Homo sapiens (human): 56262
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Entry
56262 CDS
T01001
Symbol
LRRC8A, AGM5, HsLRRC8A, LRRC8, SWELL1
Name
(RefSeq) leucine rich repeat containing 8 VRAC subunit A
KO
K22038
volume-regulated anion channel
Organism
hsa
Homo sapiens (human)
Disease
H00085
Agammaglobulinemias
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
56262 (LRRC8A)
Ion channels [BR:
hsa04040
]
Chloride channels
Chloride channel, volume-regulated (VRAC)
56262 (LRRC8A)
BRITE hierarchy
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Gene cluster
GFIT
Motif
Pfam:
Pannexin_like
LRR_8
LRR_4
LRR_14
LRR_5
LRR_R13L1-DRL21
LRR_1
LRR_9
LRR_At5g56370
LRR_LRWD1
LRR_EndoS
BPD_transp_2
LRR_6
Motif
Other DBs
NCBI-GeneID:
56262
NCBI-ProteinID:
NP_001120716
OMIM:
608360
HGNC:
19027
Ensembl:
ENSG00000136802
UniProt:
Q8IWT6
A8K1C7
Structure
PDB
PDBj
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All DBs
Position
9:128882133..128918039
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AA seq
810 aa
AA seq
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MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV
TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW
FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE
SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA
KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE
SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES
SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL
TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA
AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL
RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR
CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN
LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI
ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK
RSGLVVEEDLFNTLPPEVKERLWRADKEQA
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgattccggtgacagagctccgctactttgcggacacgcagccagcataccggatcctg
aagccgtggtgggatgtgttcacagactacatctctatcgtcatgctgatgattgccgtc
ttcggggggacgctgcaggtcacccaagacaagatgatctgcctgccttgtaagtgggtc
accaaggactcctgcaatgattcgttccggggctgggcagcccctggcccggagcccacc
taccccaactccaccattctgccgacccctgacacgggccccacaggcatcaagtatgac
ctggaccggcaccagtacaactacgtggacgctgtgtgctatgagaaccgactgcactgg
tttgccaagtacttcccctacctggtgcttctgcacacgctcatcttcctggcctgcagc
aacttctggttcaaattcccgcgcaccagctcgaagctggagcactttgtgtctatcctg
ctgaagtgcttcgactcgccctggaccacgagggccctgtcggagacagtggtggaggag
agcgaccccaagccggccttcagcaagatgaatgggtccatggacaaaaagtcatcgacc
gtcagtgaggacgtggaggccaccgtgcccatgctgcagcggaccaagtcacggatcgag
cagggtatcgtggaccgctcagagacgggcgtgctggacaagaaggagggggagcaagcc
aaggcgctgtttgagaaggtgaagaagttccggacccatgtggaggagggggacattgtg
taccgcctctacatgcggcagaccatcatcaaggtgatcaagttcatcctcatcatctgc
tacaccgtctactacgtgcacaacatcaagttcgacgtggactgcaccgtggacattgag
agcctgacgggctaccgcacctaccgctgtgcccaccccctggccacactcttcaagatc
ctggcgtccttctacatcagcctagtcatcttctacggcctcatctgcatgtatacactg
tggtggatgctacggcgctccctcaagaagtactcgtttgagtcgatccgtgaggagagc
agctacagcgacatccccgacgtcaagaacgacttcgccttcatgctgcacctcattgac
caatacgacccgctctactccaagcgcttcgccgtcttcctgtcggaggtgagtgagaac
aagctgcggcagctgaacctcaacaacgagtggacgctggacaagctccggcagcggctc
accaagaacgcgcaggacaagctggagctgcacctgttcatgctcagtggcatccctgac
actgtgtttgacctggtggagctggaggtcctcaagctggagctgatccccgacgtgacc
atcccgcccagcattgcccagctcacgggcctcaaggagctgtggctctaccacacagcg
gccaagattgaagcgcccgcgctggccttcctgcgtgagaacctgcgggcgctgcacatc
aagttcaccgacatcaaggagatcccgctgtggatctatagcctgaagacactggaggag
ctgcacctgacgggcaacctgagcgcggagaacaaccgctacatcgtcatcgacgggctg
cgggagctcaaacgcctcaaggtgctgcggctcaagagcaacctaagcaagctgccacag
gtggtcacagatgtgggcgtgcacctgcagaagctgtccatcaacaatgagggcaccaag
ctcatcgtcctcaacagcctcaagaagatggcgaacctgactgagctggagctgatccgc
tgtgacctggagcgcatcccccactccatcttcagcctccacaacctgcaggagattgac
ctcaaggacaacaacctcaagaccatcgaggagatcatcagcttccagcacctgcaccgc
ctcacctgccttaagctgtggtacaaccacatcgcctacatccccatccagatcggcaac
ctcaccaacctggagcgcctctacctgaaccgcaacaagatcgagaagatccccacccag
ctcttctactgccgcaagctgcgctacctggacctcagccacaacaacctgaccttcctc
cctgccgacatcggcctcctgcagaacctccagaacctagccatcacggccaaccggatc
gagacgctccctccggagctcttccagtgccggaagctgcgggccctgcacctgggcaac
aacgtgctgcagtcactgccctccagggtgggcgagctgaccaacctgacgcagatcgag
ctgcggggcaaccggctggagtgcctgcctgtggagctgggcgagtgcccactgctcaag
cgcagcggcttggtggtggaggaggacctgttcaacacactgccacccgaggtgaaggag
cggctgtggagggctgacaaggagcaggcctga
DBGET
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