Homo sapiens (human): 5160
Help
Entry
5160 CDS
T01001
Symbol
PDHA1, PDHA, PDHAD, PDHCE1A, PHE1A
Name
(RefSeq) pyruvate dehydrogenase E1 subunit alpha 1
KO
K00161
pyruvate dehydrogenase E1 component alpha subunit [EC:
1.2.4.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00010
Glycolysis / Gluconeogenesis
hsa00020
Citrate cycle (TCA cycle)
hsa00620
Pyruvate metabolism
hsa01100
Metabolic pathways
hsa01200
Carbon metabolism
hsa04066
HIF-1 signaling pathway
hsa04922
Glucagon signaling pathway
hsa05230
Central carbon metabolism in cancer
hsa05415
Diabetic cardiomyopathy
Module
hsa_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Disease
H00072
Pyruvate dehydrogenase complex deficiency
H01997
Pyruvate dehydrogenase E1-alpha deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
5160 (PDHA1)
00020 Citrate cycle (TCA cycle)
5160 (PDHA1)
00620 Pyruvate metabolism
5160 (PDHA1)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
5160 (PDHA1)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
5160 (PDHA1)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
5160 (PDHA1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
5160 (PDHA1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
5160 (PDHA1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1_dh
DXP_synthase_N
TPP_enzyme_C
Motif
Other DBs
NCBI-GeneID:
5160
NCBI-ProteinID:
NP_000275
OMIM:
300502
HGNC:
8806
Ensembl:
ENSG00000131828
Pharos:
P08559
(Tbio)
UniProt:
P08559
A0A024RBX9
Structure
PDB
LinkDB
All DBs
Position
X:19343927..19361718
Genome browser
AA seq
390 aa
AA seq
DB search
MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS
NT seq
1173 nt
NT seq
+upstream
nt +downstream
nt
atgaggaagatgctcgccgccgtctcccgcgtgctgtctggcgcttctcagaagccggca
agcagagtgctggtagcatcccgtaattttgcaaatgatgctacatttgaaattaagaaa
tgtgaccttcaccggctggaagaaggccctcctgtcacaacagtgctcaccagggaggat
gggctcaaatactacaggatgatgcagactgtacgccgaatggagttgaaagcagatcag
ctgtataaacagaaaattattcgtggtttctgtcacttgtgtgatggtcaggaagcttgc
tgtgtgggcctggaggccggcatcaaccccacagaccatctcatcacagcctaccgggct
cacggctttactttcacccggggcctttccgtccgagaaattctcgcagagcttacagga
cgaaaaggaggttgtgctaaagggaaaggaggatcgatgcacatgtatgccaagaacttc
tacgggggcaatggcatcgtgggagcgcaggtgcccctgggcgctgggattgctctagcc
tgtaagtataatggaaaagatgaggtctgcctgactttatatggcgatggtgctgctaac
cagggccagatattcgaagcttacaacatggcagctttgtggaaattaccttgtattttc
atctgtgagaataatcgctatggaatgggaacgtctgttgagagagcggcagccagcact
gattactacaagagaggcgatttcattcctgggctgagagtggatggaatggatatcctg
tgcgtccgagaggcaacaaggtttgctgctgcctattgtagatctgggaaggggcccatc
ctgatggagctgcagacttaccgttaccacggacacagtatgagtgaccctggagtcagt
taccgtacacgagaagaaattcaggaagtaagaagtaagagtgaccctattatgcttctc
aaggacaggatggtgaacagcaatcttgccagtgtggaagaactaaaggaaattgatgtg
gaagtgaggaaggagattgaggatgctgcccagtttgccacggccgatcctgagccacct
ttggaagagctgggctaccacatctactccagcgacccaccttttgaagttcgtggtgcc
aatcagtggatcaagtttaagtcagtcagttaa
Homo sapiens (human): 5161
Help
Entry
5161 CDS
T01001
Symbol
PDHA2, PDHAL, SPGF70
Name
(RefSeq) pyruvate dehydrogenase E1 subunit alpha 2
KO
K00161
pyruvate dehydrogenase E1 component alpha subunit [EC:
1.2.4.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00010
Glycolysis / Gluconeogenesis
hsa00020
Citrate cycle (TCA cycle)
hsa00620
Pyruvate metabolism
hsa01100
Metabolic pathways
hsa01200
Carbon metabolism
hsa04066
HIF-1 signaling pathway
hsa04922
Glucagon signaling pathway
hsa05230
Central carbon metabolism in cancer
hsa05415
Diabetic cardiomyopathy
Module
hsa_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Disease
H01282
Spermatogenic failure
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
5161 (PDHA2)
00020 Citrate cycle (TCA cycle)
5161 (PDHA2)
00620 Pyruvate metabolism
5161 (PDHA2)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
5161 (PDHA2)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
5161 (PDHA2)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
5161 (PDHA2)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
5161 (PDHA2)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
5161 (PDHA2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1_dh
TPP_enzyme_C
DXP_synthase_N
Motif
Other DBs
NCBI-GeneID:
5161
NCBI-ProteinID:
NP_005381
OMIM:
179061
HGNC:
8807
Ensembl:
ENSG00000163114
Pharos:
P29803
(Tbio)
UniProt:
P29803
LinkDB
All DBs
Position
4:95840093..95841464
Genome browser
AA seq
388 aa
AA seq
DB search
MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGL
KYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHG
VCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACK
YKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDY
YKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYR
TREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLE
ELGHHIYSSDSSFEVRGANPWIKFKSVS
NT seq
1167 nt
NT seq
+upstream
nt +downstream
nt
atgctggccgccttcatctcccgcgtgttgaggcgagttgcccagaaatcagctcgcaga
gtgctggtggcatcccgtaactcctcaaatgacgctacatttgaaattaagaaatgtgat
ctttatctgttggaagagggtccccctgtcactacagtgctcactagggcggaggggctt
aaatactacaggatgatgctgactgttcgccgcatggaattgaaggcagatcagctgtac
aaacagaaattcattcgcggtttctgtcacctgtgcgatggtcaggaagcttgttgcgtg
ggccttgaggccggcataaacccctcggatcacgtcattacatcctatagggctcatggt
gtgtgctatactcggggactttctgtccgatccattctcgcagagctgacgggaagaaga
ggaggttgtgctaaaggaaaaggaggatcgatgcatatgtataccaagaacttctatggg
ggcaatggcatcgtcggtgcacagggccccctgggcgctggcattgctctggcctgtaaa
tataaaggaaacgatgagatctgtttgactttatatggggatggcgctgcgaatcagggg
cagatagccgaagctttcaatatggcagctttatggaaattaccttgtgttttcatctgt
gagaataacctatatggaatgggaacatctactgagagagcagcagccagccctgattac
tacaagaggggcaattttatccctgggctaaaggtcgatggaatggatgttctgtgtgtt
cgtgaggcaacaaaatttgcagctaactactgtagatctggaaaggggcccatactgatg
gagctgcaaacctaccgttatcatggacacagtatgagtgatcctggagtcagttatcgt
acacgagaagaaattcaggaagtaagaagtaagagggatcctataataattctccaagat
agaatggtaaacagcaagctcgccactgtggaagaattaaaggaaattggggctgaggtg
aggaaagaaattgatgatgctgcccagtttgctaccactgatcctgagccacatttggaa
gaattaggccatcacatctacagcagtgattcatcttttgaagttcgtggtgcaaatcca
tggatcaagtttaagtccgtcagttaa
Homo sapiens (human): 5162
Help
Entry
5162 CDS
T01001
Symbol
PDHB, PDHBD, PDHE1-B, PDHE1B, PHE1B
Name
(RefSeq) pyruvate dehydrogenase E1 subunit beta
KO
K00162
pyruvate dehydrogenase E1 component beta subunit [EC:
1.2.4.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00010
Glycolysis / Gluconeogenesis
hsa00020
Citrate cycle (TCA cycle)
hsa00620
Pyruvate metabolism
hsa01100
Metabolic pathways
hsa01200
Carbon metabolism
hsa04066
HIF-1 signaling pathway
hsa04922
Glucagon signaling pathway
hsa05230
Central carbon metabolism in cancer
hsa05415
Diabetic cardiomyopathy
Module
hsa_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Disease
H00072
Pyruvate dehydrogenase complex deficiency
H01998
Pyruvate dehydrogenase E1-beta deficiency
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
5162 (PDHB)
00020 Citrate cycle (TCA cycle)
5162 (PDHB)
00620 Pyruvate metabolism
5162 (PDHB)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
5162 (PDHB)
09150 Organismal Systems
09152 Endocrine system
04922 Glucagon signaling pathway
5162 (PDHB)
09160 Human Diseases
09161 Cancer: overview
05230 Central carbon metabolism in cancer
5162 (PDHB)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
5162 (PDHB)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
5162 (PDHB)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Transket_pyr
Transketolase_C
Motif
Other DBs
NCBI-GeneID:
5162
NCBI-ProteinID:
NP_000916
OMIM:
179060
HGNC:
8808
Ensembl:
ENSG00000168291
Pharos:
P11177
(Tbio)
UniProt:
P11177
A0A384MDR8
Structure
PDB
LinkDB
All DBs
Position
3:complement(58427630..58433832)
Genome browser
AA seq
359 aa
AA seq
DB search
MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV
SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
NT seq
1080 nt
NT seq
+upstream
nt +downstream
nt
atggcggcggtgtctggcttggtgcggagaccccttcgggaggtctccgggctgctgaag
aggcgctttcactggaccgcgccggctgcgctgcaggtgacagttcgtgatgctataaat
cagggtatggatgaggagctggaaagagatgagaaggtatttctgcttggagaagaagtt
gcccagtatgatggggcatacaaggttagtcgagggctgtggaagaaatatggagacaag
aggattattgacactcccatatcagagatgggctttgctggaattgctgtaggtgcagct
atggctgggttgcggcccatttgtgaatttatgaccttcaatttctccatgcaagccatt
gaccaggttataaactcagctgccaagacctactacatgtctggtggccttcagcctgtg
cctatagtcttcagagggcccaatggtgcctcagcaggtgtagctgcccagcactcacag
tgctttgctgcctggtatgggcactgcccaggcttaaaggtggtcagtccctggaattca
gaggatgctaaaggacttattaaatcagccattcgggataacaatccagtggtggtgcta
gagaatgaattgatgtatggggttccttttgaatttcctccggaagctcagtcaaaagat
tttctgattcctattggaaaagccaaaatagaaaggcaaggaacacatataactgtggtt
tcccattcaagacctgtgggccactgcttagaagctgcagcagtgctatctaaagaagga
gttgaatgtgaggtgataaatatgcgtaccattagaccaatggacatggaaaccatagaa
gccagtgtcatgaagacaaatcatcttgtaactgtggaaggaggctggccacagtttgga
gtaggagctgaaatctgtgccaggatcatggaaggtcctgcgttcaatttcctggatgct
cctgctgttcgtgtcactggtgctgatgtccctatgccttatgcaaagattctagaggac
aactctatacctcaggtcaaagacatcatatttgcaataaagaaaacattaaatatttag
DBGET
integrated database retrieval system