Homo sapiens (human): 54464
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Entry
54464 CDS
T01001
Symbol
XRN1, SEP1
Name
(RefSeq) 5'-3' exoribonuclease 1
KO
K12618
5'-3' exoribonuclease 1 [EC:3.1.13.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa03008
Ribosome biogenesis in eukaryotes
hsa03018
RNA degradation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09122 Translation
03008 Ribosome biogenesis in eukaryotes
54464 (XRN1)
09123 Folding, sorting and degradation
03018 RNA degradation
54464 (XRN1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03019 Messenger RNA biogenesis [BR:
hsa03019
]
54464 (XRN1)
03009 Ribosome biogenesis [BR:
hsa03009
]
54464 (XRN1)
03016 Transfer RNA biogenesis [BR:
hsa03016
]
54464 (XRN1)
03036 Chromosome and associated proteins [BR:
hsa03036
]
54464 (XRN1)
Messenger RNA biogenesis [BR:
hsa03019
]
Eukaryotic type
mRNA surveillance and transport factors
mRNA cycle factors
Common to processing body (P body) and stress granule
54464 (XRN1)
mRNA degradation factors
5'-3' decay
5' exonucleases
54464 (XRN1)
Ribosome biogenesis [BR:
hsa03009
]
Eukaryotic type
Pre-60S particles
RNases
54464 (XRN1)
Transfer RNA biogenesis [BR:
hsa03016
]
Eukaryotic type
tRNA degradation factors
Rapid tRNA decay (RTD) pathway factors
54464 (XRN1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Gene silencing
piRNA pathway
54464 (XRN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
XRN_N
XRN_M
XRN1_D2_D3
XRN1_D1
SH3_12
Dicer_dimer
Motif
Other DBs
NCBI-GeneID:
54464
NCBI-ProteinID:
NP_061874
OMIM:
607994
HGNC:
30654
Ensembl:
ENSG00000114127
UniProt:
Q8IZH2
LinkDB
All DBs
Position
3:complement(142306610..142448037)
Genome browser
AA seq
1706 aa
AA seq
DB search
MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKI
FTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGE
TLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHK
IMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCA
PEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHL
HINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKW
FESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDET
EDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWY
YPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSP
IIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLM
CWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFP
TLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWP
HLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEH
YLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFD
SRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDAL
IQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFN
KKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGEN
ENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTV
KPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLF
EVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSS
SSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVL
PQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIEN
FLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQI
ANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVS
TPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALF
ALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTGWDHYGSNYALGAANIMPSSS
HLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFEN
KEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHH
KSTPISSSRRKSRKLAVNFGVSKPSE
NT seq
5121 nt
NT seq
+upstream
nt +downstream
nt
atgggagtccccaagttttacagatggatctcagagcggtatccctgtctcagcgaagtg
gtgaaagagcatcagattcctgaatttgacaacttgtacctggatatgaatggaattata
catcagtgctcccatcctaatgatgatgatgttcactttagaatttcagatgataaaatc
tttactgatatttttcactacctggaggtgttgtttcgcattattaaacccaggaaagtg
ttctttatggctgtagatggtgtggctcctcgagcaaaaatgaaccagcagcgtgggagg
cgttttaggtcagcaaaggaggcagaagacaaaattaaaaaggcaatagagaagggagaa
actcttcctacagaggccagatttgattccaactgtatcacaccaggaactgaatttatg
gccaggttacatgaacatctgaagtattttgtaaatatgaaaatttccacagacaagtca
tggcaaggagttaccatctacttctcaggccatgagactcctggagaaggagagcataaa
atcatggaatttatcagatccgagaaagcaaagccagatcatgatccaaacaccagacac
tgtctttatggtttagatgctgacttgattatgcttggattaacaagtcatgaggcacat
ttttctctcttaagagaagaagttcgatttggtggcaaaaaaacacaacgggtatgtgct
ccagaagaaactacatttcaccttctacacttgtctttaatgagagagtatattgactat
gagttttcagtattaaaagaaaagatcacatttaaatatgatattgaaaggataatagat
gattggattttgatggggtttcttgttggtaatgattttatccctcatctacctcattta
catattaatcatgatgcactgcctcttctttatggaacatatgttaccatcctgccagaa
cttgggggttatattaatgaaagtgggcacctcaacttacctcgatttgagaaatacctt
gtgaaactatcagattttgatcgggagcacttcagtgaagtttttgtggacctaaaatgg
tttgaaagcaaagttggtaacaagtacctcaatgaagcagcaggtgtcgcagcagaagaa
gccaggaactacaaggaaaagaaaaagttaaagggccaggaaaattctctgtgttggact
gctttagacaaaaatgaaggcgaaatgataacttctaaggataatttagaagatgagact
gaagatgatgacctatttgaaactgagtttagacaatataaaagaacatattacatgacg
aagatgggggttgacgtagtatctgatgactttctggctgatcaagctgcatgttatgtt
caggcaatacagtggattttgcactattactatcatggagttcagtcctggagctggtat
tatccttatcattatgcacctttcctgtctgatatacacaacatcagtacactcaaaatc
cattttgaactaggaaaaccttttaagccatttgaacagcttcttgctgtacttccagca
gccagcaaaaatttacttcctgcatgctaccagcatttgatgaccaatgaagactcacca
attatagaatattacccacctgattttaaaactgacctaaatgggaaacaacaggaatgg
gaagctgtggtgttaatcccttttattgatgagaagcgattattggaagccatggagaca
tgtaaccactccctcaaaaaggaagagaggaaaagaaaccaacatagtgagtgcctaatg
tgctggtatgatagagacacagagtttatctatccttctccatggccagaaaagttccct
gccatagaacgatgttgtacaaggtataaaataatatccttagatgcttggcgtgtagac
ataaacaaaaacaaaataaccagaattgaccagaaagcattatatttctgtggatttcct
actctgaaacacatcagacacaaattttttttgaagaaaagtggtgttcaagtattccag
caaagcagtcgtggagaaaacatgatgttggaaatcttagtggatgcagaatcagatgaa
cttaccgtagaaaatgtagcttcatcagtgcttggaaaatctgtctttgttaattggcct
caccttgaggaagctagagtcgtggctgtatcagatggagaaactaagttttacttggaa
gaacctccaggaacacagaagctttattcaggaagaactgccccaccatctaaagtggtt
catcttggagataaagaacaatctaactgggcaaaagaagtacaaggaatttcagaacac
tacctgagaagaaaaggaataataataaatgaaacatctgcagttgtgtatgctcagtta
ctcacaggtcgtaaatatcaaataaatcaaaatggtgaagttcgtctagagaaacagtgg
tcaaaacaagttgttccttttgtttatcaaactattgtcaaggacatccgagctttcgac
tcccgtttctccaatatcaaaacattggatgatttgtttcctctgagaagtatggtcttt
atgctgggaactccctattatggctgcactggagaagttcaggattcaggtgatgtgatt
acagaaggtaggattcgtgtgattttcagcattccatgtgaacccaatcttgatgcttta
atacagaaccagcataaatattctataaagtacaacccaggatatgtgttggccagtcgc
cttggagtgagtggataccttgtttcaaggtttacaggaagtatttttattggaagagga
tctaggagaaaccctcatggagaccataaagcaaatgtgggtttaaatctcaaattcaac
aagaaaaatgaggaggtacctggatatactaagaaagttggaagtgaatggatgtattca
tctgcagcagaacaacttctggcagagtacttagagagagctccagaactatttagttat
atagccaaaaatagccaagaggatgtgttctatgaagatgacatttggcctggagaaaat
gagaatggtgctgaaaaagttcaagaaattattacttggctaaaaggacatcctgtcagt
actttatctcgttcttcttgtgatttacaaattctggatgcagctattgttgagaaaatt
gaggaagaagtcgaaaagtgcaagcaaagaaagaataataagaaggtgcgagtaacagtg
aaaccccatttgctatacagacctttagaacagcaacatggagtcattcctgatcgggat
gcagaattttgtctttttgaccgtgttgtaaatgtgagagaaaacttctcagttccagtt
ggccttcgaggcaccatcataggaataaaaggagctaatagagaagccgatgtactattt
gaagtattatttgatgaagaatttcctggagggttaacaataagatgctcacctggtaga
ggttatcgactgccaacaagtgccttggtgaacctttctcatgggagtcgctctgaaact
ggaaatcagaagttgacagccatcgtaaaaccacaaccagctgtacatcaacatagctca
agttcatcagtttcctctgggcatttgggagccctcaaccattcccctcaatcacttttt
gttcctactcaagtacctactaaagatgatgatgaattctgcaacatttggcagtcctta
cagggatctggaaagatgcaatactttcagccaactatacaagagaagggtgcagttcta
cctcaagaaataagccaagtaaatcaacatcataaatctggctttaatgacaacagtgtt
aaatatcagcaaagaaaacatgaccctcacagaaaatttaaagaagagtgtaagagtcct
aaagctgagtgttggtcccaaaaaatgtccaataagcagcctaactctggaattgagaac
tttttagcatctttgaatatctccaaagaaaatgaagtacagtcatctcatcatggggag
cctccaagtgaagagcatttgtcaccacagtcatttgccatgggaacacggatgcttaaa
gaaattctaaaaattgatggctctaacactgtggaccataagaatgaaatcaaacagatt
gctaatgaaatccctgtttcctctaacagaagagatgaatatggattaccctctcagcct
aaacaaaataagaaattagcatcttatatgaacaagcctcacagtgctaatgagtaccat
aatgttcagtctatggacaatatgtgttggcctgcccccagccagatccctcctgtatcc
acaccagtaactgaactttctcgaatttgttcccttgttggaatgccacaacctgatttc
tcctttcttaggatgccacagacaatgaccgtttgccaagtaaaattatctaatggctta
ctggtacatgggccacagtgccactctgaaaatgaagccaaagagaaagctgcacttttt
gctttacaacagttgggctccttaggcatgaatttccctttgccttcacaagtatttgca
aattatccttcagctgtaccacctggaaccattcctccagcctttcccccacctactggc
tgggatcactatggaagcaactatgcattgggggcagctaatataatgccttcgtcgtct
catctctttggctcaatgccatggggaccatcggtgccagttcctgggaagcccttccat
catactttatattctgggaccatgcccatggctgggggaataccagggggtgtgcacaat
cagtttatacctctgcaggttactaaaaaaagggttgcaaacaaaaagaactttgagaat
aaggaagcccagagttctcaagccactccagttcagactagccagccagattcttccaac
attgtcaaagtaagtccacgggagagctcatcagcttctttgaagtcctctccgattgct
caacctgcatcttcttttcaagttgaaactgcctctcaaggccatagtatatctcaccat
aagtcaacaccaatctcttcttcaagaagaaaatcaagaaaactggctgttaattttggt
gtttctaaaccttctgagtaa
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integrated database retrieval system
