Homo sapiens (human): 5198
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Entry
5198 CDS
T01001
Symbol
PFAS, FGAMS, FGAR-AT, FGARAT, GATD8, PURL
Name
(RefSeq) phosphoribosylformylglycinamidine synthase
KO
K01952
phosphoribosylformylglycinamidine synthase [EC:
6.3.5.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
Module
hsa_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5198 (PFAS)
Enzymes [BR:
hsa01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.5 Carbon-nitrogen ligases with glutamine as amido-N-donor
6.3.5.3 phosphoribosylformylglycinamidine synthase
5198 (PFAS)
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Gene cluster
GFIT
Motif
Pfam:
GATase_5
FGAR-AT_PurM_N-like
AIRS_C
FGAR-AT_N
FGAR-AT_linker
AIRS
Motif
Other DBs
NCBI-GeneID:
5198
NCBI-ProteinID:
NP_036525
OMIM:
602133
HGNC:
8863
Ensembl:
ENSG00000178921
UniProt:
O15067
Q6P4B4
A8K9T9
LinkDB
All DBs
Position
17:8247608..8270486
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AA seq
1338 aa
AA seq
DB search
MSPVLHFYVRPSGHEGAAPGHTRRKLQGKLPELQGVETELCYNVNWTAEALPSAEETKKL
MWLFGCPLLLDDVARESWLLPGSNDLLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVE
TTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSFSPESMPEPLNGPINILGEG
RLALEKANQELGLALDSWDLDFYTKRFQELQRNPSTVEAFDLAQSNSEHSRHWFFKGQLH
VDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQG
LRHVVFTAETHNFPTGVCPFSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGY
NLPWEDPSFQYPGNFARPLEVAIEASNGASDYGNKFGEPVLAGFARSLGLQLPDGQRREW
IKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSVQVQGDNTSDLD
FGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDPAGAIIYTS
RFQLGDPTLNALEIWGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVL
VDDRECPVRRNGQGDAPPTPLPTPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLS
VHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQCVGPLQTPLADVAVVALSHEELIG
AATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPGEGAA
LADACEAMVAVMAALGVAVDGGKDSLSMAARVGTETVRAPGSLVISAYAVCPDITATVTP
DLKHPEGRGHLLYVALSPGQHRLGGTALAQCFSQLGEHPPDLDLPENLVRAFSITQGLLK
DRLLCSGHDVSDGGLVTCLLEMAFAGNCGLQVDVPVPRVDVLSVLFAEEPGLVLEVQEPD
LAQVLKRYRDAGLHCLELGHTGEAGPHAMVRVSVNGAVVLEEPVGELRALWEETSFQLDR
LQAEPRCVAEEERGLRERMGPSYCLPPTFPKASVPREPGGPSPRVAILREEGSNGDREMA
DAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTFHPRAG
AELRRFRKRPDTFSLGVCNGCQLLALLGWVGGDPNEDAAEMGPDSQPARPGLLLRHNLSG
RYESRWASVRVGPGPALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWA
DDDGNPTEQYPLNPNGSPGGVAGICSCDGRHLAVMPHPERAVRPWQWAWRPPPFDTLTTS
PWLQLFINARNWTLEGSC
NT seq
4017 nt
NT seq
+upstream
nt +downstream
nt
atgtccccagtccttcacttctatgttcgtccctctggccatgagggggcagcccctgga
cacactcggaggaaactgcaagggaaactgccagagctgcagggcgtcgagactgaactg
tgctacaacgtgaactggacagctgaggccctccccagtgctgaggagacaaagaagctg
atgtggctgtttggttgccccttactgctggatgatgttgctcgggagtcctggctcctt
cctggctccaatgacctgctgctggaggtcgggcccaggctgaacttctccaccccaaca
tccaccaacatcgtgtcagtgtgccgcgccactgggctggggcctgtggatcgtgtggag
accacccggcgctaccggctctcgtttgcccaccccccgtcagctgaggtggaagccatt
gctctggctaccctgcacgaccggatgacagagcagcacttcccccatcccatccagagt
ttctcccctgagagcatgccggaacccctcaatggccctatcaatatactgggtgagggc
cggcttgcgctggagaaggccaaccaggagcttggtctggctttagactcttgggaccta
gacttctacaccaagcgcttccaggagctacagcggaacccgagcactgtggaggccttt
gacttggcgcagtccaatagcgagcacagccgacactggttcttcaagggccagctccac
gtggatgggcagaagctggtgcactcactgtttgagtccatcatgagcacccaggaatcc
tcgaaccccaacaacgtcctcaaattctgtgataacagcagtgcaatccagggaaaggaa
gtccgattcctacggcctgaggaccccacacggccaagccgcttccagcaacagcaaggg
ctgagacatgttgtcttcacagcagagactcacaactttcccacaggagtatgccccttt
agtggtgcaaccactggcacagggggccggattcgagatgtccagtgcacaggccgcggg
gcccacgtggtggctggcactgccggctattgctttggaaatctgcatattccaggttac
aatctgccctgggaggatccaagcttccagtatcctgggaattttgcccggcccctggag
gttgccattgaagccagtaatggagcttctgactatggcaacaagtttggggaaccagtg
ctggctggcttcgcccgctccttgggcctccagctcccagacggccagcggcgtgagtgg
atcaagcccatcatgtttagtgggggcattgggtccatggaagctgaccacataagcaag
gaggccccagagccaggcatggaagttgtaaaggttggaggtcccgtctacaggattgga
gttggaggtggagctgcttcatctgtgcaggtgcagggagataacaccagtgacctggac
tttggggctgtgcagcgaggagacccggagatggaacagaagatgaaccgtgtgatcagg
gcttgtgtggaggcccccaagggaaaccccatctgcagccttcatgatcagggcgctggt
ggcaatggcaatgtcctaaaagagctgagtgacccagctggagccatcatttacaccagc
cgcttccagcttggggacccaaccctgaatgccctggaaatctggggggctgagtaccag
gaatcaaatgctcttctgctgaggtcccccaaccgggacttcctgactcatgtcagtgcc
cgtgaacgttgcccggcttgcttcgtgggcaccatcactggagaccggagaatagtgctg
gtggacgatcgggagtgtcctgtcagaagaaatggccagggggatgcccccccgacaccc
ctgccaacccctgtggacctggagctcgaatgggtgctgggcaagatgcctcggaaggag
ttcttcctgcagaggaagccccccatgctgcagcctctggccttgcccccagggctgagc
gtgcaccaggctctggagagggttctgaggctgcccgccgtggccagcaagcgctacctc
accaataaggtggaccgctctgtgggaggcctggtggcccagcagcagtgcgtggggccc
ctgcaaactcctctggcagatgtagcggttgtggcactgagccatgaggagctcataggg
gctgccacagccttgggagaacagccagtcaagagcctgctggacccaaaagtcgccgcc
cggctggccgtggccgaagccctcaccaacctggtgtttgctctggtcactgacctccgg
gatgtgaagtgtagcgggaactggatgtgggcagccaagctcccaggggagggcgcagct
ttggcggatgcctgtgaggctatggtggcagtgatggcagccctgggtgtggcagtggat
ggtggcaaggactccctcagcatggctgctcgggttggcactgagaccgtgcgggctcct
gggtcactggtcatctcagcctatgccgtctgcccagacatcacagccactgtgacccca
gacctcaagcatcctgaagggagaggccatctgctctatgtggctctgagccctgggcag
caccggctcgggggcacagctctggcccagtgcttctcccagcttggggaacaccctcca
gacctggaccttcctgagaacttggtgcgggccttcagcatcactcaggggctgctgaaa
gaccgcctcctctgctcaggccacgatgtcagtgacggaggcctcgtcacatgcctgctg
gagatggcctttgctggaaattgcgggctacaggtggatgtgcctgtccccagggttgat
gtcctgtctgtgctgttcgctgaggagccaggcctcgtgctggaggtgcaggagccagac
ctggcccaggtgctgaagcgttaccgggatgctggcctccattgcctggagctgggccac
acaggcgaggccgggccccacgccatggtccgggtgtcagtgaacggggctgtggttctg
gaggagcctgttggggagctgcgagccctctgggaggagacgagtttccagctggaccgg
ctacaggcagagcctcgctgtgtggcagaggaggaacggggcctgagggagcggatgggg
cccagctattgcctgccccccacctttcccaaagcctccgtgccccgtgagcctggtggt
cccagcccccgagtcgccatcttgcgagaggagggcagtaatggagaccgggagatggcc
gatgccttccacttagctgggtttgaggtatgggacgtgaccatgcaggacctctgctct
ggggcaattgggctggacactttccgtggcgtggccttcgtgggcggcttcagctatgca
gatgtcctgggctctgccaaagggtgggcagctgctgtgacctttcatcccagggctggg
gctgagctgaggcgcttccggaagcggccagacaccttcagcctgggcgtgtgtaatggc
tgtcaactgctggctctgctcggctgggtgggaggcgaccccaatgaggatgctgcagag
atgggccctgactcccagccagcccggccaggccttctgctacgccacaacctgtctggg
cgctacgagtctcgctgggccagcgtgcgtgtggggcctgggccagccctgatgctgcga
gggatggagggcgccgtgctgcccgtgtggagtgcgcacggggaaggttacgtagcattt
tcttctccggaactccaagctcagattgaggccaggggcttggctccactgcactgggct
gatgatgacgggaaccccacagagcagtaccctctgaatcccaatgggtccccagggggc
gtggctggcatctgctcctgtgatggccgccacctggctgtcatgcctcaccctgagcgg
gccgttaggccttggcagtgggcatggcgaccccctccatttgatactctgaccacctcc
ccctggctccagctctttatcaatgcccgaaactggaccctggaagggagctgctga
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