Homo sapiens (human): 5152
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Entry
5152 CDS
T01001
Symbol
PDE9A, HSPDE9A2
Name
(RefSeq) high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a
KO
K13761
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 [EC:
3.1.4.35
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
Drug target
Edelinontrine:
D13001
Tovinontrine:
D12203
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5152 (PDE9A)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
5152 (PDE9A)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PDEase_I
CUE_1
HD-CE
GcvP2_C
Motif
Other DBs
NCBI-GeneID:
5152
NCBI-ProteinID:
NP_002597
OMIM:
602973
HGNC:
8795
Ensembl:
ENSP00000291539.6
UniProt:
O76083
A0A0S2Z4T6
Structure
PDB
PDBj
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All DBs
Position
21:42653621..42775509
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AA seq
593 aa
AA seq
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MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
NT seq
1782 nt
NT seq
+upstream
nt +downstream
nt
atgggatccggctcctccagctaccggcccaaggccatctacctggacatcgatggacgc
attcagaaggtaatcttcagcaagtactgcaactccagcgacatcatggacctgttctgc
atcgccaccggcctgcctcggaacacgaccatctccctgctgaccaccgacgacgccatg
gtctccatcgaccccaccatgcccgcgaattcagaacgcactccgtacaaagtgagacct
gtggccatcaagcaactctccgctggtgtcgaggacaagagaaccacaagccgtggccag
tctgctgagagaccactgagggacagacgggttgtgggcctggagcagccccggagggaa
ggagcatttgaaagtggacaggtagagcccaggcccagagagccccagggctgctaccag
gaaggccagcgcatccctccagagagagaagaattaatccagagcgtgctggcgcaggtt
gcagagcagttctcaagagcattcaaaatcaatgaactgaaagctgaagttgcaaatcac
ttggctgtcctagagaaacgcgtggaattggaaggactaaaagtggtggagattgagaaa
tgcaagagtgacattaagaagatgagggaggagctggcggccagaagcagcaggaccaac
tgcccctgtaagtacagttttttggataaccacaagaagttgactcctcgacgcgatgtt
cccacttaccccaagtacctgctctctccagagaccatcgaggccctgcggaagccgacc
tttgacgtctggctttgggagcccaatgagatgctgagctgcctggagcacatgtaccac
gacctcgggctggtcagggacttcagcatcaaccctgtcaccctcaggaggtggctgttc
tgcgtccacgacaactacagaaacaaccccttccacaacttccggcactgcttctgcgtg
gcccagatgatgtacagcatggtctggctctgcagtctccaggagaagttctcacaaacg
gatatcctgatcctaatgacagcggccatctgccacgatctggaccatcccggctacaac
aacacgtaccagatcaatgcccgcacagagctggcggtccgctacaatgacatctcaccg
ctggagaaccaccactgcgccgtggccttccagatcctcgccgagcctgagtgcaacatc
ttctccaacatcccacctgatgggttcaagcagatccgacagggaatgatcacattaatc
ttggccactgacatggcaagacatgcagaaattatggattctttcaaagagaaaatggag
aattttgactacagcaacgaggagcacatgaccctgctgaagatgattttgataaaatgc
tgtgatatctctaacgaggtccgtccaatggaagtcgcagagccttgggtggactgttta
ttagaggaatattttatgcagagcgaccgtgagaagtcagaaggccttcctgtggcaccg
ttcatggaccgagacaaagtgaccaaggccacagcccagattgggttcatcaagtttgtc
ctgatcccaatgtttgaaacagtgaccaagctcttccccatggttgaggagatcatgctg
cagccactttgggaatcccgagatcgctacgaggagctgaagcggatagatgacgccatg
aaagagttacagaagaagactgacagcttgacgtctggggccaccgagaagtccagagag
agaagcagagatgtgaaaaacagtgaaggagactgtgcctga
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