Homo sapiens (human): 5209
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Entry
5209 CDS
T01001
Symbol
PFKFB3, IPFK2, PFK2, iPFK-2
Name
(RefSeq) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
KO
K01103
6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:
2.7.1.105
3.1.3.46
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00051
Fructose and mannose metabolism
hsa01100
Metabolic pathways
hsa04066
HIF-1 signaling pathway
hsa04152
AMPK signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00051 Fructose and mannose metabolism
5209 (PFKFB3)
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
5209 (PFKFB3)
04152 AMPK signaling pathway
5209 (PFKFB3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.105 6-phosphofructo-2-kinase
5209 (PFKFB3)
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase
5209 (PFKFB3)
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GFIT
Motif
Pfam:
6PF2K
His_Phos_1
AAA_33
KTI12
AAA_18
Zeta_toxin
DIL
AAA_17
SRP54
Motif
Other DBs
NCBI-GeneID:
5209
NCBI-ProteinID:
NP_004557
OMIM:
605319
HGNC:
8874
Ensembl:
ENSG00000170525
Pharos:
Q16875
(Tchem)
UniProt:
Q16875
Structure
PDB
PDBj
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All DBs
Position
10:6144921..6326637
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AA seq
520 aa
AA seq
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MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
NT seq
1563 nt
NT seq
+upstream
nt +downstream
nt
atgccgttggaactgacgcagagccgagtgcagaagatctgggtgcccgtggaccacagg
ccctcgttgcccagatcctgtgggccaaagctgaccaactcccccaccgtcatcgtcatg
gtgggcctccccgcccggggcaagacctacatctccaagaagctgactcgctacctcaac
tggattggcgtccccacaaaagtgttcaacgtcggggagtatcgccgggaggctgtgaag
cagtacagctcctacaacttcttccgccccgacaatgaggaagccatgaaagtccggaag
caatgtgccttagctgccttgagagatgtcaaaagctacctggcgaaagaagggggacaa
attgcggttttcgatgccaccaatactactagagagaggagacacatgatccttcatttt
gccaaagaaaatgactttaaggcgtttttcatcgagtcggtgtgcgacgaccctacagtt
gtggcctccaatatcatggaagttaaaatctccagcccggattacaaagactgcaactcg
gcagaagccatggacgacttcatgaagaggatcagttgctatgaagccagctaccagccc
ctcgaccccgacaaatgcgacagggacttgtcgctgatcaaggtgattgacgtgggccgg
aggttcctggtgaaccgggtgcaggaccacatccagagccgcatcgtgtactacctgatg
aacatccacgtgcagccgcgtaccatctacctgtgccggcacggcgagaacgagcacaac
ctccagggccgcatcgggggcgactcaggcctgtccagccggggcaagaagtttgccagt
gctctgagcaagttcgtggaggagcagaacctgaaggacctgcgcgtgtggaccagccag
ctgaagagcaccatccagacggccgaggcgctgcggctgccctacgagcagtggaaggcg
ctcaatgagatcgacgcgggcgtctgtgaggagctgacctacgaggagatcagggacacc
taccctgaggagtatgcgctgcgggagcaggacaagtactattaccgctaccccaccggg
gagtcctaccaggacctggtccagcgcttggagccagtgatcatggagctggagcggcag
gagaatgtgctggtcatctgccaccaggccgtcctgcgctgcctgcttgcctacttcctg
gataagagtgcagaggagatgccctacctgaaatgccctcttcacaccgtcctgaaactg
acgcctgtcgcttatggctgccgtgtggaatccatctacctgaacgtggagtccgtctgc
acacaccgggagaggtcagaggatgcaaagaagggacctaacccgctcatgagacgcaat
agtgtcaccccgctagccagccccgaacccaccaaaaagcctcgcatcaacagctttgag
gagcatgtggcctccacctcggccgccctgcccagctgcctgcccccggaggtgcccacg
cagctgcctggacaaaacatgaaaggctcccggagcagcgctgactcctccaggaaacac
tga
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