KEGG   Homo sapiens (human): 5394
Entry
5394              CDS       T01001                                 
Symbol
EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
Name
(RefSeq) exosome complex component 10 isoform 1
  KO
K12591  exosome complex exonuclease RRP6 [EC:3.1.13.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03018  RNA degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    5394 (EXOSC10)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5394 (EXOSC10)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    Exosome cofactors
     5394 (EXOSC10)
SSDB
Motif
Pfam: DNA_pol_A_exo1 PMC2NT HRDC
Other DBs
NCBI-GeneID: 5394
NCBI-ProteinID: NP_001001998
OMIM: 605960
HGNC: 9138
Ensembl: ENSP00000366135.4
UniProt: Q01780
Structure
LinkDB
Position
1:complement(11066618..11099869)
AA seq 885 aa
MAPPSTREPRVLSATSATKSDGEMVLPGFPDADSFVKFALGSVVAVTKASGGLPQFGDEY
DFYRSFPGFQAFCETQGDRLLQCMSRVMQYHGCRSNIKDRSKVTELEDKFDLLVDANDVI
LERVGILLDEASGVNKNQQPVLPAGLQVPKTVVSSWNRKAAEYGKKAKSETFRLLHAKNI
IRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERRERPQDRPEDLDVPPALADF
IHQQRTQQVEQDMFAHPYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVEL
NEKLLNCQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESLTDPA
IVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHLLKLYCNVDSNKQYQ
LADWRIRPLPEEMLSYARDDTHYLLYIYDKMRLEMWERGNGQPVQLQVVWQRSRDICLKK
FIKPIFTDESYLELYRKQKKHLNTQQLTAFQLLFAWRDKTARREDESYGYVLPNHMMLKI
AEELPKEPQGIIACCNPVPPLVRQQINEMHLLIQQAREMPLLKSEVAAGVKKSGPLPSAE
RLENVLFGPHDCSHAPPDGYPIIPTSGSVPVQKQASLFPDEKEDNLLGTTCLIATAVITL
FNEPSAEDSKKGPLTVAQKKAQNIMESFENPFRMFLPSLGHRAPVSQAAKFDPSTKIYEI
SNRWKLAQVQVQKDSKEAVKKKAAEQTAAREQAKEACKAAAEQAISVRQQVVLENAAKKR
ERATSDPRTTEQKQEKKRLKISKKPKDPEPPEKEFTPYDYSQSDFKAFAGNSKSKVSSQF
DPNKQTPSGKKCIAAKKIKQSVGNKSMSFPTGKSDRGFRYNWPQR
NT seq 2658 nt   +upstreamnt  +downstreamnt
atggcgccacccagtacccgggagcccagggtcctgtcggcgaccagcgcaaccaaatcc
gacggagagatggtgctgccaggcttcccggacgccgacagctttgtgaagtttgctctt
gggtccgtggtggcagtcaccaaggcatctgggggcctaccacagtttggcgatgagtat
gatttttaccgaagttttcctggcttccaagcattttgcgaaacacagggagacaggttg
cttcagtgcatgagcagagtaatgcagtaccatgggtgtcgcagcaacattaaggatcga
agtaaagtgactgagctggaagacaagtttgatttactagttgatgccaatgatgtaatt
ctggagagagtgggtattttactggatgaagcctcaggtgtaaacaagaatcaacagcct
gtcctccctgccggcttgcaggtccccaaaacggtagtgtccagctggaaccgtaaggca
gcagaatatggcaaaaaagcaaaatctgaaactttccggctgcttcatgcaaaaaatatc
atccgacctcagctcaagtttcgagagaagattgacaattccaacacaccatttcttcct
aaaatcttcatcaaacccaatgctcagaaacctctccctcaagctctctctaaggaaagg
cgggaacgcccacaggatcgtcctgaggacttggacgtcccccctgcactggctgatttc
atccatcagcagagaacccagcaggttgagcaagacatgtttgcacatccttatcaatat
gaactaaatcactttaccccagcagatgcagtgcttcaaaagccacaaccccagttatac
agacctatagaagagacaccatgccatttcatatcctccctggatgaactcgtggaactc
aacgaaaagctcttgaattgtcaggaatttgcagttgacttggagcaccactcttacagg
agcttcctgggactgacctgcctgatgcaaatttctactcggacggaagacttcatcatt
gacaccctcgagcttcgaagtgacatgtacattctcaatgagagcctcacagacccagcc
atcgttaaggtctttcatggtgctgattcagacatagaatggctacagaaagactttggg
ttgtatgtagtaaacatgtttgatactcatcaggcagcacgccttcttaacctgggcagg
cactcactcgatcatctcctgaaactctactgcaacgtggactcaaacaagcaatatcag
ctggctgattggagaatacgccctctgcccgaggagatgctcagctacgcccgggatgac
acccattacctgctatatatctatgacaaaatgaggctggagatgtgggagcgcggcaac
gggcagccggtgcagctgcaggtggtgtggcaacggagcagggacatctgcctcaagaaa
ttcatcaaacctatcttcacggatgagtcctaccttgaactctataggaagcagaagaag
caccttaacacacagcagttgacagcctttcagctgctgtttgcctggagggataaaaca
gctcgcagggaagatgaaagttacggatatgtactgccaaaccacatgatgctgaaaata
gctgaagaactgcctaaggaacctcagggcatcatagcttgctgcaacccagtaccgccc
cttgtgcggcagcagatcaacgaaatgcaccttttaatccagcaggcccgagagatgccc
ctgctcaagtctgaagttgcagccggagtgaagaagagcggaccgctgcccagtgctgag
agattggagaatgttctctttggacctcacgactgctcccatgcccctccggatggctat
ccaatcatcccaaccagtggatctgtgccagttcagaagcaggcgagcctcttccctgat
gaaaaagaagataacttgctgggtaccacatgcctgattgccacagctgtcatcacgtta
tttaatgaacctagtgctgaagacagtaaaaagggtccattgacagttgcacagaaaaaa
gcccagaacatcatggagtcctttgaaaatccatttaggatgtttctgccctcactggga
caccgtgctcccgtctctcaggcagcgaagttcgatccatcaaccaaaatctatgaaatc
agcaaccgctggaagctggcccaggtacaagtacaaaaagactctaaagaagctgtcaag
aagaaggcagctgagcaaacagctgcccgggaacaggcaaaggaggcgtgcaaagctgca
gcagaacaggccatctccgtccgacagcaggtcgtgctagaaaatgctgcaaagaagaga
gagcgagcaacaagcgacccaaggaccacagaacagaaacaagagaagaaacgactcaaa
atttccaagaagccaaaggacccagagccaccagaaaaagagtttacgccttacgactac
agccagtcagacttcaaggcttttgctggaaacagcaaatccaaagtttcttctcagttt
gatccaaataaacagaccccgtctggcaagaaatgcattgcagccaaaaaaattaaacag
tcggtgggaaacaaaagcatgtcctttccaactggaaagtcagacagaggcttcaggtac
aactggccacagagatag

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