Homo sapiens (human): 51755 Help Entry 51755             CDS       T01001                                  Symbol CDK12, CRK7, CRKR, CRKRS Name (RefSeq) cyclin dependent kinase 12   KO K08819   cyclin-dependent kinase 12/13 [EC:2.7.11.22 2.7.11.23] Organism hsa  Homo sapiens (human) Brite KEGG Orthology (KO) [BR:hsa00001]  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     51755 (CDK12) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.22  cyclin-dependent kinase      51755 (CDK12)     2.7.11.23  [RNA-polymerase]-subunit kinase      51755 (CDK12) Protein kinases [BR:hsa01001]  Serine/threonine kinases: CMGC group   CDK family    51755 (CDK12) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase Kinase-like Med15_M Motif Other DBs NCBI-GeneID:  51755 NCBI-ProteinID:  NP_057591 OMIM:  615514 HGNC:  24224 Ensembl:  ENSG00000167258 UniProt:  Q9NYV4 Structure PDBPDBj LinkDB All DBs Position 17:39461486..39567559 Genome browser AA seq 1490 aa AA seqDB search MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEA ASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSR DLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGA SYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQR SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES KGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGK VKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQAN SQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQ RTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWG KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQ LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM KQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLW YRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVW PDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL KDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVK NSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNI HSNPEMQQQLEALNQSISALTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEAS STPADMQNILAVLLSQLMKTQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAACPPHIL PPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEH QALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL SHLGESSSYQGTGSVQFPGDQDLRFARVPLALHPVVGQPFLKAEGSSNSVVHAETKLQNY GELGPGTTGASSSGAGLHWGGPTQSSAYGKLYRGPTRVPPRGGRGRGVPY NT seq 4473 nt NT seq  +upstreamnt  +downstreamnt atgcccaattcagagagacatgggggcaagaaggacgggagtggaggagcttctggaact ttgcagccgtcatcgggaggcggcagctctaacagcagagagcgtcaccgcttggtatcg aagcacaagcggcataagtccaaacactccaaagacatggggttggtgacccccgaagca gcatccctgggcacagttatcaaacctttggtggagtatgatgatatcagctctgattcc gacaccttctccgatgacatggccttcaaactagaccgaagggagaacgacgaacgtcgt ggatcagatcggagcgaccgcctgcacaaacatcgtcaccaccagcacaggcgttcccgg gacttactaaaagctaaacagaccgaaaaagaaaaaagccaagaagtctccagcaagtcg ggatcgatgaaggaccggatatcgggaagttcaaagcgttcgaatgaggagactgatgac tatgggaaggcgcaggtagccaaaagcagcagcaaggaatccaggtcatccaagctccac aaggagaagaccaggaaagaacgggagctgaagtctgggcacaaagaccggagtaaaagt catcgaaaaagggaaacacccaaaagttacaaaacagtggacagcccaaaacggagatcc aggagcccccacaggaagtggtctgacagctccaaacaagatgatagcccctcgggagct tcttatggccaagattatgaccttagtccctcacgatctcatacctcgagcaattatgac tcctacaagaaaagtcctggaagtacctcgagaaggcagtcggtcagtcccccttacaag gagccttcggcctaccagtccagcacccggtcaccgagcccctacagtaggcgacagaga tctgtcagtccctatagcaggagacggtcgtccagctacgaaagaagtggctcttacagc gggcgatcgcccagtccctatggtcgaaggcggtccagcagccctttcctgagcaagcgg tctctgagtcggagtccactccccagtaggaaatccatgaagtccagaagtagaagtcct gcatattcaagacattcatcttctcatagtaaaaagaagagatccagttcacgcagtcgt cattccagtatctcacctgtcaggcttccacttaattccagtctgggagctgaactcagt aggaaaaagaaggaaagagcagctgctgctgctgcagcaaagatggatggaaaggagtcc aagggttcacctgtatttttgcctagaaaagagaacagttcagtagaggctaaggattca ggtttggagtctaaaaagttacccagaagtgtaaaattggaaaaatctgccccagatact gaactggtgaatgtaacacatctaaacacagaggtaaaaaattcttcagatacagggaaa gtaaagttggatgagaactccgagaagcatcttgttaaagatttgaaagcacagggaaca agagactctaaacccatagcactgaaagaggagattgttactccaaaggagacagaaaca tcagaaaaggagacccctccacctcttcccacaattgcttctcccccaccccctctacca actactacccctccacctcagacaccccctttgccacctttgcctccaataccagctctt ccacagcaaccacctctgcctccttctcagccagcatttagtcaggttcctgcttccagt acttcaactttgcccccttctactcactcaaagacatctgctgtgtcctctcaggcaaat tctcagccccctgtacaggtttctgtgaagactcaagtatctgtaacagctgctattcca cacctgaaaacttcaacgttgcctcctttgcccctcccacccttattacctggagatgat gacatggatagtccaaaagaaactcttccttcaaaacctgtgaagaaagagaaggaacag aggacacgtcacttactcacagaccttcctctccctccagagctccctggtggagatctg tctcccccagactctccagaaccaaaggcaatcacaccacctcagcaaccatataaaaag agaccaaaaatttgttgtcctcgttatggagaaagaagacaaacagaaagcgactggggg aaacgctgtgtggacaagtttgacattattgggattattggagaaggaacctatggccaa gtatataaagccaaggacaaagacacaggagaactagtggctctgaagaaggtgagacta gacaatgagaaagagggcttcccaatcacagccattcgtgaaatcaaaatccttcgtcag ttaatccaccgaagtgttgttaacatgaaggaaattgtcacagataaacaagatgcactg gatttcaagaaggacaaaggtgccttttaccttgtatttgagtatatggaccatgactta atgggactgctagaatctggtttggtgcacttttctgaggaccatatcaagtcgttcatg aaacagctaatggaaggattggaatactgtcacaaaaagaatttcctgcatcgggatatt aagtgttctaacattttgctgaataacagtgggcaaatcaaactagcagattttggactt gctcggctctataactctgaagagagtcgcccttacacaaacaaagtcattactttgtgg taccgacctccagaactactgctaggagaggaacgttacacaccagccatagatgtttgg agctgtggatgtattcttggggaactattcacaaagaagcctatttttcaagccaatctg gaactggctcagctagaactgatcagccgactttgtggtagcccttgtccagctgtgtgg cctgatgttatcaaactgccctacttcaacaccatgaaaccgaagaagcaatatcgaagg cgtctacgagaagaattctctttcattccttctgcagcacttgatttattggaccacatg ctgacactagatcctagtaagcggtgcacagctgaacagaccctacagagcgacttcctt aaagatgtcgaactcagcaaaatggctcctccagacctcccccactggcaggattgccat gagttgtggagtaagaaacggcgacgtcagcgacaaagtggtgttgtagtcgaagagcca cctccatccaaaacttctcgaaaagaaactacctcagggacaagtactgagcctgtgaag aacagcagcccagcaccacctcagcctgctcctggcaaggtggagtctggggctggggat gcaataggccttgctgacatcacacaacagctgaatcaaagtgaattggcagtgttatta aacctgctgcagagccaaaccgacctgagcatccctcaaatggcacagctgcttaacatc cactccaacccagagatgcagcagcagctggaagccctgaaccaatccatcagtgccctg acggaagctacttcccagcagcaggactcagagaccatggccccagaggagtctttgaag gaagcaccctctgccccagtgatcctgccttcagcagaacagacgacccttgaagcttca agcacaccagctgacatgcagaatatattggcagttctcttgagtcagctgatgaaaacc caagagccagcaggcagtctggaggaaaacaacagtgacaagaacagtgggccacagggg ccccgaagaactcccacaatgccacaggaggaggcagcagcatgtcctcctcacattctt ccaccagagaagaggccccctgagccccccggacctccaccgccgccacctccaccccct ctggttgaaggcgatctttccagcgccccccaggagttgaacccagccgtgacagccgcc ttgctgcaacttttatcccagcctgaagcagagcctcctggccacctgccacatgagcac caggccttgagaccaatggagtactccacccgaccccgtccaaacaggacttatggaaac actgatgggcctgaaacagggttcagtgccattgacactgatgaacgaaactctggtcca gccttgacagaatccttggtccagaccctggtgaagaacaggaccttctcaggctctctg agccaccttggggagtccagcagttaccagggcacagggtcagtgcagtttccaggggac caggacctccgttttgccagggtccccttagcgttacacccggtggtcgggcaaccattc ctgaaggctgagggaagcagcaattctgtggtacatgcagagaccaaattgcaaaactat ggggagctggggccaggaaccactggggccagcagctcaggagcaggccttcactggggg ggcccaactcagtcttctgcttatggaaaactctatcgggggcctacaagagtcccacca agagggggaagagggagaggagttccttactaa

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