagactgctccatccagcggcggcaccagaaggtggtcgagattgcccccgcc
gcccacctggacccgcagcttcggactcggctcaccagcgactctgtgaaactcgctaaa
caggtgggctacgagaacgcaggcaccgtggagttcctggtggacaggcacggcaagcac
tacttcatcgaggtcaactcccgcctgcaggtggagcacacggtcacagaggagatcacc
gacgtagacctggtccatgctcagatccacgtggctgagggcaggagcctacccgacctg
ggcctgcggcaggagaacatccgcatcaacgggtgtgccatccagtgccgggtcaccacc
gaggaccccgcgcgcagcttccagccggacaccggccgcattgaggtgttccggagcgga
gagggcatgggcatccgcctggataatgcttccgccttccaaggagccgtcatctcgccc
cactacgactccctgctggtcaaagtcattgcccacggcaaagaccaccccacggccgcc
accaagatgagcagggcccttgcggagttccgcgtccgaggtgtgaagaccaacatcgcc
ttcctgcagaatgtgctcaacaaccagcagttcctggcaggcactgtggacacccagttc
atcgacgagaacccagagctgttccagctgcggcctgcacagaaccgggcccaaaagctg
ttgcactacctcggccatgtcatggtaaacggtccaaccaccccgattcccgtcaaggcc
agccccagccccacggaccccgttgtccctgcagtgcccataggcccgcccccggctggt
ttcagagacatcctgctgcgagaggggcctgagggctttgctcgagctgtgcggaaccac
ccggggctgctgctgatggacacgaccttcagggacgcccaccagtcactgctggccact
cgtgtgcgcacccacgatctcaaaaagatcgccccctatgttgcccacaacttcagcaag
ctcttcagcatggagaactggggaggagccacgtttgacgtcgccatgcgcttcctgtat
gagtgcccctggcggcggctgcaggagctccgggagctcatccccaacatccctttccag
atgctgctgcggggggccaatgctgtgggctacaccaactacccagacaacgtggtcttc
aagttctgtgaagtggccaaagagaatggcatggatgtcttccgtgtgtttgactccctc
aactacttgcccaacatgctgctgggcatggaggcggcaggaagtgccggaggcgtggtg
gaggctgccatctcatacacgggcgacgtggccgaccccagccgcaccaagtactcactg
cagtactacatgggcttggccgaagagctggtgcgagctggcacccacatcctgtgcatc
aaggacatggccgggctgctgaagcccacggcctgcaccatgctggtcagctccctccgg
gaccgcttccccgacctcccactgcacatccacacccacgacacgtcaggggcaggcgtg
gcagccatgctggcctgtgcccaggctggagctgatgtggtggatgtggcagctgattcc
atgtctgggatgacttcacagcccagcatgggggccctggtggcctgtaccagagggact
cccctggacacagaggtgcccatggagcgcgtgtttgactacagtgagtactgggagggg
gctcggggactgtacgcggccttcgactgcacggccaccatgaagtctggcaactcggac
gtgtatgaaaatgagatcccagggggccagtacaccaacctgcacttccaggcccacagc
atggggcttggctccaagttcaaggaggtcaagaaggcctatgtggaggccaaccagatg
ctgggcgatctcatcaaggtgacgccctcctccaagatcgtgggggacctggcccagttt
atggtgcagaatggattgagccgggcagaggccgaagctcaggcggaagagctgtccttt
ccccgctccgtggtggagttcctgcagggctacatcggtgtcccccatggggggttcccc
gaaccctttcgctctaaggtactgaaggacctgccaagggtggaggggcggcctggagcc
tccctccctcccctggatctgcaggcactggagaaggagctggtagaccggcatggggag
gaggtgacgccggaagatgtgctctcagcagctatgtaccccgatgtgtttgcccacttc
aaggacttcactgccacctttggccccctggatagcctgaatactcgcctcttcctgcag
ggacccaagatcgcagaggagtttgaggtggagctggagcggggcaagacgctgcacatc
aaagccctggccgtgagcgacctgaaccgggccggccagaggcaggtcttctttgagctc
aatgggcagctgcggtccatcttggtcaaggacacccaggccatgaaggagatgcacttc
caccccaaggccctaaaggacgtgaagggccagatcggggcgcccatgcctgggaaggtg
atagacatcaaagtggtggcaggggccaaggtggccaagggccagcccctgtgtgtgctc
agtgccatgaagatggagactgtggtgacctcacccatggagggtactgtccgcaaggtt
catgtgaccaaggacatgacactggaaggtgacgacctcatcctggagatcgagtga
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integrated database retrieval system
