Homo sapiens (human): 5607
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Entry
5607 CDS
T01001
Symbol
MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5
Name
(RefSeq) mitogen-activated protein kinase kinase 5
KO
K04463
mitogen-activated protein kinase kinase 5 [EC:
2.7.12.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04540
Gap junction
hsa04722
Neurotrophin signaling pathway
hsa04921
Oxytocin signaling pathway
hsa05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04921 Oxytocin signaling pathway
5607 (MAP2K5)
09156 Nervous system
04722 Neurotrophin signaling pathway
5607 (MAP2K5)
09160 Human Diseases
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
5607 (MAP2K5)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5607 (MAP2K5)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
5607 (MAP2K5)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: STE group
STE7 family
5607 (MAP2K5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
PB1
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Motif
Other DBs
NCBI-GeneID:
5607
NCBI-ProteinID:
NP_660143
OMIM:
602520
HGNC:
6845
Ensembl:
ENSG00000137764
UniProt:
Q13163
Structure
PDB
PDBj
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All DBs
Position
15:67542703..67807114
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AA seq
448 aa
AA seq
DB search
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP
NT seq
1347 nt
NT seq
+upstream
nt +downstream
nt
atgctgtggctagcccttggcccctttcctgccatggagaaccaggtgctggtaattcgc
atcaagatcccaaatagtggcgcggtggactggacagtgcactccgggccgcagttactc
ttcagggatgtgctggatgtgataggccaggttctgcctgaagcaacaactacagcattt
gaatatgaagatgaagatggtgatcgaattacagtgagaagtgatgaggaaatgaaggca
atgctgtcatattattattccacagtaatggaacagcaagtaaatggacagttaatagag
cctctgcagatatttccaagagcctgcaagcctcctggggaacggaacatacatggcctg
aaggtgaatactcgggccggaccctctcaacacagcagcccagcagtctcagattcactt
ccaagcaatagcttaaagaagtcttctgctgaactgaaaaaaatactagccaatggccag
atgaatgaacaagacatacgatatcgggacactcttggtcatggcaacggaggcacagtc
tacaaagcatatcatgtcccgagtgggaaaatattagctgtaaaggtcatactactagat
attacactggaacttcagaagcaaattatgtctgaattggaaattctttataagtgcgat
tcatcatatatcattggattttatggagcattttttgtagaaaacaggatttcaatatgt
acagaattcatggatgggggatctttggatgtatataggaaaatgccagaacatgtcctt
ggaagaattgcagtagcagttgttaaaggccttacttatttgtggagtttaaagatttta
catagagacgtgaagccctccaatatgctagtaaacacaagaggacaggttaagctgtgt
gattttggagttagcactcagctggtgaattctatagccaagacgtatgttggaacaaat
gcttatatggcgcctgaaaggatttcaggggagcagtatggaattcattctgatgtctgg
agcttaggaatctcttttatggagcttgctcttgggaggtttccatatcctcagattcag
aaaaaccagggatctttaatgcctctccagcttctgcagtgcattgttgatgaggattcg
cccgtccttccagttggagagttctcggagccatttgtacatttcatcactcagtgtatg
cgaaaacagccaaaagaaaggccagcacctgaagaattgatgggccacccgttcatcgtg
cagttcaatgatggaaatgccgccgtggtgtccatgtgggtgtgccgggcgctggaggag
aggcggagccagcaggggcccccgtga
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