Homo sapiens (human): 590
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Entry
590 CDS
T01001
Symbol
BCHE, BCHED, CHE1, CHE2, E1
Name
(RefSeq) butyrylcholinesterase
KO
K01050
cholinesterase [EC:
3.1.1.8
]
Organism
hsa
Homo sapiens (human)
Disease
H02432
Butyrylcholinesterase deficiency
Drug target
Ecothiopate (
DG01131
):
D02193
<US>
Fluostigmine:
D00043
Hexafluronium:
D04435
Ladostigil tartrate:
D03239
Rivastigmine (
DG00984
):
D02558
<US>
D03822
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09190 Not Included in Pathway or Brite
09191 Unclassified: metabolism
99980 Enzymes with EC numbers
590 (BCHE)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.8 cholinesterase
590 (BCHE)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
COesterase
AChE_tetra
BD-FAE
Abhydrolase_3
PBDC1
Motif
Other DBs
NCBI-GeneID:
590
NCBI-ProteinID:
NP_000046
OMIM:
177400
HGNC:
983
Ensembl:
ENSG00000114200
UniProt:
P06276
Structure
PDB
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All DBs
Position
3:complement(165772904..165837423)
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AA seq
602 aa
AA seq
DB search
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
NT seq
1809 nt
NT seq
+upstream
nt +downstream
nt
atgcatagcaaagtcacaatcatatgcatcagatttctcttttggtttcttttgctctgc
atgcttattgggaagtcacatactgaagatgacatcataattgcaacaaagaatggaaaa
gtcagagggatgaacttgacagtttttggtggcacggtaacagcctttcttggaattccc
tatgcacagccacctcttggtagacttcgattcaaaaagccacagtctctgaccaagtgg
tctgatatttggaatgccacaaaatatgcaaattcttgctgtcagaacatagatcaaagt
tttccaggcttccatggatcagagatgtggaacccaaacactgacctcagtgaagactgt
ttatatctaaatgtatggattccagcacctaaaccaaaaaatgccactgtattgatatgg
atttatggtggtggttttcaaactggaacatcatctttacatgtttatgatggcaagttt
ctggctcgggttgaaagagttattgtagtgtcaatgaactatagggtgggtgccctagga
ttcttagctttgccaggaaatcctgaggctccagggaacatgggtttatttgatcaacag
ttggctcttcagtgggttcaaaaaaatatagcagcctttggtggaaatcctaaaagtgta
actctctttggagaaagtgcaggagcagcttcagttagcctgcatttgctttctcctgga
agccattcattgttcaccagagccattctgcaaagtggatcctttaatgctccttgggcg
gtaacatctctttatgaagctaggaacagaacgttgaacttagctaaattgactggttgc
tctagagagaatgagactgaaataatcaagtgtcttagaaataaagatccccaagaaatt
cttctgaatgaagcatttgttgtcccctatgggactcctttgtcagtaaactttggtccg
accgtggatggtgattttctcactgacatgccagacatattacttgaacttggacaattt
aaaaaaacccagattttggtgggtgttaataaagatgaagggacagcttttttagtctat
ggtgctcctggcttcagcaaagataacaatagtatcataactagaaaagaatttcaggaa
ggtttaaaaatattttttccaggagtgagtgagtttggaaaggaatccatcctttttcat
tacacagactgggtagatgatcagagacctgaaaactaccgtgaggccttgggtgatgtt
gttggggattataatttcatatgccctgccttggagttcaccaagaagttctcagaatgg
ggaaataatgcctttttctactattttgaacaccgatcctccaaacttccgtggccagaa
tggatgggagtgatgcatggctatgaaattgaatttgtctttggtttacctctggaaaga
agagataattacacaaaagccgaggaaattttgagtagatccatagtgaaacggtgggca
aattttgcaaaatatgggaatccaaatgagactcagaacaatagcacaagctggcctgtc
ttcaaaagcactgaacaaaaatatctaaccttgaatacagagtcaacaagaataatgacg
aaactacgtgctcaacaatgtcgattctggacatcattttttccaaaagtcttggaaatg
acaggaaatattgatgaagcagaatgggagtggaaagcaggattccatcgctggaacaat
tacatgatggactggaaaaatcaatttaacgattacactagcaagaaagaaagttgtgtg
ggtctctaa
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integrated database retrieval system
