| Entry |
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| Symbol |
POLG, MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG1, POLGA, SANDO, SCAE
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| Name |
(RefSeq) DNA polymerase gamma, catalytic subunit
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| KO |
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| Organism |
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| Pathway |
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| Network |
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| Element |
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| Disease |
| H00469 | Mitochondrial DNA depletion syndrome |
| H01118 | Progressive external ophthalmoplegia |
| H01384 | Mitochondrial recessive ataxia syndrome |
| H01390 | Mitochondrial neurogastrointestinal encephalomyopathy |
| H01395 | Autosomal recessive progressive external ophthalmoplegia |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09124 Replication and repair
03410 Base excision repair
5428 (POLG)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:hsa03032]
5428 (POLG)
03029 Mitochondrial biogenesis [BR:hsa03029]
5428 (POLG)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.7 DNA-directed DNA polymerase
5428 (POLG)
DNA replication proteins [BR:hsa03032]
Eukaryotic type
DNA Replication Elongation Factors
DNA polymerase gamma complex (mitochondrial)
5428 (POLG)
Mitochondrial biogenesis [BR:hsa03029]
Mitochondrial DNA transcription, translation, and replication factors
Mitochondrial DNA replication factors
Mitochondrial DNA polymerase
5428 (POLG)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
15:complement(89316320..89334824)
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| AA seq |
1239 aa
MSRLLWRKVAGATVGPGPVPAPGRWVSSSVPASDPSDGQRRRQQQQQQQQQQQQQPQQPQ
VLSSEGGQLRHNPLDIQMLSRGLHEQIFGQGGEMPGEAAVRRSVEHLQKHGLWGQPAVPL
PDVELRLPPLYGDNLDQHFRLLAQKQSLPYLEAANLLLQAQLPPKPPAWAWAEGWTRYGP
EGEAVPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSQRLVEERYSWTSQLS
PADLIPLEVPTGASSPTQRDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLDTMSMHMA
ISGLSSFQRSLWIAAKQGKHKVQPPTKQGQKSQRKARRGPAISSWDWLDISSVNSLAEVH
RLYVGGPPLEKEPRELFVKGTMKDIRENFQDLMQYCAQDVWATHEVFQQQLPLFLERCPH
PVTLAGMLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDLANDACQLLSGERYK
EDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQ
QDVMARACLQKLKGTTELLPKRPQHLPGHPGWYRKLCPRLDDPAWTPGPSLLSLQMRVTP
KLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGVVCPYRAIESLYRKHC
LEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAAVPGQPLALT
ARGGPKDTQPSYHHGNGPYNDVDIPGCWFFKLPHKDGNSCNVGSPFAKDFLPKMEDGTLQ
AGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRAVIRHPDYDEEGLYGAI
LPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYTLVGADVDSQELWIAA
VLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTATTVGISREHAKIFNYGRIYGAGQP
FAERLLMQFNHRLTQQEAAEKAQQMYAATKGLRWYRLSDEGEWLVRELNLPVDRTEGGWI
SLQDLRKVQRETARKSQWKKWEVVAERAWKGGTESEMFNKLESIATSDIPRTPVLGCCIS
RALEPSAVQEEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYL
VREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDRCLRKEVTMDCKTP
SNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP |
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| NT seq |
3720 nt +upstreamnt +downstreamnt
atgagccgcctgctctggaggaaggtggccggcgccaccgtcgggccagggccggttcca
gctccggggcgctgggtctccagctccgtccccgcgtccgaccccagcgacgggcagcgg
cggcggcagcagcagcagcagcagcagcagcagcagcaacagcagcctcagcagccgcaa
gtgctatcctcggagggcgggcagctgcggcacaacccattggacatccagatgctctcg
agagggctgcacgagcaaatcttcgggcaaggaggggagatgcctggcgaggccgcggtg
cgccgcagcgtcgagcacctgcagaagcacgggctctgggggcagccagccgtgcccttg
cccgacgtggagctgcgcctgccgcccctctacggggacaacctggaccagcacttccgc
ctcctggcccagaagcagagcctgccctacctggaggcggccaacttgctgttgcaggcc
cagctgcccccgaagcccccggcttgggcctgggcggagggctggacccggtacggcccc
gagggggaggccgtacccgtggccatccccgaggagcgggccctggtgttcgacgtggag
gtctgcttggcagagggaacttgccccacattggcggtggccatatccccctcggcctgg
tattcctggtgcagccagcggctggtggaagagcgttactcttggaccagccagctgtcg
ccggctgacctcatccccctggaggtccctactggtgccagcagccccacccagagagac
tggcaggagcagttagtggtggggcacaatgtttcctttgaccgagctcatatcagggag
cagtacctgatccagggttcccgcatgcgtttcctggacaccatgagcatgcacatggcc
atctcagggctaagcagcttccagcgcagtctgtggatagcagccaagcagggcaaacac
aaggtccagccccccacaaagcaaggccagaagtcccagaggaaagccagaagaggccca
gcgatctcatcctgggactggctggacatcagcagtgtcaacagtctggcagaggtgcac
agactttatgtaggggggcctcccttagagaaggagcctcgagaactgtttgtgaagggc
accatgaaggacattcgtgagaacttccaggacctgatgcagtactgtgcccaggacgtg
tgggccacccatgaggttttccagcagcagctaccgctcttcttggagaggtgtccccac
ccagtgactctggccggcatgctggagatgggtgtctcctacctgcctgtcaaccagaac
tgggagcgttacctggcagaggcacagggcacttatgaggagctccagcgggagatgaag
aagtcgttgatggatctggccaatgatgcctgccagctgctctcaggagagaggtacaaa
gaagacccctggctctgggacctggagtgggacctgcaagaatttaagcagaagaaagct
aagaaggtgaagaaggaaccagccacagccagcaagttgcccatcgagggggctggggcc
cctggtgatcccatggatcaggaagacctcggcccctgcagtgaggaggaggagtttcaa
caagatgtcatggcccgcgcctgcttgcagaagctgaaggggaccacagagctcctgccc
aagcggccccagcaccttcctggacaccctggatggtaccggaagctctgcccccggcta
gacgaccctgcatggaccccgggccccagcctcctcagcctgcagatgcgggtcacacct
aaactcatggcacttacctgggatggcttccctctgcactactcagagcgtcatggctgg
ggctacttggtgcctgggcggcgggacaacctggccaagctgccgacaggtaccaccctg
gagtcagctggggtggtctgcccctacagagccatcgagtccctgtacaggaagcactgt
ctcgaacaggggaagcagcagctgatgccccaggaggccggcctggcggaggagttcctg
ctcactgacaatagtgccatatggcaaacggtagaagaactggattacttagaagtggag
gctgaggccaagatggagaacttgcgagctgcagtgccaggtcaacccctagctctgact
gcccgtggtggccccaaggacacccagcccagctatcaccatggcaatggaccttacaac
gacgtggacatccctggctgctggtttttcaagctgcctcacaaggatggtaatagctgt
aatgtgggaagcccctttgccaaggacttcctgcccaagatggaggatggcaccctgcag
gctggcccaggaggtgccagtgggccccgtgctctggaaatcaacaaaatgatttctttc
tggaggaacgcccataaacgtatcagctcccagatggtggtgtggctgcccaggtcagct
ctgccccgtgctgtgatcaggcaccccgactatgatgaggaaggcctctatggggccatc
ctgccccaagtggtgactgccggcaccatcactcgccgggctgtggagcccacatggctc
accgccagcaatgcccggcctgaccgagtaggcagtgagttgaaagccatggtgcaggcc
ccacctggctacacccttgtgggtgctgatgtggactcccaagagctgtggattgcagct
gtgcttggagacgcccactttgccggcatgcatggctgcacagcctttgggtggatgaca
ctgcagggcaggaagagcaggggcactgatctacacagtaagacagccactactgtgggc
atcagccgtgagcatgccaaaatcttcaactacggccgcatctatggtgctgggcagccc
tttgctgagcgcttactaatgcagtttaaccaccggctcacacagcaggaggcagctgag
aaggcccagcagatgtacgctgccaccaagggcctccgctggtatcggctgtcggatgag
ggcgagtggctggtgagggagttgaacctcccagtggacaggactgagggtggctggatt
tccctgcaggatctgcgcaaggtccagagagaaactgcaaggaagtcacagtggaagaag
tgggaggtggttgctgaacgggcatggaaggggggcacagagtcagaaatgttcaataag
cttgagagcattgctacgtctgacataccacgtaccccggtgctgggctgctgcatcagc
cgagccctggagccctcggctgtccaggaagagtttatgaccagccgtgtgaattgggtg
gtacagagctctgctgttgactacttacacctcatgcttgtggccatgaagtggctgttt
gaagagtttgccatagatgggcgcttctgcatcagcatccatgacgaggttcgctacctg
gtgcgggaggaggaccgctaccgcgctgccctggccttgcagatcaccaacctcttgacc
aggtgcatgtttgcctacaagctgggtctgaatgacttgccccagtcagtcgcctttttc
agtgcagtcgatattgaccggtgcctcaggaaggaagtgaccatggattgtaaaacccct
tccaacccaactgggatggaaaggagatacgggattccccagggtgaagcgctggatatt
taccagataattgaactcaccaaaggctccttggaaaaacgaagccagcctggaccatag |
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